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Prediction of VEGF inhibitor effect for malignant brain tumor

Research Project

Project/Area Number 16K10757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionHiroshima University

Principal Investigator

Yamasaki Fumiyuki  広島大学, 病院(医), 講師 (60444692)

Co-Investigator(Kenkyū-buntansha) 杉山 一彦  広島大学, 病院(医), 教授 (30243554)
栗栖 薫  広島大学, 医歯薬保健学研究科(医), 教授 (70201473)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsglioblastoma / brain metastasis / tumefactive lesion / brain abscess / histogram analysis / VEGF / radiomics / radiogenomics / germinoma / advanced MR imaging / glioma / bevacizumab / brain metastases / malignant lymphoma / hemangioblastoma / cystic malacia / 脳神経疾患 / 癌 / 治療効果予測 / MRI
Outline of Final Research Achievements

The presence of a nonenhancing peritumoral DWI high lesion (DNePDHL) was observed in 25% of glioblastoma patients, while it was conspicuously absent in patients with malignant lymphoma and metastatic brain tumors. Patients with DNePDHL had significantly early local (p=0.0467) and distant/dissemination recurrence (p<0.0001) and poor prognosis (p=0.0007). Histogram profile analysis also help for differential diagnosis of glioblastoma from other intracranial ring enhanced lesions. Evaluating ADC-MIN at b-4000 would be a useful tool for distinguishing posterior fossa tumors in both pediatric and adult patients. Lower ADC values and high lipid peaks detected on 1H-MRS are characteristics of germinomas.
The pathogenesis of multicentric gliomas is different from the mutant IDH1-R132H pathway. The expression of EZH2 is not associated with the PRC2 pathway and increases in patients with H3K27M-mutant diffuse midline glioma and a poor prognosis.

Academic Significance and Societal Importance of the Research Achievements

悪性脳腫瘍の術前診断は、手術において生検術を選択すべきか摘出術を選択すべきか、または手術ではなく放射線治療を選択すべきか、化学療法を選択すべきか、これらの意思決定に重要な役割を担っている。すなわち、悪性脳腫瘍の診断精度の向上は臨床上極めて意義が高く、学術的、社会的意義が大きいと言える。今回、膠芽腫の正確な診断法、予後推定法と、成人及び小児の後頭蓋窩腫瘍の鑑別診断法を確立したことと、germinomaの新規診断法を確立したことの医学的意義は極めて大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (82 results)

All 2019 2018 2017 2016

All Journal Article (29 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 29 results,  Open Access: 4 results,  Acknowledgement Compliant: 5 results) Presentation (53 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results)

  • [Journal Article] Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the &quot;Target Sign&quot;2019

    • Author(s)
      Ueno H, Norose K, Kamimura T, Mihara K, Yamasaki F, Hikosaka K, J Amatya V, Takeshima Y, Kurisu K, Maruyama H
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 8 Pages: 1157-1162

    • DOI

      10.2169/internalmedicine.1156-18

    • NAID

      130007632763

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-04-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increase enhancer of zeste homolog 2 (EZH2) immunostaining expression in diffuse midline glioma H3K27M-mutant patient with poor survival2019

    • Author(s)
      Karlowee V, Amatya VJ, Takayasu T, Takano M, Yonezawa U, Takeshima Y, Sugiyama K, Kurisu K, Yamasaki F
    • Journal Title

      Pathobiology

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optic pathway/hypothalamic gliomaに対するビンブラスチン治療 ~2症例報告~2019

    • Author(s)
      山崎文之、高野元気、米澤 潮、田口 慧、高安 武志、杉山 一彦、栗栖 薫
    • Journal Title

      脳神経外科

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative Evaluation of Angioscopy and Intravascular Ultrasound for Assessing Plaque Protrusion During Carotid Artery Stenting Procedures.2019

    • Author(s)
      Kondo H, Kiura Y, Sakamoto S, Okazaki T, Yamasaki F, Iida K, Tominaga A, Kurisu K.
    • Journal Title

      World Neurosurg.

