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Development of new composite artificial bone and drug delivery

Research Project

Project/Area Number 16K10848
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YOSHII Toshitaka  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50583754)

Co-Investigator(Kenkyū-buntansha) 早乙女 進一  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (20401391)
大川 淳  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
榎本 光裕  東京医科歯科大学, 医学部附属病院, 非常勤講師 (90451971)
Research Collaborator HIRAI Keigo  
EGAWA Satoru  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsハイドロキシアパタイト / 複層 / 骨再生 / 人工骨 / 再生医学
Outline of Final Research Achievements

Osteoconductive material is generally highly porous, which does not possess mechanical strength. On the other hand, dense material has enough mechanical strength but less osteoconductive. Therefore, we aimed to develop porous/dense composite hydroxyapatite (HAp) based artificial bone in this study. Dense HAp has a hollow shape that can contain highly porous HAp/collagen inside. We examined the mechanical strength of the hollow HAp and found that the mechanical strength was negatively correlated the porosity and hollow rate. HAp/col showed excellent ability of retaining BMP2 and antibiotics which were sustainably released. In vivo rat model showed a good bone regeneration of BMP2 loaded HAp/col in femoral segmental bone defect model and rabbit model showed an acceptable bone reconstruction in tibia defect model. VCM loaded Hap/col showed an excellent antibiotic and bone reconstruction ability in rat infection model.

Academic Significance and Societal Importance of the Research Achievements

現在、骨欠損を補填する方法として主に自家骨や同種骨の移植、人工の生体材料の移植等がおこなわれている。自家骨を移植するためには健常部から移植骨を採取しなければならないが、採取部の合併症や、採取量の制限などの問題がある。同種骨が普及していないわが国では、人工骨補填材料への需要が高く、これまでリン酸カルシウムを中心とした様々な人工骨が研究されてきている。一般にリン酸カルシウムを使用した人工骨は骨伝導性の優れた多孔体は強度が弱く、強度の強い緻密質ないし低気孔率人工骨は骨伝導性に劣るという問題がある。本研究で開発した複層HApは強度と優れた骨伝導性を兼ね備え、今後の骨補填材料として期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (53 results)

All 2019 2018 2017 2016

All Journal Article (23 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 23 results,  Open Access: 5 results) Presentation (30 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results)

  • [Journal Article] Co-existence of ossification of the nuchal ligament is associated with severity of ossification in the whole spine in patients with cervical ossification of the posterior longitudinal ligament -A multi-center CT study-2019

    • Author(s)
      Yoshii T, Hirai T, Iwanami A, Nagoshi N, Takeuchi K, Mori K, Yamada T, Seki S, Tsuji T, Fujiyoshi K, Furukawa M, Nishimura S,Wada K, Koda M, Furuya T, Matsuyama Y, Hasegawa T, Takeshita K, Kimura A, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Kawaguchi Y, et al.
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 24 Issue: 1 Pages: 35-41

    • DOI

      10.1016/j.jos.2018.08.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of cancer-related and mitogen-activated protein kinase signaling pathways in human mature osteoblasts isolated from patients with type 2 diabetes.2019

    • Author(s)
      Kuroiwa T, Yoshii T, Okawa A et al
    • Journal Title

      Bone Rep.

      Volume: Jun Pages: 100199-100199

    • DOI

      10.1016/j.bonr.2019.100199

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of sarcopenia on the results of lumbar spinal surgery2018

    • Author(s)
      Inose H, Yamada T,
    • Journal Title

      osteoporosis and sarcopenia

      Volume: 4 Issue: 1 Pages: 33-36

    • DOI

      10.1016/j.afos.2018.02.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autologous chondrocyte grafting promotes bone formation in the posterolateral spine2018

    • Author(s)
      Sielatycki J. Alex、Saito Masanori、Yuasa Masato、Moore-Lotridge Stephanie N.、Uppuganti Sasidhar、Colazo Juan M.、Hysong Alexander A.、Robinette J. Patton、Okawa Atsushi、Yoshii Toshitaka、Schwartz Herbert S.、Nyman Jeffry S.、Schoenecker Jonathan G.
    • Journal Title

