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Development of Radiomics for molecular diagnosis of gliomas

Research Project

Project/Area Number 16K10778
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOsaka University (2018-2019)
Osaka International Cancer Institute (2016-2017)

Principal Investigator

Kinoshita Manabu  大阪大学, 医学系研究科, 講師 (40448064)

Co-Investigator(Kenkyū-buntansha) 吉岡 芳親  大阪大学, 生命機能研究科, 特任教授(常勤) (00174897)
有田 英之  大阪大学, 医学系研究科, 招へい教員 (60570570)
金村 米博  独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (80344175)
橋本 直哉  京都府立医科大学, 医学(系)研究科(研究院), 教授 (90315945)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords神経膠腫 / MRI / Radiomics / IDH / 脳腫瘍 / 脳腫瘍学 / 遺伝子変異 / Radiogenomics
Outline of Final Research Achievements

We were able to develop a radiomics analyzing system for gliomas. This system allows the user to perform a radiomics analysis of gliomas quickly. Using the method developed by ourselves, we performed radiomics for 169 cases of lower-grade gliomas. We proved that the IDH mutation status of the tumor was predicted with a diagnostic accuracy of higher than 80%. Diagnostic accuracy of discriminating lower-grade gliomas into IDH mutant, IDH mutant with 1p19q codeletion and IDH wildtype was still as low as 56%. When deep learning algorism was introduced into radiomics analysis, diagnostic accuracy for identifying three subgroups of lower-grade glioma improved by 10%. Finally, we performed radiomics for 162 glioblastoma cases and identified imaging-based prognostic biomarkers independent of MGMT promoter methylation status.

Academic Significance and Societal Importance of the Research Achievements

本研究テーマを遂行することにより、①社会実装可能な脳腫瘍に対するAI支援下非侵襲分子診断技術が開発され、さらに②大規模臨床試験など臨床医学における大規模データを有効に活用することにより、脳腫瘍に限らず他の体幹部がん疾患でも放射線画像と遺伝子情報を中心としたビッグデータによる汎用性の高い実用的なAI支援下radiogenomics診断技術開発が進むことが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (53 results)

All 2021 2020 2019 2018 2017 2016 Other

All Journal Article (29 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 29 results,  Open Access: 18 results,  Acknowledgement Compliant: 4 results) Presentation (22 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (1 results) Remarks (1 results)

  • [Journal Article] T<sub>2</sub>-FLAIR Mismatch Sign Is Caused by Long T<sub>1</sub> and T<sub>2</sub> of <i>IDH</i>-mutant, 1p19q Non-codeleted Astrocytoma2021

    • Author(s)
      Kinoshita Manabu、Uchikoshi Masato、Sakai Mio、Kanemura Yonehiro、Kishima Haruhiko、Nakanishi Katsuyuki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 1 Pages: 119-123

    • DOI

      10.2463/mrms.bc.2019-0196

    • NAID

      130007993615

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network2019

    • Author(s)
      Fukuma Ryohei、Yanagisawa Takufumi、Kinoshita Manabu、他
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 0-0

    • DOI

      10.1038/s41598-019-56767-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiomics and MGMT promoter methylation for prognostication of newly diagnosed glioblastoma2019

    • Author(s)
      Sasaki Takahiro、Kinoshita Manabu、他
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 14435-14435

    • DOI

      10.1038/s41598-019-50849-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between normalized distributional pattern and functional outcome in patients with acute cardiogenic cerebral embolism2019

    • Author(s)
      Takagaki Masatoshi、Kinoshita Manabu、Kawaguchi Atsushi、Murasawa Akira、Nakao Kazutami、Nakamura Hajime、Kishima Haruhiko
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: 0210709-0210709

    • DOI

      10.1371/journal.pone.0210709

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma2019

    • Author(s)
      Sakata Junichi、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Nakada Mitsutoshi、Tanaka Hirotomo、Hashimoto Naoya、Kagawa Naoki、Kinoshita Manabu、Nakamizo Satoshi、Maeyama Masahiro、Nishihara Masamitsu、Hosoda Kohkichi、Kohmura Eiji
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 142 Issue: 2 Pages: 241-251

