| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
I examined the usefulness of the Aorto-caval shunt in either rats and mice as an experimental model for our research of pulmonary hypertension caused by increased pulmonary blood flow. Increased venous return through aorto-caval shunt caused enlargement of right ventricle, and then developed right ventricle failure, as described before. However, right ventricle hypertrophy as a sign of pulmonary hypertension was not caused by aorto-caval shunt. Histological findings of lung from aorto-caval shunt rats and mice failed to show either pulmonary artery stenosis or plexiform lesion known as characteristic findings of pulmonary hypertension. Then I asked a cooperative laboratory to provide samples of pulmonary artery and vein from pulmonary hypertension model and control lamb. I showed the increase of thrombin receptor expression in both pulmonary artery and vein from model animals, elucidating the relationship of thrombin and pathophysiology of pulmonary hypertension.
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