| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Adult mice were either subjected to hypoxia in 8% oxygen for 30 min or served as controls. Following hypoxia, mice underwent reoxygenation for 30 min with 21% or 100% oxygen. Reoxygenation with 100% oxygen significantly increased inflammatory cytokines in the brain but not in the kidney and liver compared with 21% oxygen 9 hours after reoxygenation. It also caused renal and liver dysfunction 24 hours after reoxygenation. These results suggest that the reoxygenation with 100% oxygen after hypoxia has harmful effects on adult brain, kidney and liver as well as neonatal brain and reoxygenation with air is effective in organ damage caused by hypoxia.
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