| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEM). The hypothesis was that sclerotic changes might cause stress to become concentrated at the lateral boundary in early-stage osteonecrosis. In all FEMs of Stage 1 hip (ONFH without a sclerotic boundary), stress was equally distributed on the femoral head surface. However, in all FEMs of both Stages 2 (ONFH with a sclerotic boundary) and 3 (ONFH with both a sclerotic boundary and <2 mm collapse) hips, stress was concentrated at the lateral boundary of the femoral head surface. In early-stage ONFH, sclerotic changes caused stress concentration, which can trigger subchondral fractures at the lateral boundary.
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