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New concept for bone and soft tissue sarcoma treatment by low-pH sensitive liposome

Research Project

Project/Area Number 16K10856
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

Asanuma Kunihiro  三重大学, 医学部附属病院, 講師 (20378285)

Co-Investigator(Kenkyū-buntansha) 吉村 哲郎  三重大学, 工学研究科, 特任教授(研究担当) (30035472)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordssarcoma / pH / acidity / liposome / pH反応性リポソーム / methotexate / 悪性骨軟部腫瘍 / 骨肉腫 / リポソーム / 酸性 / pH / 腫瘍 / pH 応答性リポソーム / pH反応性リポソーム / 骨軟部腫瘍
Outline of Final Research Achievements

pH in bone and soft tissue tumor is below 6.9. We designed liposome based on next three concept, 1) long stability and escape from immune and reticuloendothelial system by adding polyethyleneglycol, 2)infiltration from abnormal vascular and accumulation in tumor tissue by under 100nm of diameter, 3) release drugs below pH6.7. We successfully produced new concept liposome and this liposome accumulated tumor tissue using mouse xenograft model. However, by intravascular injection of methotrexate encapsulated liposome induced mouse death. From this results, this liposome had a toxicity by vascular injection. In cell experiment, this liposome deliver and release drugs by activation of low pH and deliver drugs inside of cells by endocytosis irrelatively pH. This liposome has 2 delivery system based on pH level.

Academic Significance and Societal Importance of the Research Achievements

癌に対する抗癌剤の高い効果を期待するには、高濃度の抗癌剤をがん組織に暴露させる必要がある。しかし、抗癌剤濃度があがれば、副作用が増加する。副作用の軽減方法は、副作用の少ない癌細胞の標的、薬物の種類を作成するか、あるいは抗癌剤を癌細胞選択的に集積させ、全身への濃度を少なくさせるか、に分けられる。本研究は後者であり、腫瘍の特異性として肉腫組織内の酸性度(ph6.9以下)に注目し、ph6.7前後で薬剤を放出するリポソームを開発し、抗癌剤であるメソトレキセートの封入に成功した。マウスに移植した肉腫には集積性を示したが、一定量の投与で毒性を示した。今後、リポソームのさらなる改良が必要である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (62 results)

All 2020 2019 2018 2017

All Journal Article (21 results) (of which Peer Reviewed: 20 results,  Open Access: 3 results) Presentation (41 results) (of which Int'l Joint Research: 14 results)

  • [Journal Article] Soluble programmed death-ligand 1 rather than PD-L1 on tumor cells effectively predicts metastasis and prognosis in soft tissue sarcomas2020

    • Author(s)
      Asanuma Kunihiro、Nakamura Tomoki、Hayashi Akinobu、Okamoto Takayuki、Iino Takahiro、Asanuma Yumiko、Hagi Tomohito、Kita Kouji、Nakamura Kouichi、Sudo Akihiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-020-65895-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY-ESO-1 and MAGE-A4 in high-grade soft-tissue sarcoma.2019

    • Author(s)
      Kakimoto T, Matsumine A, Kageyama S, Asanuma K, Matsubara T, Nakamura T, Iino T, Ikeda H, Shiku H, Sudo A
    • Journal Title

      Oncology Letters

      Volume: 17 Pages: 3937-3943

    • DOI

      10.3892/ol.2019.10044

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum thrombomodulin as a metastatic and prognostic marker in soft tissue sarcomas2019

    • Author(s)
      Asanuma Kunihiro、Nakamura Tomoki、Asanuma Yumiko、Kakimoto Takuya、Yada Yuki、Hagi Tomohito、Kita Kouji、Matsumine Akihiko、Sudo Akihiro
    • Journal Title

      Cancer Biomarkers

      Volume: 26 Issue: 2 Pages: 163-170

    • DOI

      10.3233/cbm-182075

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The clinical outcome of eribulin treatment in Japanese patients with advanced soft tissue sarcoma: a Tokai Musculoskeletal Oncology Consortium study2019

    • Author(s)
      Nakamura Tomoki、Tsukushi Satoshi、Asanuma Kunihiro、Katagiri Hirohisa、Ikuta Kunihiro、Nagano Akihito、Kozawa Eiji、Yamada Satoshi、Shido Yoji、Yamada Kenji、Kawanami Katsuhisa、Ishimura Daisuke、Sudo Akihiro、Nishida Yoshihiro
    • Journal Title