    • DOI

      10.1007/s11060-019-03113-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors2019

    • Author(s)
      Sonoda Yukihiko、The committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology、Yokoo Hideaki、Tanaka Shinya、Kinoshita Manabu、Nakada Mitsutoshi、Nishihara Hiroshi
    • Journal Title

      Brain Tumor Pathology

      Volume: in press Issue: 2 Pages: 56-62

    • DOI

      10.1007/s10014-019-00337-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 11C-methionine-18F-FDG dual-PET-tracer-based target delineation of malignant glioma: evaluation of its geometrical and clinical features for planning radiation therapy.2018

    • Author(s)
      Hirata T, Kinoshita M, Tamari, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa K.
    • Journal Title

      Journal of Neurosurgery

      Volume: 21 Issue: 3 Pages: 1-11

    • DOI

      10.3171/2018.4.jns1859

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carotid artery stenting for patients with occipital?vertebral anastomosis2018

    • Author(s)
      Kajikawa Ryuichiro、Fujinaka Toshiyuki、Nakamura Hajime、Kinoshita Manabu、Nishida Takeo、Kishima Haruhiko
    • Journal Title

      Interventional Neuroradiology

      Volume: 25 Issue: 2 Pages: 212-218

    • DOI

      10.1177/1591019918802924

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics and outcomes of elderly patients with diffuse gliomas: a multi-institutional cohort study by Kansai Molecular Diagnosis Network for CNS Tumors2018

    • Author(s)
      Sasaki Takahiro、Fukai Junya、Kodama Yoshinori、et al
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 140 Issue: 2 Pages: 329-339

    • DOI

      10.1007/s11060-018-2957-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas2018

    • Author(s)
      Arita Hideyuki、Kinoshita Manabu、Kawaguchi Atsushi、Takahashi Masamichi、Narita Yoshitaka、Terakawa Yuzo、Tsuyuguchi Naohiro、Okita Yoshiko、Nonaka Masahiro、Moriuchi Shusuke、Takagaki Masatoshi、Fujimoto Yasunori、et al.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11773-11773

    • DOI

      10.1038/s41598-018-30273-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereotactic image?based histological analysis reveals a correlation between 11C?methionine uptake and MGMT promoter methylation in non?enhancing gliomas2018

    • Author(s)
      Okita Yoshiko、Shofuda Tomoko、Kanematsu Daisuke、Yoshioka Ema、Kodama Yoshinori、Mano Masayuki、Kinoshita Manabu、Nonaka Masahiro、Nakajima Shin、Fujinaka Toshiyuki、Kanemura Yonehiro
    • Journal Title

      Oncology Letters

      Volume: NA Pages: 1924-1930

    • DOI

      10.3892/ol.2018.8866

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial2018

    • Author(s)
      Kayama Takamasa、Sato Shinya、Sakurada Kaori、et al
    • Journal Title

      Journal of Clinical Oncology

      Volume: 36 Issue: 33 Pages: 3282-3289

    • DOI

      10.1200/jco.2018.78.6186

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enlargement of papillary glioneuronal tumor in an adult after a follow-up period of 10 years: a case report2018

    • Author(s)
      Fujita Yuya、Kinoshita Manabu、Ozaki Tomohiko、Kitamura Masanori、Nakatsuka Shin-ichi、Kanemura Yonehiro、Kishima Haruhiko
    • Journal Title

      Journal of Surgical Case Reports

      Volume: 2018 Issue: 6

    • DOI

      10.1093/jscr/rjy123

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coil and Single-Stent Placement for Ruptured Dissecting Aneurysm of Middle Cerebral Artery: A Case Report2018

    • Author(s)
      Ozaki Tomohiko、Nishida Takeo、Fujita Yuya、Kishima Haruhiko、Kinoshita Manabu
    • Journal Title

      World Neurosurgery

      Volume: 113 Pages: 208-211

    • DOI

      10.1016/j.wneu.2018.02.117

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of region-of-interest designs on quantitative measurement of multimodal imaging of MR non-enhancing gliomas2018

