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The novel bladder preservation therapy by selective destruction of cancercells "Boron Neutron Capture Therapy at bladder"

Research Project

Project/Area Number 16K11033
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionOsaka Medical College

Principal Investigator

Azuma Haruhito  大阪医科大学, 医学部, 教授 (40231914)

Co-Investigator(Kenkyū-buntansha) 稲元 輝生  大阪医科大学, 医学部, 准教授 (20330087)
宮武 伸一  大阪医科大学, 医学部, 特別職務担当教員(教授) (90209916)
鈴木 実  京都大学, 複合原子力科学研究所, 教授 (00319724)
Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywords膀胱温存 / 浸潤癌 / BOAI / BNCT
Outline of Final Research Achievements

We have developed a BOAI-BNCT method that selectively destroys cancer cells at the bladder and pelvic lymphatic tissue. The "BOAI method selectively administers extremely high concentrations of the boron compound to the bladder and pelvic lymphatic tissue using a catheter with a balloon for blood flow embolization. "bladder cancer cell-affinitive boron compound" selectively accumulate and migrate into the nucleus of the bladder cancer cell, then neutron selectively destroys cancer cells.

Academic Significance and Societal Importance of the Research Achievements

BOAI-BNCT療法は、硼素化合物自体には抗癌剤のような毒性がなく、また中性子線においても、硼素化合物を取り込んでいる細胞を選択的に破壊するが、中性子線自体が単独で照射されてもそれ自体による障害を殆どきたさないため、高齢者やPSが低下した症例でも施行可能であり、極めて画期的な治療法である。このことは、膀胱全摘を適応とする患者に対する膀胱温存治療というのみならず、これまで、年齢、PS、あるいは、心疾患などの合併症の理由で、手術や放射線治療などの根治を考慮に入れた治療が不可能であった症例に対しても根治を考慮に入れた治療ができるという点で臨床的に極めて有用で優れた治療法であると思われる。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (83 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (27 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 27 results,  Open Access: 17 results) Presentation (56 results) (of which Int'l Joint Research: 24 results,  Invited: 6 results)

  • [Journal Article] Early Prostate-Specific Antigen (PSA) Change at Four Weeks of the First-Line Treatment Using Abiraterone and Enzalutamide Could Predict Early/Primary Resistance in Metastatic Castration-Resistant Prostate Cancer.2021

    • Author(s)
      Uchimoto T,Komura K, Fukuokaya W, Kimura T, Takahashi K, Nishimura K, Nakamori K, Fujiwara Y, Matsunaga T, Tsutsumi T, Tsujino T, Maenosono R, Yoshikawa Y, Taniguchi K, Tanaka T, Uehara H, Ibuki N, Hirano H, Nomi H, Takahara K, Inamoto T, Egawa S, Azuma H.
    • Journal Title

      Cancers

      Volume: 13 Issue: 3 Pages: 2-12

    • DOI

      10.3390/cancers13030526

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants.2020

    • Author(s)
      Minami K, Bae S, Uehara H, Zhao C, Lee D, Iske J, Fanger MW, Reder J, Morrison I, Azuma H, Wiens A, Van Keuren E, Houser B, ElKhal A, Kang PM, Tullius SG.
    • Journal Title

      Am J Transplant.

      Volume: - Issue: 6 Pages: 1527-37

    • DOI

      10.1111/ajt.15794

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.2020

    • Author(s)
      Iske J,Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG.
    • Journal Title

      Nat Commun.

