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Identification and functional analysis of novel immune cells for the establishment and maintenance of pregnancy

Research Project

Project/Area Number 16K11078
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHyogo Medical University

Principal Investigator

Fukui Atsushi  兵庫医科大学, 医学部, 准教授 (00321969)

Project Period (FY) 2016-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsNK細胞 / NKp46 / 不妊症 / 着床不全 / 不育症 / CD56 / サイトカイン / 精液 / CD16 / IFN-γ / TNF-α / 生殖免疫
Outline of Final Research Achievements

We used non-pregnant uterine endometrium and aborted decidua to evaluate the NK cell function for the establishment and maintenance of pregnancy and found that the expression of NKp46 on the surface of NK cells is altered in infertility and recurrent pregnancy loss. We showed that NK cells expressing NKp46 co-express activating and inhibitory receptors, and further that the subsequent establishment of pregnancy depends on the intensity of NKp46 expression (NKp46dim cells and NKp46bright cells). The expression of NKp46 in the non-pregnant uterine endometrium and aborted decidua may be used to predict the outcome of subsequent pregnancies. NK cells were also shown to produce cytokines when stimulated by their partner's semen.

Academic Significance and Societal Importance of the Research Achievements

体外受精・胚移植を中心とした不妊治療は、令和4年4月保険適用された。体外受精をもってしても妊娠が成立しない着床不全や流産を繰り返す不育症の方達の中には子宮内に免疫学的異常を有するものが存在することが推測される。本研究では、子宮内の免疫異常の一端を明らかにすることができ、さらにはその後の妊娠成立の有無や妊娠予後の予測出来る可能性も示した。また精液での子宮内膜刺激という新しい方法により、子宮内のより生理的な免疫状態を知ることが出来、生殖医療の発展に寄与できるものと考えている。

Report

(8 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (114 results)

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article (34 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 28 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (80 results) (of which Int'l Joint Research: 15 results,  Invited: 21 results)

  • [Journal Article] Sex difference in anti‐sperm antibodies2022

    • Author(s)
      Shibahara Hiroaki、Chen Yuekun、Honda Haruka、Wakimoto Yu、Fukui Atsushi、Hasegawa Akiko
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1

    • DOI

      10.1002/rmb2.12477

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of NKp46 expression and cytokine production of decidual NK cells in women with recurrent pregnancy loss2022

    • Author(s)
      Yamamoto Mayu、Fukui Atsushi、Mai Chuxian、Saeki Shinichiro、Takayama Ryu、Wakimoto Yu、Yamaya Ayano、Kwak‐Kim Joanne、Shibahara Hiroaki
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1

    • DOI

      10.1002/rmb2.12478

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for Reproductive Medicine in Japan2022

    • Author(s)
      Yamada Mitsutoshi、Osuka Satoko、Kanasaki Haruhiko、Kawano Yasushi、Kawamura Kazuhiro、Kishi Hiroshi、Kimura Fuminori、Kuroda Shinnosuke、Kuwahara Akira、Tamura Hiroshi、Jwa Seung Chik、Baba Tsuyoshi、Harada Miyuki、Hirata Tetsuya、Yoshino Osamu、Hirota Yasushi、Tsujimura Akira、Kuji Naoaki、Osuga Yutaka
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1 Pages: 1-1

    • DOI

      10.1002/rmb2.12483

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: a double-blind, randomised, placebo-controlled trial.2022

    • Author(s)
      Yamada H, Deguchi M, Saito S, Takeshita T, Mitsui M, Saito T, Nagamatsu T, Takakuwa K, Nakatsuka M, Yoneda S, Egashira K, Tachibana M, Matsubara K, Honda R, Fukui A, Tanaka K, Sengoku K, Endo T, Yata H.
    • Journal Title

      The Lancet Discovery Science, eClinicalMedicine.

