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Development of novel osteoprprosis treatment using ultra-fine bubble

Research Project

Project/Area Number 16K10901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

Ebina Kouske  大阪大学, 医学系研究科, 助教 (70612076)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsウルトラファインバブル / ステロイド性骨粗鬆症 / 低酸素 / 破骨細胞 / 酸素 / 末梢神経損傷 / 閉経後骨粗鬆症 / 骨粗鬆症
Outline of Final Research Achievements

Bone tissue is relatively hypoxic, and oxygen administration improves bone metabolism. Glucocorticoid-induced osteoporosis (GIO) is one of the most frequent secondary osteoporosis, and thereby novel, low-cost, convenient treatment is desired. Ultra-fine bubble (UFB; <200 nm in diameter) has several unique properties, and tested in various medical fields such as drug delivery. We investigated that oxygen ultra-fine bubbles (OUB) saline peritoneal injection prevents bone loss of GIO in mice. Moreover, OUB inhibits osteoclast differentiation and function in a dose-dependent manner in vitro. The efficacy and adaptation of OUB to other hypoxia-related diseases is also expected to be investigated in the future study.

Academic Significance and Societal Importance of the Research Achievements

UFBは医療分野で注目されている新規技術であるが、渉猟し得る限り骨代謝の改善効果を検討したものは本報告が初めてである。UFBは大量生成かつ長期間保存可能であり、より安価で利便性の高い新規治療につながる可能性が示された。また骨代謝以外にも低酸素が病態に関与する様々な疾患に有効となる可能性があり、今後更なる発展が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Administration of oxygen ultra-fine bubbles improves nerve dysfunction in a rat sciatic nerve crush injury model2018

    • Author(s)
      Matsuoka H, Ebina K, Tanaka H, Hirao M, Iwahashi T, Noguchi T, Suzuki K, Nishimoto S, Murase T, Yoshikawa H.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19(5) Issue: 5 Pages: 1395-1395

    • DOI

      10.3390/ijms19051395

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway2018

    • Author(s)
      Noguchi T, Ebina K, Hirao M, Otsuru S, Adam JG, Kawase R, Ohama T, Yamashita S, Etani Y, Okamura G, Yoshikawa H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 503(2) Issue: 2 Pages: 644-650

    • DOI

      10.1016/j.bbrc.2018.06.055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of switching oral bisphosphonates to denosumab or daily teriparatide on the progression of radiographic joint destruction in patients with biologic-naive rheumatoid arthritis2018

    • Author(s)
      Ebina K, Hirao M, Hashimoto J, Matsuoka H, Iwahashi T, Chijimatsu R, Etani Y, Okamura G, Miyama A, Yoshikawa H.
    • Journal Title

      Osteoporosis International

      Volume: 29(7) Issue: 7 Pages: 1627-1636

    • DOI

      10.1007/s00198-018-4492-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of single or combination therapy of teriparatide and anti-RANKL monoclonal antibody on bone defect regeneration in mice.2018

    • Author(s)
      Kitaguchi K, Kashii M, Ebina K, Kaito T, Okada R, Makino T, Noguchi T, Ishimoto T, Nakano T, Yoshikawa H.
    • Journal Title

      Bone

      Volume: 106 Pages: 1-10

    • DOI

      10.1016/j.bone.2017.09.021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of dexamethasone concentration on cartilage tissue formation from human synovial derived stem cells in vitro.2018

    • Author(s)
      Chijimatsu R, Kobayashi M, Ebina K, Iwahashi T, Okuno Y, Hirao M, Fukuhara A, Nakamura N, Yoshikawa H.
    • Journal Title

      Cytotechnology

      Volume: 70 Issue: 2 Pages: 819-829

    • DOI

      10.1007/s10616-018-0191-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.2017

    • Author(s)
      Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimomura K, Hart DA, Hideki Y, Norimasa N.
    • Journal Title

      Stem Cells Int

      Volume: - Pages: 1960965-1960965

    • DOI

      10.1155/2017/1960965

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxygen ultra-fine bubbles water administration prevents bone loss of glucocorticoid-induced osteoporosis in mice by suppressing osteoclast differentiation2017

    • Author(s)
      Noguchi, T., Ebina, K., Hirao, M., Morimoto, T., Koizumi, K., Kitaguchi, K., Matsuoka, H., Iwahashi, T., Yoshikawa, H.
    • Journal Title

      Osteoporos International

      Volume: 28 Issue: 3 Pages: 1063-1075

    • DOI

      10.1007/s00198-016-3830-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 酸素ウルトラファインバブル(OUB)は後根神経節細胞の軸索伸展やシュワン細胞の増殖を促進させる2019

    • Author(s)
      松岡 峰造、蛯名 耕介、田中 啓之、平尾 眞、岩橋 徹、鈴木 浩司、西本 俊介、村瀬 剛、吉川 秀樹
    • Organizer
      第62回日本手外科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸素ウルトラファインバブル水投与はラット坐骨神経損傷後の機能障害を改善する2019

    • Author(s)
      松岡 峰造、村瀬 剛、吉川 秀樹
    • Organizer
      第56回日本リハビリテーション医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] テリパラチドと抗RANKL抗体併用による骨再生に対する効果(骨粗鬆症モデル)2018

    • Author(s)
      北口 和真、柏井将文、蛯名耕介、海渡貴司、牧野孝洋、岡田倫太郎、石本卓也、中野貴由、吉川秀樹
    • Organizer
      第20回日本骨粗鬆症学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸素ウルトラファインバブルは破骨細胞分化抑制を介してステロイド性骨粗鬆症モデルマウスの骨量減少を予防する2018

    • Author(s)
      蛯名耕介 野口貴明 平尾眞 吉川秀樹
    • Organizer
      第3回日本骨免疫学会ウィンターセミナー
    • Related Report
      2017 Research-status Report
  • [Presentation] 酸素ウルトラファインバブル水の投与はステロイド性骨粗鬆症モデルマウスの骨量を改善する2017

    • Author(s)
      野口貴明 蛯名耕介 平尾眞 吉川秀樹
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 酸素ウルトラファインバブル水投与は破骨細胞分化を抑制しマウスのステロイド性骨粗鬆症を改善する2017

    • Author(s)
      野口貴明 蛯名耕介 平尾眞 吉川秀樹
    • Organizer
      第19回なにわ整形外科基礎研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 酸素ウルトラファインバブルは 破骨細胞分化抑制を介してマウスの ステロイド性骨粗鬆症重症化を予防する2016

    • Author(s)
      野口貴明、蛯名耕介、平尾眞、吉川秀樹
    • Organizer
      第18回日本骨粗鬆症学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 酸素ウルトラファインバブルは 破骨細胞分化抑制を介してマウスの ステロイド性骨粗鬆症重症化を予防する2016

    • Author(s)
      野口貴明、蛯名耕介、平尾眞、吉川秀樹
    • Organizer
      第2回日本骨免疫学会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-07-06
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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