      Volume: Epub ahead of print Pages: e448-e455

    • DOI

      10.1016/j.wneu.2019.01.102

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abscess Formation in Metastatic Brain Tumor with History of Immune Checkpoint Inhibitor: A Case Report2019

    • Author(s)
      Takayasu Takeshi、Yamasaki Fumiyuki、Shishido Takeo、Takano Motoki、Maruyama Hirofumi、Sugiyama Kazuhiko、Kurisu Kaoru
    • Journal Title

      NMC Case Report Journal

      Volume: 6 Issue: 1 Pages: 11-15

    • DOI

      10.2176/nmccrj.cr.2018-0126

    • NAID

      130007542572

    • ISSN
      2188-4226
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.2018

    • Author(s)
      Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M.
    • Journal Title

      Neuro Oncol.

      Volume: 21 Issue: 3 Pages: 348-359

    • DOI

      10.1093/neuonc/noy200

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiologic pituitary hyperplasia causing visual disturbance during adolescence.2018

    • Author(s)
      Kinoshita Y, Yamasaki F, Tominaga A, Usui S, Kurisu K.
    • Journal Title

      J Clin Neurosci.

      Volume: 61 Pages: 279-281

    • DOI

      10.1016/j.jocn.2018.11.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perfusion computed tomography parameters are useful for differentiating glioblastoma, lymphoma, and metastasis.2018

    • Author(s)
      Onishi S, Kajiwara Y, Takayasu T, Kolakshyapati M, Ishifuro M, Amatya VJ, Takeshima Y, Sugiyama K, Kurisu K, Yamasaki F.
    • Journal Title

      World Neurosurg.

      Volume: 119 Pages: e890-e897

    • DOI

      10.1016/j.wneu.2018.07.291

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved differentiation between high- and low-grade gliomas by combining dual-energy CT analysis and perfusion CT.2018

    • Author(s)
      Kaichi Y, Tatsugami F, Nakamura Y, Baba Y, Iida M, Higaki 1, Kiguchi M, Tsushima S, Yamasaki F, Amatya VJ, Takeshima Y, Kurisu K, Awai K.
    • Journal Title

      Medicine (Baltimore)

      Volume: 97 Issue: 32 Pages: e11670-e11670

    • DOI

      10.1097/md.0000000000011670

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantages of high b-value diffusion-weighted imaging for preoperative differential diagnosis between embryonal and ependymal tumors at 3T MRI.2018

    • Author(s)
      Takayasu T, Yamasaki F, Akiyama Y, Ohtaki M, Saito T, Nosaka R, Takano M, Sugiyama K, Kurisu K.
    • Journal Title

      Eur J Radiol.

      Volume: 101 Pages: 136-143

    • DOI

      10.1016/j.ejrad.2018.02.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proton Magnetic Resonance Spectroscopy Detection of High Lipid Levels and Low Apparent Diffusion Coefficient Is Characteristic of Germinomas.2018

    • Author(s)
      Yamasaki F, Kinoshita Y, Takayasu T, Usui S, Kolakshyapati M, Takano M, Tsuyuguchi S, Amatya VJ, Akiyama Y, Takeshima Y, Sugiyama K, Kurisu K.
    • Journal Title

      World Neurosurg.

      Volume: 112 Pages: e84-e94

    • DOI

      10.1016/j.wneu.2017.12.078

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging.2018

    • Author(s)
      Onishi S, Yamasaki F, Nakano Y, Takayasu T, Amatya VJ, Kolakshyapati M, Takeshima Y, Hirose T, Ichimura K, Sugiyama K, Kurisu K.
    • Journal Title

      Brain Tumor Pathol.

      Volume: 35 Issue: 1 Pages: 41-45

    • DOI

      10.1007/s10014-017-0301-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients.2018

    • Author(s)
      Saito T, Sugiyama K, Hama S, Yamasaki F, Takayasu T, Nosaka R, Muragaki Y, Kawamata T, Kurisu K.
    • Journal Title

      Neurosurg Rev.

