Diversity of Neisseria gonorrhoeae strains in the host response
| Project/Area Number |
16K11061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Shimuta Ken 国立感染症研究所, 細菌第一部, 主任研究官 (40370960)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 性感染症 / 淋菌感染症 / STI |
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| Outline of Final Research Achievements |
The differences of individual Neisseria gonorrhoeae strains about host response were examined. The same genotype, MLST, was set as the same group, and five groups were proposed as pre-dominant strains in Japan. I confirmed the differences between the groups. When the growth patterns of the strains were examined under some liquid culture conditions, the strains belonging to the MLST7359 showed a different pattern from the strains belonging to other lineage under the condition using BHI medium. The expression of thes LOS, which affects inflammatory of host response, and cell adhesion to cultured cells was confirmed, differences were observed between N. gonorrhoeae strains, but no lineages-dependent differences were observed.
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| Academic Significance and Societal Importance of the Research Achievements |
本課題の対象となる淋菌株の本邦における状況を明らかにするために、分離株の遺伝子型(MLST型)を決定した。その結果、短期間において流行株の変化が起きていることが分かった。適切な淋菌感染症における治療指針を策定するには、その時代に則したものが必要であり、そのためには対象となる分離株の最新の性状を把握することが重要であり、今回得られた情報はその策定を行う上で貢献できるものと考えられる。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates2019
Author(s)
203)Lee K, Nakayama SI, Osawa K, Yoshida H, Arakawa S, Furubayashi KI, Kameoka H, Shimuta K, Kawahata T, Unemo M, Ohnishi M.
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Journal Title
J Antimicrob Chemother
Volume: 74
Issue: 7
Pages: 1812-1819
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis.2017
Author(s)
Deguchi T, Ito S, Hatazaki K, Horie K, Yasuda M, Nakane K, Mizutani K, Tsuchiya T, Yokoi S, Hanaoka N, Shimuta K, Ohnishi M, Muratani T, Nakano M
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Journal Title
J Infect Chemother
Volume: 23
Issue: 11
Pages: 804-807
DOI
Related Report
Peer Reviewed
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[Journal Article] Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities.2017
Author(s)
Ito S, Hatazaki K, Shimuta K, Kondo H, Mizutani K, Yasuda M, Nakane K, Tsuchiya T, Yokoi S, Nakano M, Ohinishi M, Deguchi T.
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Journal Title
Sexually Transmitted Diseses
Volume: 44
Issue: 4
Pages: 205-210
DOI
Related Report
Peer Reviewed
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