| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
While amino acids have organ protective effects, it is unknown whether they have preconditioning effects against myocardial ischemia-reperfusion injury. We examined the hypothesis that glutamine, leucine and arginine have preconditioning effects for a myocardial ischemic reperfusion injury in the isolated rat heart model.
Hearts were excised from rats and assigned as follows: 1) Control group, 2) Arginine group (Arg), 3) Leucine group (Leu) and 4) Glutamine group (Glu). The hearts were perfused with each solution before no-flow ischemia and then were reperfused.
While LV dp/dt max in Gln group was higher than that in the control group at 20 min after reperfusion, those in other three groups were similar. We demonstrated that glutamine is an only amino acid which has the cardioprotective effects against myocardial ischemia reperfusion injury. Myocardial Akt phosphorylation is not a possible mechanism by which glutamine produces the cardioprotective effect.
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