Amelioration in the regenerative capacity of aged skeletal muscle by pro-IGF-II signal
| Project/Area Number |
16K10881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
UEZUMI MADOKA 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (70435866)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 老化 / 骨格筋 / 再生 / 筋再生 |
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| Outline of Final Research Achievements |
Sarcopenia, age-related muscle weakness, increases the frequency of falls and fractures in elderly people, which can trigger severe muscle injury. Rapid and successful recovery from muscle injury is essential not to cause further frailty and loss of independence. We previously reported that supplementation of pro-insulin-like growth factor-II (pro-IGF-II) ameliorates age-related inefficient regenerative response. However, it is expected to develop a more safety and specific therapeutic strategy for clinical application due to the tumor promoting activity of pro-IGF-II. In this study, we analyzed pro-IGF-II signal in mesenchymal progenitors and found the candidate factors that suppress adipogenic differentiation and do not have tumor promoting activity. Administration of the candidate factors could be the effective therapeutic strategy for muscle injury in elderly people.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢者において転倒や骨折に伴う筋損傷からの回復の遅れは、要介護への進行原因となり、健康寿命延伸のために解決すべき重要課題である。しかしながら、現在、老化筋の再生能力を改善する方法はない。本研究では、我々が老化筋の再生能力改善効果を見出したpro-IGF-IIに着目し、そのシグナルパスウェイ解析から、より安全で特異的な治療のための候補因子を同定した。この因子の投与は高齢者の筋再生能力改善のためのより安全な治療法となる可能性がある。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Reduced expression of calcitonin receptor is closely associated with age-related loss of the muscle stem cell pool.2019
Author(s)
Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, Lidan Zhang, Heying Zhou, Naohiro Hashimoto, Kikuo Okamura, Yasumoto Matsui, Koji Tsukazaki, Tohru Hosoyama, Masashi Nakatani, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, So-ichiro Fukada
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Journal Title
JCSM Rapid Commun.
Volume: 2(1)
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cell-surface protein profiling identifies distinctive markers of progenitor cells in human skeletal muscle.2016
Author(s)
Uezumi A, Nakatani M, Ikemoto-Uezumi M, Yamamoto N, Morita M, Yamaguchi A, Yamada H, Kasai T, Masuda S, Narita A, Miyagoe-Suzuki Y, Takeda S, Fukada S, Nishino I, Tsuchida K.
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Journal Title
Stem Cell Reports.
Volume: 7
Issue: 2
Pages: 263-278
DOI
Related Report
Peer Reviewed / Open Access
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