The novel bladder preservation therapy by selective destruction of cancercells "Boron Neutron Capture Therapy at bladder"

• Project/Area Number: 16K11033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka Medical College
• Principal Investigator: Azuma Haruhito 大阪医科大学, 医学部, 教授 (40231914)
• Co-Investigator(Kenkyū-buntansha): 稲元 輝生 大阪医科大学, 医学部, 准教授 (20330087) ; 宮武 伸一 大阪医科大学, 医学部, 特別職務担当教員(教授) (90209916) ; 鈴木 実 京都大学, 複合原子力科学研究所, 教授 (00319724)
• Project Period (FY): 2016-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
• Keywords: 膀胱温存 / 浸潤癌 / BOAI / BNCT

Outline of Final Research Achievements

We have developed a BOAI-BNCT method that selectively destroys cancer cells　at the bladder and pelvic lymphatic tissue. The "BOAI method selectively administers extremely high concentrations of the boron compound to the bladder and pelvic lymphatic tissue using a catheter with a balloon for blood flow embolization. "bladder cancer cell-affinitive boron compound" selectively accumulate and migrate into the nucleus of the bladder cancer cell, then neutron selectively destroys cancer cells.

Academic Significance and Societal Importance of the Research Achievements

BOAI-BNCT療法は、硼素化合物自体には抗癌剤のような毒性がなく、また中性子線においても、硼素化合物を取り込んでいる細胞を選択的に破壊するが、中性子線自体が単独で照射されてもそれ自体による障害を殆どきたさないため、高齢者やPSが低下した症例でも施行可能であり、極めて画期的な治療法である。このことは、膀胱全摘を適応とする患者に対する膀胱温存治療というのみならず、これまで、年齢、PS、あるいは、心疾患などの合併症の理由で、手術や放射線治療などの根治を考慮に入れた治療が不可能であった症例に対しても根治を考慮に入れた治療ができるという点で臨床的に極めて有用で優れた治療法であると思われる。

Research Products

• [Journal Article] Early Prostate-Specific Antigen (PSA) Change at Four Weeks of the First-Line Treatment Using Abiraterone and Enzalutamide Could Predict Early/Primary Resistance in Metastatic Castration-Resistant Prostate Cancer. (2021)
  • Author(s): Uchimoto T,Komura K, Fukuokaya W, Kimura T, Takahashi K, Nishimura K, Nakamori K, Fujiwara Y, Matsunaga T, Tsutsumi T, Tsujino T, Maenosono R, Yoshikawa Y, Taniguchi K, Tanaka T, Uehara H, Ibuki N, Hirano H, Nomi H, Takahara K, Inamoto T, Egawa S, Azuma H.
  • Journal Title: Cancers Volume: 13 Issue: 3 Pages: 2-12
  • DOI: 10.3390/cancers13030526
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants. (2020)
  • Author(s): Minami K, Bae S, Uehara H, Zhao C, Lee D, Iske J, Fanger MW, Reder J, Morrison I, Azuma H, Wiens A, Van Keuren E, Houser B, ElKhal A, Kang PM, Tullius SG.
  • Journal Title: Am J Transplant. Volume: - Issue: 6 Pages: 1527-37
  • DOI: 10.1111/ajt.15794
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. (2020)
  • Author(s): Iske J,Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG.
  • Journal Title: Nat Commun. Volume: 27 Issue: 1 Pages: 4289-4289
  • DOI: 10.1038/s41467-020-18039-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immunosuppression in vascularized composite allotransplant: the search for an effective and safe treatment continues. (2020)
  • Author(s): Matsunaga T,Azuma H, Tullius S.G.
  • Journal Title: Transplant International Volume: 33 Issue: 10 Pages: 1291-3
  • DOI: 10.1111/tri.13629
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk Stratification for the Prediction of Overall Survival Could Assists Treatment Decision Making at the Diagnosis of Castration-Resistant Prostate Cancer - a Multicenter Collaborative Study in Japan. (2020)
  • Author(s): Uchimoto T,Komura K, Fukuokaya W, Kimura T, Takahashi K, Fujiwara Y,Matsunaga T, Tsutsumi T, Tsujino T, Taniguchi K, Tanaka T, Uehara H, Ibuki N, Hirano H, Nomi H, Takahara K, Inamoto T, Egawa S, Azuma H.
