• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Inhibitory effect of arginase on pulmonary hypertension

Research Project

Project/Area Number 16K10968
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionYokohama City University

Principal Investigator

Shinbori Nobuhiro  横浜市立大学, 医学研究科, 客員准教授 (60404993)

Co-Investigator(Kenkyū-buntansha) 古賀 資和  横浜市立大学, 医学部, 助教 (00637233)
水野 祐介  横浜市立大学, 附属病院, 准教授 (80433192)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsarginase / 肺高血圧 / eNOS / arginine / 肺高血圧症 / 一酸化窒素 / 内皮細胞 / 内皮由来一酸化窒素合成酵素 / 一酸化窒素合成酵素 / 平滑筋
Outline of Final Research Achievements

Impairments of endothelial nitric oxide synthesis (eNOS) activity and nitric oxide (NO) are well known to play a critical role in developing pulmonary hypertension (PH).
In monocrolatine-induced rats, decreased eNOS activity and endothelium dependent relaxation (EDR) of PA ring were accompanied with increased arginase expression, which compete substrate with eNOS.Pretreatment of NOHA, arginase inhibitor, and arginine recovered EDR in PH rats.In PH rats, increased arginase expression and impaired availability of arginine could be associated with decreased EDR. Exploration of mechanism of arginase activity and arginine availability may be useful to develop novel treatment for PH.

Academic Significance and Societal Importance of the Research Achievements

肺高血圧症の併存は周術期の心血管合併症の発症率を有意に上昇させ、重症例では依然として管理は困難である。我々は肺高血圧ラットモデルを用い、肺高血圧症の原因の一つである肺血管内皮障害とそれに伴う一酸化窒素産生の低下を改善させる方法について、検討を行った。一酸化窒素合成酵素の活性低下の原因として、arginaseの発現亢進と一酸化窒素合成酵素の基質であるarginineの利用障害の可能性が示唆された。重症肺高血圧症の管理は依然困難であり、詳細な機序解明は新たな治療法の開発につながる可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report

Research Products

(1 results)

All 2020

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Role of protein kinase D1 in pulmonary hypertension in rats2020

    • Author(s)
      Shinya Oku
    • Organizer
      Experimental Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi