Prediction of VEGF inhibitor effect for malignant brain tumor
Project/Area Number |
16K10757
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
|
Research Institution | Hiroshima University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
杉山 一彦 広島大学, 病院(医), 教授 (30243554)
栗栖 薫 広島大学, 医歯薬保健学研究科(医), 教授 (70201473)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | glioblastoma / brain metastasis / tumefactive lesion / brain abscess / histogram analysis / VEGF / radiomics / radiogenomics / germinoma / advanced MR imaging / glioma / bevacizumab / brain metastases / malignant lymphoma / hemangioblastoma / cystic malacia / 脳神経疾患 / 癌 / 治療効果予測 / MRI |
Outline of Final Research Achievements |
The presence of a nonenhancing peritumoral DWI high lesion (DNePDHL) was observed in 25% of glioblastoma patients, while it was conspicuously absent in patients with malignant lymphoma and metastatic brain tumors. Patients with DNePDHL had significantly early local (p=0.0467) and distant/dissemination recurrence (p<0.0001) and poor prognosis (p=0.0007). Histogram profile analysis also help for differential diagnosis of glioblastoma from other intracranial ring enhanced lesions. Evaluating ADC-MIN at b-4000 would be a useful tool for distinguishing posterior fossa tumors in both pediatric and adult patients. Lower ADC values and high lipid peaks detected on 1H-MRS are characteristics of germinomas. The pathogenesis of multicentric gliomas is different from the mutant IDH1-R132H pathway. The expression of EZH2 is not associated with the PRC2 pathway and increases in patients with H3K27M-mutant diffuse midline glioma and a poor prognosis.
|
Academic Significance and Societal Importance of the Research Achievements |
悪性脳腫瘍の術前診断は、手術において生検術を選択すべきか摘出術を選択すべきか、または手術ではなく放射線治療を選択すべきか、化学療法を選択すべきか、これらの意思決定に重要な役割を担っている。すなわち、悪性脳腫瘍の診断精度の向上は臨床上極めて意義が高く、学術的、社会的意義が大きいと言える。今回、膠芽腫の正確な診断法、予後推定法と、成人及び小児の後頭蓋窩腫瘍の鑑別診断法を確立したことと、germinomaの新規診断法を確立したことの医学的意義は極めて大きい。
|
Report
(4 results)
Research Products
(82 results)
-
[Journal Article] Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign"2019
Author(s)
Ueno H, Norose K, Kamimura T, Mihara K, Yamasaki F, Hikosaka K, J Amatya V, Takeshima Y, Kurisu K, Maruyama H
-
Journal Title
Internal Medicine
Volume: 58
Issue: 8
Pages: 1157-1162
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2019-04-15
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.2018
Author(s)
Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M.
-
Journal Title
Neuro Oncol.
Volume: 21
Issue: 3
Pages: 348-359
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Perfusion computed tomography parameters are useful for differentiating glioblastoma, lymphoma, and metastasis.2018
Author(s)
Onishi S, Kajiwara Y, Takayasu T, Kolakshyapati M, Ishifuro M, Amatya VJ, Takeshima Y, Sugiyama K, Kurisu K, Yamasaki F.
-
Journal Title
World Neurosurg.
Volume: 119
Pages: e890-e897
DOI
Related Report
Peer Reviewed
-
[Journal Article] Improved differentiation between high- and low-grade gliomas by combining dual-energy CT analysis and perfusion CT.2018
Author(s)
Kaichi Y, Tatsugami F, Nakamura Y, Baba Y, Iida M, Higaki 1, Kiguchi M, Tsushima S, Yamasaki F, Amatya VJ, Takeshima Y, Kurisu K, Awai K.
-
Journal Title
Medicine (Baltimore)
Volume: 97
Issue: 32
Pages: e11670-e11670
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Proton Magnetic Resonance Spectroscopy Detection of High Lipid Levels and Low Apparent Diffusion Coefficient Is Characteristic of Germinomas.2018
Author(s)
Yamasaki F, Kinoshita Y, Takayasu T, Usui S, Kolakshyapati M, Takano M, Tsuyuguchi S, Amatya VJ, Akiyama Y, Takeshima Y, Sugiyama K, Kurisu K.
-
Journal Title
World Neurosurg.
Volume: 112
Pages: e84-e94
DOI
Related Report
Peer Reviewed
-
[Journal Article] RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging.2018
Author(s)
Onishi S, Yamasaki F, Nakano Y, Takayasu T, Amatya VJ, Kolakshyapati M, Takeshima Y, Hirose T, Ichimura K, Sugiyama K, Kurisu K.
-
Journal Title
Brain Tumor Pathol.
Volume: 35
Issue: 1
Pages: 41-45
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Review of Current Evidence Regarding Surgery in Elderly Patients with Meningioma2017
Author(s)
Ikawa F, Kinoshita Y, Takeda M, Saito T, Yamaguchi S, Yamasaki F, Iida K, Sugiyama K, Arita K, Kurisu K.
-
Journal Title
Neurologia medico-chirurgica
Volume: 57
Issue: 10
Pages: 521-533
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up.2017
Author(s)
Yamasaki F, Takayasu T, Nosaka R, Nishibuchi I, Kawaguchi H, Kolakshyapati M, Onishi S, Saito T, Sugiyama K, Kobayashi M, Kurisu K.
-
Journal Title
Child's Nervous System
Volume: 印刷中
Issue: 6
Pages: 957-964
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Nonenhancing peritumoral hyperintense lesion on diffusion-weighted imaging in glioblastoma: a novel diagnostic and specific prognostic indicator.2017
Author(s)
Kolakshyapati M, Adhikari RB, Karlowee V, Takayasu T, Nosaka R, Amatya VJ, Takeshima Y, Akiyama Y, Sugiyama K, Kurisu K, Yamasaki F.
-
Journal Title
Journal of Neurosurgery
Volume: 印刷中
Issue: 3
Pages: 667-678
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
[Journal Article] Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma.2017
Author(s)
Karlowee V, Amatya VJ, Hirano H, Takayasu T, Nosaka R, Kolakshyapati M, Yoshihiro M, Takeshima Y, Sugiyama K, Arita K, Kurisu K, Yamasaki F.
-
Journal Title
Pathobiology
Volume: 84
Issue: 2
Pages: 99-107
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] VEGF標的治療中の脳血管障害2017
Author(s)
山崎 文之, 高安 武志, 野坂 亮, 齋藤 太一, 坂本 繁幸, 井川 房夫, 杉山 一彦, 栗栖 薫
Organizer
Stroke 2017
Place of Presentation
大阪
Year and Date
2017-03-17
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-