Studies on the function of CD163, a macrophage scavenger receptor, in tumor microenvironment
| Project/Area Number |
16K10865
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 章雄 熊本大学, 大学院生命科学研究部(医), 講師 (70452886)
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| Research Collaborator |
Komohara Yoshihiro
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マクロファージ / CD163 / 腫瘍 / 腫瘍内微小環境 |
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| Outline of Final Research Achievements |
Recent findings have shown the significance of CD163-positive macrophages in tumor progression. However, there have been few studies on the functions of CD163 in macrophages. In the present study, we revealed that macrophage CD163-mediated IL-6 promotes tumor development and progression in murine and human malignant tumors, thus indicating that macrophage CD163 may be potentially new target molecule for tumor therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
マクロファージ（Mφ）CD163（ヘモグロビンスカベンジャー受容体）のヘモグロビン代謝以外の機能についてはほとんど明らかになっていなかった。近年、腫瘍内浸潤Mφが注目さるようになり、様々な腫瘍では腫瘍組織中のCD163陽性M2Mφの浸潤密度が高い症例ほど予後が悪いことからCD163の腫瘍増殖への関与が示唆されていた。本研究にてCD163の腫瘍増殖における役割が明らかになったことから、CD163をターゲットとした腫瘍の悪性度の診断や治療薬開発のための基礎的知見が得られ、将来的にガンに対する新しい治療戦略にながる可能性が示唆されたため、学術的・社会的にも意義ある研究成果であると考えられる。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] CD163 is required for protumoral activation of macrophages in human and murine sarcoma.2018
Author(s)
Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
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Journal Title
Cancer Res
Volume: in press
Issue: 12
Pages: 3255-3266
DOI
Related Report
Peer Reviewed
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[Journal Article] Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.2016
Author(s)
Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, Motohara T, Saito Y, Ikeda T, Takaishi K, Tashiro H, Yonemoto Y, Katabuchi H, Takeya M, Komohara Y.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 29588-29588
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells2016
Author(s)
Fujiwara Yukio, Horlad Hasita, Shiraishi Daisuke, Tsuboki Junko, Kudo Rino, Ikeda Tsuyoshi, Nohara Toshihiro, Takeya Motohiro, Komohara Yoshihiro
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Journal Title
Molecular Nutrition & Food Research
Volume: 60(11)
Issue: 11
Pages: 2467-2480
DOI
Related Report
Peer Reviewed
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[Presentation] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor progression by inhibiting the protumoral functions of macrophages2017
Author(s)
Yukio Fujiwara, Junko Tsuboki, Hasita Horlad, Daisuke Shiraishi, Toshihiro Nohara, Yoshihiro Komohara, Motohiro Takeya
Organizer
Keystone Symposia, Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)
Related Report
Int'l Joint Research
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