      Clinical & Experimental Metastasis

      Volume: 36 Issue: 4 Pages: 343-350

    • DOI

      10.1007/s10585-019-09980-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment strategy for malignant bone soft tissue tumor by ph-reactive liposome based on new concept2019

    • Author(s)
      Asanuma Kunihiro、Yoshimura、Nakamura Tomoki、Hagi Tomohito、Kita Kouji、Sudo Akihiro
    • Journal Title

      Impact

      Volume: 2019 Issue: 4 Pages: 22-24

    • DOI

      10.21820/23987073.2019.4.22

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma.2018

    • Author(s)
      Okuno K, Matsubara T, Nakamura T, Iino T, Kakimoto T, Asanuma K, Matsumine A, Sudo A.
    • Journal Title

      Onco Targets Ther.

      Volume: 11 Pages: 6879-6886

    • DOI

      10.2147/ott.s177605

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intra-articular synovial sarcoma in the ankle joint: A case report.2018

    • Author(s)
      Nakamura T, Hagi T, Asanuma K, Sudo A.
    • Journal Title

      Mol Clin Oncol.

      Volume: 4 Pages: 464-466

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term clinical outcome in patients with high-grade soft tissue sarcoma who were treated with surgical adjuvant therapy using acridine orange after intra-lesional or marginal resection.2018

    • Author(s)
      Nakamura T, Kusuzaki K, Matsubara T, Murata H, Hagi T, Asanuma K, Sudo A.
    • Journal Title

      Photodiagnosis Photodyn Ther.

      Volume: 23 Pages: 165-170

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Is FDG-PET/CT Useful for Diagnosing Pulmonary Metastasis in Patients with Soft Tissue Sarcoma?2018

    • Author(s)
      Hagi T, Nakamura T, Sugino Y, Matsubara T, Asanuma K, Sudo A.
    • Journal Title

      Anticancer Res.

      Volume: 38(6) Issue: 6 Pages: 3635-3639

    • DOI

      10.21873/anticanres.12638

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of soluble PD-L1 for malignant tumors.2018

    • Author(s)
      Asanuma K, Nakamura T, Hagi T, Kita K, Sudo A.
    • Journal Title

      Journal of Translational Science.

      Volume: 5 Issue: 6 Pages: 1-3

    • DOI

      10.15761/jts.1000286

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activated protein C suppresses osteoclast differentiation via endothelial protein C receptor, protease-activated receptor-1, sphingosine 1-phosphate receptor, and apolipoprotein E receptor 22018

    • Author(s)
      Yoshida Kakunoshin、Akita Nobuyuki、Okamoto Takayuki、Asanuma Kunihiro、Uchida Atsumasa、Sudo Akihiro、Shimaoka Motomu、Suzuki Koji、Hayashi Tatsuya
    • Journal Title

      Thrombosis Research

      Volume: 163 Pages: 30-40

    • DOI

      10.1016/j.thromres.2018.01.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subungual onychomycosis due to Aspergillus niger mimicking a glomus tumor: A case report.2017

    • Author(s)
      Matsuyama Y, Nakamura T, Hagi T, Asanuma K, Sudo A.
    • Journal Title

      Biomed Rep.

      Volume: 7 Pages: 532-534

    • DOI

      10.3892/br.2017.994

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The diagnostic and prognostic value of interleukin-6 in patients with soft tissue sarcomas2017

    • Author(s)
      Hagi T, Nakamura T, Iino T, Matsubara T, Asanuma K, Matsumine A, Sudo A
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 9640-9640

    • DOI

      10.1038/s41598-017-08781-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Infiltrative tumor growth patterns on magnetic resonance imaging associated with systemic inflammation and oncological outcome in patients with high-grade soft-tissue sarcoma2017

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Yada Y, Hagi T, Sudo A
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 7 Pages: e0181787-e0181787

    • DOI

      10.1371/journal.pone.0181787

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors associated with the decision of operative procedure for proximal femoral bone metastasis: Questionnaire survey to institutions participating the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group2017

    • Author(s)
      Araki Nobuhito、Tanaka Kazuhiro、Katagiri Hirohisa、Kunisada Toshiyuki、Hiruma Toru、Hiraga Hiroaki、Morioka Hideo、Nishida Yoshihiro、Abe Satoshi、Watanuki Munenori、Morii Takeshi、Sugiura Hideshi、Yoshida Yukihiro、Yokoyama Koichiro、Shimose Shoji、Iwamoto Yukihide
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 22 Issue: 5 Pages: 938-945

