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Combination therapy with X-ray or heavy ion therapy and statin for prostate cancer

Research Project

Project/Area Number 16K10995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionGunma University

Principal Investigator

Sekine Yoshitaka  群馬大学, 大学院医学系研究科, 助教 (00516370)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords前立腺癌 / スタチン / 放射線 / 重粒子 / PAPR阻害剤 / DNA修復 / 癌 / トランスレーショナルリサーチ
Outline of Final Research Achievements

Statin decreased many gene expressions, which are related to DNA repair, in androgen independent prostate cancer cells. The combination of X-ray or heavy ion therapy and simvastatin further enhanced the inhibition of cell proliferation compared with treatment with either treatment alone in androgen independent prostate cancer cells. Moreover, the combination of Olaparib and simvastatin further enhanced the inhibition of cell proliferation compared with treatment with either drug alone in androgen independent prostate cancer cells, but not in normal prostate stroma cells. These data suggested that the combination of radiation or PARP inhibitor and statin can potentially affect castration-resistant prostate cancer growth.

Academic Significance and Societal Importance of the Research Achievements

前立腺癌患者は、日本において増加傾向にあり、新規アンドロゲン剤や抗癌剤が無効な患者に対する新規治療の開発は急務である。スタチンは、高脂血症に対して広く使用されている薬剤であるため、もし癌治療に応用することができれば、臨床的には使用しやすいことが予想される。まだまだ追加の研究が必要ではあるが、今回の研究結果において、現在、治療に難渋している去勢抵抗性前立腺癌に対して、スタチンが放射線やPARP阻害剤などとの併用で、治療効果がある可能性が示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2019

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] DNA修復遺伝子群を介したスタチンとPARP阻害剤の併用による去勢抵抗性前立腺癌細胞増殖抑制効果の解明2019

    • Author(s)
      関根芳岳
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Combination therapy with PARP inhibitor and statin for castration-resistant and taxane-resistant prostate cancer2019

    • Author(s)
      Yoshitaka Sekine
    • Organizer
      114th AUA Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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