      Volume: 27 Issue: 1 Pages: 4289-4289

    • DOI

      10.1038/s41467-020-18039-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immunosuppression in vascularized composite allotransplant: the search for an effective and safe treatment continues.2020

    • Author(s)
      Matsunaga T,Azuma H, Tullius S.G.
    • Journal Title

      Transplant International

      Volume: 33 Issue: 10 Pages: 1291-3

    • DOI

      10.1111/tri.13629

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Risk Stratification for the Prediction of Overall Survival Could Assists Treatment Decision Making at the Diagnosis of Castration-Resistant Prostate Cancer - a Multicenter Collaborative Study in Japan.2020

    • Author(s)
      Uchimoto T,Komura K, Fukuokaya W, Kimura T, Takahashi K, Fujiwara Y,Matsunaga T, Tsutsumi T, Tsujino T, Taniguchi K, Tanaka T, Uehara H, Ibuki N, Hirano H, Nomi H, Takahara K, Inamoto T, Egawa S, Azuma H.
    • Journal Title

      BJU Int

      Volume: 127 Issue: 2 Pages: 212-21

    • DOI

      10.1111/bju.15187

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Down-Grading of Ipsilateral Hydronephrosis by Neoadjuvant Chemotherapy Correlates with Favorable Oncological Outcomes in Patients Undergoing Radical Nephroureterectomy for Ureteral Carcinoma ..2020

    • Author(s)
      Miyake M,Marugami N, Fujiwara Y, Komura K,Inamoto T,Azuma H, Matsumoto H, Matsuyama H, Fujimoto K.
    • Journal Title

      Diagnostics

      Volume: 10(1) Issue: 1 Pages: 10-10

    • DOI

      10.3390/diagnostics10010010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Single-Centre Study of Post-Transplant Diabetes Mellitus (PTDM) in Japa.2020

    • Author(s)
      Hirano H,Kanatsuna N,Fujiwara Y,Matsunaga T,Taniguchi S,Uehara H, Nomi H, Ichihashi A, Kobayashi D, Tsutsumi T, Komura K, Ibuki N, Inamoto T,Azuma H.
    • Journal Title

      Transplantation Case Reports

      Volume: 1(1) Pages: 2-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of periodic examinations after transplants; a case of pulmonary cryptococcosis after kidney transplantation.2019

    • Author(s)
      Hirano H,Maenosono R, Matsunaga T, Uehara H, Nomi H, Ichihashi A,Kobayashi D,Taniguchi S,Tsutsumi T,Tsujino T,Komura K, Ibuki N,Inamoto T,Azuma H, Fujiwara Y, Kano Y, Minami K, Kojima A, Kinoshita S, Tokunaga Y, Doi Y, Nakamori K.
    • Journal Title

      Transplantation Reports.

      Volume: - Issue: 2 Pages: 100021-100021

    • DOI

      10.1016/j.tpr.2019.100021

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort.2019

    • Author(s)
      Komura K,Fujiwara Y,UchimotoT,Saito K,Tanda N,Matsunaga T, Ichihashi A,Tsutsumi T, Tsujino T,Yoshikawa Y,Nishimoto Y,Takai T,Minami K,Taniguchi K,Tanaka T, Uehara H,Hirano H,Nomi H,Ibuki N, Takahara K,Inamoto T,Azuma H.
    • Journal Title

      J. Clin. Med.

      Volume: 8(8) Issue: 8 Pages: 1251-1251

    • DOI

      10.3390/jcm8081251

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer.2019

    • Author(s)
      Tsujino T,Sugito N, Taniguchi K, Honda R, Komura K, Yoshikawa Y, Takai T, Minami K, Kuranaga Y, Shinohara H, Tokumaru Y, Heishima K, Inamoto T, Azuma H, Akao Y.
    • Journal Title

      Cancer Sci.

      Volume: 110(7) Issue: 7 Pages: 2189-9

    • DOI

      10.1111/cas.14035

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan.2019

    • Author(s)
      Komura K,Hashimoto T, Tsujino T, Muraoka R, Tsutsumi T, Satake N, Matsunaga T, Yoshikawa Y, Takai T, Minami K, Taniguchi K, Uehara H, Tanaka T, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Ohno Y, Azuma H.
    • Journal Title

      Ann Surg Oncol.

      Volume: 26(9) Issue: 9 Pages: 2994-3004

    • DOI

      10.1245/s10434-019-07530-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between response to rituximab and antibody-mediated rejection in ABO-incompatible living kidney transplantation.2019

    • Author(s)
      Maenosono R,Unagami K, Kakuta Y, Furusawa M, Okumi M, Azuma H, Ishida H3 Tanabe K.
    • Journal Title

      Int J Urol.

