The novel bladder preservation therapy by selective destruction of cancercells "Boron Neutron Capture Therapy at bladder"
Project/Area Number |
16K11033
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Osaka Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
稲元 輝生 大阪医科大学, 医学部, 准教授 (20330087)
宮武 伸一 大阪医科大学, 医学部, 特別職務担当教員(教授) (90209916)
鈴木 実 京都大学, 複合原子力科学研究所, 教授 (00319724)
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Project Period (FY) |
2016-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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Keywords | 膀胱温存 / 浸潤癌 / BOAI / BNCT |
Outline of Final Research Achievements |
We have developed a BOAI-BNCT method that selectively destroys cancer cells at the bladder and pelvic lymphatic tissue. The "BOAI method selectively administers extremely high concentrations of the boron compound to the bladder and pelvic lymphatic tissue using a catheter with a balloon for blood flow embolization. "bladder cancer cell-affinitive boron compound" selectively accumulate and migrate into the nucleus of the bladder cancer cell, then neutron selectively destroys cancer cells.
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Academic Significance and Societal Importance of the Research Achievements |
BOAI-BNCT療法は、硼素化合物自体には抗癌剤のような毒性がなく、また中性子線においても、硼素化合物を取り込んでいる細胞を選択的に破壊するが、中性子線自体が単独で照射されてもそれ自体による障害を殆どきたさないため、高齢者やPSが低下した症例でも施行可能であり、極めて画期的な治療法である。このことは、膀胱全摘を適応とする患者に対する膀胱温存治療というのみならず、これまで、年齢、PS、あるいは、心疾患などの合併症の理由で、手術や放射線治療などの根治を考慮に入れた治療が不可能であった症例に対しても根治を考慮に入れた治療ができるという点で臨床的に極めて有用で優れた治療法であると思われる。
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Report
(6 results)
Research Products
(83 results)
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[Journal Article] Early Prostate-Specific Antigen (PSA) Change at Four Weeks of the First-Line Treatment Using Abiraterone and Enzalutamide Could Predict Early/Primary Resistance in Metastatic Castration-Resistant Prostate Cancer.2021
Author(s)
Uchimoto T,Komura K, Fukuokaya W, Kimura T, Takahashi K, Nishimura K, Nakamori K, Fujiwara Y, Matsunaga T, Tsutsumi T, Tsujino T, Maenosono R, Yoshikawa Y, Taniguchi K, Tanaka T, Uehara H, Ibuki N, Hirano H, Nomi H, Takahara K, Inamoto T, Egawa S, Azuma H.
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Journal Title
Cancers
Volume: 13
Issue: 3
Pages: 2-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants.2020
Author(s)
Minami K, Bae S, Uehara H, Zhao C, Lee D, Iske J, Fanger MW, Reder J, Morrison I, Azuma H, Wiens A, Van Keuren E, Houser B, ElKhal A, Kang PM, Tullius SG.
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Journal Title
Am J Transplant.
Volume: -
Issue: 6
Pages: 1527-37
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.2020
Author(s)
Iske J,Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG.
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Journal Title
Nat Commun.
Volume: 27
Issue: 1
Pages: 4289-4289
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Risk Stratification for the Prediction of Overall Survival Could Assists Treatment Decision Making at the Diagnosis of Castration-Resistant Prostate Cancer - a Multicenter Collaborative Study in Japan.2020
Author(s)
Uchimoto T,Komura K, Fukuokaya W, Kimura T, Takahashi K, Fujiwara Y,Matsunaga T, Tsutsumi T, Tsujino T, Taniguchi K, Tanaka T, Uehara H, Ibuki N, Hirano H, Nomi H, Takahara K, Inamoto T, Egawa S, Azuma H.
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Journal Title
BJU Int
Volume: 127
Issue: 2
Pages: 212-21
DOI
Related Report
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[Journal Article] A Single-Centre Study of Post-Transplant Diabetes Mellitus (PTDM) in Japa.2020
Author(s)
Hirano H,Kanatsuna N,Fujiwara Y,Matsunaga T,Taniguchi S,Uehara H, Nomi H, Ichihashi A, Kobayashi D, Tsutsumi T, Komura K, Ibuki N, Inamoto T,Azuma H.
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Journal Title
Transplantation Case Reports
Volume: 1(1)
Pages: 2-3
Related Report
Peer Reviewed / Open Access
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[Journal Article] Importance of periodic examinations after transplants; a case of pulmonary cryptococcosis after kidney transplantation.2019
Author(s)
Hirano H,Maenosono R, Matsunaga T, Uehara H, Nomi H, Ichihashi A,Kobayashi D,Taniguchi S,Tsutsumi T,Tsujino T,Komura K, Ibuki N,Inamoto T,Azuma H, Fujiwara Y, Kano Y, Minami K, Kojima A, Kinoshita S, Tokunaga Y, Doi Y, Nakamori K.
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Journal Title
Transplantation Reports.
