| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Partial thickness cartilage defects (PTCDs) were created on the medial condyle of the femur in various ages of rats. Natural healing process was examined by histologically. As results, 1) PTCDs of 3-week old rats healed with normal cartilage, 2) those of 6-week old rats healed nearly normal cartilage, and 3) those of 10 or 14 week old rats did not heal but deteriorated. Intra-articular administration of mesenchymal stem cells (MSCs) had healing effects on PTCDs of 14-week rats but platelet rich plasma (PRP) did not. In addition, administration of MSCs was only effective when they were injected at the time of PTCDs creation. One or two week delay in administration did not exhibit any healing effects.
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