prevention of hip fracture for non-bedrriden status

• Project/Area Number: 16K10894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Niigata University
• Principal Investigator: Endo Naoto 新潟大学, 医歯学系, 教授 (10251810)
• Research Collaborator: Imai Norio
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 大腿骨近位部骨折 / 認知機能 / ビタミンD / 骨粗鬆症 / 寝たきり / 運動機能障害 / フレイル / 骨折連鎖 / 既存骨折 / 骨折危険因子 / 骨組織動態 / 骨折 / リハビリテ－ション / 臨床 / 老化

Outline of Final Research Achievements

The incidence of hip fracture in patients aged over50 years in 2015 in Niigata Prefecture, Japan was investigated. In 2015, 3214 hip fractures (282.7 per 100,000 persons per year) occurred in Niigata Prefecture. Only 26% of patients were considered cognitively normal assessed with MMSE score in the elderly with hip fracture. Cognitive impairment is associated with low serum 25-hydorxyvitamin D.We should focus on the prevention of hip fracture in eldery people for non-beddriden status in our sciety.

Academic Significance and Societal Importance of the Research Achievements

本研究は大腿骨近位部骨折を来す方の特徴が明らかとなり、その危険因子の対策をすることで二次骨折を予防することにつながり、ひいては骨折ゼロ・寝たきりゼロをめざす治療・予防方法の立案に有用な情報を提供することができた。

Research Products

• [Journal Article] Low serum 25-OHD increases coginitive impairment in elderly people (2019)
  • Author(s): Sakuma M., Kitamura K., Endo N., Ikeuchi T,Yokoseki A, Onodera O, Oinuma T.Momotsu T, Sato K, Nakamura K,Narita I.
  • Journal Title: J Bone Miner Metab Volume: 37 Issue: 2 Pages: 68-375
  • DOI: 10.1007/s00774-018-0934-z
  • Peer Reviewed
• [Journal Article] Surgery of hip fractures in Japan: Recent trends in prevalence and treatment (2017)
  • Author(s): Hagino H., Endo N., Harada A., Mashiba T.,Mori S., Ohtori S., Sakai A., Yamamoto T.,
  • Journal Title: JOS Volume: 22 Pages: 909-914
  • Peer Reviewed
• [Journal Article] Effect of Elcatonin versus Non-Steroidal Anti-inflammatory Medications for Acute Back Pain in Patients with Osteoporotic Vertebral Fracture:A Multi-clinic Randomized Controlled Trial. (2017)
  • Author(s): Endo N, Fujino K, Doi T, Akai M, Hoshino Y, Nakano T, Iwaya T.
  • Journal Title: J Bone Miner Metab. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Osteoporosis as a cause of locomotive syndrome: the influence on functional mobility and activities of daily living. (2016)
  • Author(s): Endo N.
  • Journal Title: Clinical Reviews in Bone and Mineral Metabolism. Volume: 14 Pages: 74-76
  • Peer Reviewed
• [Journal Article] Disrupted bone metabolism in long-term bedridden patients. (2016)
  • Author(s): Eimori k., Endo N., Uchiyama S., Takahashi Y., Kawashima H., Watanabe K.
  • Journal Title: PLOS ONE Volume: 11(6) Issue: 6 Pages: e0156991-e0156991
  • DOI: 10.1371/journal.pone.0156991
  • Peer Reviewed
• [Journal Article] 非定型大腿骨（転子下・骨幹部）骨折の診断と治療. (2016)
  • Author(s): 遠藤直人，近藤直樹，普久原朝海，宮坂 大，今井教雄，山本智章
  • Journal Title: JJOS. Volume: 2 Pages: 383-387
  • NAID: 40021025573
  • Peer Reviewed
• [Presentation] 脊柱変形がもたらすQOL低下とその対策. (2016)
  • Author(s): 遠藤直人
  • Organizer: 第18回日本骨粗鬆症学会シンポジウム４：脊柱変形と疼痛対策
  • Place of Presentation: 仙台勝山館（宮城県仙台市）
  • Year and Date: 2016-10-07
• [Presentation] 骨粗鬆症診療における多職種連携による包括的治療：高齢者大腿骨近位部骨折ゼロをめざす. (2016)
  • Author(s): 遠藤直人
  • Organizer: 第28回日本運動器科学会 特別講演２
  • Place of Presentation: 会津若松ワシントンホテル（福島県会津若松市）
  • Year and Date: 2016-07-09
  • Invited
• [Presentation] サルコぺニアに対する整形外科医の取り組み. (2016)
  • Author(s): 遠藤直人
  • Organizer: 第89回日本整形外科学会学術総会 シンポジウム23
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-05-15
• [Book] チームで診る高齢者脆弱性骨折 (2017)
  • Author(s): 遠藤直人
  • Total Pages: 219
  • Publisher: 医薬ジャーナル