    • DOI

      10.1016/j.jos.2017.05.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Do exercise habits during middle age affect locomotive syndrome in old age?2017

    • Author(s)
      Nishimura Akinobu、Ito Naoya、Asanuma Kunihiro、Akeda Koji、Ogura Toru、Sudo Akihiro
    • Journal Title

      Mod Rheumatol

      Volume: 28 Issue: 2 Pages: 334-338

    • DOI

      10.1080/14397595.2017.1333670

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] mpact of tumor volume doubling time on post-metastatic survival in bone or soft-tissue sarcoma patients treated with metastasectomy and/or radiofrequency ablation of the lung.2017

    • Author(s)
      Nakamura T, Matsumine A, Takao M, Nakatsuka A, Matsubara T, Asanuma K, Sudo A.
    • Journal Title

      Onco Targets Ther.

      Volume: 10 Pages: 559-564

    • DOI

      10.2147/ott.s121562

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of pulmonary nodules in patients with high-grade soft tissue sarcomas2017

    • Author(s)
      Nakamura T, Matsumine A, Matsusaka M, Mizumoto K, Mori M, Yoshizaki T, Matsubara T, Asanuma K, Sudo A
    • Journal Title

      PLoS One

      Volume: 12 Issue: 2 Pages: e0172148-e0172148

    • DOI

      10.1371/journal.pone.0172148

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison between MRI, pathology and immunohistochemistry of the dedifferentiated liposarcoma2017

    • Author(s)
      中村 公一、中村 知樹、松原 孝夫、淺沼 邦洋、松峯 昭彦、須藤 啓広
    • Journal Title

      The Central Japan Journal of Orthopaedic Surgery & Traumatology

      Volume: 60 Issue: 4 Pages: 689-690

    • DOI

      10.11359/chubu.2017.689

    • NAID

      130006206354

    • ISSN
      0008-9443, 1349-0885
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 右側頭骨骨肉腫の1例2017

    • Author(s)
      真弓 徳大, 松峯 昭彦, 中村 知樹, 淺沼 邦洋, 松原 孝夫, 須藤 啓広, 内田 克典, 林 昭伸, 今井 裕, 白石 泰三, 村田 哲也
    • Journal Title

      東海骨軟部腫瘍

      Volume: 28 Pages: 33-34

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 左腸骨骨巨細胞腫の悪性転化に対して、腫瘍用人工骨頭を用いたhip transposition法で再建を行った一例2017

    • Author(s)
      南端 翔多, 直江 祐樹, 松峯 昭彦, 中村 知樹, 松原 孝夫, 淺沼 邦洋, 須藤 啓広
    • Journal Title

      国立大学リハビリテーション療法士学術大会誌

      Volume: 38回 Pages: 68-71

    • NAID

      40021201413

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 骨肉腫に対する2剤併用療法の検討2019

    • Author(s)
      淺沼邦洋、 中村 知樹、 萩 智仁、喜多 晃司、須藤 啓広
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 原発性および転移性骨・軟部腫瘍におけるcryoablation2019

    • Author(s)
      淺沼邦洋、中塚 豊真、中村 知樹、萩 智仁、喜多 晃司、須藤 啓広
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軟部腫瘍における血中soluble Thrombomodulinの臨床的意義2019

    • Author(s)
      浅沼邦洋、中村知樹、萩智仁、喜多晃司、須藤 啓広
    • Organizer
      第41回日本血栓止血学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肉腫,癌腫の転移性骨腫瘍に対するcryoablationおよびその併用療法2019

    • Author(s)
      淺沼邦洋 中塚 豊真 中村 知樹 萩 智仁 喜多 晃司 須藤  啓広
    • Organizer
      第52回 日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clinical outcome in patients with bone tumor using calcium phosphate cement following more than 5 years2019

    • Author(s)
      Tomohito Hagi, Tomoki Nakamura, Kunihiro Asanuma, Koji Kita, Akihiro Sudo
    • Organizer
      20th of General Meeting of the International Society of Limb Salvage.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soluble Pd-L1 in Patients with Soft Tissue Tumors2018