      JOR Spine

      Volume: 1 Issue: 1

    • DOI

      10.1002/jsp2.1001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surgical outcomes for lumbar spinal canal stenosis with coexisting cervical stenosis (tandem spinal stenosis): a retrospective analysis of 565 cases2018

    • Author(s)
      Yamada Tsuyoshi、Yoshii Toshitaka、Yamamoto Naoki、Hirai Takashi、Inose Hiroyuki、Okawa Atsushi
    • Journal Title

      Journal of Orthopaedic Surgery and Research

      Volume: 13 Issue: 1 Pages: 60-60

    • DOI

      10.1186/s13018-018-0765-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term results of a prospective study of anterior decompression with fusion and posterior decompression with laminoplasty for treatment of cervical spondylotic myelopathy2018

    • Author(s)
      Hirai Takashi、Yoshii Toshitaka、Sakai Kenichiro、Inose Hiroyuki、Yamada Tsuyoshi、Kato Tsuyoshi、Kawabata Shigenori、Arai Yoshiyasu、Shinomiya Kenichi、Okawa Atsushi
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 23 Issue: 1 Pages: 32-38

    • DOI

      10.1016/j.jos.2017.07.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multi-train electrical stimulation protocol facilitates transcranial electrical motor evoked potentials and increases induction rate and reproducibility even in patients with preoperative neurological deficits2017

    • Author(s)
      Ushio Shuta、Kawabata Shigenori、Sumiya Satoshi、Kato Tsuyoshi、Yoshii Toshitaka、Yamada Tsuyoshi、Enomoto Mitsuhiro、Okawa Atsushi
    • Journal Title

      Journal of Clinical Monitoring and Computing

      Volume: 32 Issue: 3 Pages: 549-558

    • DOI

      10.1007/s10877-017-0045-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Augmentation of fracture healing by hydroxyapatite/collagen paste and bone morphogenetic protein-2 evaluated using a rat femur osteotomy model2017

    • Author(s)
      Wei Xuetao、Egawa Satoru、Matsumoto Renpei、Yasuda Hiroaki、Hirai Keigo、Yoshii Toshitaka、Okawa Atsushi、Nakajima Takehiko、Sotome Shinichi
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 36(1) Issue: 1 Pages: 129-137

    • DOI

      10.1002/jor.23646

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Outcomes of Cervical Spinal Surgery for Cervical Myelopathic Patients with Coexisting Lumbar Spinal Canal Stenosis (Tandem Spinal Stenosis) A retrospective analysis of 297 cases2017

    • Author(s)
      Yamada Tsuyoshi、Yoshii Toshitaka、Yamamoto Naoki、Hirai Takashi、Inose Hiroyuki、Kato Tsuyoshi、Kawabata Shigenori、Okawa Atsushi
    • Journal Title

      SPINE

      Volume: 43(4) Issue: 4 Pages: E234-E241

    • DOI

      10.1097/brs.0000000000002289

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Comparative Study of Anterior Decompression With Fusion and Posterior Decompression With Laminoplasty for the Treatment of Cervical Spondylotic Myelopathy Patients With Large Anterior Compression of the Spinal Cord2017

    • Author(s)
      Hirai Takashi、Yoshii Toshitaka、Arai Yoshiyasu、Sakai Kenichiro、Torigoe Ichiro、Maehara Hidetsugu、Tomori Masaki、Taniyama Takashi、Sato Hirokazu、Okawa Atsushi
    • Journal Title

      Clinical Spine Surgery

      Volume: 30 Issue: 8 Pages: E1137-E1142

    • DOI

      10.1097/bsd.0000000000000500

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraoperative evaluation using mobile computed tomography in anterior cervical decompression with floating method for massive ossification of the posterior longitudinal ligament.2017

    • Author(s)
      Yoshii T, Hirai T, Yamada T, Inose H, Kato T, Sakai K, Enomoto M, Kawabata S, Arai Y, Okawa A.
    • Journal Title

      J Orthop Surg Res.