      Volume: 41 Issue: 2 Pages: 621-628

    • DOI

      10.1007/s10143-017-0903-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack2017

    • Author(s)
      Yoshida Y, Wang H, Hiwasa T, Machida T, Takiguchi M, Iwadate Y, et al.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 3 Pages: 8836-8848

    • DOI

      10.1007/s11060-018-2831-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Review of Current Evidence Regarding Surgery in Elderly Patients with Meningioma2017

    • Author(s)
      Ikawa F, Kinoshita Y, Takeda M, Saito T, Yamaguchi S, Yamasaki F, Iida K, Sugiyama K, Arita K, Kurisu K.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 57 Issue: 10 Pages: 521-533

    • DOI

      10.2176/nmc.ra.2017-0011

    • NAID

      130006882480

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pitfalls of Neuroendoscopic Biopsy of Intraventricular Germ Cell Tumors.2017

    • Author(s)
      Kinoshita Y, Yamasaki F, Tominaga A, Saito T, Sakoguchi T, Takayasu T, Usui S, Sugiyama K, Arita K, Kurisu K.
    • Journal Title

      World Neurosurg.

      Volume: 106 Pages: 430-434

    • DOI

      10.1016/j.wneu.2017.07.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role for loss of nuclear PTEN in a harbinger of brain metastases.2017

    • Author(s)
      Nosaka R, Yamasaki F, Saito T, Takayasu T, Kolakshyapati M, Amatya VJ, Takeshima Y, Sugiyama K, Kurisu K.
    • Journal Title

      J Clin Neurosci.

      Volume: 44 Pages: 148-154

    • DOI

      10.1016/j.jocn.2017.06.004

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas.2017

    • Author(s)
      Saito T, Sugiyama K, Hama S, Yamasaki F, Takayasu T, Nosaka R, Onishi S, Muragaki Y, Kawamata T, Kurisu K.
    • Journal Title

      World Neurosurg.

      Volume: 105 Pages: 282-288

    • DOI

      10.1016/j.wneu.2017.05.165

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide.2017

    • Author(s)
      Saito T, Sugiyama K, Takeshima Y, Amatya VJ, Yamasaki F, Takayasu T, Nosaka R, Muragaki Y, Kawamata T, Kurisu K.
    • Journal Title

      Journal of Neurosurgery

      Volume: 印刷中 Issue: 3 Pages: 679-684

    • DOI

      10.3171/2016.11.jns162326

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple's disease: a case report and literature review.2017

    • Author(s)
      Karlowee V, Kolakshyapati M, Amatya VJ, Takayasu T, Nosaka R, Sugiyama K, Kurisu K, Yamasaki F.
    • Journal Title

      Child's Nervous System

      Volume: 印刷中 Issue: 8 Pages: 1411-1414

    • DOI

      10.1007/s00381-017-3405-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up.2017

    • Author(s)
      Yamasaki F, Takayasu T, Nosaka R, Nishibuchi I, Kawaguchi H, Kolakshyapati M, Onishi S, Saito T, Sugiyama K, Kobayashi M, Kurisu K.
    • Journal Title

      Child's Nervous System

      Volume: 印刷中 Issue: 6 Pages: 957-964

    • DOI

      10.1007/s00381-017-3400-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nonenhancing peritumoral hyperintense lesion on diffusion-weighted imaging in glioblastoma: a novel diagnostic and specific prognostic indicator.2017

    • Author(s)
      Kolakshyapati M, Adhikari RB, Karlowee V, Takayasu T, Nosaka R, Amatya VJ, Takeshima Y, Akiyama Y, Sugiyama K, Kurisu K, Yamasaki F.
    • Journal Title