  • Journal Title: BJU Int Volume: 127 Issue: 2 Pages: 212-21
  • DOI: 10.1111/bju.15187
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Down-Grading of Ipsilateral Hydronephrosis by Neoadjuvant Chemotherapy Correlates with Favorable Oncological Outcomes in Patients Undergoing Radical Nephroureterectomy for Ureteral Carcinoma .. (2020)
  • Author(s): Miyake M,Marugami N, Fujiwara Y, Komura K,Inamoto T,Azuma H, Matsumoto H, Matsuyama H, Fujimoto K.
  • Journal Title: Diagnostics Volume: 10(1) Issue: 1 Pages: 10-10
  • DOI: 10.3390/diagnostics10010010
  • Peer Reviewed / Open Access
• [Journal Article] A Single-Centre Study of Post-Transplant Diabetes Mellitus (PTDM) in Japa. (2020)
  • Author(s): Hirano H,Kanatsuna N,Fujiwara Y,Matsunaga T,Taniguchi S,Uehara H, Nomi H, Ichihashi A, Kobayashi D, Tsutsumi T, Komura K, Ibuki N, Inamoto T,Azuma H.
  • Journal Title: Transplantation Case Reports Volume: 1(1) Pages: 2-3
  • Peer Reviewed / Open Access
• [Journal Article] Importance of periodic examinations after transplants; a case of pulmonary cryptococcosis after kidney transplantation. (2019)
  • Author(s): Hirano H,Maenosono R, Matsunaga T, Uehara H, Nomi H, Ichihashi A,Kobayashi D,Taniguchi S,Tsutsumi T,Tsujino T,Komura K, Ibuki N,Inamoto T,Azuma H, Fujiwara Y, Kano Y, Minami K, Kojima A, Kinoshita S, Tokunaga Y, Doi Y, Nakamori K.
  • Journal Title: Transplantation Reports. Volume: - Issue: 2 Pages: 100021-100021
  • DOI: 10.1016/j.tpr.2019.100021
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort. (2019)
  • Author(s): Komura K,Fujiwara Y,UchimotoT,Saito K,Tanda N,Matsunaga T, Ichihashi A,Tsutsumi T, Tsujino T,Yoshikawa Y,Nishimoto Y,Takai T,Minami K,Taniguchi K,Tanaka T, Uehara H,Hirano H,Nomi H,Ibuki N, Takahara K,Inamoto T,Azuma H.
  • Journal Title: J. Clin. Med. Volume: 8(8) Issue: 8 Pages: 1251-1251
  • DOI: 10.3390/jcm8081251
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer. (2019)
  • Author(s): Tsujino T,Sugito N, Taniguchi K, Honda R, Komura K, Yoshikawa Y, Takai T, Minami K, Kuranaga Y, Shinohara H, Tokumaru Y, Heishima K, Inamoto T, Azuma H, Akao Y.
  • Journal Title: Cancer Sci. Volume: 110(7) Issue: 7 Pages: 2189-9
  • DOI: 10.1111/cas.14035
  • Peer Reviewed / Open Access
• [Journal Article] The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan. (2019)
  • Author(s): Komura K,Hashimoto T, Tsujino T, Muraoka R, Tsutsumi T, Satake N, Matsunaga T, Yoshikawa Y, Takai T, Minami K, Taniguchi K, Uehara H, Tanaka T, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Ohno Y, Azuma H.
  • Journal Title: Ann Surg Oncol. Volume: 26(9) Issue: 9 Pages: 2994-3004
  • DOI: 10.1245/s10434-019-07530-5
  • Peer Reviewed / Open Access
• [Journal Article] Association between response to rituximab and antibody-mediated rejection in ABO-incompatible living kidney transplantation. (2019)
  • Author(s): Maenosono R,Unagami K, Kakuta Y, Furusawa M, Okumi M, Azuma H, Ishida H3 Tanabe K.
  • Journal Title: Int J Urol. Volume: - Issue: 12 Pages: 1114-1120
  • DOI: 10.1111/iju.14108
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer. (2019)
  • Author(s): Uchimoto T,Komura K, Fujiwara Y, Saito K, Tanda N, Matsunaga T, Ichihashi A, Tsutsumi T, Tsujino T, Yoshikawa Y, Nishimoto Y, Takai T, Minami K, Taniguchi K, Tanaka T, Uehara H, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
  • Journal Title: Medical Oncology Volume: 37(1) Issue: 1 Pages: 9-9
  • DOI: 10.1007/s12032-019-1332-7
  • Peer Reviewed / Open Access
• [Journal Article] Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo. (2019)
  • Author(s): Takai T、 Tsujino T, Yoshikawa Y, Inamoto T, Sugito N, Kuranaga Y, Heishima K, Soga T, Hayashi K, Miyata K, Kataoka K, Azuma H, Akao Y.