      Volume: 12(1):12 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s13018-017-0515-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Comparative Study of Anterior Decompression With Fusion and Posterior Decompression With Laminoplasty for the Treatment of Cervical Spondylotic Myelopathy Patients With Large Anterior Compression of the Spinal Cord.2017

    • Author(s)
      Hirai T, Yoshii T, Arai Y, Sakai K, Torigoe I, Maehara H, Tomori M, Taniyama T, Sato H, Okawa A.
    • Journal Title

      Clin Spine Surg.

      Volume: In press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasmin Prevents Dystrophic Calcification After Muscle Injury.2017

    • Author(s)
      Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AR, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, Flick MJ, Cates JM, Schoenecker JG.
    • Journal Title

      J Bone Miner Res.

      Volume: 32(2) Issue: 2 Pages: 294-308

    • DOI

      10.1002/jbmr.2973

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of the surgical treatment for degenerative cervical myelopathy on the preoperative cervical sagittal balance: a review of prospective comparative cohort between anterior decompression with fusion and laminoplasty.2017

    • Author(s)
      Sakai K, Yoshii T, Hirai T, Arai Y, Shinomiya K, Okawa A.
    • Journal Title

      Eur Spine J.

      Volume: 26(1) Issue: 1 Pages: 104-112

    • DOI

      10.1007/s00586-016-4717-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fall-related Deterioration of Subjective Symptoms in Patients with Cervical Myelopathy.2017

    • Author(s)
      Kimura A, Seichi A, Takeshita K, Inoue H, Kato T, Yoshii T, Furuya T, Koda M, Takeuchi K, Matsunaga S, Seki S, Ishikawa Y, Imagama S, Yamazaki M, Mori K, Kawasaki Y, Fujita K, Endo K, Sato K, Okawa A.
    • Journal Title

      Spine (Phila Pa 1976)

      Volume: 42 Issue: 7 Pages: E398-E403

    • DOI

      10.1097/brs.0000000000001798

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Outcomes of Spinal Surgery for Patients Undergoing Hemodialysis.2016

    • Author(s)
      Yamada T, Yoshii T, Hirai T, Inose H, Kato T, Kawabata S, Okawa A.
    • Journal Title

      Orthopedics

      Volume: 39(5) Issue: 5

    • DOI

      10.3928/01477447-20160509-06

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anterior decompression with fusion versus posterior decompression with fusion for massive cervical ossification of the posterior longitudinal ligament with a 50% canal occupying ratio: a lticenter2016

    • Author(s)
      38.Yoshii T, Sakai K, Hirai T, Yamada T, Inose H, Kato T, Enomoto M, Tomizawa S, Kawabata S, Arai Y, Okawa A.
    • Journal Title

      Spine J

      Volume: 16(11) Issue: 11 Pages: 1351-1357

    • DOI

      10.1016/j.spinee.2016.07.532

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anterior Cervical Corpectomy and Fusion Using a Synthetic Hydroxyapatite Graft for Ossification of the Posterior Longitudinal Ligament.2016

    • Author(s)
      Yoshii T, Hirai T, Sakai K, Sotome S, Enomoto M, Yamada T, Inose H, Kato T, Kawabata S, Okawa A.
    • Journal Title

      Orthopedics

      Volume: - Issue: 2

    • DOI

      10.3928/01477447-20161208-02

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study.2016

    • Author(s)
      Mori K, Yoshii T, Hirai T, et al.
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 1;17(1) Pages: 492-492

    • NAID

      120007134948

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone Turnover Markers as a New Predicting Factor for Non-union After Spinal Fusion Surgery.2016

    • Author(s)
      Inose H, Yamada T, Mulati M, Hirai T, Ushio S, Yoshii T, Kato T, Kawabata S, Okawa A.
    • Journal Title

      Spine (Phila Pa 1976).