      Volume: - Issue: 12 Pages: 1114-1120

    • DOI

      10.1111/iju.14108

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer.2019

    • Author(s)
      Uchimoto T,Komura K, Fujiwara Y, Saito K, Tanda N, Matsunaga T, Ichihashi A, Tsutsumi T, Tsujino T, Yoshikawa Y, Nishimoto Y, Takai T, Minami K, Taniguchi K, Tanaka T, Uehara H, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
    • Journal Title

      Medical Oncology

      Volume: 37(1) Issue: 1 Pages: 9-9

    • DOI

      10.1007/s12032-019-1332-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.2019

    • Author(s)
      Takai T、 Tsujino T, Yoshikawa Y, Inamoto T, Sugito N, Kuranaga Y, Heishima K, Soga T, Hayashi K, Miyata K, Kataoka K, Azuma H, Akao Y.
    • Journal Title

      Mol Ther.

      Volume: S1525-0016(19) Issue: 5 Pages: 30090-5

    • DOI

      10.1016/j.ymthe.2019.03.004

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Are there any metastases to the chest in non-muscle-invasive bladder cancer patients on follow-up computed tomography?2018

    • Author(s)
      Juri H、Koyama M, Azuma H, Narumi Y.
    • Journal Title

      Int Urol Nephrol.

      Volume: 50(10) Issue: 10 Pages: 1771-8

    • DOI

      10.1007/s11255-018-1952-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tetramodal therapy using balloon-occluded arterial infusion of anticancer agents, the Azuma regimen, for lymph node-involved bladder cancer2018

    • Author(s)
      Azuma Haruhito、Inamoto Teruo、Takahara Kiyoshi、Ibuki Naokazu、Nomi Hayahito、Komura Kazumasa、Uehara Hirofumi、Minami Koichiro、Yamamoto Kazuhiro、Narumi Yoshifumi
    • Journal Title

      International Journal of Oncology

      Volume: 54(1) Pages: 167-76

    • DOI

      10.3892/ijo.2018.4619

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] hibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D.2018

    • Author(s)
      Komura K、Yoshikawa Y, Shimamura T, Chakraborty G, Gerke TA, Hinohara K, Chadalavada K, Jeong SH, Armenia J, Du SY, Mazzu YZ, Taniguchi K, Ibuki N, Meyer CA, Nanjangud GJ, Inamoto T, Lee GM, Mucci LA, Azuma H, Sweeney CJ, Kantoff PW.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128(7) Issue: 7 Pages: 2979-95

    • DOI

      10.1172/jci96769

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Systematic Conversion to Generic Mycophenolate Mofetil2018

    • Author(s)
      Hirano H、Matsunaga T, Maenosonoa R,Taniguchia S,Ueharaa H,Nomia H,Kanoa Y,Fujiwara Y, Ichihashi A, Kobayashia D,Tsutsumia T,Komura K,Ibukia N,Inamoto T,Matsumura H,Ashida H,Azuma H.
    • Journal Title

      Transplant Proc.

      Volume: 50(10) Issue: 10 Pages: 3255-7

    • DOI

      10.1016/j.transproceed.2018.04.064

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recall features and allorecognition in innate immunity.2018

    • Author(s)
      Uehara H,Minami K, Quante M, Nian Y, Heinbokel T, Azuma H, Khal AE, Tullius SG.
    • Journal Title

      Transpl Int.