  • Journal Title: Mol Ther. Volume: S1525-0016（１９） Issue: 5 Pages: 30090-5
  • DOI: 10.1016/j.ymthe.2019.03.004
  • Peer Reviewed / Open Access
• [Journal Article] Are there any metastases to the chest in non-muscle-invasive bladder cancer patients on follow-up computed tomography? (2018)
  • Author(s): Juri H、Koyama M, Azuma H, Narumi Y.
  • Journal Title: Int Urol Nephrol. Volume: 50(10) Issue: 10 Pages: 1771-8
  • DOI: 10.1007/s11255-018-1952-4
  • Peer Reviewed / Open Access
• [Journal Article] Tetramodal therapy using balloon-occluded arterial infusion of anticancer agents, the Azuma regimen, for lymph node-involved bladder cancer (2018)
  • Author(s): Azuma Haruhito、Inamoto Teruo、Takahara Kiyoshi、Ibuki Naokazu、Nomi Hayahito、Komura Kazumasa、Uehara Hirofumi、Minami Koichiro、Yamamoto Kazuhiro、Narumi Yoshifumi
  • Journal Title: International Journal of Oncology Volume: 54(1) Pages: 167-76
  • DOI: 10.3892/ijo.2018.4619
  • Peer Reviewed / Open Access
• [Journal Article] hibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. (2018)
  • Author(s): Komura K、Yoshikawa Y, Shimamura T, Chakraborty G, Gerke TA, Hinohara K, Chadalavada K, Jeong SH, Armenia J, Du SY, Mazzu YZ, Taniguchi K, Ibuki N, Meyer CA, Nanjangud GJ, Inamoto T, Lee GM, Mucci LA, Azuma H, Sweeney CJ, Kantoff PW.
  • Journal Title: Journal of Clinical Investigation Volume: 128(7) Issue: 7 Pages: 2979-95
  • DOI: 10.1172/jci96769
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Systematic Conversion to Generic Mycophenolate Mofetil (2018)
  • Author(s): Hirano H、Matsunaga T, Maenosonoa R,Taniguchia S,Ueharaa H,Nomia H,Kanoa Y,Fujiwara Y, Ichihashi A, Kobayashia D,Tsutsumia T,Komura K,Ibukia N,Inamoto T,Matsumura H,Ashida H,Azuma H.
  • Journal Title: Transplant Proc. Volume: 50(10) Issue: 10 Pages: 3255-7
  • DOI: 10.1016/j.transproceed.2018.04.064
  • Peer Reviewed / Open Access
• [Journal Article] Recall features and allorecognition in innate immunity. (2018)
  • Author(s): Uehara H,Minami K, Quante M, Nian Y, Heinbokel T, Azuma H, Khal AE, Tullius SG.
  • Journal Title: Transpl Int. Volume: 31(2) Issue: 1 Pages: 6-13
  • DOI: 10.1111/tri.13073
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mast cells regulate CD4+ T cell differentiation in absence of antigen presentation. (2018)
  • Author(s): H. Uehara,H. Rodriguez Cetina Biefer, T. Heinbokel, V. Camacho, K. Minami, Y. Nian, S. Koduru, R. El Fatimy, I. Ghiran, A. J. Trachtenberg, M. A. de la Fuente, H. Azuma, O. Akbari, S. G. Tullius, A. Vasudevan, A. Elkhal.
  • Journal Title: J. Allergy Clin. Immunol Volume: 1 Issue: 6 Pages: 1894-1908.e7
  • DOI: 10.1016/j.jaci.2018.01.038
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Remarkable response to fluorouracil, leucovorin, oxaliplatin, and irinotecan therapy in urothelial cancer of the renal pelvis: a case report. (2017)
  • Author(s): Takuya Tsujino,Kiyoshi Takahara, Tomohisa Matsunaga, Yuki Yoshikawa, Tomoaki Takai, Taizo Uchimoto,Kenkichi Saito, Naoki Tanda, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Teruo Inamoto ,Haruhito Azuma.