      Volume: In press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and Distribution of Ossified Lesions in the Whole Spine of Patients with Cervical Ossification of the Posterior Longitudinal Ligament A Multicenter Study (JOSL CT study).2016

    • Author(s)
      Hirai T, Yoshii T, Iwanami A, Takeuchi K, Mori K, Yamada T, Wada K, Koda M, Matsuyama Y, Takeshita K, Abematsu M, Haro H, Watanabe M, Watanabe K, Ozawa H, Kanno H, Imagama S, Fujibayashi S, Yamazaki M, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y.
    • Journal Title

      PLoS One.

      Volume: 11(8) Issue: 8 Pages: e0160117-e0160117

    • DOI

      10.1371/journal.pone.0160117

    • NAID

      120005997756

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cervical pedicle screw placement using intraoperative computed tomography imaging with a mobile scanner gantry.2016

    • Author(s)
      Yoshii T, Hirai T, Sakai K, Inose H, Kato T, Okawa A.
    • Journal Title

      Eur Spine J.

      Volume: 25(6) Issue: 6 Pages: 1690-7

    • DOI

      10.1007/s00586-016-4508-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Drain Tip Culture is Not Prognostic for Surgical Site Infection in Spinal Surgery Under Prophylactic Use of Antibiotics.2016

    • Author(s)
      Yamada T, Yoshii T, Egawa S, Takada R, Hirai T, Inose H, Kato T, Jinno T, Okawa A.
    • Journal Title

      Spine (Phila Pa 1976).

      Volume: 41(14): Issue: 14 Pages: 1179-84

    • DOI

      10.1097/brs.0000000000001503

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 腰椎椎体間固定術における新しい人工骨,多孔質ハイドロキシアパタイト/コラーゲン複合体の臨床使用-局所骨との前向き比較研究-2018

    • Author(s)
      吉井 俊貴, 湯浅 将人,平井 高志,加藤 剛,山田 剛史,猪瀬 弘之,坂井 顕一郎,新井 容嘉,川端 茂徳,大川 淳
    • Organizer
      第47回 日本脊椎脊髄病学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 重症外傷患者に対する新たなビスフォスフォネートを用いた治療法2018

    • Author(s)
      齊藤 正徳, 湯浅 将人, Stephanie Moore-Lotridge, 吉井 俊貴, Jonathan Schoenecker , 大川 淳
    • Organizer
      第91回 日本整形外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳癌骨転移モデルラットに対するパクリタキセル含浸HAp/Colによる局所制御実験2018

    • Author(s)
      松本連平, 江川聡, 平井敬悟, 山田剛史, 湯浅将人, 吉井俊貴, 大川淳, 早乙女進一
    • Organizer
      第33回 日本整形外科学会基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当科で開発した人工骨、多孔質ハイドロキシアパタイト/コラーゲン複合体の脊椎固定術における臨床使用と骨癒合評価2018

    • Author(s)
      吉井 俊貴, 早乙女 進一, 江川 聡, 平井 敬悟, 松本 連平, 平井 高志, 湯浅 将人, 猪瀬 弘之, 新井 容嘉, 大川 淳
    • Organizer
      第33回 日本整形外科学会基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ガンマ線照射が多孔質ハイドロキシアパタイト・コラーゲン複合体(HAp/Col)に与える影響 筋組織内での評価2018

    • Author(s)
      平井 敬悟, 江川 聡, 松本 連平, 湯浅 将人, 吉井 俊貴, 大川 淳, 中島 武彦, 早乙女 進一
    • Organizer
      第33回 日本整形外科学会基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラット大腿骨急性骨髄炎モデルにおける抗菌剤含有ハイドロキシアパタイト・コラーゲン複合体(HAp/Col)の治療効果2018

