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Role of endothelial glycocalyx in transplant immune responses; a mechanism of different susceptibility for rejection in various blood vessels

Research Project

Project/Area Number 16K11070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionShowa University

Principal Investigator

Honda Kazuho  昭和大学, 医学部, 教授 (10256505)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords臓器移植 / 拒絶反応 / 移植片対宿主反応 / 血管内皮 / グリコキャリックス / 低真空走査型電子顕微鏡 / 腎移植 / 骨髄移植 / GVHD
Outline of Final Research Achievements

Endothelial glycocalyx (GCX) is a thin layer covering endothelial cell membrane and regulates various biological reactions in the blood vessels. To investigate the relationship between GCX and vascular immunological responses in transplant organ, we established a simple method for 3-dimensional visualization of endothelial GCX by scanning electron microscopy using formalin fixed paraffin embedded (FFPE) samples with immersion of Alcian blue containing fixative. After periodic acid methenamine silver (PAM) staining of the section, the Alcian blue particles attached to the endothelial GCX are visualized clearly by SEM. This method will enable us to evaluate the endothelial GCX alterations in organ transplant rejection and graft versus host disease.

Academic Significance and Societal Importance of the Research Achievements

血管内皮のグリコキャリックスは,1ミクロン以下の壊れやすい薄層で,通常の標本作成手技では喪失しやすく,さらに可視化には血管内色素潅流などが必要で,ヒト臨床検体への応用は困難であった.今回確立したアルシアン青含有固定液と銀染色による血管内皮グリコキャリックスの3次元的可視化法は,浸漬固定材料にも応用が可能で,今後ヒトの臨床検体を用いて移植拒絶反応や移植片対宿主反応の病態の解明や新たな治療の確立に役立つことが期待できる.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (80 results)

All 2020 2019 2018 2017 2016

All Journal Article (32 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 28 results,  Open Access: 10 results,  Acknowledgement Compliant: 2 results) Presentation (47 results) (of which Int'l Joint Research: 15 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] An Unusual Case of Lysosomal Paraprotein Accumulation in Glomerular Endothelial Cells2020

    • Author(s)
      Taneda Sekiko、Honda Kazuho、Horita Shigeru、Matsue Kosei、Usui Yoshiaki、Mitobe Michihiro、Ogura Shota、Nitta Kosaku、Oda Hideaki
    • Journal Title

      Kidney International Reports

      Volume: 5 Issue: 1 Pages: 109-115

    • DOI

      10.1016/j.ekir.2019.09.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fate of full‐house immunofluorescence staining in renal allograft: A case report2019

    • Author(s)
      Sawada Anri、Unagami Kohei、Horita Shigeru、Kawanishi Kunio、Okumi Masayoshi、Taneda Sekiko、Ishida Hideki、Hattori Motoshi、Tanabe Kazunari、Honda Kazuho、Uchida Keiko、Shimizu Akira、Koike Junki、Nitta Kosaku、Nagashima Yoji
    • Journal Title

      Pathology International

      Volume: 69 Issue: 11 Pages: 655-660

    • DOI

      10.1111/pin.12847

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Practical Issues and Future Perspectives for Inflammation in Areas of Interstitial Fibrosis and Tubular Atrophy in Chronic Active T cell-Mediated Rejection: Three Case Reports with Commentary2019

    • Author(s)
      Taneda Sekiko、Koike Junki、Oda Hideaki、Honda Kazuho
    • Journal Title

      Transplantation Proceedings

      Volume: 51 Issue: 10 Pages: 3286-3292

    • DOI

      10.1016/j.transproceed.2019.08.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maximum Glomerular Diameter and Oxford MEST-C Score in IgA Nephropathy: The Significance of Time-Series Changes in Pseudo-R2 Values in Relation to Renal Outcomes2019

    • Author(s)
      Kataoka Hiroshi、Moriyama Takahito、Manabe Shun、Kawachi Keiko、Ushio Yusuke、Watanabe Saki、Akihisa Taro、Makabe Shiho、Sato Masayo、Iwasa Naomi、Sawara Yukako、Ohara Mamiko、Taneda Sekiko、Uchida Keiko、Honda Kazuho、Mochizuki Toshio、Tsuchiya Ken、Nitta Kosaku
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8 Issue: 12 Pages: 2105-2105