  • Journal Title: J Med Case Rep. Volume: 11(99) Issue: 1
  • DOI: 10.1186/s13256-017-1263-x
  • Peer Reviewed
• [Journal Article] Preoperative Measurement of the Modified Glasgow Prognostic Score Predicts Patient Survival in Non-Metastatic Renal Cell Carcinoma Prior to Nephrectomy. (2017)
  • Author(s): Tsujino T,Komura K, Matsunaga T, Yoshikawa Y, Takai T, Uchimoto T, Saito K, Tanda N, Oide R, Minami K, Uehara H, Jeong SH, Taniguchi K, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
  • Journal Title: Ann Surg Oncol. Volume: 24(9) Issue: 9 Pages: 2787-93
  • DOI: 10.1245/s10434-017-5948-6
  • Peer Reviewed
• [Journal Article] What has changed in kidney transplantation in small islands in Japan? Experience in our center. (2017)
  • Author(s): Hajime Hirano,Ryoichi Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi,Takuya Tsujino, Naoki Tanda, Kenkichi Saito, Taizo Uchimoto, Naokazu Ibuki, Teruo Inamoto,Yoshihiro Tokeshia, Haruhito Azuma.
  • Journal Title: Renal Replacement Therapy Volume: 3(46) Issue: 1
  • DOI: 10.1186/s41100-017-0127-6
  • Peer Reviewed
• [Journal Article] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma. (2017)
  • Author(s): Inamoto T,Matsuyama H, Sakano S, Ibuki N, Takahara K, Komura K, Takai T, Tsujino T, Yoshikawa Y, Minami K, Nagao K, Inoue R, Azuma H.
  • Journal Title: Oncotarget Volume: 8(68) Issue: 68 Pages: 113248-57
  • DOI: 10.18632/oncotarget.22641
  • Peer Reviewed
• [Journal Article] The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma. (2017)
  • Author(s): Takuya Tsujino,Kazumasa Komura, Atsushi Ichihashi, Takeshi Tsutsumi,Tomohisa Matsunaga, Yuki Yoshikawa, Ryoichi Maenosono, Kyohei Okita,Tomoaki Takai, Rintaro Oide, Koichiro Minami, Hirofumi Uehara, Kohei Taniguchi, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Kiyoshi Takahara,Teruo Inamoto, Haruhito Azuma.
  • Journal Title: Oncotarget Volume: 8 Issue: 66 Pages: 110311-25
  • DOI: 10.18632/oncotarget.22688
  • Peer Reviewed
• [Journal Article] Novel Software-Assisted Hemodynamic Evaluation of Pelvic Flow During Chemoperfusion of Pelvic Arteries for Bladder Cancer: Double- Versus Single-Balloon Technique. (2016)
  • Author(s): Yamamoto K, Yamamoto K, Nakai G, Azuma H, Narumi Y.
  • Journal Title: Cardiovasc Intervent Radiol. Volume: 39 Issue: 6 Pages: 824-30
  • DOI: 10.1007/s00270-016-1296-3
  • Peer Reviewed / Open Access
• [Journal Article] Detection of bladder cancer: comparison of low-dose scans with AIDR 3D and routine-dose scans with FBP on the excretory phase in CT urography. (2016)
  • Author(s): Juri H, Tsuboyama T, Kumano S, Inada Y, Koyama M, Azuma H, Narumi Y.
  • Journal Title: Br J Radiol. Volume: 89 Issue: 1058 Pages: 1058-1058
  • DOI: 10.1259/bjr.20150495
  • Peer Reviewed / Open Access
• [Presentation] 新規膀胱温存療法「OMC-regimen」の治療成績 (2021)
  • Author(s): 東 治人
  • Organizer: 第204回香川県泌尿器科医会
  • Invited
• [Presentation] Update on bladder preservation protocols (2020)
  • Author(s): Haruhito Azuma
  • Organizer: 23rd IUA Annual Congress
  • Int'l Joint Research
• [Presentation] DNA 複製ストレスを利用した泌尿器がん合成致死誘導治療法の確立 (2020)
  • Author(s): 小村 和正、稲元輝生、東 治人
  • Organizer: 第108回日本泌尿器科学会総会
• [Presentation] 去勢抵抗性前立腺癌(CRPC)における1次治療開始時点CRP-Albumin ratio（CAR）の治療予後予測因子としての意義. (2020)
  • Author(s): 内本泰三、小村和正、藤原裕也、齊藤賢吉、反田直希、市橋淳、上原博史、伊夫貴 直和、平野 一、能見勇人、稲元輝生、東 治人.