    • Author(s)
      Takano Koji、Kinoshita Manabu、Arita Hideyuki、Okita Yoshiko、Chiba Yasuyoshi、Kagawa Naoki、Watanabe Yoshiyuki、Shimosegawa Eku、Hatazawa Jun、Hashimoto Naoya、Fujimoto Yasunori、Kishima Haruhiko
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 7934-7940

    • DOI

      10.3892/ol.2018.8319

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voxel-based lesion mapping of meningioma: a comprehensive lesion location mapping of 260 lesions2017

    • Author(s)
      Hirayama Ryuichi、Kinoshita Manabu、Arita Hideyuki、Kagawa Naoki、Kishima Haruhiko、Hashimoto Naoya、Fujimoto Yasunori、Yoshimine Toshiki
    • Journal Title

      Journal of Neurosurgery

      Volume: ― Issue: 6 Pages: 1-6

    • DOI

      10.3171/2017.3.jns17169

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preservation of Motor Function After Resection of Lower-Grade Glioma at the Precentral Gyrus and Prediction by Presurgical Functional Magnetic Resonance Imaging and Magnetoencephalography2017

    • Author(s)
      Izutsu Nobuyuki、Kinoshita Manabu、Yanagisawa Takufumi、Nakanishi Katsuhiko、Sakai Mio、Kishima Haruhiko
    • Journal Title

      World Neurosurg.

      Volume: 107 Pages: 1045.e5-1045.e8

    • DOI

      10.1016/j.wneu.2017.07.152

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis.2017

    • Author(s)
      Verburg N, Hoefnagels FWA, Barkhof F, Boellaard R, Goldman S, Guo J, Heimans JJ, Hoekstra OS, Jain R, Kinoshita M, Pouwels PJW, Price SJ, Reijneveld JC, Stadlbauer A, Vandertop WP, Wesseling P, Zwinderman AH, De Witt Hamer PC.
    • Journal Title

      American Journal of Neuroradiology

      Volume: in press Issue: 10 Pages: 1884-1891

    • DOI

      10.3174/ajnr.a5368

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia2017

    • Author(s)
      Ozaki Tomohiko、Nakamura Hajime、Izutsu Nobuyuki、Masaie Hiroaki、Ishikawa Jun、Kinoshita Manabu
    • Journal Title

      Interv Neuroradiol

      Volume: 23 Issue: 5 Pages: 527-530

    • DOI

      10.1177/1591019917710810

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Voxel-Based Lesion Mapping of Cryptogenic Stroke in Patients with Advanced Cancer: A Detailed Magnetic Resonance Imaging Analysis of Distribution Pattern2017

    • Author(s)
      Achiha T, Takagaki M, Oe H, Sakai M, Matsui H, Nakanishi K, Ozaki T, Fujimoto Y, Yoshimine T, Nakanishi K, Kinoshita M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub ahead of print Issue: 7 Pages: 1521-1527

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.02.038

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report.2017

    • Author(s)
      Takagaki M, Kinoshita M, Nishino K, Nakano M, Adachi H, Ueno M, Kitamura M, Fujimoto Y, Tashiro K, Tomita Y, Imamura F, Yoshimine T.
    • Journal Title

      Oncol. Lett.

      Volume: 13 Issue: 4 Pages: 2085-2088

    • DOI

      10.3892/ol.2017.5677

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide DNA methylation profiles identifies primary central nervous system lymphomas as a distinct entity from systemic diffuse large B-cell lymphomas2017

    • Author(s)
      Nakamura T, Yamashita S, Fukumura K, Tanaka K, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K
    • Journal Title

      Acta Neuropathol

      Volume: 133 Issue: 2 Pages: 321-324

    • DOI

      10.1007/s00401-016-1664-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Voxel-based lesion mapping of meningioma: A comprehensive lesion location mapping of 260 lesions2017

    • Author(s)
      Ryuichi Hirayama, Manabu Kinoshita, Hideyuki Arita, Naoki Kagawa, Haruhiko Kishima, M Naoya Hashimoto, Yasunori Fujimoto, Toshiki Yoshimine
    • Journal Title