    • DOI

      10.3390/jcm8122105

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomics of human glomerulonephritis by laser microdissection and liquid chromatography‐tandem mass spectrometry2019

    • Author(s)
      Kawata Naoto、Kang Dedong、Aiuchi Toshihiro、Obama Takashi、Yoshitake Osamu、Shibata Takanori、Takimoto Masafumi、Itabe Hiroyuki、Honda Kazuho
    • Journal Title

      Nephrology

      Volume: 25 Issue: 4 Pages: 351-359

    • DOI

      10.1111/nep.13676

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Membranous nephropathy caused by rheumatoid arthritis2019

    • Author(s)
      Iida Ayana、Wada Yukihiro、Hayashi Junichi、Tachibana Shohei、Inaba Taro、Iyoda Masayuki、Honda Kazuho、Shibata Takanori
    • Journal Title

      CEN Case Reports

      Volume: 8 Issue: 4 Pages: 233-238

    • DOI

      10.1007/s13730-019-00399-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic Monoaminergic Pathology in a Neurodevelopmental Rat Model Showing Prenatal 5-Bromo-2′-Deoxyuridine Treatment-Induced Hyperactivity and Hyporeproductivity2019

    • Author(s)
      Kuwagata Makiko、Muneoka Katsumasa、Honda Kazuho、Miyazaki Akira
    • Journal Title

      Neuropsychobiology

      Volume: 79 Issue: 2 Pages: 161-169

    • DOI

      10.1159/000504552

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury?2019

    • Author(s)
      Sawada A, Kawanishi K, Horita S, Omoto K, Okumi M, Shimizu T, Taneda S, Fuchinoue S, Ishida H, Honda K, Hattori M, Tanabe K, Koike J, Nagashima Y, Nitta K.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 34 Issue: 4 Pages: 711-717

    • DOI

      10.1093/ndt/gfy256

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis: A case report.2019

    • Author(s)
      Kataoka H, Mochizuki T, Akihisa T, Kawasoe K, Kawachi K, Makabe S, Sawada A, Manabe S, Sato M, Amemiya N, Mitobe M, Akanuma T, Ito Y, Inoue T, Suzuki T, Matsui K, Moriyama T, Horita S, Ohara M, Honda K, Nitta K.
    • Journal Title

      Medicine (Baltimore)

      Volume: 98 Issue: 2 Pages: e14014-e14014

    • DOI

      10.1097/md.0000000000014014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Autopsy Case of Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody (MPO-ANCA)-associated Vasculitis Accompanied by Cryoglobulinemic Vasculitis Affecting the Kidneys, Skin, and Gastrointestinal Tract2018

    • Author(s)
      Hasegawa J, Wakai S, Kono M, Imaizumi Y, Masuda S, Ishizu A, Honda K.
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 18 Pages: 2739-2745

    • DOI

      10.2169/internalmedicine.0720-17

    • NAID

      130007484316

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-09-15
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation.2018

    • Author(s)
      Tamura T, Unagami K, Okumi M, Kakuta Y, Horita S, Ishida H, Koike J, Honda K, Tanabe K, Nitta K.
    • Journal Title

      Nephrology (Carlton)

      Volume: 23(Suppl 2) Issue: S2 Pages: 76-80

    • DOI

      10.1111/nep.13280

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and Pathological Features of Plasma Cell-Rich Acute Rejection After Kidney Transplantation.2018

    • Author(s)
      Hasegawa J, Honda K, Omoto K, Wakai S, Shirakawa H, Okumi M, Ishida H, Fuchinoue S, Hattori M, Tanabe K.
    • Journal Title

      Transplantation

      Volume: 102 Issue: 5 Pages: 853-859

    • DOI

      10.1097/tp.0000000000002041

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent Membranous Nephropathy After Kidney Transplantation Associated With Phospholipase A2 Receptor and Successfully Treated With Rituximab: A Case Report.2018

    • Author(s)
      Ishiwatari A, Wakai S, Shirakawa H, Honda K.
    • Journal Title

      Transplant Proc.

      Volume: 50 Issue: 8 Pages: 2565-2568

    • DOI

      10.1016/j.transproceed.2018.03.083

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Focal segmental glomerulosclerosis lesion associated with inhibition of tyrosine kinases by lenvatinib: a case report.2018

    • Author(s)
      Furuto Y, Hashimoto H, Namikawa A, Outi H, Takahashi H, Horiuti H, Honda K, Shibuya Y.
    • Journal Title

      BMC Nephrol.

