Research Project
Grant-in-Aid for Scientific Research (C)
Recently, we are living in a stressful world. Depression is a big problem. The solution and new therapies for depression is awaited. In this study, we revealed following by the research using depression model rats.1. Neurogenesis in the hippocampus of Wistar Kyoto rats with depression-like behavior is declined.2. Intraventricular transplantation of encapsulated mesenchymal stem cells against Wistar Kyoto rats exerts therapeutic potentials with enhanced neurogenesis.3. The mechanisms underlying the therapeutic potentials contains secretions several trophic factors from the transplanted cells,
今日確立されている治療法によっても難治のうつ病が存在し、新たな治療法が望まれている。本研究はうつ病と神経新生の関係を明らかにし、新たな治療ターゲットを示すだけでなく、うつ病に対する細胞治療の可能性を示している。また、治療効果を有する可能性のある栄養因子や成長因子も明らかになり、治療薬への発展も期待される。さらに、学術的に考えると、単なる骨髄幹細胞移植よりもカプセル化骨髄幹細胞移植の方が治療効果が高く、細胞治療の「ドラッグデリバリーシステム」としての可能性を示したものとも考えられる。
All 2019 2018 2017 2016
All Journal Article (21 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 20 results, Open Access: 6 results) Presentation (63 results) (of which Int'l Joint Research: 4 results) Book (5 results)
Medical Science Digest (MSD)
Volume: 45 Pages: 132-135
Acta Medica Okayama
Volume: 72 Issue: 1 Pages: 73-76
10.18926/AMO/55666
120006398866
https://ousar.lib.okayama-u.ac.jp/55666
Frontiers in Aging Neuroscience
Volume: 10
10.3389/fnagi.2018.00029
Physiology and Biochemistry
Volume: 46 Issue: 1 Pages: 57-68
10.1159/000488409
脳神経外科と漢方
Volume: 4 Pages: 54-56
40021694517
神経外傷
Volume: 41 Pages: 33-35
130007836910
総合リハビリテーション
Volume: 46 Pages: 1029-1032
Geriatric Neurosurgery
Volume: 30 Pages: 47-51
Behavioural Brain Research
Volume: 329 Pages: 148-156
10.1016/j.bbr.2017.04.046
Volume: 71 Issue: 4 Pages: 263-268
10.18926/AMO/55302
120006333873
https://ousar.lib.okayama-u.ac.jp/55302
Brain Circulation
Volume: 3 Pages: 156-162
Volume: 45 Pages: 21-26
脳卒中
Volume: 39 Pages: 396-399
130006099381
脳卒中の外科
Volume: 45 Pages: 476-482
130006267751
Journal of the Neurological Sciences
Volume: 373 Pages: 152-154
10.1016/j.jns.2016.12.040
Exp. Neurol.
Volume: 275 Pages: 220-231
10.1016/j.expneurol.2015.11.003
Global Spine J
Volume: 6 Issue: 4 Pages: 322-328
10.1055/s-0035-1563405
Clin Genet
Volume: 印刷中 Issue: 6 Pages: 739-743
10.1111/cge.12752
J Stroke Cerebrovasc Dis
Volume: 25 Issue: 3 Pages: e25-e27
10.1016/j.jstrokecerebrovasdis.2015.11.029
Neurologia medico-chirurgica
Volume: 56 Issue: 9 Pages: 574-579
10.2176/nmc.oa.2016-0085
130005414926
機能的脳神経外科
Volume: 55 Pages: 50-54