Depression and Neurogenesis
| Project/Area Number |
16K10722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
Yasuhara Takao 岡山大学, 医歯薬学総合研究科, 講師 (50457214)
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| Co-Investigator(Kenkyū-buntansha) |
市川 智継 岡山大学, 医歯薬学総合研究科, 准教授 (10362964)
黒住 和彦 岡山大学, 医歯薬学総合研究科, 准教授 (20509608)
道上 宏之 岡山大学, 中性子医療研究センター, 准教授 (20572499)
亀田 雅博 岡山大学, 医歯薬学総合研究科, 助教 (50586427)
上利 崇 岡山大学, 大学病院, 助教 (60423290)
菱川 朋人 岡山大学, 大学病院, 講師 (60509610)
佐々木 達也 岡山大学, 大学病院, 助教 (80790865)
藤井 謙太郎 岡山大学, 医歯薬学総合研究科, 助教 (40799318)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | うつ症状 / 神経新生 / 神経保護 / 脳梗塞 / 細胞療法 / 電気刺激 |
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| Outline of Final Research Achievements |
Recently, we are living in a stressful world. Depression is a big problem. The solution and new therapies for depression is awaited. In this study, we revealed following by the research using depression model rats.1. Neurogenesis in the hippocampus of Wistar Kyoto rats with depression-like behavior is declined.2. Intraventricular transplantation of encapsulated mesenchymal stem cells against Wistar Kyoto rats exerts therapeutic potentials with enhanced neurogenesis.3. The mechanisms underlying the therapeutic potentials contains secretions several trophic factors from the transplanted cells,
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| Academic Significance and Societal Importance of the Research Achievements |
今日確立されている治療法によっても難治のうつ病が存在し、新たな治療法が望まれている。本研究はうつ病と神経新生の関係を明らかにし、新たな治療ターゲットを示すだけでなく、うつ病に対する細胞治療の可能性を示している。また、治療効果を有する可能性のある栄養因子や成長因子も明らかになり、治療薬への発展も期待される。さらに、学術的に考えると、単なる骨髄幹細胞移植よりもカプセル化骨髄幹細胞移植の方が治療効果が高く、細胞治療の「ドラッグデリバリーシステム」としての可能性を示したものとも考えられる。
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Electrical stimulation enhances migratory ability of transplanted bone marrow stromal cells in a rodent ischemic stroke model2018
Author(s)
Morimoto J , Yasuhara T , Kameda M, Umakoshi M , Kin I , Kuwahara K , Kin K , Okazaki M , Takeuchi H , Sasaki T , Toyoshima A , Tajiri N , Agari T , Borlongan CV , Date I
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Journal Title
Physiology and Biochemistry
Volume: 46
Issue: 1
Pages: 57-68
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis2017
Author(s)
Sato K , Tsunoda K , Yamashita T, Takemoto M , Hishikawa N, Ohta Y , Takahashi T , Nakashima I , Yasuhara T , Date I , Abe K
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Journal Title
Journal of the Neurological Sciences
Volume: 373
Pages: 152-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease.2016
Author(s)
Sasaki, T., Liu, K., Agari, T., Yasuhara, T., Morimoto, J., Okazaki, M., Takeuchi, H., Toyoshima, A., Sasada, S., Shinko, A., Kondo, A., Kameda, M., Miyazaki, I., Asanuma, M., Borlongan, C.V., Nishibori, M. and Date, I.
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Journal Title
Exp. Neurol.
Volume: 275
Pages: 220-231
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Perioperative Management Center (PERIO) for Neurosurgical Patients2016
Author(s)
Yasuhara T, Hishikawa T, Agari T, Kurozumi K, Ichikawa T, Kameda M, Shinko A, Ishida J, Hiramatsu M, Kobayashi M, Matsuoka Y, Sasaki T, Soga Y, Yamanaka R, Ashiwa T, Arioka A, Hashimoto Y, Misaki A, Ishihara Y, Sato M, Morimatsu H, Date I
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Journal Title
Neurologia medico-chirurgica
Volume: 56
Issue: 9
Pages: 574-579
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed / Open Access
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[Presentation] Intracerebral transplantation of mesenchymal stem cells in Wistar Kyoto rat as an animal model of depression2017
Author(s)
Kin K , Yasuhara T , Tomita Y , Umakoshi M , Kuwahara K , Kin I , Morimoto J, Okazaki M , Sasaki T , Kameda M , Tajiri N , Date I
Organizer
NEUROSCIENCE 2017：Society for Neuroscience 47th Annual Meeting
Related Report
Int'l Joint Research
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