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Omics analysis of macrophage-related molecules for urolithiasis dissolution therapy

Research Project

Project/Area Number 16K11054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

Taguchi Kazumi  名古屋市立大学, 大学院医学研究科, 研究員 (00595184)

Co-Investigator(Kenkyū-buntansha) 郡 健二郎  名古屋市立大学, その他部局等, 学長 (30122047)
安井 孝周  名古屋市立大学, 大学院医学研究科, 教授 (40326153)
戸澤 啓一  名古屋市立大学, 大学院医学研究科, 教授 (40264733)
岡田 淳志  名古屋市立大学, 大学院医学研究科, 准教授 (70444966)
濱本 周造  名古屋市立大学, 大学院医学研究科, 講師 (80551267)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords尿路結石症 / マクロファージ / 結晶貪食 / 溶解治療 / M1 / M2 / 結石モデルマウス / flow cytometry / マルチプレックス解析 / 遺伝子発現解析 / マイクロアレイ / 尿路結石 / 腎乳頭部 / 腎乳頭石灰化 / オミックス解析
Outline of Final Research Achievements

We previously reported that the relationship between renal stone formation and macrophage. In this study, we focused on the phenotype of macrophage, in particular, M2-type anti-inflammatory macrophages and performed functional analyses for stone formation.
The M2-type macrophage was less expressed in renal papilla plaque, a precursor of stone, as well as urine sample in kidney stone patients compared with controls. More importantly, the treatment of M2-type macrophage in a stone model mouse demonstrated the suppression effect for stone development. These results indicate that potential therapeutic use of M2-type macrophage for kidney stone disease.

Academic Significance and Societal Importance of the Research Achievements

本研究は、これまで有効な薬物治療がなかった尿路結石症に対して、M2型マクロファージによる結晶貪食作用を利用し、結石溶解治療への可能性を示したものである。この研究成果は、再発予防に有用なだけでなく、将来的に現在主流となっている外科的治療に取って代わるものとなりうる可能性を秘めている。尿路結石症の生涯罹患率が今や10%に達成している現状を鑑みると、治療法の躍進につながる発見と考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Book (1 results)

  • [Int'l Joint Research] University of California San Francisco(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of California San Francisco(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of California San Francisco(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Helper T-cell signaling and inflammatory pathway lead to formation of calcium phosphate but not calcium oxalate stones on Randall's plaques.2019

    • Author(s)
      Taguchi K, Hamamoto S, Okada A, Sugino T, Unno R, Ando R, Gao B, Tozawa K, Kohri K, Yasui T
    • Journal Title

      Int J Urol

      Volume: - Issue: 6 Pages: 670-677

    • DOI

      10.1111/iju.13950

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of new urinary risk markers for urinary stones using a logistic model and multinomial logit model2019

    • Author(s)
      Okada Atsushi、Ando Ryosuke、Taguchi Kazumi、Hamamoto Shuzo、Unno Rei、Sugino Teruaki、Tanaka Yutaro、Mizuno Kentaro、Tozawa Keiichi、Kohri Kenjiro、Yasui Takahiro
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 23 Issue: 5 Pages: 710-716

    • DOI

      10.1007/s10157-019-01693-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing RNA Extraction of Renal Papilla Biopsy Tissue in Kidney Stone Formers: A New Methodology for Genomic Study.2017

    • Author(s)
      Taguchi K, Usawachintachit M, Hamamoto S, Unno R, Tzou DT, Sherer BA, Wang Y, Okada A, Stoller ML, Yasui T, Chi T.
    • Journal Title

      J Endourol

      Volume: 31 Issue: 9 Pages: 922-929

    • DOI

      10.1089/end.2017.0320

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.2017

    • Author(s)
      Taguchi Kazumi, Yasui Takahiro, Milliner Schmautz Dawn, Hoppe Bernd, Chi Thomas
    • Journal Title

      EUROPEAN UROLOGY FOCUS

      Volume: 3 Issue: 1 Pages: 71-81

    • DOI

      10.1016/j.euf.2017.04.010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Animal models of urinary stone disease.Animal models of urinary stone disease.2017

    • Author(s)
      Tzou DT, Taguchi K, Chi T, Stoller ML.
    • Journal Title

      Int J Surg

      Volume: 35 Pages: 596-606

    • DOI

      10.1016/j.ijsu.2016.11.018

    • Related Report
      2017 Research-status Report
  • [Journal Article] Genome-wide gene expression profiling of Randall's plaques in calcium oxalate stone formers2017