  • Organizer: 第108回日本泌尿器科学会総会
• [Presentation] 非転移性去勢抵抗性前立腺癌に対するアパルタミド以前の治療の成績の検討 (2020)
  • Author(s): 稲元輝生、伊夫貴 直和、小村和正、南 幸一郎、高 朋聡、上原博史、市橋 淳、谷口俊理、堤 岳之、辻野拓也、松永知久、能見勇人、東 治人.
  • Organizer: 第108回日本泌尿器科学会総会
• [Presentation] 腎癌薬物療法―I-O 時代におけるソラフェニブの役割とは? (2020)
  • Author(s): 稲元輝生、大家基嗣、赤座英之、東 治人.
  • Organizer: 第108回日本泌尿器科学会総会
• [Presentation] BU1B/BUBR1異常発現によるMutagenic NHEJとintact ATMの意義 (2020)
  • Author(s): 小村 和正、稲元輝生、東 治人
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Donor and recipient sex affect transplant outcomes in an age-specific fashion. (2020)
  • Author(s): Maenosono R、Nian Y,Iske J, Liu Y,Azuma H,Milford E,Tullius SG.
  • Organizer: TTS 2020
  • Int'l Joint Research
• [Presentation] The impact of the expression of the transcription factor MYBL2 on outcomes of patients with localized and advanced prostate cancer. (2020)
  • Author(s): Yoshikawa Y,Wang XV, Chen YH, Mazzu YZ, Chakraborty G, Jehane LE, Rajanala SH,Hirani R, Nandakumar S,Stopsack KH, Lee GSM, Davicioni E, Liu G, DiPaola RS, Carducci MA, Kantoff PW, Sweeney C.
  • Organizer: Genitourinary Cancers Symposium
  • Int'l Joint Research
• [Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例 (2020)
  • Author(s): 上原博史,平野 一,岡部知太,木村孝平,寺本昌司,高倉一平,西村一希,木下将宏,徳永雄希,中森啓太,市橋 淳,谷口俊理,小林大介,堤 岳之,小村和正,伊夫貴 直和,稲元輝生能見勇人,東 治人.
  • Organizer: 第53回日本臨床腎移植学会
• [Presentation] Cardiovascular disease (CVD)を有する進行性腎細胞癌に対するソラフェニブの成績 (2019)
  • Author(s): 稲元輝生,東 治人,大家基嗣,赤座英之.
  • Organizer: 第107回日本泌尿器科学会総会
• [Presentation] Treatment outcome of dose reduction of enzalutamide against CRPC? (2019)
  • Author(s): Ibuki N,IInamoto T,Ichihashi A,Uehara H,Komura K,Hirano H,Nomi H,Azma H.
  • Organizer: AUA 2019
  • Int'l Joint Research
• [Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例 (2019)
  • Author(s): 松永 知久,上原博史,平野 一,小林大介,堤 岳之,加納陽祐,藤原裕也,能見勇人,伊夫貴 直和,小村和正,稲元輝生,東 治人.
  • Organizer: 第35回腎移植血管外科研究会
• [Presentation] Promoting a medical system for renal transplantation in the remote island in Japan.Long time Efficacy and Safety follow-up for 10yaears. (2019)
  • Author(s): Hirano H,Tokeshi Y,Fujiwara Y, Matsunaga T,Uehara H,Nomi H,Komura K,Ibuki N, Inamoto T,Azuma H.
  • Organizer: CAST2019
  • Int'l Joint Research
• [Presentation] Post transplant diabetes mellitus (PTDM) in our institution. (2019)
  • Author(s): Hirano H,Fujiwara Y, Matsunaga T,Uehara H,Nomi H,Komura K,Ibuki N, Inamoto T,Azuma H.
  • Organizer: CAST2019
  • Int'l Joint Research
• [Presentation] Management of alpha-herpesvirus infection following kidney transplantation: Our experience (7 cases) (2019)
  • Author(s): Uehara H, Hirano H, Matsunaga T, Minami K,Kazumasa K, Ibuki N,Inamoto T,Nomi H,Azuma H.