      Volume: 31(2) Issue: 1 Pages: 6-13

    • DOI

      10.1111/tri.13073

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mast cells regulate CD4+ T cell differentiation in absence of antigen presentation.2018

    • Author(s)
      H. Uehara,H. Rodriguez Cetina Biefer, T. Heinbokel, V. Camacho, K. Minami, Y. Nian, S. Koduru, R. El Fatimy, I. Ghiran, A. J. Trachtenberg, M. A. de la Fuente, H. Azuma, O. Akbari, S. G. Tullius, A. Vasudevan, A. Elkhal.
    • Journal Title

      J. Allergy Clin. Immunol

      Volume: 1 Issue: 6 Pages: 1894-1908.e7

    • DOI

      10.1016/j.jaci.2018.01.038

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Remarkable response to fluorouracil, leucovorin, oxaliplatin, and irinotecan therapy in urothelial cancer of the renal pelvis: a case report.2017

    • Author(s)
      Takuya Tsujino,Kiyoshi Takahara, Tomohisa Matsunaga, Yuki Yoshikawa, Tomoaki Takai, Taizo Uchimoto,Kenkichi Saito, Naoki Tanda, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Teruo Inamoto ,Haruhito Azuma.
    • Journal Title

      J Med Case Rep.

      Volume: 11(99) Issue: 1

    • DOI

      10.1186/s13256-017-1263-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative Measurement of the Modified Glasgow Prognostic Score Predicts Patient Survival in Non-Metastatic Renal Cell Carcinoma Prior to Nephrectomy.2017

    • Author(s)
      Tsujino T,Komura K, Matsunaga T, Yoshikawa Y, Takai T, Uchimoto T, Saito K, Tanda N, Oide R, Minami K, Uehara H, Jeong SH, Taniguchi K, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
    • Journal Title

      Ann Surg Oncol.

      Volume: 24(9) Issue: 9 Pages: 2787-93

    • DOI

      10.1245/s10434-017-5948-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] What has changed in kidney transplantation in small islands in Japan? Experience in our center.2017

    • Author(s)
      Hajime Hirano,Ryoichi Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi,Takuya Tsujino, Naoki Tanda, Kenkichi Saito, Taizo Uchimoto, Naokazu Ibuki, Teruo Inamoto,Yoshihiro Tokeshia, Haruhito Azuma.
    • Journal Title

      Renal Replacement Therapy

      Volume: 3(46) Issue: 1

    • DOI

      10.1186/s41100-017-0127-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma.2017

    • Author(s)
      Inamoto T,Matsuyama H, Sakano S, Ibuki N, Takahara K, Komura K, Takai T, Tsujino T, Yoshikawa Y, Minami K, Nagao K, Inoue R, Azuma H.
    • Journal Title

      Oncotarget

      Volume: 8(68) Issue: 68 Pages: 113248-57

    • DOI

      10.18632/oncotarget.22641

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma.2017

    • Author(s)
      Takuya Tsujino,Kazumasa Komura, Atsushi Ichihashi, Takeshi Tsutsumi,Tomohisa Matsunaga, Yuki Yoshikawa, Ryoichi Maenosono, Kyohei Okita,Tomoaki Takai, Rintaro Oide, Koichiro Minami, Hirofumi Uehara, Kohei Taniguchi, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Kiyoshi Takahara,Teruo Inamoto, Haruhito Azuma.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 66 Pages: 110311-25

    • DOI

      10.18632/oncotarget.22688

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel Software-Assisted Hemodynamic Evaluation of Pelvic Flow During Chemoperfusion of Pelvic Arteries for Bladder Cancer: Double- Versus Single-Balloon Technique.2016

    • Author(s)
      Yamamoto K, Yamamoto K, Nakai G, Azuma H, Narumi Y.
    • Journal Title

      Cardiovasc Intervent Radiol.

      Volume: 39 Issue: 6 Pages: 824-30

    • DOI

      10.1007/s00270-016-1296-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of bladder cancer: comparison of low-dose scans with AIDR 3D and routine-dose scans with FBP on the excretory phase in CT urography.2016

    • Author(s)
      Juri H, Tsuboyama T, Kumano S, Inada Y, Koyama M, Azuma H, Narumi Y.
    • Journal Title

      Br J Radiol.

