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A new understanding of muscle fatigue axial pain due to kyphostic deformity

Research Project

Project/Area Number 16K10834
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionWakayama Medical University

Principal Investigator

Yamada Hiroshi  和歌山県立医科大学, 医学部, 教授 (70275361)

Co-Investigator(Kenkyū-buntansha) 岡 敬之  東京大学, 医学部附属病院, 特任准教授 (60401064)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords脊柱後弯症 / 腰痛 / 疫学 / 成人脊柱変形 / 不良姿勢 / 住民コホート / 運動器検診 / 筋疲労性軸性疼痛 / 姿勢不良 / 脊柱矢状面アライメント / 大規模住民コホート / 疫学調査 / 健康関連QOL / 矢状面アライメント / 臨床 / 外科 / 脊柱後弯
Outline of Final Research Achievements

Spinal balance at upright posture is unconsciously maintained with minimal muscle activity energy consumption. On the other hand, an unbalanced spine induces excessive energy loss of back muscle activity to maintain its standing position. This is the mechanism of muscle fatigue low back pain due to kyphotic deformity, resulting in standing and walking disorder in the elderly. Therefore, in order to reconstruct spinal alignment capable of standing and walking for a long time by surgical treatment, it is necessary to elucidate an ideal posture in which energy consumption is minimized. For this reason, we surveyed the spinal alignment of the volunteers who did not experience low back pain in daily life in a large population cohort study. As a result, it turned out that it is an ideal posture when people form the lumbar lordosis corresponding to their pelvic incidence.

Academic Significance and Societal Importance of the Research Achievements

ヒトは固有の骨盤形態角に相当する腰椎前弯を形成し直立位を保つことが理想の姿勢であることを本疫学研究で解明した。また、加齢に伴い脊柱後弯が進行し、骨盤形態角と腰椎前弯の間に解離を認めるようになると、筋疲労性に背部痛や腰痛などの軸性疼痛が発生するリスクが高まることも証明した。本病態は過去において原因のわからない腰痛、非特異的腰痛とみなされていたものである。新しい疾患概念としての脊柱後弯症による筋疲労性軸性疼痛の病態を理解することで、既存の治療体系の中に存在する不必要もしくは有害とみなされる医療が駆逐され、腰痛治療成績のより一層の向上が期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (46 results)

All 2018 2017 2016

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (31 results) (of which Int'l Joint Research: 9 results,  Invited: 15 results)

  • [Journal Article] 新しい疾患概念としての脊柱後彎変形による筋疲労性軸性疼痛と起立歩行障害2018

    • Author(s)
      山田 宏
    • Journal Title

      和歌山医学

      Volume: 69 Pages: 9-13

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 成人脊柱変形の矯正手術において固定上位端をL1もしくはL2におくことは、治療としてあり得る2018

    • Author(s)
      筒井 俊二、山田 宏、橋爪 洋、湯川 泰紹、南出 晃人、中川 幸洋、岩崎 博、高見 正成、中尾 慎一、籠谷 良平、吉田 宗人
    • Journal Title

      Journal of Spine Research

      Volume: 9 Pages: 1350-1353

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Factory and construction work is associated with an increased risk of severe lumbar spinal stenosis on MRI: A case control analysis within the wakayama spine study.2018

    • Author(s)
      Yuyu Ishimoto, Cyrus Cooper , Georgia Ntani , Hiroshi Yamada, Hiroshi Hashizume, Keiji Nagata, Shigeyuki Muraki, Sakae Tanaka, Noriko Yoshimura, Munehito Yoshida, Karen Walker-Bone
    • Journal Title

      American Journal of Industrial Medicine

      Volume: 62(5) Pages: 430-438

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association of high-intensity zones on MRI and low back pain: a systematic review2018

