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Diagnosis of brain injury and functional prognosis prediction with blood biomarkers in mild traumatic brain injury patients

Research Project

Project/Area Number 16K10725
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionYamaguchi University

Principal Investigator

SUEHIRO Eiichi  山口大学, 医学部附属病院, 助教 (10363110)

Co-Investigator(Kenkyū-buntansha) 鈴木 倫保  山口大学, 大学院医学系研究科, 教授 (80196873)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords軽症頭部外傷 / 血清バイオマーカー / Dダイマー / 組織因子 / 高次脳機能 / 頭部外傷 / バイオマーカー / 凝固線溶障害 / 頭部CT / 頭部CT / 高次脳機能障害
Outline of Final Research Achievements

In this study, the serum values of D-dimer were investigated as blood biomarkers for detection of structural disorder in mild traumatic brain injury without CT scans. The value of D-dimer on admission was significantly higher (19.5 μg/ml vs 1.1μg/ml) in the lesion(+) group. The sensitivity and specificity were 0.91 and 0.90 at a D-dimer cutoff of 1.7 μg/ml. Abnormal findings of higher brain function were not obtained in this study. The examinations between biomarker and function could not be performed. A significant correlation between NSE and D-dimer was seen on admittance. Furthermore, a significant correlation between soluble tissue factor and D-dimer was seen on admittance. The blood level of D-dimer accurately reflected the degree of brain tissue damage indicated by NSE levels. Our data suggest that the release of tissue factor induced by brain tissue damage may activate the coagulation cascade leading to elevation in D-dimer levels.

Academic Significance and Societal Importance of the Research Achievements

頭部外傷における脳損傷の程度を血清D-dimer値の測定にて数値化することが可能となった。また、組織因子による上昇機序を示すことにより信用性も増した。D-dimerの測定は、日本では日常的に可能な検査である。中枢神経領域の診察や画像診断は、非専門医にとっては、苦手意識もあり敬遠されがちである。D-dimerの測定は、非専門医にとっても頭部外傷の診断が容易に可能となるtoolと成り得る。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (28 results)

All 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (5 results)

  • [Journal Article] Probability of Soluble Tissue Factor Release Lead to the Elevation of D-dimer as a Biomarker for Traumatic Brain Injury2019

    • Author(s)
      Suehiro E, Fujiyama Y, Kiyohira M, Motoki Y, Nojima J, Suzuki M.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 2 Pages: 63-67

    • DOI

      10.2176/nmc.oa.2018-0254

    • NAID

      130007595389

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk of deterioration of geriatric traumatic brain injury in patients treated with antithrombotic drugs2019

    • Author(s)
      Suehiro E, Fujiyama Y, Kiyohira M, Haji K, Ishihara H, Nomura S, Suzuki M, the Japan Neurotrauma Data Bank Committee
    • Journal Title

      World Neurosurgery

      Volume: in press Pages: e1221-e1227

    • DOI

      10.1016/j.wneu.2019.04.108

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 連載 日常診療に役立つ"頭部外傷"のminimum essence (4)高齢者頭部外傷治療におけるピットフォール2018

    • Author(s)
      Suehiro E, Suzuki M
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 46 Issue: 12 Pages: 1127-1135

    • DOI

      10.11477/mf.1436203880

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2018-12-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slow rewarming improved the neurological outcomes of prolonged mild therapeutic hypothermia in patients with severe traumatic brain injury and an evacuated hematoma2018

    • Author(s)
      Kaneko T, Fujita M, Yamashita S, Oda Y, Suehiro E, Dohi K, Kasaoka S, Kuroda Y, Kobata H, Maekawa T
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 11630-11630

    • DOI

      10.1038/s41598-018-30119-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mild decrease in heart rate during early phase of targeted temperature management following tachycardia on admission is associated with unfavorable neurological outcomes after severe traumatic brain injury: a post hoc analysis of a multicenter randomized controlled trial2018

    • Author(s)
      Inoue Akihiko、on behalf of the Brain Hypothermia (B-HYPO) Study Group in Japan、Hifumi Toru、Kuroda Yasuhiro、Nishimoto Naoki、Kawakita Kenya、Yamashita Susumu、Oda Yasutaka、Dohi Kenji、Kobata Hitoshi、Suehiro Eiichi、Maekawa Tsuyoshi
    • Journal Title

      Critical Care

      Volume: 22 Issue: 1 Pages: 352-352

    • DOI

      10.1186/s13054-018-2276-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Directions for use of intracranial pressure monitoring in treatment of severe traumatic brain injury using data from the Japan Neurotrauma Data Bank2017

    • Author(s)
      Suehiro E, Fujiyama Y, Koizumi H, Suzuki M
    • Journal Title

      J Neurotrauma

      Volume: 34 Issue: 14 Pages: 2230-2234

    • DOI

      10.1089/neu.2016.4948

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] D-dimer elevation as a blood biomarker for detection of structural disorder in mild traumatic brain injury2017

    • Author(s)
      Sugimoto K, Suehiro E, Shinoyama M, Sadahiro H, Haji K, Fujiyama Y, Kawano R, Nishioka M, Suzuki M
    • Journal Title

      J Neurotrauma

      Volume: 34 Issue: 23 Pages: 3245-3248

    • DOI

      10.1089/neu.2017.5240

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 軽症・中等症頭部外傷への対応2017

    • Author(s)
      末廣栄一、藤山雄一、杉本至健、五島久陽、篠山瑞也、小泉博靖、石原秀行、野村貞宏、鈴木倫保
    • Journal Title

