| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Early brain injury (EBI) after rupture of rupture inducing subarachnoid hemorrhage (SAH) is characterized by a severe reduction in cerebral blood flow suggesting alterations on the cerebral small vessels. In this early vascular injury on small vessels after SAH, vasoactive dysfunction via potassium channels is unclear. We investigated whether SAH induced immediate ATP-sensitive potassium (KATP) channels dysfunction in rat experimental SAH model, and free radical scavenger restored KATP channels dysfunction. To investigate the KATP channels function, the activator was applied with or without free radical scavenger. The vasodilatory responses to the activator were attenuated in SAH rats but not saline injection and sham surgery rats. Free radical scavenger-treated arteriolar dilatory response to the activator was partially restored compared with non-treated arteriolar response. KATP channels may inactivate immediately after SAH, and the dysfunction may be induced by free radical.
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