    • Author(s)
      Teraguchi M, Yim R, Cheung J, Samartzis D
    • Journal Title

      Scoliosis Spinal Disord

      Volume: 13 Pages: 13-22

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors associated with lumbar spinal stenosis in a large-scale, population-based cohort: The Wakayama Spine Study2018

    • Author(s)
      Takahiro Maeda, Hiroshi Hashizume, Noriko Yoshimura, Hiroyuki Oka, Yuyu Ishimoto, Keiji Nagata, Masanari Takami, Shunji Tsutsui, Hiroshi Iwasaki, Akihito Minamide, Yukihiro Nakagawa, Yasutsugu Yukawa, Shigeyuki Muraki, Sakae Tanaka, Hiroshi Yamada, Munehito Yoshida
    • Journal Title

      PLoS One

      Volume: 13(7)

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI-defined paraspinal muscle morphology in Japanese population: The Wakayama Spine Study2017

    • Author(s)
      Sasaki T, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Iwahashi H,Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M
    • Journal Title

      PLoS One

      Volume: Nov 8;12(11)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sagittal spino-pelvic alignment in adults2017

    • Author(s)
      Asai Y, Tsutsui S, Oka H, Yoshimura N, Hashizume H, Yamada H, Akune T, Muraki S, Matsudaira K, Kawaguchi H, Nakamura K, Tanaka S, Yoshida M.
    • Journal Title

      PLoS One

      Volume: Jun 6;12(6) Issue: 6 Pages: e0178697-e0178697

    • DOI

      10.1371/journal.pone.0178697

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study2017

    • Author(s)
      Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M
    • Journal Title

      Eur Spine J

      Volume: in press Issue: 10 Pages: 2529-2535

    • DOI

      10.1007/s00586-017-5072-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study2017

    • Author(s)
      Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S,Yoshida M
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 25(7) Pages: 1122-1131

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study.2017

    • Author(s)
      Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
    • Journal Title

      Spine

      Volume: 印刷中 Issue: 11 Pages: E666-E671

    • DOI

      10.1097/brs.0000000000001960

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 成人脊柱変形に対する新しい低侵襲手術2016

    • Author(s)
      山田 宏
    • Journal Title

      大阪臨床整形外科医会会報

      Volume: 42 Pages: 81-83

    • Related Report
      2016 Research-status Report
  • [Journal Article] The association between the cross-sectional area of the dural sac and low back pain in a large population: The Wakayama Spine Study2016

    • Author(s)
      Iwahashi H, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Shintou K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M
    • Journal Title

      PLoS ONE

      Volume: 11(8)

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Classification of high intensity zones of the lumbar spine and their association with other spinal MRI phenotypes2016

    • Author(s)
      Teraguchi M, Samartzis D, Hashizume H, Yamada H, Muraki S, Oka H, J. Cheung PY, Kagotani R, Iwahashi H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Cheung KM, Yoshimura N, Yoshida M
    • Journal Title

      PLoS ONE

      Volume: 11(9)

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study2016

    • Author(s)
      Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Mnamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M
    • Journal Title

      PLoS ONE

      Volume: 11(2)

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study2016

    • Author(s)
      Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M
    • Journal Title

      Spine

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] SEVERE LUMBAR SPINAL STENOSIS ON MRI SCANS IS RELATED WITH HEAVY MANUAL WORK: The Wakayama Spine Study2018

    • Author(s)
      Yuyu Ishimoto, Cyrus Cooper, Georgia Ntani , Hiroshi Yamada, Hiroshi Hashizume, Shigeyuki Muraki, Sakae Tanaka, Munehito Yoshida, Noriko Yoshimura, Karen Walker-Bone
    • Organizer
      Bone Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HEAVY MANUAL WORK IS ASSOCIATED WITH AN INCREASED RISK OF SEVERE LUMBAR SPINAL STENOSIS ON MRI SCANS (914)2018