      Volume: 89 Issue: 1058 Pages: 1058-1058

    • DOI

      10.1259/bjr.20150495

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規膀胱温存療法「OMC-regimen」の治療成績2021

    • Author(s)
      東 治人
    • Organizer
      第204回香川県泌尿器科医会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Update on bladder preservation protocols2020

    • Author(s)
      Haruhito Azuma
    • Organizer
      23rd IUA Annual Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA 複製ストレスを利用した泌尿器がん合成致死誘導治療法の確立2020

    • Author(s)
      小村 和正、稲元輝生、東 治人
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 去勢抵抗性前立腺癌(CRPC)における1次治療開始時点CRP-Albumin ratio(CAR)の治療予後予測因子としての意義.2020

    • Author(s)
      内本泰三、小村和正、藤原裕也、齊藤賢吉、反田直希、市橋淳、上原博史、伊夫貴 直和、平野 一、能見勇人、稲元輝生、東 治人.
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 非転移性去勢抵抗性前立腺癌に対するアパルタミド以前の治療の成績の検討2020

    • Author(s)
      稲元輝生、伊夫貴 直和、小村和正、南 幸一郎、高 朋聡、上原博史、市橋 淳、谷口俊理、堤 岳之、辻野拓也、松永知久、能見勇人、東 治人.
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 腎癌薬物療法―I-O 時代におけるソラフェニブの役割とは?2020

    • Author(s)
      稲元輝生、大家基嗣、赤座英之、東 治人.
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] BU1B/BUBR1異常発現によるMutagenic NHEJとintact ATMの意義2020

    • Author(s)
      小村 和正、稲元輝生、東 治人
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Donor and recipient sex affect transplant outcomes in an age-specific fashion.2020

    • Author(s)
      Maenosono R、Nian Y,Iske J, Liu Y,Azuma H,Milford E,Tullius SG.
    • Organizer
      TTS 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The impact of the expression of the transcription factor MYBL2 on outcomes of patients with localized and advanced prostate cancer.2020

    • Author(s)
      Yoshikawa Y,Wang XV, Chen YH, Mazzu YZ, Chakraborty G, Jehane LE, Rajanala SH,Hirani R, Nandakumar S,Stopsack KH, Lee GSM, Davicioni E, Liu G, DiPaola RS, Carducci MA, Kantoff PW, Sweeney C.
    • Organizer
      Genitourinary Cancers Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例2020

    • Author(s)
      上原博史,平野 一,岡部知太,木村孝平,寺本昌司,高倉一平,西村一希,木下将宏,徳永雄希,中森啓太,市橋 淳,谷口俊理,小林大介,堤 岳之,小村和正,伊夫貴 直和,稲元輝生能見勇人,東 治人.
    • Organizer
      第53回日本臨床腎移植学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Cardiovascular disease (CVD)を有する進行性腎細胞癌に対するソラフェニブの成績2019

    • Author(s)
      稲元輝生,東 治人,大家基嗣,赤座英之.
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Treatment outcome of dose reduction of enzalutamide against CRPC?2019

    • Author(s)
      Ibuki N,IInamoto T,Ichihashi A,Uehara H,Komura K,Hirano H,Nomi H,Azma H.
    • Organizer
      AUA 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例2019

    • Author(s)
      松永 知久,上原博史,平野 一,小林大介,堤 岳之,加納陽祐,藤原裕也,能見勇人,伊夫貴 直和,小村和正,稲元輝生,東 治人.
    • Organizer
      第35回腎移植血管外科研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Promoting a medical system for renal transplantation in the remote island in Japan.Long time Efficacy and Safety follow-up for 10yaears.2019

    • Author(s)
      Hirano H,Tokeshi Y,Fujiwara Y, Matsunaga T,Uehara H,Nomi H,Komura K,Ibuki N, Inamoto T,Azuma H.
    • Organizer
      CAST2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Post transplant diabetes mellitus (PTDM) in our institution.2019

    • Author(s)
      Hirano H,Fujiwara Y, Matsunaga T,Uehara H,Nomi H,Komura K,Ibuki N, Inamoto T,Azuma H.
    • Organizer
      CAST2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Management of alpha-herpesvirus infection following kidney transplantation: Our experience (7 cases)2019

