closed-loop optogeentic deep brain stimulation for movement disorders.

• Project/Area Number: 16K10787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kyushu University
• Principal Investigator: YOSHIDA Fumiaki 九州大学, 大学病院, 講師 (60529791)
• Co-Investigator(Kenkyū-buntansha): 平田 雅之 大阪大学, 国際医工情報センター, 寄附研究部門教授 (30372626)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 光遺伝学 / 病的脳波 / ニューロもデュレーション / オプトジェネティクス / 脳深部刺激療法

Outline of Final Research Achievements

Parkinson’s disease (PD) is one of the major human movement disorders in terms of prevalence and morbidity. Our research aim to employ abnormal oscillatory and synchronised activity across populations of neurons recorded from basal ganglia as a biomarker for controlling optogenetic deep brain stimulation. Our increased understanding of how different patterns of population activity are associated with different forms of movement disorders raises the possibility of improving DBS through closed loop stimulation. In closed-loop mode, stimulation could be titrated using a biomarker such as a particular pattern of abnormal activity to determine when and how much stimulation is necessary. In this study we examined a dozen of optogentics tools in marmosets and mice to determine which one is the best for our purpose. By using it, we succeeded in simultaneous recording and optogenetic neural modulation. We moved to assemble optogenetic deep brain simulation system.

Academic Significance and Societal Importance of the Research Achievements

脳深部刺激療法は、脳神経疾患により制限されている人間の身体機能を回復・補完するための確立された治療法であり、本研究において飛躍的な改善を行うことで、脳神経疾患により苦しんでいる患者の生活の質を改善、また社会の経済的負担を軽減することに貢献する。

Research Products

• [Int'l Joint Research] MIT(米国)
• [Int'l Joint Research] Oxford University(英国)
• [Int'l Joint Research] マサチューセッツ工科大学(米国)
• [Int'l Joint Research]
• [Journal Article] Real-Time Neurofeedback to Modulate β-Band Power in the Subthalamic Nucleus in Parkinson's Disease Patients (2018)
  • Author(s): Ryohei Fukuma, Takufumi Yanagisawa, Masataka Tanaka, Fumiaki Yoshida, Koichi Hosomi, Satoru Oshino, Naoki Tani, and Haruhiko Kishima
  • Journal Title: eNeuro Volume: 5 Issue: 6 Pages: 0246-18
  • DOI: 10.1523/eneuro.0246-18.2018
  • Peer Reviewed / Open Access
• [Journal Article] Non-invasive quantification of human swallowing using a simple motion tracking system. (2018)
  • Author(s): Hashimoto H, Hirata M, Takahashi K, Kameda S, Katsuta Y, Yoshida F, Hattori N, Yanagisawa T, Palmer J, Oshino S, Yoshimine T, Kishima H
  • Journal Title: Sci Rep. Volume: 8:5095 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41598-018-23486-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging. (2017)
  • Author(s): Piatkevich KD, Suk HJ, Kodandaramaiah SB, Yoshida F, DeGennaro EM, Drobizhev M, Hughes TE, Desimone R, Boyden ES＊, Verkhusha VV
  • Journal Title: Biophys J. Volume: 13(10) Pages: 2299-2309
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Implantable wireless 64-channel system with flexible ECoG electrode and optogenetics probe (2016)
  • Author(s): Shusuke Yoshimoto, Teppei Araki, Takafumi Uemura, Toshikazu Nezu, Tsuyoshi Sekitani, Takafumi Suzuki, Fumiaki Yoshida, Masayuki Hirata
  • Journal Title: Biomedical Circuits and Systems Conference (BioCAS), 2016 IEEE Volume: 166 Pages: 476-479
  • DOI: 10.1109/biocas.2016.7833835
  • Peer Reviewed
• [Journal Article] Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies (2016)
  • Author(s): Paul W Tillberg, Fei Chen, Kiryl D Piatkevich, Yongxin Zhao, Chih-Chieh Jay Yu, Brian P English, Linyi Gao, Anthony Martorell, Ho-Jun Suk, Fumiaki Yoshida, Ellen M DeGennaro, Douglas H Roossien, Guanyu Gong, Uthpala Seneviratne, Steven R Tannenbaum, Robert Desimone, Dawen Cai, Edward S Boyden
  • Journal Title: Nature biotechnology Volume: 34 Issue: 9 Pages: 987-992
  • DOI: 10.1038/nbt.3625
  • Peer Reviewed
• [Presentation] Potential of bi-directional brain machine interface using ECoG recording and optogenetic neuromodulation (2018)
  • Author(s): Fumiaki Yoshida, Masayuki Hirata, Koji Iihara
  • Organizer: 23rd Congress of the European Society for Stereotactic and Functional Neurosurgery
  • Int'l Joint Research
• [Presentation] Potential of bi-directional brain machine interface using neural recording and optogenetic neuromodulation (2018)
  • Author(s): Fumiaki Yoshida, Masayuki Hirata
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] 光操作法による運動誘発電位記録 (2018)
  • Author(s): 吉田史章
  • Organizer: 第57回日本定位・機能神経外科学会