      Volume: 19 Issue: 1 Pages: 273-273

    • DOI

      10.1186/s12882-018-1074-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral rehydration solution increases SGLT1 and improves dehydration in a mouse heatstroke model.2018

    • Author(s)
      Miyamoto K, Ohtaki H, Takayasu H, Maeda A, Sasaki J, Honda K, Dohi K, Hayashi M.
    • Journal Title

      Critical Care Medicine

      Volume: 46 Issue: 1 Pages: 252-252

    • DOI

      10.1097/01.ccm.0000528551.63676.f8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recommandations for pathological diagnosis on biopsy samples from peritoneal dialysis patients.2017

    • Author(s)
      Kawanishi K, Honda K, Hamada C.
    • Journal Title

      Pleura and Peritoneum

      Volume: 2 Pages: 3-15

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of new membrane formation in peritoneal biopsies of peritoneal dialysis patients: A case-control study.2017

    • Author(s)
      Honda K, Hamada C, Kawanishi K, Nakayama M, Miyazaki M, Ito Y, and on behalf of the Peritoneal Pathology Study Committee of Japanese Society of Peritoneal Dialysis (JSPD)
    • Journal Title

      Renal Replacement Therapy

      Volume: 3 Pages: 3-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antineutrophil cytoplasmic antibody-associated glomerulonephritis with immunoglobulin deposition.2017

    • Author(s)
      Hirose O, Itabashi M, Takei T, Honda K, Nitta K.
    • Journal Title

      Clin Exp Nephrol

      Volume: 21 Issue: 4 Pages: 643-650

    • DOI

      10.1007/s10157-016-1341-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice.2017

    • Author(s)
      Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, Shioda S, Nagasaka S, Honda K, Izumizaki M.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 10 Pages: e0186637-e0186637

    • DOI

      10.1371/journal.pone.0186637

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion.2017

    • Author(s)
      Sasaki S, Watanabe J, Ohtaki H, Matsumoto M, Murai N, Nakamachi T, Hannibal J, Fahrenkrug J, Hashimoto H, Watanabe H, Sueki H, Honda K, Miyazaki A, Shioda S.
    • Journal Title

      Br J Dermatol.

      Volume: 176 Issue: 2 Pages: 413-422

    • DOI

      10.1111/bjd.14885

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 被嚢性腹膜硬化症(EPS)に関するエビデンス 腹膜生検2017

    • Author(s)
      本田一穂
    • Journal Title

      腎と透析

      Volume: 82 Pages: 103-108

    • Related Report
      2016 Research-status Report
  • [Journal Article] Immunoglobulin A Nephropathy in a Living Kidney Donor Diagnosed and Treated After Transplantation: A Case Report2016

    • Author(s)
      M. Kono, J. Hasegawa, T. Ogawa, M. Endo, S. Wakai, H. Shirakawa, and K. Honda
    • Journal Title

      Transplantation Proceedings

      Volume: 48 Issue: 3 Pages: 940-942

    • DOI

      10.1016/j.transproceed.2015.10.077

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Vascular endothelial cell injury is an important factor in the development of encapsulating peritoneal sclerosis in long-term peritoneal dialysis patients.2016

    • Author(s)
      Tawada M, Ito Y, Hamada C, Honda K, Mizuno M, Suzuki Y, Sakata F, Terabayashi T, Matsukawa Y, Maruyama S, Imai E, Matsuo S, Takei Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 4 Pages: e0154644-e0154644

    • DOI

      10.1371/journal.pone.0154644

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Thrombotic microangiopathy caused by oral contraceptives in a kidney transplant recipient.2016

    • Author(s)
      Shirai H, Yashima J, Tojimbara T, Honda K.
    • Journal Title

      Nephrology (Carlton)

      Volume: 21 Suppl 1 Issue: S1 Pages: 41-43

    • DOI

      10.1111/nep.12769

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interstitial fibrosis is the critical determinant of impaired renal function in transplant glomerulopathy.2016