    • Author(s)
      Uehara H, Hirano H, Matsunaga T, Minami K,Kazumasa K, Ibuki N,Inamoto T,Nomi H,Azuma H.
    • Organizer
      CAST2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Successful Treatment of Antibody-Mediated Rejection (AMR) by de novo Donor specific antibody (DSA) after primary renal transplantation in a recipient from a cadaveric donor: A Case Report2019

    • Author(s)
      Matsunaga T, Hirano H, Tsutsumi T,Tsujino T, Yoshikawa Y, Takai T,Minami K,Uehara H, Komura K,Nomi H, Ibuki N,Inamoto T,Azuma H.
    • Organizer
      CAST2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 免疫療法時代における進行性腎細胞癌に対するソラフェニブの立ち位置の再考2019

    • Author(s)
      稲元輝生,東 治人.
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] CRPC1次療法でのAbiraterone, Enzalutamideの傾向スコアマッチングによる治療効果比較.2019

    • Author(s)
      小村和正,稲元輝生, 藤原裕也, 伊夫貴 直和, 内本泰三, 齋藤賢吉, 反田直希, 辻野拓也, 上原博史, 平野 一, 能見勇人, 東 治人.
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Nivolumab have been approved for treatment for patients with metastatic renal cell carcinoma. We retrospectively evaluated patients with mRCC who were treated with Nivolumab our institution.2019

    • Author(s)
      Kano Y,Ibuki N,Fujiwara Y,Tsutsumi T,Kojima A,Uehara H,Komura M,Inamoto T,Azuma H.
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] CRP/Albumin ratioの腎細胞がんにおける予後規定因子としての有用性2019

    • Author(s)
      小村和正,辻野拓也、金原裕則、鈴木俊明、瀬川直樹、和田誠次、丸山栄勲、橋本 剛、稲元輝生、濱田修史、大野芳正、東 治人.
    • Organizer
      第69回日本泌尿器科学会中部総会
    • Related Report
      2019 Research-status Report
  • [Presentation] ロボット支援腹腔鏡下腎部分切除術(RAPN)におけるTrifectaが術後成績に与える影響.2019

    • Author(s)
      内本泰三,伊夫貴 直和、木下将宏、徳永雄希、中森啓太、土井 由紀子、小林大介、小村和正、上原博史、稲元輝生、東 治人.
    • Organizer
      第33回日本泌尿器内視鏡学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] TURBTと化学放射線療法・動注化学療法を用いた 高齢MIBC患者治療2019

    • Author(s)
      稲元 輝生,伊夫貴 直和, 小林大介,堤 岳之,小村和正,上原博史、平野 一、 能見勇人, 東 治人, 山本和宏, 鳴海善文.
    • Organizer
      第33回日本泌尿器内視鏡学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高齢筋層浸潤性膀胱癌患者に対するTURBTと化学放射線療法・動注化学療法を用いた根治的治療の成績.2019

    • Author(s)
      稲元輝生,伊夫貴 直和, 小林大介,堤 岳之,小村和正,上原博史、平野 一, 能見勇人, 東 治人, 山本和宏, 鳴海善文.
    • Organizer
      第32回日本内視鏡外科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規膀胱温存療法 OMC-Regimenの治療成績2019

    • Author(s)
      東 治人
    • Organizer
      第2回 京葉泌尿器癌研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Aberrant Error-Prone DNA Damage Repair as a Potential Therapeutic Target in Advanced Urothelial Carcinoma.2019

    • Author(s)
      Komura K , Inamoto T, Uehara H, Ibuki , Minami K, Tsujino T, Azuma H.
    • Organizer
      EAU2019
    • Related Report
      2018 Research-status Report
  • [Presentation] バルーン塞栓動脈内抗癌剤投与法(BOAI)によるシスプラチン投与と血液透析とを併用する集学的治療2018

    • Author(s)
      東 治人
    • Organizer
      第18回日本Men's Health 医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 局所注入によるがん治療と抗がん薬曝露対策2018

    • Author(s)
      東 治人
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] NIBCに対する膀胱温存療法25年の経過報告2018