      Volume: 50 Pages: 101527-101527

    • DOI

      10.1016/j.eclinm.2022.101527

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 合併増大号 今月の臨床 生殖医療の基礎知識アップデート-患者説明に役立つ最新エビデンス・最新データ 不育症の検査・治療 不育症に対する免疫系検査の意義2021

    • Author(s)
      福井 淳史、山谷 文乃、柴原 浩章
    • Journal Title

      臨床婦人科産科

      Volume: 75 Issue: 1 Pages: 165-172

    • DOI

      10.11477/mf.1409210241

    • ISSN
      0386-9865, 1882-1294
    • Year and Date
      2021-01-10
    • Related Report
      2020 Research-status Report
  • [Journal Article] Anti‐sperm antibodies and reproductive failures2021

    • Author(s)
      Shibahara Hiroaki、Wakimoto Yu、Fukui Atsushi、Hasegawa Akiko
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 85 Issue: 4

    • DOI

      10.1111/aji.13337

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Introduction of the special issue, "Clinical reproductive immunology"2021

    • Author(s)
      Kwak‐Kim Joanne、Sung Nayoung、Saab Wael、Fukui Atsushi
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 85 Issue: 4

    • DOI

      10.1111/aji.13415

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] NK cells that differ in expression of NKp46 might play different roles in endometrium2021

    • Author(s)
      Mai Chuxian、Fukui Atsushi、Takeyama Ryu、Yamamoto Mayu、Saeki Shinichiro、Yamaya Ayano、Kato Toru、Ukita Yuji、Wakimoto Yu、Shibahara Hiroaki
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 147 Pages: 103367-103367

    • DOI

      10.1016/j.jri.2021.103367

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sperm immobilization test and quantitative sperm immobilization test using frozen‐thawed sperm preparation applied with computer‐aided sperm analysis2021

    • Author(s)
      Wakimoto Yu、Fukui Atsushi、Kojima Teruhito、Wakimoto Goh、Okamura Naoya、Kamei Hidetake、Sugiyama Yukiko、Kato Toru、Hasegawa Akiko、Shibahara Hiroaki
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 20 Issue: 3 Pages: 321-326

    • DOI

      10.1002/rmb2.12387

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss2021

    • Author(s)
      Takeyama Ryu、Fukui Atsushi、Mai Chuxian、Yamamoto Mayu、Saeki Shinichiro、Yamaya Ayano、Shibahara Hiroaki
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 145 Pages: 103324-103324

    • DOI

      10.1016/j.jri.2021.103324

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The chronological change in transvaginal ultrasound images of a hemorrhagic ovarian cyst observed during infertility treatment: A case report and literature review2021

    • Author(s)
      Fujii Yu、Wakimoto Yu、Omote Maya、Sugiyama Yukiko、Ukita Yuji、Kato Toru、Fukui Atushi、Shibahara Hiroaki
    • Journal Title

      Clinical Case Reports

      Volume: 9 Issue: 7

    • DOI

      10.1002/ccr3.4199

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 今月の臨床 着床環境の改善はどこまで可能か?-エキスパートに聞く最新研究と具体的対処法 子宮内免疫 免疫が着床に及ぼす影響-Th1/Th2比,NK細胞2020

    • Author(s)
      福井 淳史、麦 楚嫻、柴原 浩章
    • Journal Title

      臨床婦人科産科

      Volume: 74 Issue: 12 Pages: 1246-1251

    • DOI

      10.11477/mf.1409210203

    • ISSN
      0386-9865, 1882-1294
    • Year and Date
      2020-12-10
    • Related Report
      2020 Research-status Report
  • [Journal Article] Pelvic endometriosis and natural killer cell immunity2020

    • Author(s)
      Fukui Atsushi、Mai Chuxian、Saeki Shinichiro、Yamamoto Mayu、Takeyama Ryu、Kato Toru、Ukita Yuji、Wakimoto Yu、Yamaya Ayano、Shibahara Hiroaki
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 85 Issue: 4

    • DOI

      10.1111/aji.13342

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A semen-based stimulation method to analyze cytokine production by uterine CD56bright natural killer cells in women with recurrent pregnancy loss2020

    • Author(s)
      Taima Ayako、Fukui Atsushi、Yamaya Ayano、Yokota Megumi、Fukuhara Rie、Yokoyama Yoshihito
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 142 Pages: 103206-103206

    • DOI

      10.1016/j.jri.2020.103206

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] COVID-19 and immunomodulation treatment for women with reproductive failures2020

    • Author(s)
      Kwak-Kim Joanne、Ota Kuniaki、Sung Nayoung、Huang Changsheng、Alsubki Lujain、Lee Sungki、Han Jae Won、Han Aera、Yang Xiuhua、Saab Wael、Derbala Youssef、Wang Wen-Juan、He Qiaohua、Liao Aihua、Takahashi Toshifumi、Cavalcante Marcelo Borges、Barini Ricardo、Bao Shihua、Fukui Atsushi、L?d?e Nathalie、Coulam Carolyn
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 141 Pages: 103168-103168