    • Author(s)
      Toki D, Inui M, Ishida H, Okumi M, Shimizu T, Shirakawa H, Omoto K, Unagami K, Setoguchi K, Koike J, Honda K, Yamaguchi Y, Tanabe K.
    • Journal Title

      Nephrology (Carlton)

      Volume: 21 Suppl 1 Issue: S1 Pages: 20-25

    • DOI

      10.1111/nep.12765

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Kidney transplantation from a mother with unrecognized Fabry disease to her son with low α-galactosidase A activity: A 14-year follow-up without enzyme replacement therapy.2016

    • Author(s)
      Odani K, Okumi M, Honda K, Ishida H, Tanabe K.
    • Journal Title

      Nephrology (Carlton)

      Volume: 21 Suppl 1 Issue: S1 Pages: 57-59

    • DOI

      10.1111/nep.12771

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Flow Cytometric Analysis of Ovarian Cancer Ascites: Response of Mesothelial Cells and Macrophages to Cancer2016

    • Author(s)
      Hashimoto K, Honda K, Matsui H, Nagashima Y, Oda H.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 3579-3584

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects and mechanism of conditioned media from human mesenchymal stem cells on anti-GBM glomerulonephritis in WKY rats.2016

    • Author(s)
      Iseri K, Iyoda M, Ohtaki H, Matsumoto K, Wada Y, Suzuki T, Yamamoto Y, Saito T, Hihara K, Tachibana S, Honda K, Shibata T.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 10 Issue: 11 Pages: 1152-1152

    • DOI

      10.1152/ajprenal.00165.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 腎腫大を伴い急速に腎機能が悪化した髄質嚢胞腎の1例2016

    • Author(s)
      雨宮伸幸、杉浦秀和、神山貴弘、生方政光、能木場宏彦、山崎麻由子、武井卓、本田一穂、新田孝作
    • Journal Title

      日本腎臓学会誌

      Volume: 58 Pages: 660-667

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腎臓移植 拒絶反応以外の合併症2016

    • Author(s)
      金綱友木子、本田一穂
    • Journal Title

      病理と臨床

      Volume: 34 Pages: 158-168

    • Related Report
      2016 Research-status Report
  • [Journal Article] 膜性増殖性糸球体腎炎の病理:過去・現在・未来2016

    • Author(s)
      本田一穂
    • Journal Title

      日本腎臓学会誌

      Volume: 58 Pages: 638-647

    • Related Report
      2016 Research-status Report
  • [Journal Article] 補体制御異常と糸球体腎炎―C3GN, DDD, MPGNを中心に―2016

    • Author(s)
      本田一穂 水野正司
    • Journal Title

      日本腎臓学会誌

      Volume: 34 Pages: 1286-1295

    • Related Report
      2016 Research-status Report
  • [Presentation] WS10-2 移植腎拒絶反応の病理2019

    • Author(s)
      本田一穂
    • Organizer
      第108回日本病理学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 2P-75 糸球体内皮細胞の細胞質内に顆粒状封入体を有したパラプロテイン血症の1例2019

    • Author(s)
      種田 積子、廣瀬 織江、宇都 健太、吉澤佐恵子、明石 慶子、 本田 一穂、小田 秀明
    • Organizer
      第108回日本病理学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] P-044 レーザーマイクロダイセクションと質量分析による腎生検組織の蛋白解析法の腎疾患診断や病態評価への応用2019

    • Author(s)
      川田 尚人,康 徳東, 柴田 孝則, 吉武 理, 村上 雅彦, 瀧本 雅文, 板部 洋之, 本田 一穂
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] P-125 クローン病合併IgA腎症の臨床病理学的検討2019

    • Author(s)
      秋山美奈子,下村浩祐,吉本 宏,阿部佳子,本田一穂
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] FR-PO956: Proteomics of Human Glomerulonephritis by Laser Microdissection and Liquid Chromatograph-Tandem Mass Spectrometry (LMD-LC MS/MS)2019

    • Author(s)
      Kawata N, Kang D, Honda K et al.
    • Organizer
      Kidney Week 2019, American Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of 3-dimensional electron microscopy to human renal biopsy specimen; from a case study of lupus nephritis revealing direct connection between podocytes and mesangial cells.2019

    • Author(s)
      Takaki T, Kang D, Joh K, Honda K.
    • Organizer
      The 8th Japanese-Chinese Renal Pathology Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ES1-1: Pathological understanding of PD-related peritoneal sclerosis and encapsulating peritoneal sclerosis.2019

