Development of continuous blood glucose concentration monitoring system using photo-technology

• Project/Area Number: 16K10956
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Doi Matsuyuki 浜松医科大学, 医学部附属病院, 准教授 (10155616)
• Project Period (FY): 2016-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 血中濃度測定 / ブドウ糖 / 光技術 / ブドウ糖濃度測定 / 光テクノロジー / 血液ブドウ糖濃度 / ブドウ糖濃度 / 蛍光 / 吸光スペクトラム

Outline of Final Research Achievements

The aim of this study was to develop a fiber-optic intravenous catheter system for continuous blood glucose concentration monitoring. We investigated techniques to estimate blood glucose concentration using photo-technology. Anthracene-phenyl-diboronic acid with glucose emitted 430 nm fluorescence with 370 nm excitation light. The intensity of the fluorescence depended on glucose concentration, but was unstable beyond 2 hours monitoring time. We could not solve this issue in this study. We also investigated light absorption of glucose in near infra-red up to 1200 nm. We could not find any wave length suitable for blood glucose concentration estimation.

Academic Significance and Societal Importance of the Research Achievements

集中治療を必要とする急性期重症患者では血中ブドウ糖濃度が大きく変動するが、その濃度を至適な範囲に調節することにより予後が改善することが知られている。精密な血中ブドウ糖濃度制御のためには高精度のブドウ糖濃度連続測定が重要であるが、現在臨床使用に適した装置はない。そこで光技術を用いた光ファイバー内蔵血管内カテーテルによる血中ブドウ糖連続測定システムの開発を行った。