      Journal of Neurosurgery

      Volume: 印刷中 Issue: 3 Pages: 667-678

    • DOI

      10.3171/2016.10.jns161694

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Advantage of high b value diffusion-weighted imaging for differentiation of hemangioblastoma from brain metastases in posterior fossa.2017

    • Author(s)
      Onishi S, Hirose T, Takayasu T, Nosaka R, Kolakshyapati M, Saito T, Akiyama Y, Sugiyama K, Kurisu K, Yamasaki F.
    • Journal Title

      World Neurosurgery

      Volume: 印刷中 Pages: 643-650

    • DOI

      10.1016/j.wneu.2017.01.100

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transsphenoidal Posterior Pituitary Lobe Biopsy in Patients with Neurohypophysial Lesions.2017

    • Author(s)
      Kinoshita Y, Yamasaki F, Tominaga A, Usui S, Arita K, Sakoguchi T, Sugiyama K, Kurisu K.
    • Journal Title

      World Neurosurgery

      Volume: 99 Pages: 543-547

    • DOI

      10.1016/j.wneu.2016.09.072

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma.2017

    • Author(s)
      Karlowee V, Amatya VJ, Hirano H, Takayasu T, Nosaka R, Kolakshyapati M, Yoshihiro M, Takeshima Y, Sugiyama K, Arita K, Kurisu K, Yamasaki F.
    • Journal Title

      Pathobiology

      Volume: 84 Issue: 2 Pages: 99-107

    • DOI

      10.1159/000447951

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 小児脳腫瘍の治療. 手術と化学療法の組み合わせ ~Optic pathway glioma~.2016

    • Author(s)
      山崎文之、杉山一彦、栗栖 薫.
    • Journal Title

      脳神経外科速報

      Volume: 26 Pages: 1177-1185

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Solitary Langerhans cell histiocytosis located in the neurohypophysis with a positive titer HCG-beta in the cerebrospinal fluid2016

    • Author(s)
      Kinoshita, Y. Yamasaki, F. Usui, S. Amatya, V. J. Tominaga, A. Sugiyama, K. Kurisu, K.
    • Journal Title

      Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

      Volume: 32 Issue: 5 Pages: 901-904

    • DOI

      10.1007/s00381-015-2949-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] グリオーマの画像診断2016

    • Author(s)
      山崎文之、杉山一彦、栗栖 薫.
    • Journal Title

      脳神経外科速報

      Volume: 26 Pages: 453-460

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging and the apparent diffusion coefficient on 3T MR imaging in the differentiation of craniopharyngiomas and germ cell tumors2016

    • Author(s)
      Kinoshita, Y. Yamasaki, F. Tominaga, A. Ohtaki, M. Usui, S. Arita, K. Sugiyama, K. Kurisu, K.
    • Journal Title

      Neurosurg Rev

      Volume: 39 Issue: 2 Pages: 207-213

    • DOI

      10.1007/s10143-015-0660-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳梗塞と初期診断され、後に脳腫瘍と診断された症例の特徴2019

    • Author(s)
      山崎 文之、坂本 繁幸、岡崎 貴仁、武田 正明、木下 康之  光原 崇文、大下 純平、石井 大造、阿美古 将、高野 元気、米澤 潮、田口 慧、栗栖 薫
    • Organizer
      Stroke 2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳腫瘍の病理所見と画像所見の比較2019

    • Author(s)
      山崎 文之
    • Organizer
      第42回日本脳神経CI学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 小児、AYA世代の悪性脳腫瘍サバイバーにおける内分泌学的問題点2019

    • Author(s)
      山崎 文之,木下 康之,碓井 智,岡田 賢,高野 元気,米澤 潮,宮川 真一郎,富永 篤,杉山 一彦,小林 正夫,栗栖 薫
    • Organizer
      第29回日本間脳下垂体腫瘍学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Optico-hypothalamic gliomaに対する治療戦略2019