    • Author(s)
      Asanuma K, Nakamura T, Hagi T, Kita K, Sudo A
    • Organizer
      The CTOS 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 軟部腫瘍における免疫関連タンパクの発現2018

    • Author(s)
      淺沼邦洋、松峯昭彦、柿本拓也、中村知樹、萩 智仁、淺沼由美子、須藤啓広
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 軟部腫瘍における血中soluble PD-L1 抗原の解析2018

    • Author(s)
      淺沼邦洋、中村知樹、萩 智仁、須藤啓広
    • Organizer
      第51回日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 悪性軟部腫瘍の初回再発に関わる因子の検討2018

    • Author(s)
      淺沼邦洋、中村知樹、萩 智仁、淺沼由美子、須藤啓広
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 骨肉腫に対する2 剤併用療法の検討2018

    • Author(s)
      淺沼邦洋、中村知樹、萩 智仁、須藤啓広
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Tenascin C Expression in High Grade Soft Tissue Sarcomas2018

    • Author(s)
      Asanuma K, Nakamura T, Iino T, Hagi T, Asanuma Y, Tsujii M, Hasegawa M, Yoshida T, Sudo A
    • Organizer
      Orthopaedic Research Society(ORS) 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Screening of Synergistic Reagent with Pazopanib Against Osteosarcoma Using Compound Library.2018

    • Author(s)
      ada Y, Asanuma K, Kita K, Hagi T, Nakamura T, Sudo A,
    • Organizer
      The CTOS 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical Adjuvant Therapy Using Acridine Orange after Intra-Lesional or Marginal Resection in Patients with High-Grade Soft Tissue Sarcoma2018

    • Author(s)
      Nakamura T, Kusuzaki K, Asanuma K, Hagi T, Kita K, Murata H, Matsubara T, Sudo A
    • Organizer
      The CTOS 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical Outcome in Patients with Soft Tissue Sarcoma Who Received Additional Excision after Unplanned Excision: Report from the Bone and Soft Tissue Tumor Registry in Japan2018

    • Author(s)
      Nakamura T, Kawai A, Hagi T, Kita K, Asanuma K, Sudo A
    • Organizer
      The CTOS 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Prognostic Value of Interleukin-6 in Patients with Soft Tissue Sarcoma2018

    • Author(s)
      Hag T, Nakamura T, Kita K, Asanuma K, Sudo A
    • Organizer
      The CTOS 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Value of Pretreatment Serum Interleukin-6 in Patients With Soft Tissue Sarcomas2018

    • Author(s)
      Hagi T, Nakamura T, Iino T, Asanuma K, Matsumine A, Sudo A
    • Organizer
      Orthopaedic Research Society(ORS) 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tenascin C Expression in High Grade Soft Tissue Sarcomas2018

    • Author(s)
      Asanuma K, Nakamura T, Iino T, Hagi T, Asanuma Y, Tsujii M, Hasegawa M, Yoshida T, Sudo A
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Value of Pretreatment Serum Interleukin-6 in Patients with Soft Tissue Sarcomas2018

    • Author(s)
      Hagi T, Nakamura T, Iino T, Asanuma K, Matsumine A, Sudo A
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 軟部腫瘍に対するcryoablationの画像評価と病理組織評価2018

    • Author(s)
      淺沼邦洋
    • Organizer
      第1回日本サルコーマ治療研究学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Infitrative Tumor Patterns on MRI May Be Associated with Systemic Inflammation in Patients with High-grade Soft-tissue Sarcoma2017

    • Author(s)
      Nakamura T, Matsumine A, Hagi T, Yada Y, Matsubara T, Asanuma K, Sudo A
    • Organizer
      The 19th International Society of Limb Salvage General Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical Evaluation of High Grade Soft Tissue Sarcoma Based on Primary Tumor Doubling Time2017

    • Author(s)
      Asanuma K, Matsumine A, Matsubara T, Nakamura T, Yada Y, Hagi T, Sudo A
    • Organizer
      The 19th International Society of Limb Salvage General Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical Outcome of Reconstruction Using Free Musculocutaneous Flap of Latissimus Dorsi after Resection of Soft Tissue Sarcoma2017

    • Author(s)
      Yada Y, Oi T, Matsubara T, Asanuma K, Matsumine A, Sudo A
    • Organizer
      The 19th International Society of Limb Salvage General Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Screening of Synergistic Reagent with Pazopanib Against Osteosaroma Using Compound Library2017