    • DOI

      10.1016/j.jri.2020.103168

    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Treatment with Laevo (l)-carnitine reverses the mitochondrial function of human embryos2020

    • Author(s)
      Morimoto Naoharu、Hashimoto Shu、Yamanaka Masaya、Satoh Manabu、Nakaoka Yoshiharu、Fukui Atsushi、Morimoto Yoshiharu、Shibahara Hiroaki
    • Journal Title

      Journal of Assisted Reproduction and Genetics

      Volume: 38 Issue: 1 Pages: 71-78

    • DOI

      10.1007/s10815-020-01973-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial oxygen consumption rate of human embryos declines with maternal age2020

    • Author(s)
      Morimoto Naoharu、Hashimoto Shu、Yamanaka Masaya、Nakano Tatsuya、Satoh Manabu、Nakaoka Yoshiharu、Iwata Hisataka、Fukui Atsushi、Morimoto Yoshiharu、Shibahara Hiroaki
    • Journal Title

      Journal of Assisted Reproduction and Genetics

      Volume: 37 Issue: 8 Pages: 1815-1821

    • DOI

      10.1007/s10815-020-01869-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集 リプロダクションの現在-いま精子力を考える 〈総論〉 ARTに関する基礎知識2019

    • Author(s)
      柴原 浩章、加藤 徹、福井 淳史
    • Journal Title

      臨床泌尿器科

      Volume: 73 Issue: 13 Pages: 946-954

    • DOI

      10.11477/mf.1413206765

    • ISSN
      0385-2393, 1882-1332
    • Year and Date
      2019-12-20
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between spontaneous ovulation and serum anti‐Mullerian hormone levels in a premature ovarian insufficiency patient after a multimodal treatment for breast cancer2019

    • Author(s)
      Wakimoto Yu、Fukui Atushi、Wakimoto Goh、Ikezawa Yuji、Matsuoka Michie、Omote Maya、Sugiyama Yukiko、Ukita Yuji、Kato Toru、Shibahara Hiroaki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 45 Issue: 11 Pages: 2297-2301

    • DOI

      10.1111/jog.14101

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Removal of a retroperitoneal foreign body by laparoscopic surgery2019

    • Author(s)
      Wakimoto Yu、Shinichiro Saeki、Kamei Hidetake、Fukui Atsushi、Shibahara Hiroaki
    • Journal Title

      Gynecology and Minimally Invasive Therapy

      Volume: 8 Issue: 2 Pages: 86-86

    • DOI

      10.4103/gmit.gmit_84_18

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 子宮鏡を用いた卵管閉塞の手術 子宮鏡補助下卵管鏡下卵管形成術の適応、術式、意義2019

    • Author(s)
      福井淳史
    • Journal Title

      産科と婦人科

      Volume: 11 Pages: 1381-1386

    • Related Report
      2019 Research-status Report
  • [Journal Article] Tubal infertility and falloposcopy2019

    • Author(s)
      福井 淳史、佐伯 信一朗、柴原 浩章
    • Journal Title

      ADVANCES IN OBSTETRICS AND GYNECOLOGY

      Volume: 71 Issue: 2 Pages: 155-159

    • DOI

      10.11437/sanpunosinpo.71.155

    • NAID

      130007668854

    • ISSN
      0370-8446, 1347-6742
    • Related Report
      2019 Research-status Report
  • [Journal Article] Fertility preservation and pregnancy outcomes in adolescent and young adult male patients with cancer2018

    • Author(s)
      Ukita Yuji、Wakimoto Yu、Sugiyama Yukiko、Fujii Yuta、Fukui Atsushi、Hasegawa Akiko、Kondoh Nobuyuki、Yamamoto Shingo、Shibahara Hiroaki
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 17 Issue: 4 Pages: 449-453

    • DOI

      10.1002/rmb2.12211

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Application of computer-aided sperm analysis (CASA) for detecting sperm-immobilizing antibody2018

    • Author(s)
      Wakimoto Yu、Fukui Atsushi、Kojima Teruhito、Hasegawa Akiko、Shigeta Minoru、Shibahara Hiroaki
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 79 Issue: 3

    • DOI

      10.1111/aji.12814

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 当センターにおける不妊患者の周産期予後の検討2018

    • Author(s)
      松岡 理恵, 浮田 祐司, 浮田 美里, 脇本 裕, 坂根 理矢, 原田 佳世子, 福井 淳史, 田中 宏幸, 柴原 浩章
    • Journal Title

