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Establishment of new immunotherapy targeting malignant glioma stem cell marker ALCAM

Research Project

Project/Area Number 16K10755
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

Fujimoto Yasunori  大阪大学, 医学系研究科, 招へい准教授 (80589789)

Co-Investigator(Kenkyū-buntansha) 阿知波 孝宗  大阪大学, 医学系研究科, 特任研究員 (00771908)
福永 貴典  大阪大学, 医学系研究科, 招へい教員 (30745005)
香川 尚己  大阪大学, 医学系研究科, 講師 (50444542)
福屋 章悟  大阪大学, 医学部附属病院, 医員 (50726502)
有田 英之  大阪大学, 医学系研究科, 招へい教員 (60570570)
永野 大輔  大阪大学, 医学部附属病院, 医員 (70726520)
木嶋 教行  大阪大学, 医学系研究科, 特任助教 (80534627)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsALCAM / CD6 / グリオーマ / 膠芽腫 / 髄芽腫 / 免疫療法 / CD166 / 悪性グリオーマ / 悪性グリオーマ幹細胞
Outline of Final Research Achievements

In this study, we investigated the role of ALCAM (Activated leukocyte cell adhesion molecule), a novel marker of malignant glioma stem cells, in tumor immune response. Furthermore, for further research on ALCAM, we analyzed ALCAM expression and function in childhood malignant glioma medulloblastoma.
As a study of CD6, which is a ligand of ALCAM, we confirmed CD6-positive T cells were present in glioblastoma intratumoral lymphocytes by immunostaining. We revealed that ALCAM expression showed a strong significant correlation to molecular subgroups in medulloblastoma. In addition, functional analysis using a medulloblastoma cell line showed that ALCAM expression was associated with cell proliferation.

Academic Significance and Societal Importance of the Research Achievements

本研究により悪性グリオーマにおけるALCAMの腫瘍免疫の関与について端緒を得ることができた。未だに有効な治療法が不十分である悪性グリオーマに対して、免疫療法の可能性について更なる追求が必要である。又、小児悪性グリオーマである髄芽腫でのALCAMの発現及び機能解析の結果については新しい知見であり、本研究の成果について社会に還元をするため現在国際誌に投稿し、査読・修正中である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (32 results)

All 2019 2018 2017 2016

All Journal Article (17 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 16 results,  Open Access: 10 results) Presentation (15 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Differentiating between Glioblastoma and Primary CNS Lymphoma Using Combined Whole-tumor Histogram Analysis of the Normalized Cerebral Blood Volume and the Apparent Diffusion Coefficient2019

    • Author(s)
      Bao Shixing、Watanabe Yoshiyuki、Takahashi Hiroto、Tanaka Hisashi、Arisawa Atsuko、Matsuo Chisato、Wu Rongli、Fujimoto Yasunori、Tomiyama Noriyuki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 1 Pages: 53-61

    • DOI

      10.2463/mrms.mp.2017-0135

    • NAID

      130007555061

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts2019

    • Author(s)
      Umehara Toru、Arita Hideyuki、Yoshioka Ema、Shofuda Tomoko、Kanematsu Daisuke、Kinoshita Manabu、Kodama Yoshinori、Mano Masayuki、Kagawa Naoki、Fujimoto Yasunori、Okita Yoshiko、Nonaka Masahiro、Nakajo Kosuke、Uda Takehiro、Tsuyuguchi Naohiro、Fukai Junya、Fujita Koji、Kishima Haruhiko、Kanemura Yonehiro et al.
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Issue: 1 Pages: 131-131

    • DOI

      10.1186/s40478-019-0749-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of magnetic resonance imaging-based automatic high-grade glioma segmentation accuracy via 11C-methionine positron emission tomography2019

    • Author(s)
      Ozaki Tomohiko、Kinoshita Manabu、Arita Hideyuki、Kagawa Naoki、Fujimoto Yasunori、Kanemura Yonehiro、Sakai Mio、Watanabe Yoshiyuki、Nakanishi Katsuyuki、Shimosegawa Eku、Hatazawa Jun、Kishima Haruhiko
    • Journal Title