      J Neurosurg

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia2017

    • Author(s)
      Tomohiko Ozaki, Hajime Nakamura, Nobuyuki Izutsu, Hiroaki Masaie, Jun Ishikawa, Manabu Kinoshita
    • Journal Title

      Interventional Neuroradiology

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.2016

    • Author(s)
      Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T
    • Journal Title

      J Neurosurg

      Volume: 印刷中 Issue: 5 Pages: 1136-1142

    • DOI

      10.3171/2015.11.jns151848

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reduction of misregistration on cerebral four-dimensional computed tomography angiography images using advanced patient motion correction reconstruction.2016

    • Author(s)
      Kunitomi Y, Arisawa A, Tsukabe A, Tanaka H, Takahashi H, Nishida T, Kinoshita M, Nakamura H, Tomiyama N.
    • Journal Title

      Jpn J Radiol

      Volume: 34 Issue: 9 Pages: 605-610

    • DOI

      10.1007/s11604-016-0563-1

    • NAID

      50010071581

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas.2016

    • Author(s)
      Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimokawa A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Suzuki K, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, et al.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 4 Issue: 1 Pages: 79-79

    • DOI

      10.1186/s40478-016-0351-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas.2016

    • Author(s)
      Kinoshita M, Sakai M, Arita H, Shofuda T, Chiba Y, Kagawa N, Watanabe Y, Hashimoto N, Fujimoto Y, Yoshimine T, Nakanishi K, Kanemura Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0164268-e0164268

    • DOI

      10.1371/journal.pone.0164268

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of Quantification of Intracranial Aneurysm Pulsation with 4D CTA with Manual and Computer-Aided Post-Processing.2016

    • Author(s)
      Illies T, Saering D, Kinoshita M, Fujinaka T, Bester M, Fiehler J, Tomiyama N, Watanabe Y
    • Journal Title

      PLoS One

      Volume: 11 Issue: 11 Pages: e0166810-e0166810

    • DOI

      10.1371/journal.pone.0166810

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 悪性神経膠腫の「増悪」判定の意味するものとは?2020

    • Author(s)
      木下 学
    • Organizer
      第39回医用画像学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] グリオーマの画像診断と遺伝子解析・病理2020

    • Author(s)
      木下 学
    • Organizer
      第43回日本脳神経CI学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Radiomicsの展開と 大規模臨床データの利用2020

    • Author(s)
      木下 学
    • Organizer
      第9回 画像医療システム産業研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 膠芽腫のRadiogenomics2019

    • Author(s)
      木下 学
    • Organizer
      第39回日本脳神経外科コングレス総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Radiomics in Glioma2019

    • Author(s)
      木下 学
    • Organizer
      第78回日本医学放射線学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Imapact of 11C-methionine/FDG dural tracer PET-based, compared with MRI-based target delination of malignant gliomas for radiation planning.2018

    • Author(s)
      Kinoshita M, Hirata T, Tamari K, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa
    • Organizer
      Society for Neuro-onclogy (SNO) meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiogenomics of 154 WHO grade 2 and 3 gliomas via machine learning and the impact of texture analysis.2018

    • Author(s)
      Kinoshita M, Arita H, Kawaguchi A, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura K, Kanemura Y
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 26th Scientific Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳腫瘍に対するradiogenomics解析システムの開発と応用2018

    • Author(s)
      木下学、有田英之、川口 淳、高橋雅道、深井順也、石橋謙一、露口尚弘、沖田典子、成田善孝、市村幸一、金村米博
    • Organizer
      第47回日本神経放射線学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Grade2,3神経膠腫のRadiogenomics2017

    • Author(s)
      木下 学
    • Organizer
      第40回日本脳神経CI学会総会
    • Place of Presentation
      鹿児島サンロイヤルホテル(鹿児島)
    • Year and Date
      2017-03-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 非温熱生態作用による集束超音波治療の未来2017