    • Author(s)
      Yuyu Ishimoto, Cyrus Cooper, Karen Walker-Bone, Georgia Ntani, Hiroshi Yamada, Hiroshi Hashizume , Keiji Nagata , Shigeyuki Muraki , Sakae Tanaka, Noriko Yoshimura, Munehito Yoshida
    • Organizer
      ISSLS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RISK OF SEVERE LUMBAR SPINAL STENOSIS ON MRI SCANS IS INCREASED BY HEAVY MANUAL WORK: The Wakayama Spine Study2018

    • Author(s)
      Yuyu Ishimoto, Cyrus Cooper, Karen Walker-Bone, Georgia Ntani, Hiroshi Yamada, Hiroshi Hashizume , Keiji Nagata , Shigeyuki Muraki, Sakae Tanaka, Noriko Yoshimura , Munehito Yoshida
    • Organizer
      WCO IOF-EFCEO
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of cervical myelopathy and symptomatic lumbar spinal stenosis among participants with radiographic tandem spinal stenosis2018

    • Author(s)
      Keiji Nagata, Noriko Yoshimura, Hiroshi Hashizume, Yuyu Ishimoto, Hiroshi Yamada, Akihito Minamide, Shigeyuki Muraki, Munehito Yoshida
    • Organizer
      Spine Across the Sea
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sagittal imbalance of the spine-pelvis-lower extremity axis is associated with back-related disability in inhabitant volunteers2018

    • Author(s)
      Teraguchi M, Kawakami M, Ishimoto Y, Nagata K, Kagotani R, Nakagawa M, Minetama M, Yamada H
    • Organizer
      International society for study of lumbar spine, 45th annual meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sagittal imbalance of the spine-pelvis-lower extremity axis is associated with back-related disability in inhabitant volunteers2018

    • Author(s)
      Teraguchi M, Kawakami M, Ishimoto Y, Nagata K, Kagotani R, Nakagawa M, Minetama M, Yamada H
    • Organizer
      Spine Across the Sea
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DIABETES MELLITUS AND LOWER ABI ARE ASSOCIATED WITH SYMPTOMATIC LUMBAR SPINAL STENOSIS THE WAKAYAMA SPINE STUDY2018

    • Author(s)
      Takahiro Maeda, Hiroshi Hashizume, Noriko Yoshimura, Yuyu Ishimoto, Hiroyuki Oka, Takaaki Fujiki, Keiji Nagata, Masanari Takami, Shunji Tsutsui, Hiroshi Iwasaki, Yukihiro Nakagawa, Akihito Minamide, Yasutsugu Yukawa, Munehito Yoshida, Hiroshi Yamada
    • Organizer
      45th Annual Meeting of The International Society for the Study of the Lumbar Spine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日常診療に役立つ脊椎加齢変性疾患の疫学実態-The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第55回日本リハビリテーション医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脊椎加齢変性疾患の疫学実態に基づく治療戦略-The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第14回関西医科大学脊椎グループ研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新しい疾患概念としての脊柱後弯症による筋疲労性軸性疼痛と間欠跛行2018

    • Author(s)
      山田 宏
    • Organizer
      南燈会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいたaging spineの治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第94回北九州脊椎・脊髄研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第5回福島骨粗鬆症性椎体骨折研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第8回阪神運動器疾患セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第239回阪神整形外科懇話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第17回OCUM整形勤務医会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第131回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      第18回桜整形外科セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2018

    • Author(s)
      山田 宏
    • Organizer
      浜松整形外科セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 実臨床に役立つ脊椎加齢変性疾患の疫学実態 -The Wakayama spine study-2018

    • Author(s)
      山田 宏
    • Organizer
      第234回新潟整形外科研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Lumbar high-intensity zones on MRI: imaging biomarkers for severe, prolonged low back pain and sciatica in a population-based cohort2018

    • Author(s)
      Teraguchi M, Cheung J, Karppinen J, Bow C, Hashizume H, Luk K, Cheung K, Samartzis D
    • Organizer
      第47回日本脊椎脊髄病学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腰椎High Intensity Zoneと腰痛との関係について; -Hong Kong Degenerative Disc Study-2018

