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Biochemical analysis of joint effusion and analysis of degenerative process of articular cartilage in low back pain arising from facet joints

Research Project

Project/Area Number 16K10820
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTottori University

Principal Investigator

NAGASHIMA Hideki  鳥取大学, 医学部, 教授 (00271049)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腰痛 / 椎間関節 / 変性 / 腰椎 / MRI
Outline of Final Research Achievements

One study entitled "Evaluation of age-related changes in lumbar fecet joints using T2 mapping" has been completed, and showed that T2 value of facet joints was significantly increased as age rose. This study was published in Journal of Orthopaedic Science.
Other two studies entitled "Relationship between T2 value of facet joints and low back pain arising from facet joints" and "Analysis of microRNA in degenerative facet joints" have been started just after approvals by our institutional ethical committee. Since their sample sizes have not satisfied yet, we have to continue these studies in 2020. After collecting enough samples, we will analyse these data and submit papers to international journals.

Academic Significance and Societal Importance of the Research Achievements

世界中には、極めて多くの人々が腰痛に悩まされており、腰痛の機序を解明し、治療に結びつける研究を行うことで、世界に貢献することができる。今までの腰痛の研究は、椎間板と神経に重点が置かれてきたことは否めない。そこで、本研究では、今までのアプローチと視点を変えて、椎間関節性腰痛に注目した。
簡便に非侵襲的に関節軟骨の変性を評価できるT2 mappingに注目し、椎間関節のT2値は加齢とともに上昇することを明らかにした。これらを基準値として患者のT2値の特徴を求めれば、変性軟骨の定量化が可能となることが期待できる。「椎間関節の変性に関わるmicroRNAの解析」では、病態の解明に繋がる可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2020 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Evaluation of age-related changes in lumbar facet joints using T2 mapping2020

    • Author(s)
      Shinpei Enokida , Shinji Tanishima, Atsushi Tanida, Tokumitsu Mihara, Chikako Takeda , Eijiro Yamashita, Hideki Nagashima
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 25 Issue: 1 Pages: 46-51

    • DOI

      10.1016/j.jos.2019.02.017

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] MRT2 mappingを用いた腰椎椎間関節における年齢階層別評価2018

    • Author(s)
      榎田信平, 谷島伸二, 谷田敦, 三原徳満, 武田知加子, 永島英樹, 山下栄二郎
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] MRI T2 mappingを用いた健常者の腰椎椎間関節および椎間板の年齢階層別評価2017

    • Author(s)
      榎田信平、谷島伸二、永島英樹
    • Organizer
      第46回日本脊椎脊髄病学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 年代別に評価した腰椎椎間関節および椎間板におけるMRI T2値の基準値作成の試み2016

    • Author(s)
      榎田信平、谷島伸二、永島英樹
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 年代別に評価した腰椎椎間関節および椎間板におけるMRI T2値の基準値作成の試み2016

    • Author(s)
      榎田信平、谷島伸二、永島英樹
    • Organizer
      第24回日本腰痛学会
    • Place of Presentation
      甲府富士屋ホテル(山梨県甲府市)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 年代別に評価した腰椎椎間関節および椎間板におけるMRI T2値の基準値作成の試み2016

    • Author(s)
      榎田信平、谷島伸二、永島英樹
    • Organizer
      第85回西日本脊椎研究会
    • Place of Presentation
      大正製薬九州支店(福岡県福岡市)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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