      Oncology Letters

      Volume: 18 Pages: 4074-4081

    • DOI

      10.3892/ol.2019.10734

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors2018

    • Author(s)
      Eino Daisuke、Tsukada Yohei、Naito Hisamichi、Kanemura Yonehiro、Iba Tomohiro、Wakabayashi Taku、Muramatsu Fumitaka、Kidoya Hiroyasu、Arita Hideyuki、Kagawa Naoki、Fujimoto Yasunori、Takara Kazuhiro、Kishima Haruhiko、Takakura Nobuyuki
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 23 Pages: 6607-6620

    • DOI

      10.1158/0008-5472.can-18-0498

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas2018

    • Author(s)
      Arita Hideyuki、Kinoshita Manabu、Kawaguchi Atsushi、Takahashi Masamichi、Narita Yoshitaka、Terakawa Yuzo、Tsuyuguchi Naohiro、Okita Yoshiko、Nonaka Masahiro、Moriuchi Shusuke、Takagaki Masatoshi、Fujimoto Yasunori、et al.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11773-11773

    • DOI

      10.1038/s41598-018-30273-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of region-of-interest designs on quantitative measurement of multimodal imaging of MR non-enhancing gliomas2018

    • Author(s)
      Takano Koji、Kinoshita Manabu、Arita Hideyuki、Okita Yoshiko、Chiba Yasuyoshi、Kagawa Naoki、Watanabe Yoshiyuki、Shimosegawa Eku、Hatazawa Jun、Hashimoto Naoya、Fujimoto Yasunori、Kishima Haruhiko
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 7934-7940

    • DOI

      10.3892/ol.2018.8319

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small Hyperintensities in the Area of the Perforating Arteries in Patients with Seizure2018

    • Author(s)
      Izutsu Nobuyuki、Fujimoto Yasunori、Yamada Naoaki、Kajikawa Ryuichiro、Yoshimura Kazuhiro、Nagashima Munenori、Wakayama Akatsuki、Yoshimine Toshiki
    • Journal Title

      European Neurology

      Volume: 79 Issue: 3-4 Pages: 221-227

    • DOI

      10.1159/000488673

    • Related Report
      2018 Research-status Report
  • [Journal Article] Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report.2017

    • Author(s)
      Takagaki M, Kinoshita M, Nishino K, Nakano M, Adachi H, Ueno M, Kitamura M, Fujimoto Y, Tashiro K, Tomita Y, Imamura F, Yoshimine T.
    • Journal Title

      Oncol. Lett.

      Volume: 13 Issue: 4 Pages: 2085-2088

    • DOI

      10.3892/ol.2017.5677

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voxel-Based Lesion Mapping of Cryptogenic Stroke in Patients with Advanced Cancer: A Detailed Magnetic Resonance Imaging Analysis of Distribution Pattern2017

    • Author(s)
      Achiha T, Takagaki M, Oe H, Sakai M, Matsui H, Nakanishi K, Ozaki T, Fujimoto Y, Yoshimine T, Nakanishi K, Kinoshita M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub ahead of print Issue: 7 Pages: 1521-1527

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.02.038

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Voxel-based lesion mapping of meningioma: a comprehensive lesion location mapping of 260 lesions2017

    • Author(s)
      Hirayama Ryuichi、Kinoshita Manabu、Arita Hideyuki、Kagawa Naoki、Kishima Haruhiko、Hashimoto Naoya、Fujimoto Yasunori、Yoshimine Toshiki
    • Journal Title

      Journal of Neurosurgery

      Volume: ― Issue: 6 Pages: 1-6

    • DOI

      10.3171/2017.3.jns17169

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vessel-Masked Perfusion Magnetic Resonance Imaging With Histogram Analysis Improves Diagnostic Accuracy for the Grading of Glioma.2017