    • Author(s)
      山崎 文之、木下 康之、碓井 智、高野 元気、米澤 潮、田口 慧、富永 篤、杉山一彦、栗栖 薫
    • Organizer
      第29回日本間脳下垂体腫瘍学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Imaging of germinoma2019

    • Author(s)
      山崎 文之, 木下 康之, 碓井 智, 高野 元気, 米澤 潮, 田口 慧, 杉山 一彦, 栗栖 薫
    • Organizer
      第48回 日本神経放射線学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 頭蓋内胚細胞腫瘍の長期予後因子の検討2018

    • Author(s)
      山崎 文之、木下 康之、高安 武志、碓井 智、高野 元気、米澤 潮、富永 篤、杉山 一彦、栗栖 薫
    • Organizer
      第36回 日本脳腫瘍学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中枢神経原発胚細胞性腫瘍の診断のための手術の課題と対策2018

    • Author(s)
      山崎 文之、木下 康之、高安 武志、碓井 智、高野 元気、米澤 潮、富永 篤、杉山 一彦、栗栖 薫
    • Organizer
      第60回 日本小児血液・がん学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 転移性脳腫瘍のMR画像診断2018

    • Author(s)
      山崎 文之、Manish Kolakshyapati、橋詰 顕、高安 武志、碓井 智、 Vega Karlowee、大西 俊平、高野 元気、米澤 潮、杉山 一彦、栗栖 薫
    • Organizer
      第56回 日本癌治療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Germinomaの長期予後因子の検討2018

    • Author(s)
      山崎 文之、木下 康之、碓井 智、高安 武志、高野 元気、米澤 潮、富永 篤、杉山 一彦、栗栖 薫
    • Organizer
      第77回日本脳神経外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Radiation-induced meningiomas: Experience at the Hiroshima University Hospital and review of the literature.2018

    • Author(s)
      Yamasaki F, Takayasu T, Takano M, Yonezawa U, Sugiyama K, Kurisu K
    • Organizer
      International Congress of Neuropathology (ICN) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] H3.3 K27M抗体陽性gliomaの臨床的・免疫組織学的検討2018

    • Author(s)
      山崎 文之, 高安 武志、高野 元気、米澤潮、Vishwa J. Amatya、吉廣 正子、武島 幸男、杉山 一彦、栗栖 薫、Vega Karlowee
    • Organizer
      第36回日本脳腫瘍病理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 長期予後を考慮したoptic pathway gliomaに対する手術戦略と治療戦略2018

    • Author(s)
      山崎 文之、高安 武志、木下 康之、碓井 智、高野 元気、米澤 潮、富永 篤、杉山 一彦、栗栖 薫
    • Organizer
      第23回日本脳腫瘍の外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] リング状造影病変のプロファイル解析2018

    • Author(s)
      山崎 文之、Manish Kolakshyapati、橋詰 顕、越智 一秀、上野 弘貴、海地 陽子、碓井 智、高安 武志、粟井 和夫、丸山 博文、杉山 一彦、栗栖 薫
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 転移性脳腫瘍と、その他の頭蓋内腫瘍性病変のMRIによる鑑別診断2018

    • Author(s)
      山崎 文之、橋詰 顕、Manish Kolakshyapati、高安 武志、碓井 智、 Vega Karlowee、大西 俊平、高野 元気、山田 直人、杉山 一彦、栗栖 薫
    • Organizer
      第16回日本臨床腫瘍学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経下垂体部 germinomaの長期予後因子2018

    • Author(s)
      山崎 文之、木下 康之、碓井 智、高安 武志、高野 元気、山田 直人、杉山 一彦、栗栖 薫
    • Organizer
      第46回 日本小児神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳児側脳室脈絡叢腫瘍の手術2018

    • Author(s)
      山崎 文之、高安 武志、高野 元気、山田 直人、杉山 一彦、栗栖 薫
    • Organizer
      第46回 日本小児神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳梗塞と初期診断され、後に脳腫瘍と診断された症例の特徴2018