  • Organizer: CAST2019
  • Int'l Joint Research
• [Presentation] Successful Treatment of Antibody-Mediated Rejection (AMR) by de novo Donor specific antibody (DSA) after primary renal transplantation in a recipient from a cadaveric donor: A Case Report (2019)
  • Author(s): Matsunaga T, Hirano H, Tsutsumi T,Tsujino T, Yoshikawa Y, Takai T,Minami K,Uehara H, Komura K,Nomi H, Ibuki N,Inamoto T,Azuma H.
  • Organizer: CAST2019
  • Int'l Joint Research
• [Presentation] 免疫療法時代における進行性腎細胞癌に対するソラフェニブの立ち位置の再考 (2019)
  • Author(s): 稲元輝生,東 治人.
  • Organizer: 第57回日本癌治療学会学術集会
• [Presentation] CRPC1次療法でのAbiraterone, Enzalutamideの傾向スコアマッチングによる治療効果比較. (2019)
  • Author(s): 小村和正,稲元輝生， 藤原裕也， 伊夫貴 直和， 内本泰三， 齋藤賢吉， 反田直希， 辻野拓也， 上原博史， 平野 一， 能見勇人， 東 治人.
  • Organizer: 第57回日本癌治療学会学術集会
• [Presentation] Nivolumab have been approved for treatment for patients with metastatic renal cell carcinoma. We retrospectively evaluated patients with mRCC who were treated with Nivolumab our institution. (2019)
  • Author(s): Kano Y,Ibuki N,Fujiwara Y,Tsutsumi T,Kojima A,Uehara H,Komura M,Inamoto T,Azuma H.
  • Organizer: 第57回日本癌治療学会学術集会
• [Presentation] CRP/Albumin ratioの腎細胞がんにおける予後規定因子としての有用性 (2019)
  • Author(s): 小村和正,辻野拓也、金原裕則、鈴木俊明、瀬川直樹、和田誠次、丸山栄勲、橋本 剛、稲元輝生、濱田修史、大野芳正、東 治人.
  • Organizer: 第69回日本泌尿器科学会中部総会
• [Presentation] ロボット支援腹腔鏡下腎部分切除術（RAPN）におけるTrifectaが術後成績に与える影響. (2019)
  • Author(s): 内本泰三,伊夫貴 直和、木下将宏、徳永雄希、中森啓太、土井 由紀子、小林大介、小村和正、上原博史、稲元輝生、東 治人.
  • Organizer: 第33回日本泌尿器内視鏡学会総会
• [Presentation] TURBTと化学放射線療法・動注化学療法を用いた 高齢MIBC患者治療 (2019)
  • Author(s): 稲元 輝生,伊夫貴 直和， 小林大介，堤 岳之，小村和正，上原博史、平野 一、 能見勇人， 東 治人， 山本和宏， 鳴海善文.
  • Organizer: 第33回日本泌尿器内視鏡学会総会
• [Presentation] 高齢筋層浸潤性膀胱癌患者に対するTURBTと化学放射線療法・動注化学療法を用いた根治的治療の成績. (2019)
  • Author(s): 稲元輝生,伊夫貴 直和， 小林大介，堤 岳之，小村和正，上原博史、平野 一， 能見勇人， 東 治人， 山本和宏， 鳴海善文.
  • Organizer: 第32回日本内視鏡外科学会総会
• [Presentation] 新規膀胱温存療法 OMC-Regimenの治療成績 (2019)
  • Author(s): 東 治人
  • Organizer: 第２回 京葉泌尿器癌研究会
  • Invited
• [Presentation] Aberrant Error-Prone DNA Damage Repair as a Potential Therapeutic Target in Advanced Urothelial Carcinoma. (2019)
  • Author(s): Komura K , Inamoto T, Uehara H, Ibuki , Minami K, Tsujino T, Azuma H.
  • Organizer: EAU2019
• [Presentation] バルーン塞栓動脈内抗癌剤投与法（BOAI）によるシスプラチン投与と血液透析とを併用する集学的治療 (2018)
  • Author(s): 東 治人
  • Organizer: 第18回日本Men's Health 医学会
  • Invited
• [Presentation] 局所注入によるがん治療と抗がん薬曝露対策 (2018)
  • Author(s): 東 治人
  • Organizer: 第56回日本癌治療学会学術集会
  • Invited
• [Presentation] NIBCに対する膀胱温存療法25年の経過報告 (2018)
  • Author(s): 東 治人
  • Organizer: 高知尿路悪性腫瘍研究会2018
  • Invited
• [Presentation] Risk stratification by means of treatment phase related factors predicts resistance-free survival in patients with CRPC treated by ARTs. (2018)
  • Author(s): Inamnoto T,Ibuki N, Komura K,Minami K,Takai T,Uchimoto T, Saito K ,Tanda N ,Tsujino T , Matsunaga T,Yoshikawa Y , Hirano H, Nomi H,Azuma H.