    • Author(s)
      Taguchi K, Hamamoto S, Okada A, Unno R, Kamisawa H, Naiki T, Ando R, Mizuno K, Kawai N, Tozawa K, Kohri K, Yasui T
    • Journal Title

      J Am Soc Nephrol

      Volume: 28 Issue: 1 Pages: 333-347

    • DOI

      10.1681/asn.2015111271

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development2017

    • Author(s)
      70.Taguchi Kazumi, Okada Atsushi, Hamamoto Shuzo, Unno Rei, Moritoki Yoshinobu, Ando Ryosuke, Mizuno Kentaro, Tozawa Keiichi, Kohri Kenjiro, Yasui Takaihro
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 35167-35167

    • DOI

      10.1038/srep35167

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 腎乳頭部Randall's Plaqueの遺伝子発現解析からみる分子標的治療の可能性2018

    • Author(s)
      田口 和己、濵本 周造、岡田 淳志、安井 孝周
    • Organizer
      第83回日本泌尿器科学会東部総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pro-inflammatory and immune-active responses predominantly leading to Randall’s plaque formation on calcium phosphate stone2018

    • Author(s)
      Taguchi Kazumi, Hamamoto Shuzo, Unno Rei, Tanaka Yutaro, Sugino Teruaki, Ando Ryosuke, Okada Atsushi, Kohri Kenjiro, Yasui Takahiro
    • Organizer
      American Urological Association Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of fatty acid binding protein 4 as an essential molecule for the development of kidney stones: A new understanding of the relationship between obesity and nephrolithiasis.2018

    • Author(s)
      Taguchi Kazumi, Chen L, Usawachintachit Manint, Hamamoto Shuzo, Kang M, Unno Rei, Tzou David, Sherer Benjamin, Yasui Takahiro, Ho S, Stoller Marshall, Chi Thomas
    • Organizer
      4th Anuual EAU Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevention of recurrent urolithiasis up to date.2018

    • Author(s)
      Taguchi Kazumi
    • Organizer
      The 33rd Annual EAU Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimizing RNA extraction of renal papilla biopsy tissue in kidney stone formers: a new methodology for genomic study.2017

    • Author(s)
      Taguchi Kazumi, Usawachintachit Manint, Tzou T David, Hamamoto Shuzo, Sherer A Benjamin, Stoller L Marshall, Yasui Takahiro, Chi Thomas
    • Organizer
      The 35th World Congress of the Endourology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] カルシウム結石溶解へ挑戦2017

    • Author(s)
      田口 和己、濵本 周造、岡田 淳志、戸澤 啓一、安井 孝周
    • Organizer
      日本尿路結石症学会第27回学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 尿路結石形成機構の解明と溶解治療への挑戦2017

    • Author(s)
      田口 和己、濵本 周造、岡田 淳志、安井 孝周
    • Organizer
      第67回日本泌尿器科学会中部総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Discovery of Randall’s plaque gene expression profiling in calcium oxalate stone formers by immunohistochemical genome-wide analysis.2016

    • Author(s)
      Taguchi K, Hamamoto S, Sugino T, Unno R, Hirose M, Ando R, Okada A, Tozawa K, Chi T, Stoller ML, Kohri K, Yasui T
    • Organizer
      13th International Symposium on Urolithiasis
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-07-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discovery of Randall’s plaque gene expression profiling in calcium oxalate stone formers by immunohistochemical genome-wide analysis.2016

    • Author(s)
      Taguchi K, Unno R, Kamisawa H, Naiki T, Hamamoto S, Ando R, Okada A, Tozawa K, Kohri K, Yasui T
    • Organizer
      American Urological Association Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-05-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Different roles of M1/M2 macrophage phenotype for renal crystal formation.2016

    • Author(s)
      Taguchi K, Unno R, Fujii Y, Hirose Y, Usami M, Hamamoto S, Ando R, Okada A, Itoh Y, Tozawa K, Kohri K, Yasui T
    • Organizer
      American Urological Association Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-05-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rising star report マクロファージによる結石溶解療法。2016

    • Author(s)
      田口 和己、濵本 周造、安藤 亮介、岡田 淳志、戸澤 啓一、郡 健二郎、安井 孝周
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センターほか(宮城県仙台市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] マクロファージと尿路結石。腎臓内科・泌尿器科2016

    • Author(s)
      田口 和己、岡田 淳志、安井 孝周
    • Publisher
      科学評論社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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