Therapy for bladder cancer by means of a novel delivery carrier for miR-145
Project/Area Number |
16K11034
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Osaka Medical College |
Principal Investigator |
Inamoto Teruo 大阪医科大学, 医学部, 准教授 (20330087)
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Co-Investigator(Kenkyū-buntansha) |
東 治人 大阪医科大学, 医学部, 教授 (40231914)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 腫瘍学 / 膀胱癌 |
Outline of Final Research Achievements |
Of nine miRNAs, six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p). Patients with the high-risk miRNA signature exhibited poorer OS than patients expressing the low-risk miRNA profile (HR = 7.05, p < 0.001).
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Academic Significance and Societal Importance of the Research Achievements |
マイクロRNA (miRNA; miR)を利用した承認済みの臨床の場での癌治療薬は未だに存在していないが海外を中心として開発が進められている。miR薬剤の実現にはその導入に必要なキャリアーの存在が必須となる。本研究が目指した新規キャリアーの実現はその面で必要不可欠な部分を占める。膀胱癌は診断時点で他臓器転移している進展型として発見されるケースがあり、さらに、既存の抗がん剤が効かなくなる薬剤耐性も問題であり、早期診断法及び効果的な治療薬が期待されている。miRは組織特異性が高い一方でヒト癌組織における発現は正常組織の発現様式と大きく異なるため癌種に特異的でマーカーとして有用である。
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer2019
Author(s)
Uchimoto T, Komura K, Fujiwara Y, Saito K, Tanda N, Matsunaga T, Ichihashi A, Tsutsumi T, Tsujino T, Yoshikawa Y, Nishimoto Y, Takai T, Minami K, Taniguchi K, Tanaka T, Uehara H, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Azuma H.
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Journal Title
Med Oncol.
Volume: 21
Pages: 1332-7
Related Report
Peer Reviewed
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[Journal Article] Influence of the Body Mass Index and its Effect on Tumor Characteristics and Survival among a Population with Access to Surgical Management of Upper Tract Urothelial Carcinoma2019
Author(s)
Inamoto T, Sassa N, Hattori R, Ibuki N, Komura K, Minami K, Takai T, Uchimoto T, Saito K, Tanda N, Tsujino T, Sano T, Kato M, Tsuzuki T, Gotoh M, Azuma H.
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Journal Title
Curr Urol.
Volume: 12
Pages: 201-9
Related Report
Peer Reviewed / Open Access
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[Journal Article] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma.2017
Author(s)
Inamoto T,Matsuyama H, Sakano S, Ibuki N, Takahara K, Komura K, Takai T, Tsujino T, Yoshikawa Y, Minami K, Nagao K, Inoue R, Azuma H.
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Journal Title
Oncotarget
Volume: 8(68)
Issue: 68
Pages: 113248-57
DOI
Related Report
Peer Reviewed
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[Presentation] Risk stratification by means of treatment phase related factors predicts resistance-free survival in patients with CRPC treated by ARTs.2018
Author(s)
Teruo Inamoto,Naokazu Ibuki, Kazumasa Komura, Koichiro Minami, Tomoaki Takai, Taizo Uchimoto , Kenkichi Saito , Naoki Tanda , Takuya Tsujino , Tomohisa Matsunaga, Yuki Yoshikawa , Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
Organizer
16th UAA Congress2018
Related Report
Int'l Joint Research
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[Presentation] Risk stratification by means of the biological age related factors better predicts cancer-specific survival than the chronological age in patients with upper tract urothelial carcinoma (UTUC): a multi-institutional database study .2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
Organizer
AUA2017 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Multimodal bladder preservation technique for muscle invasive bladder cancer: results from a prospective trial.2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
Organizer
AUA2017 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Gender-specific differences in cancer-specific survival after nephroureterectomy with bladder cuff for patients with upper tract urothelial carcinoma.2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano), Kazuhiro Nagao , Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma, and Nishinihon Uro-Oncology Collaborative Group.
Organizer
AUA2017 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] A panel of micro-RNA signature as a tool for predicting survival of patients with urothelial carcinoma of the bladder.2017
Author(s)
Teruo Inamoto,Kiyoshi Takahara, Naokazu Ibuki, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Haruhito Azuma.
Organizer
AUA2017 Annual Meeting
Related Report
Int'l Joint Research
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