  • Organizer: 16th UAA Congress2018
  • Int'l Joint Research
• [Presentation] DNA replication stress by the loss of male specific histone demethylase ‘KDM5D’ in aggressive prostate cancer (2018)
  • Author(s): Kazumasa Komura , Teruo Inamoto , Naokazu Ibuki , Christopher J. Sweeney , Haruhito Azuma , Philip W. Kantoff.
  • Organizer: AUA 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Expanding the donor pool : Experience of living kidney transplantation from very old aged donor in our center. (2018)
  • Author(s): HiranoH,Maenosono R, Matsunaga T, Uehara H,Nomi H,Kano Y,Fujiwara Y, Taniguchi S,Tsutsumi T,Ichihashi A, Kobayashi D,Ohkita K, Hayashi K,Komura K,Ibuki N,Inamoto T, Azuma H.
  • Organizer: TTS 2018
  • Int'l Joint Research
• [Presentation] Synthetic Lethal Approach Exploiting DNA Replication Stress in Aggressive Prostate Cancer Deficient in JARID1D. (2018)
  • Author(s): Kazumasa Komura , Teruo Inamoto ,Naokazu Ibuki, Christopher J. Sweeney , Philip W. Kantoff , Haruhito Azuma .
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] Evaluation of the safety and short term effects of Pembrolizumab in patients with chemotherapy resistant metastatic urothelial carcinoma. (2018)
  • Author(s): Ibuki N,Inamoto T,Ohkita K, Hayashi K, Kojima A,Komura K, Uehara H, Hirano H, Noumi H,Azuma H.
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] Importance of periodic examinations after transplants ; a case of pulmonary cryptococcosis after kidney transplantation. (2018)
  • Author(s): Hirano H, Fujiwara Y, Minami K,Kano Y, Taniguchi S, Uehara H,Ibuki N, Nomi H, Inamoto T, Azuma H.
  • Organizer: ATW 2018
  • Int'l Joint Research
• [Presentation] 膀胱癌におけるKLF4とPTBP1を介したmicroRNA-145とワーバーグ効果の関係性 (2018)
  • Author(s): 南 幸一郎,小村 和正,伊夫貴 直和,稲元 輝生,能見 勇人,東 治人.
  • Organizer: 16th UAA Congress2018
• [Presentation] Evaluation of hemoglobin dynamics in relation to efficacy of second-generation anti-androgens in patients with castrate-resistant prostate cancer (2018)
  • Author(s): 稲元 輝生、伊夫貴直和、小村 和正、小林大介、市橋淳、谷口俊理、堤岳之、松永 知久、能見 勇人、東 治人.
  • Organizer: 第106回日本泌尿器科学会総会
• [Presentation] Moderated Poster 2（Management of ureteral obstruction） (2018)
  • Author(s): 稲元 輝生、東 治人.
  • Organizer: 第106回日本泌尿器科学会総会
• [Presentation] Bladder preservation therapy for localized muscle-invasive bladder cancer (2018)
  • Author(s): 稲元 輝生 ,東 治人.
  • Organizer: 日本泌尿器腫瘍学会 第4回学術集会
• [Presentation] combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) for prediction of treatment outcome for patients with localized renal cell carcinoma. (2018)
  • Author(s): Kazumasa Komura,Takuya Tsujino,Naokazu Ibuki,Teruo Inamoto,Haruhito Azuma.
  • Organizer: 2018 Genitourinary Cancers Symposium
  • Int'l Joint Research
• [Presentation] Evaluation of the safety and short term pathological effects of tri-modal therapy in patients with bladder cancer: a multicenter prospective trial. (2018)
  • Author(s): Naokazu Ibuki,Teruo Inamoto, Kazumasa Komura, Kiyoshi Takahara, Hajime Hirano, Hayahito Noumi, Haruhito Azuma.