    • Author(s)
      山崎 文之、高安 武志、高野 元気、杉山一彦、栗栖 薫
    • Organizer
      Stroke 2018
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳腫瘍の拡散強調画像とみかけの拡散係数2018

    • Author(s)
      山崎文之、木下康之、高安武志、碓井智、高野元気、Manish Kolakshyapati、大西 俊平、渡邊陽祐、富永 篤、栗栖薫
    • Organizer
      第41回日本脳神経CI学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] リング状造影病変のヒストグラム解析2018

    • Author(s)
      山崎 文之、Manish Kolakshyapati、橋詰 顕、越智 一秀、上野 弘貴、海地 陽子、碓井 智、高安 武志、粟井 和夫、丸山 博文、杉山 一彦、栗栖 薫
    • Organizer
      第47回日本神経放射線学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 長期予後を考慮したoptic pathway gliomaに対する治療戦略2018

    • Author(s)
      山崎 文之、木下 康之、高安 武志、碓井 智、高野 元気、富永 篤、杉山 一彦、栗栖 薫
    • Organizer
      第28回日本間脳下垂体腫瘍学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 認知機能が低下した高齢者のがん治療 ~脳神経外科の視点~2018

    • Author(s)
      山崎 文之、大野 誠、水谷 友紀、長島 文夫、濱口 哲弥 ,小川 朝生、栗栖 薫
    • Organizer
      第31回日本老年脳神経外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] VEGF標的治療中の脳血管障害2017

    • Author(s)
      山崎 文之, 高安 武志, 野坂 亮, 齋藤 太一, 坂本 繁幸, 井川 房夫, 杉山 一彦, 栗栖 薫
    • Organizer
      Stroke 2017
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 膠芽腫に特異的な画像所見: 造影部周囲の拡散強調画像高信号2017

    • Author(s)
      山崎 文之, Manish Kolakshyapati, 高安 武志, 野坂 亮, 齋藤 太一, 杉山 一彦, 栗栖 薫
    • Organizer
      第40回 日本脳神経CI学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2017-03-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭蓋内悪性リンパ腫とグリオーマの鑑別 ~1HMRSでの高いlipidのピークの検出~2017

    • Author(s)
      山崎 文之, 高安 武志, 野坂 亮, 齋藤 太一, 杉山 一彦, 栗栖 薫
    • Organizer
      第46回 日本神経放射線学会
    • Place of Presentation
      東京
    • Year and Date
      2017-02-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 「当院での脳腫瘍診療現状」-脳神経外科の立場から-2017

    • Author(s)
      山崎 文之
    • Organizer
      第5回 せとうち小児がんセミナー
    • Place of Presentation
      広島
    • Year and Date
      2017-01-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 1HMRSでのlipids検出による脳腫瘍の鑑別診断2017

    • Author(s)
      山崎 文之、 木下康之、高安 武志、碓井智、高野 元気、杉山 一彦、栗栖 薫
    • Organizer
      第35回日本脳腫瘍学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Cystic enlargement during chemotherapy and growing teratoma syndrome in non-germinomatous germ cell tumor2017

    • Author(s)
      Fumiyuki Yamasaki, Takeshi Takayasu, Yasuyuki Kinoshita, Satoshi Usui, Motoki Takano1, Manish Kolakshyapati, Sayuru Miyamura, Kazuhiko Sugiyama, Kaoru Kurisu
    • Organizer
      22nd Society for Neuro-Oncology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Non-germinomatous germ cell tumors 治療中の嚢胞性増大と growing teratoma syndrome2017

    • Author(s)
      山崎 文之、高安 武志、木下 康之、碓井 智、高野 元気、Manish Kolakshyapati、露口 冴、杉山 一彦、栗栖 薫
    • Organizer
      第59回 小児血液・がん学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Single voxel proton MR spectroscopic detection of high lipid levels and low ADC is characteristics of germinoma2017