    • Author(s)
      Arisawa A, Watanabe Y, Tanaka H, Takahashi H, Matsuo C, Fujiwara T, Fujimoto Y, Yamamoto K, Tomiyama N
    • Journal Title

      Journal Of Computer Assisted Tomography

      Volume: 41 Issue: 6 Pages: 910-915

    • DOI

      10.1097/rct.0000000000000614

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Whole-tumor histogram analysis of the cerebral blood volume map: tumor volume defined by 11C-methionine positron emission tomography image improves the diagnostic accuracy of cerebral glioma grading2017

    • Author(s)
      Wu Rongli、Watanabe Yoshiyuki、Arisawa Atsuko、Takahashi Hiroto、Tanaka Hisashi、Fujimoto Yasunori、Watabe Tadashi、Isohashi Kayako、Hatazawa Jun、Tomiyama Noriyuki
    • Journal Title

      Japanese Journal of Radiology

      Volume: 35 Issue: 10 Pages: 613-621

    • DOI

      10.1007/s11604-017-0675-2

    • NAID

      50012797148

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enchondromatosis-associated oligodendroglioma: case report and literature review2017

    • Author(s)
      Achiha Takamune、Arita Hideyuki、Kagawa Naoki、Murase Tsuyoshi、Ikeda Jun-ichiro、Morii Eiichi、Kanemura Yonehiro、Fujimoto Yasunori、Kishima Haruhiko
    • Journal Title

      Brain Tumor Pathology

      Volume: 35 Issue: 1 Pages: 36-40

    • DOI

      10.1007/s10014-017-0303-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心原性脳塞栓二次予防における経口抗凝固薬の選択行動2016

    • Author(s)
      藤本康倫、梶川隆一郎、井筒伸之、平山龍一、永島宗紀、芳村憲泰、中村洋平、久村英嗣、若山暁、吉峰俊樹
    • Journal Title

      脳卒中

      Volume: 38 Pages: 239-244

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 内視鏡下経鼻手術における鼻副鼻腔機能の温存2016

    • Author(s)
      藤本康倫、端山昌樹、吉峰俊樹
    • Journal Title

      脳神経外科

      Volume: 44 Pages: 1009-1017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decompressive Craniectomy in Conjunction with Evacuation of Intracranial Hemorrhagic Lesions is Associated with Worse Outcomes in Elderly Patients with Traumatic Brain Injury2016

    • Author(s)
      Kinoshita T, Yoshiya K, Fujimoto Y, Kajikawa R, Kiguchi T, Hara M, Wakayama A, Yoshimine T
    • Journal Title

      A Propensity Score Analysis. World Neurosurgery

      Volume: 89 Pages: 187-192

    • DOI

      10.1016/j.wneu.2016.01.071

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.2016

    • Author(s)
      Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T
    • Journal Title

      J Neurosurg

      Volume: 印刷中 Issue: 5 Pages: 1136-1142

    • DOI

      10.3171/2015.11.jns151848

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 藤本康倫, 大西諭一郎, 端山昌樹, 北口善之, 中島伸彦, 貴島晴彦2019

    • Author(s)
      下内側型眼窩内海綿状血管腫に対して内視鏡下経鼻手術を行った2例
    • Organizer
      第31回日本頭蓋底外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 藤本康倫2019

    • Author(s)
      内視鏡下経鼻手術における止血-フロシールを中心に-
    • Organizer
      第31回日本頭蓋底外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Activated Leukocyte Cell Adhesion Molecule(ALCAM)の髄芽腫WNT subgroupにおける発現と浸潤性への関与2018

    • Author(s)
      阿知波孝宗、木嶋教行、児玉良典、香川尚己、藤本康倫、埜中正博、西田南海子、山中巧、原田敦子、森鑑二、深井順也、露口尚弘、宇田武弘、石橋謙一、友金祐介、阪本大輔、正札智子、吉岡絵麻、兼松大介、眞能正幸、Betty Luu、Michael Taylor、金村米博、貴島晴彦
    • Organizer
      第36回日本脳腫瘍学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Expression and functional analysis of the CD166/activated leukocyte cell adhesion molecule (ALCAM) in medulloblastoma2018

