Noninvasive biomarker for the assessment for glioma subtype and the response to treeatment
| Project/Area Number |
16K10749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
麦倉 俊司 東北大学, 大学病院, 准教授 (20375017)
前川 正充 東北大学, 大学病院, 助教 (70572882)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経膠腫 / 代謝産物 / 予後予測 / 分子診断 / MR spectroscpopy / 質量分析 / preoperative / molecular / diagnosis / glioma / Glioma / proton MR spectroscopy / バイオマーカー / 悪性神経膠腫 |
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| Outline of Final Research Achievements |
In this study, we evaluated the metabolic product of tumor by a noninvasive or quick method to help a preoperative or intraoperative diagnosis and early prediction of response to treatment. To this end, we established a rapid method to evaluate the metabolic product in vivo and with 1H-MR spectroscopy and mass spectrometry. We found the metabolic products for prediction of the prognosis and the molecular diagnosis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により術前や術中の遺伝子診断につながる簡便な方法が確立された。また遺伝子異常の予測が可能となる代謝産物が同定された。今後、神経膠腫に限らず、網羅的な代謝産物の解析がすすむことが予測され、代謝産物による予後予測や腫瘍のサブタイプの診断が可能となることを示すことができたことが本研究と意義と考える。
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Rapid detection of mutation in isocitrate dehydrogenase 1 and 2 genes using mass spectrometry.2018
Author(s)
Kanamori M, Maekawa M, Shibahara I, Saito R, Chonan M, Shimada M, Sonoda Y, Kumabe T, Watanabe M, Mano N, Tominaga T.
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Journal Title
Brain Tumor Pathol
Volume: 35
Issue: 2
Pages: 90-96
DOI
Related Report
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