    • Author(s)
      Fumiyuki Yamasaki, Yasuyuki Kinoshita, Takeshi Takayasu, Satoshi Usui, Manish Kolakshyapati, Motoki Takano, Sayuru Tsuyuguchi, Kazuhiko Sugiyama, Kaoru Kurisu
    • Organizer
      The 14th Meeting of Asian Society for Neuro-Oncology, 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 子どもとAYA 世代の脳腫瘍治療後の晩期合併症に対する検診の重要性2017

    • Author(s)
      山崎 文之、高安 武志、高野 元気、西淵 いくの、川口 浩史、杉山 一彦、小林 正夫、栗栖 薫
    • Organizer
      第55回日本癌治療学会
    • Related Report
      2017 Research-status Report
  • [Presentation] H3.3 K27M抗体陽性gliomaの臨床免疫組織学的検討2017

    • Author(s)
      山崎 文之、Vega Karlowee、高安 武志、高野 元気、Manish Kolakshyapati、杉山 一彦、栗栖 薫
    • Organizer
      第76回日本脳神経外科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膠芽腫に特異的な画像所見:造影部周囲の拡散強調画像高信号2017

    • Author(s)
      山崎 文之、Manish Kolakshyapati、Vega Karlowe 、高安 武志、穐山 雄次、杉山 一彦、栗栖 薫
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児脳腫瘍患者におけるラクトソーブスピンダウンによる頭蓋骨固定の有用性2017

    • Author(s)
      山崎 文之、高安 武志、野坂 亮、高野 元気、木下 康之、井川 房夫、栗栖 薫
    • Organizer
      第22回日本脳腫瘍の外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 認知機能が低下した高齢者のがん治療 -脳神経外科の視点-2017

    • Author(s)
      山崎 文之、大野 誠、水谷 友紀、濱口 哲弥、小川 朝生、長島 文夫
    • Organizer
      第15回 日本臨床腫瘍学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳梗塞と初期診断され、後に脳腫瘍と診断された症例の特徴2017

    • Author(s)
      山崎 文之、斎藤 太一、高安 武志、野坂 亮、杉山 一彦、栗栖 薫
    • Organizer
      第20回日本臨床脳神経外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Diffuse Leptomeningeal glioneuronal tumor の1例2017

    • Author(s)
      山崎 文之、齋藤 太一、高安 武志、野坂 亮、Vega Karlowee、城間 紀之、Vishwa Jeet Amatya、武島 幸男、杉山 一彦、栗栖 薫
    • Organizer
      第34回日本脳腫瘍病理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児脳腫瘍への高線量放射線治療後 cystic malacia の検討 -特徴と危険因子を探る2017

    • Author(s)
      山崎 文之、高安 武志、野坂 亮、齋藤 太一、井川 房夫、杉山 一彦、栗栖 薫
    • Organizer
      第45回日本小児神経外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Proton MR spectroscopy detection of high lipid levels without central necrosis and high intensity on DWI is characteristics of germinoma2017

    • Author(s)
      Fumiyuki Yamasaki, Yasuyuki Kinoshita, Satoshi Usui, Takeshi Takayasu, Ryo Nosaka, Manish Kolakshyapati, Taiichi Saito, Kazuhiko Sugiyama, Kaoru Kurisu
    • Organizer
      ISMRM 25th annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小児脳腫瘍への高線量放射線治療後 cystic malacia の検討 -特徴と危険因子を探る-2016

    • Author(s)
      山崎 文之, 高安 武志, 野坂 亮, 齋藤 太一, 井川 房夫, 杉山 一彦, 栗栖 薫
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児の高悪性度グリオーマと脳幹部グリオーマ2016

    • Author(s)
      山崎 文之
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Optic pathway gliomaと脳幹gliomaを含めたgliomaに対するCV療法2016

    • Author(s)
      山崎 文之, 高安 武志, 野坂 亮, 齋藤 太一, 杉山 一彦, 栗栖 薫
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2016-12-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 認知症と高齢者について 脳神経外科の視点より2016

