| Project/Area Number |
16K10831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Matsuda Nozomu 福島県立医科大学, 医学部, 助教 (90726457)
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| Co-Investigator(Kenkyū-buntansha) |
久保 均 福島県立医科大学, 公私立大学の部局等, 教授 (00325292)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨格筋MRI / Whole-body MRI / 末梢神経障害 / 炎症性筋疾患 / 脱神経筋マッピング / マルチパラメトリックイメージング / 遺伝性感覚運動ニューロパチー / 慢性炎症性脱髄性多発神経根炎 / 骨格筋マルチパラメトリックイメージング / Dixon法 / IVIM法 / 定量評価 / 筋疾患 / 末梢神経疾患 / 骨格筋マルチバラメトリックイメージング / whole-body MRI / 神経筋疾患 / 筋・神経病学 |
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| Outline of Final Research Achievements |
The aim of our study was to develop a protocol of muscle evaluation for neuromuscular disorders (NMDs) using multiparametric whole-body MRI (WB-MRI). We prospectively scanned WB-MRI in 40 patients with NMDs including peripheral neuropathy, motor neuron disease and idiopathic inflammatory myopathy. WB-MRI was performed with a 3-Tesla MRI system. The following sequence was used: T1WI, T2WI, STIR, Dixon and intravoxel incoherent motion methods. We selected the bilateral 108 muscles that could be reliably identified. Multiparametric WB-MRI was found to be powerful in detecting subclinical muscle involvements or affected muscles that are clinically difficult to evaluate. In addition, WB-MRI has a potential to discriminate subtypes of idiopathic inflammatory myopathies and revealed precise distribution of denervation muscles in peripheral neuropathies. While our methods still depend on semi-quantitative evaluation, more quantitative, ideally automated, measures should be developed.
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| Academic Significance and Societal Importance of the Research Achievements |
転移性脊髄腫瘍による運動障害レベル、炎症性筋疾患における体幹筋障害を筋MRIで検出し報告した。現在、炎症性筋疾患の10例において網羅的に全身108の筋で炎症の有無を解析し、投稿予定である。定量法としてはintravoxel incoherent motion imaging法による急性脱神経・炎症の定量解析を検討した。しかし、期間内に達成できなかった。Dixon法による脂肪浸潤の定量解析は実現した。
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