    • Author(s)
      東 治人
    • Organizer
      高知尿路悪性腫瘍研究会2018
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Risk stratification by means of treatment phase related factors predicts resistance-free survival in patients with CRPC treated by ARTs.2018

    • Author(s)
      Inamnoto T,Ibuki N, Komura K,Minami K,Takai T,Uchimoto T, Saito K ,Tanda N ,Tsujino T , Matsunaga T,Yoshikawa Y , Hirano H, Nomi H,Azuma H.
    • Organizer
      16th UAA Congress2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] DNA replication stress by the loss of male specific histone demethylase ‘KDM5D’ in aggressive prostate cancer2018

    • Author(s)
      Kazumasa Komura , Teruo Inamoto , Naokazu Ibuki , Christopher J. Sweeney , Haruhito Azuma , Philip W. Kantoff.
    • Organizer
      AUA 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expanding the donor pool : Experience of living kidney transplantation from very old aged donor in our center.2018

    • Author(s)
      HiranoH,Maenosono R, Matsunaga T, Uehara H,Nomi H,Kano Y,Fujiwara Y, Taniguchi S,Tsutsumi T,Ichihashi A, Kobayashi D,Ohkita K, Hayashi K,Komura K,Ibuki N,Inamoto T, Azuma H.
    • Organizer
      TTS 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthetic Lethal Approach Exploiting DNA Replication Stress in Aggressive Prostate Cancer Deficient in JARID1D.2018

    • Author(s)
      Kazumasa Komura , Teruo Inamoto ,Naokazu Ibuki, Christopher J. Sweeney , Philip W. Kantoff , Haruhito Azuma .
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluation of the safety and short term effects of Pembrolizumab in patients with chemotherapy resistant metastatic urothelial carcinoma.2018

    • Author(s)
      Ibuki N,Inamoto T,Ohkita K, Hayashi K, Kojima A,Komura K, Uehara H, Hirano H, Noumi H,Azuma H.
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Importance of periodic examinations after transplants ; a case of pulmonary cryptococcosis after kidney transplantation.2018

    • Author(s)
      Hirano H, Fujiwara Y, Minami K,Kano Y, Taniguchi S, Uehara H,Ibuki N, Nomi H, Inamoto T, Azuma H.
    • Organizer
      ATW 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膀胱癌におけるKLF4とPTBP1を介したmicroRNA-145とワーバーグ効果の関係性2018

    • Author(s)
      南 幸一郎,小村 和正,伊夫貴 直和,稲元 輝生,能見 勇人,東 治人.
    • Organizer
      16th UAA Congress2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluation of hemoglobin dynamics in relation to efficacy of second-generation anti-androgens in patients with castrate-resistant prostate cancer2018

    • Author(s)
      稲元 輝生、伊夫貴直和、小村 和正、小林大介、市橋淳、谷口俊理、堤岳之、松永 知久、能見 勇人、東 治人.
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Moderated Poster 2(Management of ureteral obstruction)2018

    • Author(s)
      稲元 輝生、東 治人.
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Bladder preservation therapy for localized muscle-invasive bladder cancer2018

    • Author(s)
      稲元 輝生 ,東 治人.
    • Organizer
      日本泌尿器腫瘍学会 第4回学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) for prediction of treatment outcome for patients with localized renal cell carcinoma.2018

    • Author(s)
      Kazumasa Komura,Takuya Tsujino,Naokazu Ibuki,Teruo Inamoto,Haruhito Azuma.
    • Organizer
      2018 Genitourinary Cancers Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the safety and short term pathological effects of tri-modal therapy in patients with bladder cancer: a multicenter prospective trial.2018

    • Author(s)
      Naokazu Ibuki,Teruo Inamoto, Kazumasa Komura, Kiyoshi Takahara, Hajime Hirano, Hayahito Noumi, Haruhito Azuma.
    • Organizer
      EAU 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Aggressive prostate cancer by the loss of male specific histone demethylase ‘KDM5D’.2018

    • Author(s)
      Komura K,Inamoto T, Ibuki N, Sweeney C, Azuma H, Kantoff P.
    • Organizer
      EAU 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decreased Expression of Male Specific Histone Demethylase “KDM5D” is Prognostic for Development of Castration-Resistant Prostate Cancer.2017