    • Author(s)
      江川 聡, 松本 連平, 平井 敬悟, 吉井 俊貴, 大川 淳, 早乙女 進一
    • Organizer
      第33回 日本整形外科学会基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨折治療の基礎研究 重症外傷患者に対するビスフォスフォネートを用いた新たな治療法2018

    • Author(s)
      齊藤 正徳, Lotridge-Moore Stephanie, 湯浅 将人, 吉井 俊貴, 大川 淳, Scwartz Herbert, Schoenecker Jonathan
    • Organizer
      第33回 日本整形外科学会基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ガンマ線照射が多孔質ハイドロキシアパタイト・コラーゲン複合体(HAp/Col)に与える影響2018

    • Author(s)
      平井 敬悟, 江川 聡, 松本 連平, 吉井 俊貴, 大川 淳, 中島 武彦, 早乙女 進一
    • Organizer
      第40回 日本バイオマテリアル学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Therapeutic Effect of Antibiotic-loaded Hydroxyapatite Collagen(HAp/Col)Composite on Acute, Bone-Destructive Osteomyelitis in Rats2018

    • Author(s)
      Satoru Egawa, Keigo Hirai, Rempei Matsumoto,Toshitaka Yoshii, Atsushi Okawa, Shinichi Sotome
    • Organizer
      Orthopaedic Research Society 2019 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 硬膜欠損を伴う脳表ヘモジデリン沈着症における欠損部同定(MRI balanced sequence法の有用性)2017

    • Author(s)
      吉井 俊貴, 平井 高志, 山田 剛史, 猪瀬 弘之, 江川 聡, 大川 淳
    • Organizer
      第46回日本脊椎脊髄病学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨粗鬆症性椎体圧潰に対する片側後方進入椎体亜全摘再建術の有用性 多施設研究2017

    • Author(s)
      吉井 俊貴, 坂井 顕一郎, 富澤 將司, 山田 剛史, 友利 正樹, 平井 高志, 猪瀬 弘之, 川端 茂徳, 新井 嘉容, 大川 淳
    • Organizer
      第46回日本脊椎脊髄病学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頸椎後縦靱帯骨化症に対する前方骨化浮上術における術中CTの有用性2017

    • Author(s)
      吉井 俊貴, 猪瀬 弘之, 平井 高志, 山田 剛史, 川端 茂徳, 大川 淳
    • Organizer
      第46回日本脊椎脊髄病学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頸椎後縦靱帯骨化症患者における項靱帯骨化の併存と脊椎靱帯骨化傾向との関連性 多施設CT研究2017

    • Author(s)
      吉井 俊貴, 平井 高志, 岩波 明生, 竹内 一裕, 森 幹士, 西村 空也, 中村 雅也, 松本 守雄, 大川 淳, 川口 善治
    • Organizer
      第90回 日本整形外科学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨粗鬆症性椎体骨折の手術治療 ―当科の工夫―2017

    • Author(s)
      吉井 俊貴
    • Organizer
      第14回 名古屋脊椎脊髄セミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 成人脊柱変形に対する後方矯正固定術における出血コントロールの工夫2017

    • Author(s)
      吉井俊貴, 平井高志, 山田剛史, 猪瀬弘之, 大川淳
    • Organizer
      第26回 日本脊椎インストゥルメンテーション学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨粗鬆症性椎体骨折に対する手術治療2017

    • Author(s)
      吉井 俊貴
    • Organizer
      第25回日本腰痛学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頚椎後縦靱帯骨化症(OPLL)に対する術式選択2017

    • Author(s)
      吉井 俊貴
    • Organizer
      第52回 日本脊髄障害医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新しい人工骨、多孔質ハイドロキシアパタイト/コラーゲン複合体の臨床使用2017

    • Author(s)
      吉井 俊貴, 湯浅 将人, 新井 容嘉, 大川 淳, 早乙女 進一
    • Organizer
      第39回 日本バイオマテリアル学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 28.T Yoshii, T Hirai, K Sakai, A Okawa, K Shinomiya., A Prospective Comparative Study in Skin Antiseptic Solutions for Posterior Spine Surgeries: Chlorhexidine-Gluconate Ethanol Vs. Povidone-Iodine2016