    • Author(s)
      Takamune Achiha, Noriyuki Kijima, Naoki Kagawa, Chisato Yokota, Yasunori Fujimoto, Haruhiko Kishima
    • Organizer
      18th International Symposium on Pediatric Neuro-Oncology (ISPNO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 髄膜腫に対する術前塞栓術の有用性とASL-MR灌流画像評価2017

    • Author(s)
      藤本康倫、浅井 克則、西田武生、中村元、福永貴典、渡邉嘉之、木下学、梅原徹、有田英之、香川尚己、貴島晴彦
    • Organizer
      第22回日本脳腫瘍の外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 内視鏡下経鼻手術におけるtwo-surgeon technique: 耳鼻咽喉科医からの学び2017

    • Author(s)
      藤本康倫、端山昌樹、Henrique Ramos, Pedro Mariani, 有田英之、香川尚己、貴島晴彦
    • Organizer
      第76回日本脳神経外科学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 再発膠芽腫の診療における臨床試験の影響2017

    • Author(s)
      藤本康倫、福屋章悟、有田英之、香川尚己、梅原徹、阿知波孝宗、横田千里、福永貴典、永野大輔、貴島晴彦
    • Organizer
      第35回日本脳腫瘍学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 髄芽腫におけるCD166/ALCAM発現の検討2017

    • Author(s)
      阿知波孝宗、木嶋教行、横田千里、福永貴典、永野大輔、有田英之、香川尚己、藤本康倫、貴島晴彦
    • Organizer
      第76回日本脳神経外科学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 髄膜腫に対するSRS後の嚢胞開窓術の経験:嚢胞内のarachnoid trabeculaの切断について2016

    • Author(s)
      藤本康倫、横田千里、有田英之、香川尚己
    • Organizer
      第16回新都心神経内視鏡症例検討会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 髄膜腫に対する術前塞栓術の画像評価と腫瘍摘出術における有用性2016

    • Author(s)
      藤本康倫、浅井 克則、中村元、西田武生、 渡邉嘉之、 木下学、有田英之、香川尚己、吉峰俊樹
    • Organizer
      第21回日本脳腫瘍の外科学会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 内視鏡下経鼻手術におけるpitfallと術後合併症への対策2016

    • Author(s)
      藤本康倫、端山昌樹、Aldo Stamm、Pedro Mariani、吉峰俊樹
    • Organizer
      日本脳神経外科学会第75回学術総会
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
  • [Presentation] 鼻副鼻腔機能を考慮した内視鏡下経鼻手術2016

    • Author(s)
      藤本康倫、端山昌樹、Pedro Mariani、有田英之、香川尚己、吉峰俊樹
    • Organizer
      第23回日本神経内視鏡学会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] テモゾロミドに関連する感染症の予防と問題点2016

    • Author(s)
      藤本康倫、香川尚己、有田英之、福屋章悟、永野大輔、福永貴典、横田千里、阿知波孝宗、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍学会
    • Place of Presentation
      山梨(甲府市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 経鼻内視鏡手術におけるCoblatorの有用性2016

    • Author(s)
      藤本康倫、識名崇、端山昌樹、有田英之、香川直己、吉峰俊樹
    • Organizer
      第21回関西脳神経外科手術研究会
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report
  • [Presentation] Endoscopic triportal approach for extracarnial trigeminal schwannomas2016

    • Author(s)
      Yasunori Fujimoto, Takashi Shikina, Masaki Hayama, Henrique F. Ramos, Hidenori Inohara, Toshiki Yoshimine
    • Organizer
      7th International Congress of the World Federation of Skull Base Societies
    • Place of Presentation
      Osaka,JAPAN
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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