    • Author(s)
      Yada Y, Asanuma K, Hagi T, Nakamura T, Matsubara T, Matsumine A, Sudo A
    • Organizer
      Orthopaedic Research Society 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 骨肉腫に対するpazopanib,crizotinib併用とその責任分子2017

    • Author(s)
      矢田祐樹、淺沼邦洋、萩 智仁、中村知樹、松原孝夫、松峯昭彦、須藤啓広
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 悪性軟部腫瘍における血清interleukin-6の診断および予後予測因子としての有用性2017

    • Author(s)
      萩 智仁、中村知樹、飯野隆大、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 進行期軟部肉腫に対してエリブリンで加療を行った症例検討2017

    • Author(s)
      中村知樹、萩 智仁、淺沼邦洋、須藤啓広
    • Organizer
      第55回日本癌治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当科におけるAYA(adolescent and young adult)世代の悪性軟部腫瘍の治療成績2017

    • Author(s)
      萩 智仁、中村知樹、淺沼邦洋、須藤啓広
    • Organizer
      第55回日本癌治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脱分化型脂肪肉腫のMRIの病理所見の検討2017

    • Author(s)
      中村公一、中村知樹、淺沼邦洋、松原孝夫、松峯昭彦、須藤啓広
    • Organizer
      第128回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 悪性軟部腫瘍切除後に深部感染を認め、全外側大腿筋弁を用いて加療を行った1例2017

    • Author(s)
      萩 智仁、中村知樹、辻井雅也、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第128回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動器疾患・腰痛・膝痛はロコモ度に影響を与えるか?―旧宮川村コホート研究より―2017

    • Author(s)
      西村明展、伊東直也、明田浩司、淺沼邦洋、加藤 公、須藤啓広
    • Organizer
      第128回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 外反母趾と運動機能・腰痛・膝痛の関係―旧宮川村コホート研究より―2017

    • Author(s)
      西村明展、伊東直也、松峯昭彦、長谷川正裕、若林弘樹、明田浩司、淺沼邦洋、松原孝夫、中村知樹、加藤 公、須藤啓広
    • Organizer
      第90回日本整形外科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 変形性膝関節症における大腿四頭筋筋力と痛み、身体機能の関連について―旧宮川村コホート研究より―2017

    • Author(s)
      伊東直也、西村明展、松峯昭彦、長谷川正裕、若林弘樹、明田浩司、淺沼邦洋、辻井雅也、松原孝夫、中村知樹、須藤啓広
    • Organizer
      第90回日本整形外科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 軟部肉腫における造影MRIの腫瘍浸潤像と炎症性マーカーとの関連2017

    • Author(s)
      中村知樹、松峯昭彦、萩 智仁、矢田祐樹、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第90回日本整形外科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 悪性軟部腫瘍切除後に遊離広背筋皮弁を用いて再建を行った治療成績2017

    • Author(s)
      萩 智仁、中村知樹、辻井雅也、矢田祐樹、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第90回日本整形外科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当科における粘液型脂肪肉腫の治療成績2017

    • Author(s)
      中村公一、中村知樹、松峯昭彦、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第90回日本整形外科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 下肢長管骨骨肉腫5 年以上生存例の検討2017

    • Author(s)
      萩 智仁、中村知樹、松原孝夫、淺沼邦洋、松峯昭彦、矢田祐樹、須藤啓広
    • Organizer
      第50回日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラジオ波焼灼術を行った悪性骨軟部腫瘍肺転移症例の治療成績2017

    • Author(s)
      中村知樹、淺沼邦洋、萩 智仁、須藤啓広
    • Organizer
      第129回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 後腹膜腔に発生した悪性軟部腫瘍の成績2017

    • Author(s)
      淺沼邦洋、中村知樹、萩 智仁、須藤啓広
    • Organizer
      第129回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 悪性軟部腫瘍患者の転移性肺腫瘍に対するFDG-PET/CTの有用性2017

    • Author(s)
      萩 智仁、中村知樹、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第129回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 中指に発生したNeurothekeomaの一例2017

    • Author(s)
      松波山水、中村知樹、辻井雅也、淺沼邦洋、須藤啓広
    • Organizer
      第129回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 内転筋群に発生した軟部腫瘍の治療成績2017

    • Author(s)
      中村公一、中村知樹、萩 智仁、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第129回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2023-12-25  

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