Development of new composite artificial bone and drug delivery
Project/Area Number |
16K10848
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
YOSHII Toshitaka 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50583754)
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Co-Investigator(Kenkyū-buntansha) |
早乙女 進一 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (20401391)
大川 淳 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
榎本 光裕 東京医科歯科大学, 医学部附属病院, 非常勤講師 (90451971)
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Research Collaborator |
HIRAI Keigo
EGAWA Satoru
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | ハイドロキシアパタイト / 複層 / 骨再生 / 人工骨 / 再生医学 |
Outline of Final Research Achievements |
Osteoconductive material is generally highly porous, which does not possess mechanical strength. On the other hand, dense material has enough mechanical strength but less osteoconductive. Therefore, we aimed to develop porous/dense composite hydroxyapatite (HAp) based artificial bone in this study. Dense HAp has a hollow shape that can contain highly porous HAp/collagen inside. We examined the mechanical strength of the hollow HAp and found that the mechanical strength was negatively correlated the porosity and hollow rate. HAp/col showed excellent ability of retaining BMP2 and antibiotics which were sustainably released. In vivo rat model showed a good bone regeneration of BMP2 loaded HAp/col in femoral segmental bone defect model and rabbit model showed an acceptable bone reconstruction in tibia defect model. VCM loaded Hap/col showed an excellent antibiotic and bone reconstruction ability in rat infection model.
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Academic Significance and Societal Importance of the Research Achievements |
現在、骨欠損を補填する方法として主に自家骨や同種骨の移植、人工の生体材料の移植等がおこなわれている。自家骨を移植するためには健常部から移植骨を採取しなければならないが、採取部の合併症や、採取量の制限などの問題がある。同種骨が普及していないわが国では、人工骨補填材料への需要が高く、これまでリン酸カルシウムを中心とした様々な人工骨が研究されてきている。一般にリン酸カルシウムを使用した人工骨は骨伝導性の優れた多孔体は強度が弱く、強度の強い緻密質ないし低気孔率人工骨は骨伝導性に劣るという問題がある。本研究で開発した複層HApは強度と優れた骨伝導性を兼ね備え、今後の骨補填材料として期待される。
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Co-existence of ossification of the nuchal ligament is associated with severity of ossification in the whole spine in patients with cervical ossification of the posterior longitudinal ligament -A multi-center CT study-2019
Author(s)
Yoshii T, Hirai T, Iwanami A, Nagoshi N, Takeuchi K, Mori K, Yamada T, Seki S, Tsuji T, Fujiyoshi K, Furukawa M, Nishimura S,Wada K, Koda M, Furuya T, Matsuyama Y, Hasegawa T, Takeshita K, Kimura A, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Kawaguchi Y, et al.
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Journal Title
Journal of Orthopaedic Science
Volume: 24
Issue: 1
Pages: 35-41
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasmin Prevents Dystrophic Calcification After Muscle Injury.2017
Author(s)
Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AR, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, Flick MJ, Cates JM, Schoenecker JG.
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Journal Title
J Bone Miner Res.
Volume: 32(2)
Issue: 2
Pages: 294-308
DOI
Related Report
Peer Reviewed
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[Journal Article] Fall-related Deterioration of Subjective Symptoms in Patients with Cervical Myelopathy.2017
Author(s)
Kimura A, Seichi A, Takeshita K, Inoue H, Kato T, Yoshii T, Furuya T, Koda M, Takeuchi K, Matsunaga S, Seki S, Ishikawa Y, Imagama S, Yamazaki M, Mori K, Kawasaki Y, Fujita K, Endo K, Sato K, Okawa A.
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Journal Title
Spine (Phila Pa 1976)
Volume: 42
Issue: 7
Pages: E398-E403
DOI
Related Report
Peer Reviewed
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[Journal Article] Anterior decompression with fusion versus posterior decompression with fusion for massive cervical ossification of the posterior longitudinal ligament with a 50% canal occupying ratio: a lticenter2016
Author(s)
38.Yoshii T, Sakai K, Hirai T, Yamada T, Inose H, Kato T, Enomoto M, Tomizawa S, Kawabata S, Arai Y, Okawa A.
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Journal Title
Spine J
Volume: 16(11)
Issue: 11
Pages: 1351-1357
DOI
Related Report
Peer Reviewed
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[Journal Article] Prevalence and Distribution of Ossified Lesions in the Whole Spine of Patients with Cervical Ossification of the Posterior Longitudinal Ligament A Multicenter Study (JOSL CT study).2016
Author(s)
Hirai T, Yoshii T, Iwanami A, Takeuchi K, Mori K, Yamada T, Wada K, Koda M, Matsuyama Y, Takeshita K, Abematsu M, Haro H, Watanabe M, Watanabe K, Ozawa H, Kanno H, Imagama S, Fujibayashi S, Yamazaki M, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y.
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Journal Title
PLoS One.
Volume: 11(8)
Issue: 8
Pages: e0160117-e0160117
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 頚椎OPLLによる脊髄損傷2016
Author(s)
吉井俊貴
Organizer
日本骨髄間葉系幹細胞治療学会第1回学術集会
Place of Presentation
札幌プリンスホテル(北海島札幌市)
Year and Date
2016-10-22
Related Report
Invited
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[Presentation] 18.吉井 俊貴, 平井 高志, 山田 剛史, 猪瀬 弘之, 川端 茂徳, 大川 淳, 脊椎後方手術における術野消毒液の検討 前向き比較試験2016
Author(s)
18.吉井 俊貴, 平井 高志, 山田 剛史, 猪瀬 弘之, 川端 茂徳, 大川 淳
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-05-12
Related Report
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