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Expolaration of epileptic networks using cortico-cortical evoked potential

Research Project

Project/Area Number 16K10795
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionSapporo Medical University

Principal Investigator

Enatsu Rei  札幌医科大学, 医学部, 助教 (70749960)

Co-Investigator(Kenkyū-buntansha) 三國 信啓  札幌医科大学, 医学部, 教授 (60314217)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsCCEP / epileptic network / cortical stimulation / brain mapping / 皮質-皮質間誘発電位 / 電気刺激 / てんかんネットワーク / 脳内ネットワーク
Outline of Final Research Achievements

The aim of this study is to explore the epileptic networks using cortico-cortical evoked potentials. We recorded the cortico-cortical evoked potentials in the stimulation of epileptogenic regions in 33 patients, and are analyzing the data. Furthermore, in association with this study, we have reported the networks of frontal aslant tract, basal temporal language areas, auditory cortex, and distribution of eloquent cortices and afterdischarges in the electrical cortical stimulation.

Academic Significance and Societal Importance of the Research Achievements

本研究により、皮質‐皮質間誘発電位記録が、焦点の診断と発作ネットワークの解析に役立ち、従来の発作記録を代替、もしくは補完しうることが示されれば、発作焦点診断に有用な情報が得られるだけでなく、てんかん波の伝播に関わる異常なネットワークの解明にも役立つ情報が得られ、臨床上の意義は大変大きいものと思われる。 また、本研究に関連して得られた生理的なネットワークと機能野の分布に関する知識は、脳科学の発展に寄与するのみならず、脳外科手術の安全性を高めるうえで有用な情報となる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] The Influence of Anesthesia on Corticocortical Evoked Potential Monitoring Network Between Frontal and Temporoparietal Cortices2019

    • Author(s)
      Suzuki Yuto、Enatsu Rei、Kanno Aya、Yokoyama Rintaro、Suzuki Hime、Tachibana Shunsuke、Akiyama Yukinori、Mikami Takeshi、Ochi Satoko、Yamakage Michiaki、Mikuni Nobuhiro
    • Journal Title

      World Neurosurgery

      Volume: 123 Pages: e685-e692

    • DOI

      10.1016/j.wneu.2018.11.253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Location and Threshold of Electrical Cortical Stimulation for Functional Brain Mapping2018

    • Author(s)
      Kanno Aya、Enatsu Rei、Ookawa Satoshi、Ochi Satoko、Mikuni Nobuhiro
    • Journal Title

      World Neurosurgery

      Volume: 119 Pages: e125-e130

    • DOI

      10.1016/j.wneu.2018.07.059

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Threshold and distribution of afterdischarges with electrical cortical stimulation2018

    • Author(s)
      Suzuki Hime、Enatsu Rei、Kanno Aya、Suzuki Yuto、Yokoyama Rintaro、Ookawa Satoshi、Ochi Satoko、Mikuni Nobuhiro
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 55 Pages: 71-75

    • DOI

      10.1016/j.jocn.2018.06.039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The auditory cortex network in the posterior superior temporal area2018

    • Author(s)
      Suzuki Yuto、Enatsu Rei、Kanno Aya、Ochi Satoko、Mikuni Nobuhiro
    • Journal Title

      Clinical Neurophysiology

      Volume: 129 Issue: 10 Pages: 2132-2136

    • DOI

      10.1016/j.clinph.2018.07.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and Network of Basal Temporal Language Areas: A Study of the Combination of Electric Cortical Stimulation and Diffusion Tensor Imaging2017

    • Author(s)
      Enatsu Rei、Kanno Aya、Ookawa Satoshi、Ochi Satoko、Ishiai Sumio、Nagamine Takashi、Mikuni Nobuhiro
    • Journal Title

      World Neurosurgery

      Volume: 106 Pages: 1-8

    • DOI

      10.1016/j.wneu.2017.06.116

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study2017

    • Author(s)
      Ookawa Satoshi、Enatsu Rei、Kanno Aya、Ochi Satoko、Akiyama Yukinori、Kobayashi Tamaki、Yamao Yukihiro、Kikuchi Takayuki、Matsumoto Riki、Kunieda Takeharu、Mikuni Nobuhiro
    • Journal Title

      World Neurosurgery

      Volume: 107 Pages: 239-248

    • DOI

      10.1016/j.wneu.2017.07.166

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 全身麻酔による皮質-皮質間誘発電位への影響2018

    • Author(s)
      鈴木 脩斗、江夏 怜、菅野 彩、秋山 幸功、越智 さと子、三國 信啓
    • Organizer
      日本脳神経外科学会 第77回学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The influence of anesthesia on cortico-cortical evoked potential2018

    • Author(s)
      Rei Enatsu, Yuto Suzuki, Aya Kanno, Rintaro Yokoyama, Hime Suzuki, Yukinori Akiyama, Satoko Ochi, Nobuhiro Mikuni
    • Organizer
      American epilepsy society annual meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CCEPと術中皮質脳波を用いたてんかんネットワークの同定2017

    • Author(s)
      江夏 怜
    • Organizer
      第40回日本てんかん外科学会
    • Place of Presentation
      ナレッジキャピタル他(大阪府大阪市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] CCEPと術中皮質脳波を用いたてんかんネットワークの同定2017

    • Author(s)
      江夏 怜、大川 聡史、菅野 彩、越智 さと子、三國 信啓
    • Organizer
      第40回日本てんかん外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳機能マッピングにおける症候とafterdischarge誘発の皮質電気刺激閾値2017

    • Author(s)
      江夏 怜、菅野 彩、大川 聡史、越智 さと子、三國 信啓
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] The threshold of electrical cortical stimulation for functional brain mapping2017

    • Author(s)
      Rei Enatsu, Aya Kanno, Satoshi Ookawa, Satoko Ochi, Nobuhiro Mikuni
    • Organizer
      American epilepsy society annual meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] てんかんにおけるネットワーク探索.2016

    • Author(s)
      江夏 怜
    • Organizer
      第50回日本てんかん学会学術集会
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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