    • Author(s)
      Honda K
    • Organizer
      The 9th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolving criteria for the diagnosis of antibody-mediated rejection in kidney allografts2019

    • Author(s)
      Honda K.
    • Organizer
      Asian Transplantation Week 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] TP-1 Banff分類におけるCATCMRの捉え方2019

    • Author(s)
      本田一穂
    • Organizer
      第53回日本臨床腎移植学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 2pmC-3:LMD-LC-MS/MS法を用いたラット膜性腎症モデルの病態に関与する蛋白の検討2019

    • Author(s)
      康 徳東、高木 孝士、小濱孝士、板部洋之、本田 一穂
    • Organizer
      第125回日本解剖学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] P-060: 培養糸球体内皮細胞を用いたゲムシタビンの腎障害機序の検討2019

    • Author(s)
      佐野真理子、澤智華、康徳東、髙木孝士、本田一穂.
    • Organizer
      第125回日本解剖学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] P-191: FFPE 切片を用いた LV-SEM による腎血管内皮の Glycocalyx の新たな可視化法の確立2019

    • Author(s)
      向井俊平、高木孝士、南雲佑、佐野真理子、康徳東、本田一穂、瀧本雅文
    • Organizer
      第125回日本解剖学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] P1-243 ホルマリン固定パラフィン包埋切片の低真空走査電子顕微鏡(LV-SEM)による3次元的観察:病理診断への応用法の検討2018

    • Author(s)
      向井俊平、高木孝士、南雲 佑、佐野真理子、瀧本雅文、本田一穂
    • Organizer
      第107回日本病理学会学術総会(2018/6/21-6/23, 札幌・ホテルロイトン)
    • Related Report
      2018 Research-status Report
  • [Presentation] よくわかるシリーズ2 「腎疾患と感染症」2018

    • Author(s)
      本田 一穂
    • Organizer
      第61回日本腎臓学会学術総会(2018/6/8-10, 朱鷺メッセ・ホテル日航新潟)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] O6-2 低真空走査電子顕微鏡によるホルマリン固定パラフィン包埋切片の3次元的観察2018

    • Author(s)
      向井俊平,高木孝士,南雲 佑,佐野真理子,永井智子,本田一穂,瀧本雅文
    • Organizer
      第50回日本臨床分子形態学会総会・学術集会(2018/9/7-9/8, 北里大学大村記念ホール, 東京)
    • Related Report
      2018 Research-status Report
  • [Presentation] CLEM法を用いた腎血管Glycocalyx検出の試み2018

    • Author(s)
      向井俊平,本田一穂,高木孝士,南雲 佑,佐野真理子,瀧本雅文
    • Organizer
      第50回日本臨床分子形態学会総会・学術集会(2018/9/7-9/8, 北里大学大村記念ホール, 東京)
    • Related Report
      2018 Research-status Report
  • [Presentation] 教育セミナー38:病理からみた腹膜傷害とその対策2018

    • Author(s)
      本田一穂
    • Organizer
      第24回日本腹膜透析医学会学術集会・総会(2018/10/6-7, 徳島)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] SY1-4: 沈着物の多様性から観る腎症の病因と病態2018

    • Author(s)
      康徳東,本田一穂,清水 章
    • Organizer
      第48回日本腎臓学会東部学術大会(2018/10/20-21, 京王プラザホテル新宿,東京)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Pathological implication of iIFTA in chronic active T cell mediated rejection; having worth or not?2018

    • Author(s)
      Sekiko Taneda, Kazuho Honda
    • Organizer
      The 7th Japanese-Chinese Renal Pathology Conference (2019/1/13, 獨協医科大学埼玉医療センター大会議室,越谷)
    • Related Report
      2018 Research-status Report
  • [Presentation] P-051: 培養内皮細胞を用いた血管内皮細胞傷害時のGlycocalyxの変化とその意義2018

    • Author(s)
      佐野真理子、澤智華、秋山美奈子、川田尚人、康徳東、向井俊平、髙木孝士、本田一穂.
    • Organizer
      第124回日本解剖学会総会・学術集会 (2019/3/28~2019/3/30,朱鷺メッセ・ホテル日航新潟)
    • Related Report
      2018 Research-status Report
  • [Presentation] P-096:低真空走査型電子顕微鏡(LV-SEM)を用いた実験的ラットHeymann腎炎モデルにおける糸球体係蹄基底膜傷害の検討2018