Volume: -
Issue: 2
Pages: 100021-100021
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort.2019
Author(s)
Komura K,Fujiwara Y,UchimotoT,Saito K,Tanda N,Matsunaga T, Ichihashi A,Tsutsumi T, Tsujino T,Yoshikawa Y,Nishimoto Y,Takai T,Minami K,Taniguchi K,Tanaka T, Uehara H,Hirano H,Nomi H,Ibuki N, Takahara K,Inamoto T,Azuma H.
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Journal Title
J. Clin. Med.
Volume: 8(8)
Issue: 8
Pages: 1251-1251
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer.2019
Author(s)
Tsujino T,Sugito N, Taniguchi K, Honda R, Komura K, Yoshikawa Y, Takai T, Minami K, Kuranaga Y, Shinohara H, Tokumaru Y, Heishima K, Inamoto T, Azuma H, Akao Y.
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Journal Title
Cancer Sci.
Volume: 110(7)
Issue: 7
Pages: 2189-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan.2019
Author(s)
Komura K,Hashimoto T, Tsujino T, Muraoka R, Tsutsumi T, Satake N, Matsunaga T, Yoshikawa Y, Takai T, Minami K, Taniguchi K, Uehara H, Tanaka T, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Ohno Y, Azuma H.
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Journal Title
Ann Surg Oncol.
Volume: 26(9)
Issue: 9
Pages: 2994-3004
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer.2019
Author(s)
Uchimoto T,Komura K, Fujiwara Y, Saito K, Tanda N, Matsunaga T, Ichihashi A, Tsutsumi T, Tsujino T, Yoshikawa Y, Nishimoto Y, Takai T, Minami K, Taniguchi K, Tanaka T, Uehara H, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
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Journal Title
Medical Oncology
Volume: 37(1)
Issue: 1
Pages: 9-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.2019
Author(s)
Takai T、 Tsujino T, Yoshikawa Y, Inamoto T, Sugito N, Kuranaga Y, Heishima K, Soga T, Hayashi K, Miyata K, Kataoka K, Azuma H, Akao Y.
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Journal Title
Mol Ther.
Volume: S1525-0016(19)
Issue: 5
Pages: 30090-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] hibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D.2018
Author(s)
Komura K、Yoshikawa Y, Shimamura T, Chakraborty G, Gerke TA, Hinohara K, Chadalavada K, Jeong SH, Armenia J, Du SY, Mazzu YZ, Taniguchi K, Ibuki N, Meyer CA, Nanjangud GJ, Inamoto T, Lee GM, Mucci LA, Azuma H, Sweeney CJ, Kantoff PW.
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Journal Title
Journal of Clinical Investigation
Volume: 128(7)
Issue: 7
Pages: 2979-95
DOI
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[Journal Article] Effect of Systematic Conversion to Generic Mycophenolate Mofetil2018
Author(s)
Hirano H、Matsunaga T, Maenosonoa R,Taniguchia S,Ueharaa H,Nomia H,Kanoa Y,Fujiwara Y, Ichihashi A, Kobayashia D,Tsutsumia T,Komura K,Ibukia N,Inamoto T,Matsumura H,Ashida H,Azuma H.
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Journal Title
Transplant Proc.
Volume: 50(10)
Issue: 10
Pages: 3255-7
DOI
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[Journal Article] Mast cells regulate CD4+ T cell differentiation in absence of antigen presentation.2018
Author(s)
H. Uehara,H. Rodriguez Cetina Biefer, T. Heinbokel, V. Camacho, K. Minami, Y. Nian, S. Koduru, R. El Fatimy, I. Ghiran, A. J. Trachtenberg, M. A. de la Fuente, H. Azuma, O. Akbari, S. G. Tullius, A. Vasudevan, A. Elkhal.
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Journal Title
J. Allergy Clin. Immunol
Volume: 1
Issue: 6
Pages: 1894-1908.e7
DOI
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[Journal Article] Remarkable response to fluorouracil, leucovorin, oxaliplatin, and irinotecan therapy in urothelial cancer of the renal pelvis: a case report.2017
Author(s)
Takuya Tsujino,Kiyoshi Takahara, Tomohisa Matsunaga, Yuki Yoshikawa, Tomoaki Takai, Taizo Uchimoto,Kenkichi Saito, Naoki Tanda, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Teruo Inamoto ,Haruhito Azuma.
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Journal Title
J Med Case Rep.
Volume: 11(99)
Issue: 1
DOI
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[Journal Article] Preoperative Measurement of the Modified Glasgow Prognostic Score Predicts Patient Survival in Non-Metastatic Renal Cell Carcinoma Prior to Nephrectomy.2017
Author(s)
Tsujino T,Komura K, Matsunaga T, Yoshikawa Y, Takai T, Uchimoto T, Saito K, Tanda N, Oide R, Minami K, Uehara H, Jeong SH, Taniguchi K, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
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Journal Title
Ann Surg Oncol.