    • Author(s)
      山崎 文之, 大野 誠
    • Organizer
      JCOG高齢者研究委員会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 転移性脳腫瘍の画像診断2016

    • Author(s)
      山崎 文之
    • Organizer
      転移性脳腫瘍セミナーin 広島
    • Place of Presentation
      広島
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Development of cystic malacia after high dose cranial irradiation of pediatric CNS embryonal tumors in long-term follow-up2016

    • Author(s)
      Fumiyuki Yamasaki, Manish Kolakshyapati, Takeshi Takayasu, Ryo Nosaka, Kazuhiko Sugiyama, Kaoru Kurisu
    • Organizer
      21ST annual scientific meeting of SNO (Society for Neuro-oncology)
    • Place of Presentation
      Scottsdale (U.S.A.)
    • Year and Date
      2016-11-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 子どもの脳腫瘍と晩期合併症2016

    • Author(s)
      山崎 文之
    • Organizer
      第2回 小児がんフォーラム in 岡山/第4回 がんの子どもを守る会中国四国支部合同交流会
    • Place of Presentation
      岡山
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 膠芽腫周囲の非造影拡散強調画像高信号は膠芽腫に特異的かつ予後不良因子である2016

    • Author(s)
      山崎 文之, Manish Kolakshyapati, 高安 武志, 野坂 亮, 杉山 一彦, 栗栖 薫
    • Organizer
      第54回 日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児脳腫瘍への高線量放射線治療後 cystic malacia の検討 -特徴と危険因子を探る-2016

    • Author(s)
      山崎 文之, 高安 武志, 野坂 亮, 齋藤 太一, 井川 房夫, 杉山 一彦, 栗栖 薫
    • Organizer
      第75回 日本脳神経外科学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] The usefulness of T2*WI for the detection of cavernous angioma in long-term survivors of childhood embryonal tumors treated by cranial irradiation2016

    • Author(s)
      第44回日本磁気共鳴医学会大会
    • Organizer
      Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Masahiro Kenjo, Yuji Akiyama, Kazuhiko Sugiyama, Manish Kobayashi, Kaoru Kurisu
    • Place of Presentation
      大宮
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
  • [Presentation] The risk of the cerebrovascular disease at the patients with VEGF targeting therapy2016

    • Author(s)
      Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Taiich Saito, Kazuhiko Sugiyama, Kaoru Kurisu
    • Organizer
      2016 the Japanese Society of Medical Oncology Annual meeting
    • Place of Presentation
      Kobe (Japan)
    • Year and Date
      2016-07-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 胚細胞腫の診断における advanced MR imaging の有用性の検討2016

    • Author(s)
      山崎 文之, 木下 康之, 碓井 智, 高安 武志, 野坂 亮, 齋藤 太一, 富永 篤, 杉山 一彦, 栗栖 薫
    • Organizer
      第44回 日本小児神経外科学会
    • Place of Presentation
      つくば
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 広島大学病院における視神経・視床下部神経膠腫の治療経験2016

    • Author(s)
      山崎 文之, 木下 康之, 高安 武志, 碓井 智, 野坂 亮, 齋藤 太一, 富永 篤, 杉山 一彦, 栗栖 薫
    • Organizer
      第44回 日本小児神経外科学会
    • Place of Presentation
      つくば
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Diffuse Leptomeningeal Oligodendrogliomatosis の1例2016

    • Author(s)
      山崎 文之, 齋藤 太一, 高安 武志, 野坂 亮, Vega Karlowee, 城間 紀之, Vishwa Jeet Amatya, 武島 幸男, 杉山 一彦, 栗栖 薫
    • Organizer
      第34回 日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Diffusion MRI of brain tumors2016

    • Author(s)
      Fumiyuki Yamasaki
    • Organizer
      ISMRM (International Society for Magnetic Resonance in Medicine) 24th Annual Meeting in Singapore
    • Place of Presentation
      Singapore (Singapore)
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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