    • Author(s)
      寺口 真年, Dino Samartzis, Jason Cheung, 橋爪 洋, Keith Luk, Kenneth Cheung
    • Organizer
      第91回日本整形外科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大規模住民コホートにおける腰部脊柱管狭窄症の発症関連因子 -The Wakayama Spine2018

    • Author(s)
      前田 孝浩, 吉村 典子, 橋爪 洋, 山田 宏, 岡 敬之, 石元 優々, 長田 圭司, 村木 重之, 南出 晃人, 中川 幸洋, 湯川 泰嗣, 吉田 宗人
    • Organizer
      第47回日本脊椎脊髄病学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新しい疾患概念としての筋疲労性軸性疼痛(いわゆる腰曲がり)の診断と治療2017

    • Author(s)
      山田 宏
    • Organizer
      弘前大学整形外科あすなろセミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 疫学実態に基づいた脊椎加齢変性疾患の治療戦略 -The Wakayama Spine Study-2017

    • Author(s)
      山田 宏
    • Organizer
      第97回京都運動器フォーラム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 新しい成人脊柱変形の治療戦略はUIVの選択自由度を広げる2017

    • Author(s)
      山田 宏 吉田宗人 橋爪 洋 湯川泰紹 南出晃人 中川幸洋 岩崎 博 筒井俊二 高見正成 中尾慎一 籠谷良平
    • Organizer
      第7回日本成人脊柱変形学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 成人脊柱変形の矯正手術において固定上位端をL1 もしくはL2におくことは、治療選択肢としてあり得る2017

    • Author(s)
      山田 宏 吉田宗人 橋爪 洋 湯川泰紹 南出晃人 中川幸洋 岩崎 博 筒井俊二 高見正成 中尾慎一 籠谷良平
    • Organizer
      第46回日本脊椎脊髄病学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparison of minimally invasive V.S. traditional open posterior procedure combined with XLIF in the treatment of low back pain due to adult spinal deformity in the elderly.2016

    • Author(s)
      Hiroshi Yamada, Munehito Yoshida, Hiroshi Hashizume, Akihito Minamide, Yukihiro Nakagawa, Hiroshi Iwasaki, Shunji Tsutsui, Takami Masanari, Shinichi Nakao, Ryohei Kagotani
    • Organizer
      International society for study of lumbar spine, 43th annual meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] XLIFによる成人側弯症の治療成績-従来法との比較―2016

    • Author(s)
      山田宏 吉田宗人 橋爪洋 南出晃人 中川幸洋 岩﨑博 筒井俊二 高見正成 中尾慎一 籠谷良平
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] XLIFによる成人側弯症の治療成績-従来法との比較―2016

    • Author(s)
      山田宏 吉田宗人 橋爪洋 南出晃人 中川幸洋 岩﨑博 筒井俊二 高見正成 中尾慎一 籠谷良平
    • Organizer
      第45回日本脊椎脊髄病学会
    • Place of Presentation
      幕張市
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparison of minimally invasive V.S. open posterior procedure combined with XLIF in adult spinal deformity in the elderly2016

    • Author(s)
      Hiroshi Yamada, Munehito Yoshida, Hiroshi Hashizume, Akihito Minamide, Yukihiro Nakagawa, Hiroshi Iwasaki, Shunji Tsutsui, Takami Masanari, Shinichi Nakao, Ryohei Kagotani
    • Organizer
      16th annual conference, The international society for advancement of spine surgery,
    • Place of Presentation
      Las Vegas
    • Year and Date
      2016-04-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 腰椎疾患の疫学;The Wakayama Spine Study-2016

    • Author(s)
      山田 宏
    • Organizer
      秋田県腰痛フォーラム
    • Place of Presentation
      秋田市
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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