    • Author(s)
      木下 学
    • Organizer
      第56回日本定位・機能神経外科学
    • Place of Presentation
      グランフロント大阪(大阪)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 超音波の非温熱作用を用いた集束超音波による脳治療2017

    • Author(s)
      木下学
    • Organizer
      第16回日本超音波治療研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 大規模脳腫瘍画像データの網羅的な解析を目指しRadiomics解析の開発2017

    • Author(s)
      木下学、有田英之、佐々木貴浩、藤田浩二、高橋雅道、成田善孝、金村米博、貴島晴彦
    • Organizer
      第76回日本脳神経外科学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 国内大規模画像コホートを用いた人工知能による Grade II-III 神経膠腫の画像分子診断2017

    • Author(s)
      木下学、福間良平、柳澤琢史、篠崎隆志、貴島晴彦、高橋雅道、成田善孝 、有田英之、藤本康倫、寺川雄三、露口尚弘、深井順也、沖田典子、高垣匡寿、 石橋謙一、児玉良典、埜中正博、 森内秀祐、泉本修一、中 島義和、森鑑二、正札智子、市村幸一、 金村米博
    • Organizer
      第35回日本脳腫瘍学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Radionomic analysis of WHO grade 2 and 3 gliomas with genetic subgroup prediction.2017

    • Author(s)
      Kinoshita M, Arita H, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura K, Kanemura Y
    • Organizer
      Society for Neuro-onclogy (SNO) meeting.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiogenomics of 201 WHO grade 2 and 3 gliomas2017

    • Author(s)
      Kinoshita M, Arita H, Tkahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Noanaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodoma Y, More K, Ichimura K, Kanemura Y
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 25th Scientific Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経放射線画像から見える脳腫瘍の分子病理2017

    • Author(s)
      木下 学
    • Organizer
      第121回東京脳腫瘍研究会
    • Place of Presentation
      東京医科大学(東京)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 国内大規模コホートを用いたRadiogenomicsによるGrade II-III神経膠腫の画像分子診断2016

    • Author(s)
      木下 学、有田英之、金村米博ほか
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      甲府富士屋ホテル(甲府、山梨)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 膠芽腫におけるTERTプロモーター変異とMGMTメチル化状態の予後因子としての意義2016

    • Author(s)
      有田英之、木下 学、金村米博ほか
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      甲府富士屋ホテル(甲府、山梨)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Grade II-III神経膠腫の遺伝子変異と発生部位:国内大規模コホートRadiogenomics解析2016

    • Author(s)
      有田英之、木下 学、金村米博ほか
    • Organizer
      有田英之、木下 学、金村米博ほか
    • Place of Presentation
      甲府富士屋ホテル(甲府、山梨)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Impact of genetic alterations on tumor locatios and lesion heterogeneity for WHO grade 2 and 3 gliomas: A voxel-based lesion mapping and image texture analysis of 201 gliomas2016

    • Author(s)
      Kinoshita M, Hideyuki Arita, Yonehiro Kanemura, et al.
    • Organizer
      2016 Society for Neuro-onclogy (SNO) meeting
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiogenomics解析を目指したWHOグレード2、 3神 経膠腫のMRIテクスチャ解析2016

    • Author(s)
      木下学、酒井 美緒、有田 英之、千葉 泰良,、香川尚己、 渡辺 嘉之、橋本 直哉、藤本 康倫、吉峰 俊樹,、中西 克之、金村 米博
    • Organizer
      日本脳神経外科学会第75回学術総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] MR based texture and location analysis of lower grade gliomas combined with genetic mutation information2016

    • Author(s)
      Kinoshita M. Hideyuki Arita, Mio Sakai, Naoki Kagawa, Yonehiro Kanemura, Yasunori Fujimoto, Katsuyuki Nakanishi, Toshiki Yoshimine
    • Organizer
      International Society for Magnetic Resonance in Medicine 2016
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL): INCIDENCE, MANAGEMENT AND OUTCOMES.2016

    • Author(s)
      Kinoshita M
    • Total Pages
      289
    • Publisher
      Nova Science Pub Inc
    • Related Report
      2016 Research-status Report
  • [Remarks] 研究内容紹介

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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