    • Author(s)
      T Yoshii, T Hirai, K Sakai, A Okawa, K Shinomiya.
    • Organizer
      CSRS
    • Place of Presentation
      Toronto、Canada
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頚椎OPLLに対する前方法の有用性2016

    • Author(s)
      吉井俊貴
    • Organizer
      第51回 日本脊髄障害医学会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 頚椎OPLLによる脊髄損傷2016

    • Author(s)
      吉井俊貴
    • Organizer
      日本骨髄間葉系幹細胞治療学会第1回学術集会
    • Place of Presentation
      札幌プリンスホテル(北海島札幌市)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 頚椎後縦靭帯骨化症に対する手術治療 -術式選択ー2016

    • Author(s)
      吉井俊貴
    • Organizer
      北大脊椎脊髄外科セミナー
    • Place of Presentation
      北海道大学医学部学友会館フラテホール(北海道札幌市)
    • Year and Date
      2016-07-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 頚椎後縦靭帯骨化症に対する手術治療 -合併症とその対策ー2016

    • Author(s)
      吉井俊貴
    • Organizer
      北大脊椎脊髄外科セミナー
    • Place of Presentation
      北海道大学医学部学友会館フラテホール(北海道札幌市)
    • Year and Date
      2016-07-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 頚椎後縦靭帯骨化症による頚髄損傷,2016

    • Author(s)
      吉井俊貴
    • Organizer
      第30回日本外傷学会
    • Place of Presentation
      御茶ノ水ソラシティ(東京都文京区)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 18.吉井 俊貴, 平井 高志, 山田 剛史, 猪瀬 弘之, 川端 茂徳, 大川 淳, 脊椎後方手術における術野消毒液の検討 前向き比較試験2016

    • Author(s)
      18.吉井 俊貴, 平井 高志, 山田 剛史, 猪瀬 弘之, 川端 茂徳, 大川 淳
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] A prospective, randomized study comparing selective laminectomy and conventional laminoplasty for cervical spondylotic myelopathy,2016

    • Author(s)
      20.吉井俊貴、平井高志、山田剛史、猪瀬弘之、加藤剛、川端茂徳、大川淳
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Co-existence of Ossification of the Nuchal Ligament is Associated with Hyperostosis in the Whole Spine in Patients with Cervical Ossification of the Posterior Longitudinal Ligament2016

    • Author(s)
      T Yoshii, T. Hirai, A Iwanami, K Takeuchi, K Mori, A Okawa, Y Kawaguchi.
    • Organizer
      CSRS-AP
    • Place of Presentation
      Seoul(韓国)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頸椎後縦靱帯骨化症患者における項靱帯骨化の併存と脊椎靱帯骨化傾向との関連性2016

    • Author(s)
      9.吉井 俊貴, 平井 高志, 岩波 明生, 竹内 一裕, 森 幹士, 中村 雅也, 松本 守雄, 大川 淳, 川口 善治,
    • Organizer
      第45回 日本脊椎脊髄病学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 走行型術中CTを使用した頸椎椎弓根スクリュー挿入 fluoroscopy側面透視下挿入との精度の比較2016

    • Author(s)
      14.吉井 俊貴, 平井 高志, 坂井 顕一郎, 山田 剛史, 猪瀬 弘之, 加藤 剛, 川端 茂徳, 新井 嘉容, 大川 淳
    • Organizer
      第45回 日本脊椎脊髄病学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] A prospective comparative study in surgical preparation solutions for posterior spine surger-ies:Chlorhexidine-gluconate ethanol vs povidoneiodine,2016

    • Author(s)
      15.吉井俊貴、平井高志、山田剛史、猪瀬弘之、加藤剛、大川淳
    • Organizer
      第45回 日本脊椎脊髄病学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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