Volume: 24(9)
Issue: 9
Pages: 2787-93
DOI
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[Journal Article] What has changed in kidney transplantation in small islands in Japan? Experience in our center.2017
Author(s)
Hajime Hirano,Ryoichi Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi,Takuya Tsujino, Naoki Tanda, Kenkichi Saito, Taizo Uchimoto, Naokazu Ibuki, Teruo Inamoto,Yoshihiro Tokeshia, Haruhito Azuma.
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Journal Title
Renal Replacement Therapy
Volume: 3(46)
Issue: 1
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[Journal Article] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma.2017
Author(s)
Inamoto T,Matsuyama H, Sakano S, Ibuki N, Takahara K, Komura K, Takai T, Tsujino T, Yoshikawa Y, Minami K, Nagao K, Inoue R, Azuma H.
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Journal Title
Oncotarget
Volume: 8(68)
Issue: 68
Pages: 113248-57
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[Journal Article] The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma.2017
Author(s)
Takuya Tsujino,Kazumasa Komura, Atsushi Ichihashi, Takeshi Tsutsumi,Tomohisa Matsunaga, Yuki Yoshikawa, Ryoichi Maenosono, Kyohei Okita,Tomoaki Takai, Rintaro Oide, Koichiro Minami, Hirofumi Uehara, Kohei Taniguchi, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Kiyoshi Takahara,Teruo Inamoto, Haruhito Azuma.
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Journal Title
Oncotarget
Volume: 8
Issue: 66
Pages: 110311-25
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[Presentation] The impact of the expression of the transcription factor MYBL2 on outcomes of patients with localized and advanced prostate cancer.2020
Author(s)
Yoshikawa Y,Wang XV, Chen YH, Mazzu YZ, Chakraborty G, Jehane LE, Rajanala SH,Hirani R, Nandakumar S,Stopsack KH, Lee GSM, Davicioni E, Liu G, DiPaola RS, Carducci MA, Kantoff PW, Sweeney C.
Organizer
Genitourinary Cancers Symposium
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[Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例2020
Author(s)
上原博史,平野 一,岡部知太,木村孝平,寺本昌司,高倉一平,西村一希,木下将宏,徳永雄希,中森啓太,市橋 淳,谷口俊理,小林大介,堤 岳之,小村和正,伊夫貴 直和,稲元輝生能見勇人,東 治人.
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第53回日本臨床腎移植学会
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[Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例2019
Author(s)
松永 知久,上原博史,平野 一,小林大介,堤 岳之,加納陽祐,藤原裕也,能見勇人,伊夫貴 直和,小村和正,稲元輝生,東 治人.
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第35回腎移植血管外科研究会
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[Presentation] Successful Treatment of Antibody-Mediated Rejection (AMR) by de novo Donor specific antibody (DSA) after primary renal transplantation in a recipient from a cadaveric donor: A Case Report2019
Author(s)
Matsunaga T, Hirano H, Tsutsumi T,Tsujino T, Yoshikawa Y, Takai T,Minami K,Uehara H, Komura K,Nomi H, Ibuki N,Inamoto T,Azuma H.
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CAST2019
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[Presentation] Risk stratification by means of treatment phase related factors predicts resistance-free survival in patients with CRPC treated by ARTs.2018
Author(s)
Inamnoto T,Ibuki N, Komura K,Minami K,Takai T,Uchimoto T, Saito K ,Tanda N ,Tsujino T , Matsunaga T,Yoshikawa Y , Hirano H, Nomi H,Azuma H.
Organizer
16th UAA Congress2018
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[Presentation] Expanding the donor pool : Experience of living kidney transplantation from very old aged donor in our center.2018
Author(s)
HiranoH,Maenosono R, Matsunaga T, Uehara H,Nomi H,Kano Y,Fujiwara Y, Taniguchi S,Tsutsumi T,Ichihashi A, Kobayashi D,Ohkita K, Hayashi K,Komura K,Ibuki N,Inamoto T, Azuma H.
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TTS 2018
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[Presentation] Risk stratification by means of the biological age related factors better predicts cancer-specific survival than the chronological age in patients with upper tract urothelial carcinoma (UTUC): a multi-institutional database study .2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
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AUA 2017 Annual Meeting
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[Presentation] Multimodal bladder preservation technique for muscle invasive bladder cancer: results from a prospective trial.2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
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AUA 2017 Annual Meeting
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[Presentation] Gender-specific differences in cancer-specific survival after nephroureterectomy with bladder cuff for patients with upper tract urothelial carcinoma.2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano), Kazuhiro Nagao , Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
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AUA 2017 Annual Meeting
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[Presentation] A panel of micro-RNA signature as a tool for predicting survival of patients with urothelial carcinoma of the bladder.2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
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AUA 2017 Annual Meeting
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[Presentation] Study on safety of elderly living kidney donors - Two cases of the donors older than 80 in our hospital.2017
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Hajime Hirano,Ryoici Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi, Atushi Ichihashi, Daisuke Kobayashi, Shyunri Taniguchi, Takeshi Tsutsumi, Takuya Tsujino, Kazumasa Komura, Naokazu Ibuki, Teruo Inamoto, Haruhito Azuma.
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CAST2017
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