Shape of the titanium implants and bone ingrowth
| Project/Area Number |
16K10804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Akita Cerebrospinal and Cardiovascular Center |
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Principal Investigator |
Sugawara Taku 秋田県立循環器・脳脊髄センター(研究所), 医工学研究部, 研究部長 (80241660)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | インプラント形状 / チタン合金 / 骨再生 / チタンプレート / 微細加工 / チタン / インプラント / 骨癒合 / 骨再生誘導 |
|---|
| Outline of Final Research Achievements |
The relationship between the shape of the titanium implants and bone ingrowth was examined. Various sizes/shapes of mesh structure of the titamium alloy (Titanium 6Al 4V) implant are tested for in vitro and in vivo studies. Titanium plates were imersed in the artificial body fluid for 1 week and the crystals on their surface were identified by X-ray diffraction. The similar titanium plates were implanted on the cranium and ilium in Beagle dogs and followed by CT scanning for 3 months, and finally excised and underwent visual inspection, high-resolution insdustrial CT and scanning electron microscope. In conclusion, mesh plates with 2mm round-shaped holes were the best bone ingrowth enhancing structure.
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| Academic Significance and Societal Importance of the Research Achievements |
チタン製インプラントは骨補強・補填のためにひろく使用されているが、どのような形状が骨再生を促すかは十分な研究がされていなかった。今回、様々な形状のチタンプレートにおける骨再生をin vitroとin vivoで検証した。その結果、直剣2mmの円形のメッシュ構造が最も骨再生を促すことが判明し、今後インプラント形状の決定において重要な知見と考えられる。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Clinical application of 3D printing technology to the surgical treatment of atlantoaxial subluxation in small breed dogs.2019
Author(s)
Kamishina H, Sugawara T, Nakata K, Nishida H, Yada N, Fujioka T, Nagata Y, Doi A, Konno N, Uchida F, Maeda S
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] High dose of antibiotic colistin induces oligomerization of molecular chaperone HSP90.2017
Author(s)
Togashi S, Takahashi K, Tamura A, Toyota I, Hatakeyama S, Komatsuda A, Kudo I, Sasaki Kudoh E, Okamoto T, Haga A, Miyamoto A, Grave E, Sugawara T, Shimizu H
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Journal Title
J Biochem
Volume: 162
Issue: 1
Pages: 27-36
DOI
NAID
Related Report
Peer Reviewed
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