  • Organizer: EAU 2018
  • Int'l Joint Research
• [Presentation] Aggressive prostate cancer by the loss of male specific histone demethylase ‘KDM5D’. (2018)
  • Author(s): Komura K,Inamoto T, Ibuki N, Sweeney C, Azuma H, Kantoff P.
  • Organizer: EAU 2018
  • Int'l Joint Research
• [Presentation] Decreased Expression of Male Specific Histone Demethylase “KDM5D” is Prognostic for Development of Castration-Resistant Prostate Cancer. (2017)
  • Author(s): Kazumasa Komura,Seong Ho Jeong, Kunihiko Hinohara, Gwo-Shu Mary Lee, Christopher J. Sweeney, Haruhito Azuma, and Philip W. Kantoff.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] CD4+IFN-γ+IL-10+ cells facilitate a prolongation of graft survival in old recipient mice treated with Rapamycin. (2017)
  • Author(s): Koichiro Minami,Timm Heinbokel, Markus Quante, Hirofumi Uehara, Abdala Elkhal, Haruhito Azuma, Stefan G. Tullius.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] MiR-145 modulates Warburg effect by targeting KLF4/PTB1/PKMs axis in bladder cancer cells. (2017)
  • Author(s): Koichiro Minami,Kohei Taniguchi, Teruo Inamoto, Kiyoshi Takahara, Kazumasa Komura, Tomoaki Takai, Yuki Yoshikawa, Yukihiro Akao, Haruhito Azuma .
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Risk stratification by means of the biological age related factors better predicts cancer-specific survival than the chronological age in patients with upper tract urothelial carcinoma (UTUC): a multi-institutional database study . (2017)
  • Author(s): Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Multimodal bladder preservation technique for muscle invasive bladder cancer: results from a prospective trial. (2017)
  • Author(s): Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Gender-specific differences in cancer-specific survival after nephroureterectomy with bladder cuff for patients with upper tract urothelial carcinoma. (2017)
  • Author(s): Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano), Kazuhiro Nagao , Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] A panel of micro-RNA signature as a tool for predicting survival of patients with urothelial carcinoma of the bladder. (2017)
  • Author(s): Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] PSA nadir and PSA flare are the predictors of biochemical failure after High-Intensity Focused Ultrasound treatment of localized prostate cancer. (2017)
  • Author(s): Naokazu Ibuk,Teruo Inamoto, Yudai Nishimoto, Kiyoshi Takahara, Toshikazu Watsuji, Haruhito Azuma.
  • Organizer: AUA 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Study on safety of elderly living kidney donors - Two cases of the donors older than 80 in our hospital. (2017)
  • Author(s): Hajime Hirano,Ryoici Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi, Atushi Ichihashi, Daisuke Kobayashi, Shyunri Taniguchi, Takeshi Tsutsumi, Takuya Tsujino, Kazumasa Komura, Naokazu Ibuki, Teruo Inamoto, Haruhito Azuma.
  • Organizer: CAST2017
  • Int'l Joint Research
• [Presentation] OMC-regimen for the purpose of multimodality-bladder preservation therapy for patients with MIBC: a multicenter prospective trial . (2017)
  • Author(s): 稲元 輝生,伊夫貴直和、高原 健、辻野拓也、松永 知久、吉川 勇希、齋藤 賢吉、内本 泰三、反田 直希、平野 一、能見 勇人、山本 和宏、鳴海 善文、東 治人.
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] 血液透析併用動注化学療法(BOAI)を用いたOMC-regimen. (2017)
  • Author(s): 稲元 輝生,東 治人
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] 腎移植、免疫寛容の誘導に向けて (2017)
  • Author(s): 東 治人
  • Organizer: 第38回日本循環制御医学会総会・学術集会
  • Invited
• [Presentation] 前立腺癌に対する新規治療戦略 -体性間葉系幹細胞を用いたテーラーメイド硼素中性子捕捉療法（BNCT）の確立 (2017)
  • Author(s): 高原 健、東 治人.
  • Organizer: 第17回東名泌尿器科研究会
  • Place of Presentation: 名古屋〈名古屋）
• [Presentation] 前立腺癌に対する硼素中性子捕捉療法（BNCT）の制癌効果 -脂肪幹細胞ナノDDS技術を駆使した新規テーラーメイド療法を目指して- (2016)
  • Author(s): 高原 健,稲元輝生、南幸一郎、吉川勇希、高井朋聡、平野 一、能見勇人、木山 賢、鈴木 実、切畑 光統、東 治人.
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台国際センター(福岡）