Analysis of serum biomarkers in patients with spinal ossification
Project/Area Number |
16K10815
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | University of Toyama |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
北島 勲 富山大学, 大学院医学薬学研究部(医学), 教授 (50214797)
箭原 康人 富山大学, 附属病院, 医員 (60456390)
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Research Collaborator |
YASUDA taketoshi
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 脊椎脊髄病学 / 脊柱靭帯骨化症 / 骨化関連因子 |
Outline of Final Research Achievements |
We have investigated the serum biomarkers which might be related to the pathology of spinal ossification. Hyper-sensitive C-reactive protein (hs-CRP) in patients with the spinal ossification was higher than that in the control. Hs-CRP had a positive correlation with the progression of the spinal ossification. Serum inorganic phosphate (IP) was lower in patients with the spinal ossification, compared to the control. IP had a negative correlation with the extent of the spinal ossification. Serum FGF-23 was higher in patients with the spinal ossification. Based on these studies, we wrote a review paper regarding the relationship between the serum biomarkers and spinal ossification. These results are important to understand the pathology of spinal ossification.
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Academic Significance and Societal Importance of the Research Achievements |
脊柱靭帯骨化症は原因不明の疾患である。本研究はこの病因についてバイオマーカーを用いて検討し、以下の2つの知見を得た。1)脊柱靭帯骨化には炎症が関与し、特に骨化巣の伸展と正の相関があること、2)脊柱靭帯骨化では血清リン値が低下し、骨化巣の広がりと負の相関があること。またこれらのデータを基に文献的にレビューを行い、脊柱靭帯骨化症に関わるバイオマーカーを調べまとめた。以上の結果は脊柱靭帯骨化症の病因の解明のみならず、治療の糸口を探るために重要であると考えられた。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Co-existence of ossification of the nuchal ligament is associated with severity of ossification in the whole spine in patients with cervical ossification of the posterior longitudinal ligament -A multi-center CT study-2019
Author(s)
Yoshii T, Hirai T, Iwanami A, Nagoshi N, Takeuchi K, Mori K, Yamada T, Seki S, Tsuji T, Fujiyoshi K, Furukawa M, Nishimura S,Wada K, Koda M, Furuya T, Matsuyama Y, Hasegawa T, Takeshita K, Kimura A, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Kawaguchi Y, et al.
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Journal Title
Journal of Orthopaedic Science
Volume: 24
Issue: 1
Pages: 35-41
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increase of the serum FGF-23 in ossification of the posterior longitudinal ligament2018
Author(s)
Kawaguchi Y, Kitajima I, Nakano M, Yasuda T, Seki S, Suzuki K, Yahara Y, Makino H, Ujihara Y, Ueno T, Kimura T
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Journal Title
Global Spine Journal
Volume: -
Issue: 5
Pages: 492-498
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prevalence and distribution of diffuse idiopathic skeletal hyperostosis on whole-spine computed tomography in patients with cervical ossification of the posterior longitudinal ligament2018
Author(s)
Nishimura S, Nagoshi N, Iwanami A, Takeuchi A, Hirai T, Yoshii T, Takeuchi K, Mori K, Yamada T, Seki S, Tsuji T, Fujiyoshi K, Furukawa M, Wada K, Koda M, Furuya T, Matsuyama Y, Hasegawa T, Takeshita K, Kimura A, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Kawaguchi Y, et al.
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Journal Title
Clinical Spine Surgery
Volume: 31
Issue: 9
Pages: E460-E465
DOI
Related Report
Peer Reviewed
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[Journal Article] Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: a multicenter study (JOSL CT study).2018
Author(s)
Hirai T, Yoshii T, Nagoshi N, Takeuchi K, Mori K, Ushio S, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Ando K, Fujibayashi S, Koda M, Yamazaki M, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y.
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Journal Title
BMC Musculoskelet Disord.
Volume: 19(1)
Issue: 1
Pages: 107-107
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Perioperative complications after surgery for thoracic ossification of posterior longitudinal ligament- nationwide multicenter prospective study2018
Author(s)
Imagama S, Ando K, Takeuchi K, Kato S, Murakami H, Aizawa T, Ozawa H, Hasegawa T, Matsuyama Y, Koda M, Yamazaki M, Chikuda H, Shindo S, Nakagawa Y, Kimura A, Takeshita K, Wada K, Katoh H, Watanabe M, Yamada K, Furuya T, Tsuji T, Fujibayashi S, Mori K, Kawaguchi Y, Watanabe K, Matsumoto M, Yoshii T, Okawa A
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Journal Title
SPINE
Volume: 43
Issue: 23
Pages: E1389-E1397
DOI
Related Report
Peer Reviewed
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