    • Author(s)
      康 徳東、蘭 平、余 暁洋、梁 非、高木 孝士、清水 章、本田 一穂
    • Organizer
      第124回日本解剖学会総会・学術集会 (2019/3/28~2019/3/30,朱鷺メッセ・ホテル日航新潟)
    • Related Report
      2018 Research-status Report
  • [Presentation] マウス熱中症モデルにおける経口補水液(OS-1)の有用性について2018

    • Author(s)
      宮本和幸, 大滝博和, 髙安弘美, 前田敦雄, 佐々木純, 本田一穂, 土肥謙二, 林宗貴
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] CLEM 法を用いた腎血管 Glycocalyx 検出の試み2018

    • Author(s)
      向井俊平、本田 一穂、高木孝士、南雲佑、佐野真理子、瀧本雅文
    • Organizer
      第123回日本解剖学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 低真空走査電顕(LV-SEM)による腎パラフィン切片の三次元的解析:導電処理法の検討2018

    • Author(s)
      本田一穂、向井俊平、佐野真理子、南雲 佑、澤 智華、高木孝士
    • Organizer
      第123回日本解剖学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 培養ヒト臍帯静脈内皮細胞(HUVEC)を用いたGlycocalyxの検出方法の検討2018

    • Author(s)
      佐野真理子、澤智華、向井俊平、髙木孝士、本田一穂
    • Organizer
      第123回日本解剖学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 細胞外核酸の細胞障害性に対する検討2018

    • Author(s)
      澤智華、 佐野真理子、井上由理子、杉 正人、本田一穂
    • Organizer
      第123回日本解剖学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脊髄損傷後のケモカインの局在とヒト間葉系幹細胞を用いた組織修復への関与2018

    • Author(s)
      矢倉一道、大滝博和、圓谷智海、佐藤敦、渡邊潤、宮本和幸、平泉裕、本田一穂
    • Organizer
      第123回日本解剖学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腎内血管内皮の多様性の検討:低真空SEMによる腎生検パラフィン切片の三次元的解析.2017

    • Author(s)
      本田一穂,南雲 佑,種田積子,舟橋久幸,大滝博和,澤 智華,渡邊 潤,瀧本雅文,小田秀明,新田孝作,大塚成人
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス、長崎
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] New membrane formation in the peritoneal biopsy at catheter removal could not predict the development of encapsulating peritoneal sclerosis in peritoneal dialysis patients.2017

    • Author(s)
      Kazuho Honda, Kunio Kawanishi, Chieko Hamada, Masaaki Nakayama, Masanobu Miyazaki, Yasuhiko Ito, and on behalf of the Peritoneal Pathology Study Committee of Japanese Society of Peritoneal Dialysis (JSPD)
    • Organizer
      The 8th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis
    • Place of Presentation
      Guangzhou, China
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] An autopsy case of combined cryoglobulinemic and MPO-ANCA associated vasculitis affecting kidney, skin and gastrointestinal tract.2017

    • Author(s)
      Jumpei Hasegawa, Momoko Kono, Yusuke Imaizumi, Sachiko Wakai, Kazuho Honda
    • Organizer
      The 3rd International Renal Pathology Conference
    • Place of Presentation
      All India Institute of Medical Sciences, New Delhi, India
    • Year and Date
      2017-02-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 低真空SEMを用いた移植腎毛細血管症の血管内皮および基底膜病変の三次元的解析2017

    • Author(s)
      本田一穂、南雲 佑、種田積子、小田秀明、長嶋洋治、大塚成人、瀧本雅文、新田孝作、田邉一成
    • Organizer
      第106回日本病理学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] PACAP38の外傷性脳損傷抑制効果と抗酸化能向上作用について2017

    • Author(s)
      宮本和幸, 大滝博和, 髙安弘美, 前田敦雄, 佐々木純, 本田一穂, 林宗貴, 土肥謙二.
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Production of MCP-1 (CCL2) from human mesenchymal stem/stromal cells in ischemic brain2017