    • Author(s)
      Kazumasa Komura,Seong Ho Jeong, Kunihiko Hinohara, Gwo-Shu Mary Lee, Christopher J. Sweeney, Haruhito Azuma, and Philip W. Kantoff.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CD4+IFN-γ+IL-10+ cells facilitate a prolongation of graft survival in old recipient mice treated with Rapamycin.2017

    • Author(s)
      Koichiro Minami,Timm Heinbokel, Markus Quante, Hirofumi Uehara, Abdala Elkhal, Haruhito Azuma, Stefan G. Tullius.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] MiR-145 modulates Warburg effect by targeting KLF4/PTB1/PKMs axis in bladder cancer cells.2017

    • Author(s)
      Koichiro Minami,Kohei Taniguchi, Teruo Inamoto, Kiyoshi Takahara, Kazumasa Komura, Tomoaki Takai, Yuki Yoshikawa, Yukihiro Akao, Haruhito Azuma .
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Risk stratification by means of the biological age related factors better predicts cancer-specific survival than the chronological age in patients with upper tract urothelial carcinoma (UTUC): a multi-institutional database study .2017

    • Author(s)
      Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multimodal bladder preservation technique for muscle invasive bladder cancer: results from a prospective trial.2017

    • Author(s)
      Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gender-specific differences in cancer-specific survival after nephroureterectomy with bladder cuff for patients with upper tract urothelial carcinoma.2017

    • Author(s)
      Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano), Kazuhiro Nagao , Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A panel of micro-RNA signature as a tool for predicting survival of patients with urothelial carcinoma of the bladder.2017

    • Author(s)
      Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] PSA nadir and PSA flare are the predictors of biochemical failure after High-Intensity Focused Ultrasound treatment of localized prostate cancer.2017

    • Author(s)
      Naokazu Ibuk,Teruo Inamoto, Yudai Nishimoto, Kiyoshi Takahara, Toshikazu Watsuji, Haruhito Azuma.
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on safety of elderly living kidney donors - Two cases of the donors older than 80 in our hospital.2017

    • Author(s)
      Hajime Hirano,Ryoici Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi, Atushi Ichihashi, Daisuke Kobayashi, Shyunri Taniguchi, Takeshi Tsutsumi, Takuya Tsujino, Kazumasa Komura, Naokazu Ibuki, Teruo Inamoto, Haruhito Azuma.
    • Organizer
      CAST2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] OMC-regimen for the purpose of multimodality-bladder preservation therapy for patients with MIBC: a multicenter prospective trial .2017

    • Author(s)
      稲元 輝生,伊夫貴直和、高原 健、辻野拓也、松永 知久、吉川 勇希、齋藤 賢吉、内本 泰三、反田 直希、平野 一、能見 勇人、山本 和宏、鳴海 善文、東 治人.
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 血液透析併用動注化学療法(BOAI)を用いたOMC-regimen.2017

    • Author(s)
      稲元 輝生,東 治人
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腎移植、免疫寛容の誘導に向けて2017

    • Author(s)
      東 治人
    • Organizer
      第38回日本循環制御医学会総会・学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 前立腺癌に対する新規治療戦略 -体性間葉系幹細胞を用いたテーラーメイド硼素中性子捕捉療法(BNCT)の確立2017

    • Author(s)
      高原 健、東 治人.
    • Organizer
      第17回東名泌尿器科研究会
    • Place of Presentation
      名古屋〈名古屋)
    • Related Report
      2016 Research-status Report
  • [Presentation] 前立腺癌に対する硼素中性子捕捉療法(BNCT)の制癌効果 -脂肪幹細胞ナノDDS技術を駆使した新規テーラーメイド療法を目指して-2016

    • Author(s)
      高原 健,稲元輝生、南幸一郎、吉川勇希、高井朋聡、平野 一、能見勇人、木山 賢、鈴木 実、切畑 光統、東 治人.
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(福岡)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-01-27  

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