| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
In this study, exhaustive gene expression analysis of approximately 24,500 genes were conducted of human cartilage pieces from femoral heads harvested from surgeries for patients with femoral neck fracture (non-osteoarthritic: non-OA group) and secondary osteoarthritis (OA group). DPT, IGFBP7, FOXO1 and KLF2 were the genes identified as the new OA-related genes as they were highly expressed in chondrocytes of Japanese hip OA compared to non-OA. Out of overexpressed genes in OA, only 10% of the genes were common between Japanese and western population. Our study elucidated the difference in gene expression patterns of OA chonderocytes between Japanese and western population although the phenotype of OA is similar between different ethnic origins.
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