    • Author(s)
      Hirokazu Ohtaki, Kazumichi Yagura, Yuki Tanaka, Jun Watanabe, Kazuyuki Miyamoto, Yutaka Hiraizumi, Kenji Dohi, Kazuho Honda
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Administration of TSG-6 form MSCs improves memory after traumatic brain injury in mice2017

    • Author(s)
      Watanabe J, Ohtaki H, Yagura K, Honda K, Arata S
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Regulation of CCL2 (MCP-1) expression from human mesenchymal stem/stromal cells after ischemia through inflammatory cytokines.2017

    • Author(s)
      Ohtaki H, Yagura K, Watanabe J, Miyamoto K, Dohi K, Honda K
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新生被膜(Newly-formed membrane)は必ずしもEPS発症に関連しない2017

    • Author(s)
      本田一穂
    • Organizer
      第23回日本腹膜透析医学会学術集会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Human mesenchymal stem/stromal cells express CCL2 (MCP-1) on ischemic hippocampal homogenate exposure (Tu-P10-16)2017

    • Author(s)
      Ohtaki H, Watanabe J, Yagura K, Miyamoto K, Iwakura Y, Dohi K, Honda K
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression patterns and distributions of chemokines and their receptors after spinal cord injury (SCI) in mice.2017

    • Author(s)
      Yagura K, Ohtaki H, Tsumuraya T, Sato A, Watanabe J, Hiraizumi Y, Honda K.
    • Organizer
      The5th Annual Meeting of the International Cytokine and Interferon Society (ICIS2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Administrations of mesenchymal stem/stromal cells (MSCs) produced beneficial effects in models of traumatic brain injury via prevention of blood brain barrier leakage.2017

    • Author(s)
      Watanabe J, Ohtaki H, Yagura K, Honda K, Arata S.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Suppression of nitric oxide level from microglia by co-culturing with human mesenchymal stem/progenitor cells.2017

    • Author(s)
      Ohtaki H, Watanabe J, Yagura K, Miyamoto K, Hiraizumi Y, Honda K, Dohi K.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gene and cellular localizations of chemokines and their receptors after spinal cord injury(SCI) in mice.2017

    • Author(s)
      Yagura K, Ohtaki H, Tsumuraya T, Sato A, Watanabe J, Miyamoto K, Tanaka S, Hiraizumi Y, Kanzaki K, Honda K.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷マウスにおけるケモカインの変動と役割2017

    • Author(s)
      矢倉 一道,大滝 博和,圓谷 智海,佐藤 敦,渡邊 潤,宮本 和幸,平泉 裕,本田 一穂
    • Organizer
      第64回昭和大学学士会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] PACAP promotes sweat secretion in eccrine gland via PAC1R.2017

    • Author(s)
      Watanabe J, Sasaki S, Ohtaki H, Arata S Honda K, Shioda S.
    • Organizer
      13th International Symposium on VIP, PACAP and Related Peptides.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Therapeutic time-window for edaravone treatment of traumatic brain injury in mice.2017

    • Author(s)
      Miyamoto K, Ohtaki H, Dohi, K, Sitho H, Maeda A, Sasaki J, Honda K, Hayashi M.
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Responses of human mesenchymal stem/stromal cells on brain ischemia.2016

    • Author(s)
      Ohtaki H, Taniguchi S, Tanaka Y, Watanabe J, Miyamoto K, Yoshikawa A, Dohi K, Honda K.
    • Organizer
      SFN2016
    • Place of Presentation
      San Diego Convention Center (San Diego, CA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳虚血マウスにおける移植ヒト骨髄間葉系幹・前駆細胞(hMSCs)の応答.2016

    • Author(s)
      大滝博和,渡邊潤,宮本和幸,平泉裕,本田一穂
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Suppression of Spinal Cord Injury by Human Mesenchymal Stem/Stromal Cells (hMSCs) via Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Mice.2016

    • Author(s)
      Ohtaki H, Tsumuraya T, Sato A, Miyamoto K, Yoshikawa A, Watanabe J, Hiraizumi Y, Dohi K, Hashimoto H, Honda K.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 腎生検病理アトラス2017

    • Author(s)
      小川弥生、串田吉生、清水章、城謙輔、長田道夫、本田一穂、日本腎病理協会、日本腎臓学会
    • Total Pages
      384
    • Publisher
      東京医学社
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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