      脳外誌

      Volume: 26 Pages: 178-184

    • NAID

      130006821313

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 救急傷病の画像診断戦略 -頭部外傷-2016

    • Author(s)
      末廣栄一、鈴木倫保
    • Journal Title

      救急医学

      Volume: 40 Pages: 1199-1209

    • Related Report
      2016 Research-status Report
  • [Presentation] 脳神経蘇生と頭蓋内圧管理2019

    • Author(s)
      末廣栄一、藤山雄一、清平美和、土師康平、鈴木倫保
    • Organizer
      第24回日本脳神経外科救急学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 抗血栓薬を服用している頭部外傷患者への中和療法の実状2019

    • Author(s)
      末廣栄一、藤山雄一、清平美和、土師康平、鈴木倫保
    • Organizer
      第42回日本脳神経外傷学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗血栓薬を服用している高齢者頭部外傷への対応2018

    • Author(s)
      末廣栄一、石原秀行、藤山雄一、土師康平、野村貞宏、鈴木倫保
    • Organizer
      第38回日本脳神経外科コングレス総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 抗血栓薬を内服している高齢者頭部外傷の日本におけるリアルワールド2018

    • Author(s)
      末廣栄一、藤山雄一、鈴木倫保
    • Organizer
      第32回日本外傷学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗血栓剤服用者の頭部外傷:日本頭部外傷データバンクから2018

    • Author(s)
      末廣栄一、石原秀行、藤山雄一、清平美和、土師康平、鈴木倫保
    • Organizer
      第27回日本脳ドック学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Management of elderly severe traumatic brain injury patients with anti-thrombotic drugs in Japan2018

    • Author(s)
      Eiichi Suehiro, Yuichi Fujiyama, Miwa Kiyohira, Kouhei Haji, Michiyasu Suzuki
    • Organizer
      NeuroTrauma 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Current status of neurocritical care in patients with traumatic brain injury based on data from the Japan Neurotrauma Data Bank2018

    • Author(s)
      Eiichi Suehiro, Yuichi Fujiyama, Miwa Kiyohira, Kouhei Haji, Michiyasu Suzuki, The Japan Neurotrauma Data Bank Committee
    • Organizer
      NCS 16th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本頭部外傷データバンク プロジェクト2015の概要2018

    • Author(s)
      末廣栄一、藤山雄一、清平美和、土師康平、宮田昭宏、横田裕行、鈴木倫保
    • Organizer
      日本脳神経外科学会 第77回学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢化社会を迎えた日本における頭部外傷診療チーム内のそれぞれの役割2018

    • Author(s)
      末廣栄一、藤山雄一、土師康平、鈴木倫保
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 頭部外傷患者におけるD-dimer値と組織因子値の関係2018

    • Author(s)
      末廣栄一、藤山雄一、清平美和、土師康平、本木由香里、野島順三、鈴木倫保
    • Organizer
      第23回日本脳神経外科救急学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭部単独外傷にて脳損傷のbiomarkerとしてのD-dimer値上昇の機序の検討2018

    • Author(s)
      末廣栄一、藤山雄一、清平美和、土師康平、本木由香里、野島順三、鈴木倫保
    • Organizer
      第41回日本脳神経外傷学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭部外傷(軽・中等症)を伴う多発外傷における高次脳機能評価の重要性2017

    • Author(s)
      末廣栄一、藤山雄一、清平美和、田中信宏、小泉博靖、鈴木倫保
    • Organizer
      第22回日本脳神経外科救急学会
    • Place of Presentation
      かがわ国際会議場(香川県高松市)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Association of released tissue factor with elevated D-dimer as a serum biomarker of traumatic brain injury2017

    • Author(s)
      Eiichi Suehiro, Yuichi Fujiyama, Miwa Kiyohira, Yukari Motoki, Junzo Nojima, Michiyasu Suzuki
    • Organizer
      The 35th Annual Symposium of the National Neurotrauma Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Coagulopathy as serum biomarker can detect structural damage in mild traumatic brain injury2016

    • Author(s)
      Eiichi Suehiro, Kazutaka Sugimoto, Yuichi Fujiyama, Miwa Kiyohira, Hiroyasu Koizumi, Michiyasu Suzuki
    • Organizer
      International conference on recent advances in neurotraumatology (ICRAN)
    • Place of Presentation
      Hotel Tequendama, Bogota, Colombia
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Annual Review 神経2019

    • Author(s)
      末廣栄一、鈴木倫保
    • Total Pages
      330
    • Publisher
      中外医学者
    • ISBN
      9784498328303
    • Related Report
      2018 Annual Research Report
  • [Book] 新NS NOW No.14 脳・脊髄外傷の治療2018

    • Author(s)
      末廣栄一、鈴木倫保
    • Total Pages
      160
    • Publisher
      メジカルビュー社
    • ISBN
      9784758315746
    • Related Report
      2018 Annual Research Report
  • [Book] 老年脳神経外科診療マニュアル2018

    • Author(s)
      末廣栄一、鈴木倫保
    • Total Pages
      255
    • Publisher
      メジカルビュー社
    • ISBN
      9784758318440
    • Related Report
      2017 Research-status Report
  • [Book] 神経外傷診療ガイドブック2017

    • Author(s)
      末廣栄一、鈴木倫保
    • Total Pages
      239
    • Publisher
      メジカルビュー社
    • ISBN
      9784758315609
    • Related Report
      2017 Research-status Report
  • [Book] 頭頚部・体幹のスポーツ外傷2017

    • Author(s)
      末廣栄一、鈴木倫保
    • Total Pages
      211
    • Publisher
      メジカルビュー社
    • ISBN
      9784758315784
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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