      産婦人科の実際

      Volume: 67 Pages: 1043-1046

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 不育症診療 新たな治療戦略とその限界2018

    • Author(s)
      福井淳史、柴原浩章
    • Journal Title

      産婦人科の実際

      Volume: 67 Pages: 1651-1658

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 子宮内膜症合併不妊~次の一手は~ 子宮内膜症性嚢胞合併不妊症に対するエタノール固定術2018

    • Author(s)
      福井淳史、山谷文乃、横田 恵、福原理恵、柴原浩章
    • Journal Title

      日本エンドメトリオーシス学会会誌

      Volume: 39 Pages: 46-49

    • Related Report
      2018 Research-status Report
  • [Journal Article] Expression of natural cytotoxicity receptors and cytokine production on endometrial natural killer cells in women with recurrent pregnancy loss or implantation failure, and the expression of natural cytotoxicity receptors on peripheral blood natural kille2017

    • Author(s)
      Fukui Atsushi、Funamizu Ayano、Fukuhara Rie、Shibahara Hiroaki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 43 Issue: 11 Pages: 1678-1686

    • DOI

      10.1111/jog.13448

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Inability of Human Sperm with Chromosomal Abnormalities to Penetrate the Oocyte in Assisted Reproductive Technology (ART): Risk Factors and the Role of Seminal Plasma2017

    • Author(s)
      Watanabe Seiji、Fukui Atsushi、Nakamura Rika、Fukuhara Rie、Funamizu Ayano
    • Journal Title

      Journal of Mammalian Ova Research

      Volume: 34 Issue: 2 Pages: 65-73

    • DOI

      10.1274/jmor.34.65

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Current Perspectives on the Mammalian Zona Pellucida2017

    • Author(s)
      Hasegawa Akiko、Fukui Atsushi、Shibahara Hiroaki
    • Journal Title

      Journal of Mammalian Ova Research

      Volume: 34 Issue: 2 Pages: 57-64

    • DOI

      10.1274/jmor.34.57

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 不育症の診断と治療2017

    • Author(s)
      福井淳史
    • Journal Title

      産婦人科の進歩

      Volume: 69 Pages: 403-404

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2回目以上の自然流産における絨毛染色体検査の検討2017

    • Author(s)
      脇本裕、澤井英明、森本篤、杉山由希子、脇本剛、福井淳史、小林眞一郎、大濱尚子、繁田実、柴原浩章
    • Journal Title

      日本受精着床学会雑誌

      Volume: 34 Pages: 340-345

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 子宮内膜症における子宮内膜NK細胞Natural Cytotoxicity Recceptor発現2017

    • Author(s)
      船水文乃、福井淳史、當麻絢子、淵之上康平、佐々木幸江、中村理果、福原理恵、横山良仁
    • Journal Title

      日本エンドメトリオーシス学会会誌

      Volume: 38 Pages: 154-157

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of retinoid-related orphan receptor (ROR)γt on NK22 cells in the peripheral blood and uterine endometrium of women with unexplained recurrent pregnancy loss and unexplained infertility2016

    • Author(s)
      Kohei Fuchinoue, Atsushi Fukui, Hitomi Chiba, Mai Kamoi, Ayano Funamizu, Ayako Taima, Rie Fukuhara and Hideki Mizunuma
    • Journal Title

      The Journal of Obstetrical and Gynecology Research

      Volume: 42 Issue: 11 Pages: 1541-1552

    • DOI

      10.1111/jog.13075

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 子宮内膜症における腹水中 NK 細胞受容体の発現強度の解析2023

    • Author(s)
      佐伯信一朗、福井 淳史、山谷 文乃、麦 加藤 徹、柴原 浩章
    • Organizer
      日本エンドメトリオーシス学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ライフステージを考慮したシームレスな子宮内膜症治療2023

    • Author(s)
      福井淳史
    • Organizer
      日本エンドメトリオーシス学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Prediction and diagnosis of reproductive failures based on NKp46 expression on endometrial and decidual NK cells2022

    • Author(s)
      Atsushi FUKUI, Shinichiro SAEKI, Ryu TAKEYAMA, Ayano YAMAYA, Hiroaki SHIBAHARA
    • Organizer
      米国生殖医学会(ASRM)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Co-expression of activating and inhibitory receptors on peritoneal fluid NK cells differs between deep endometriosis and peritoneal endometriosis2022

    • Author(s)
      Shinichiro SAEKI, Atsushi FUKUI, Ayano Yamaya, Ryu TAKEYAMA,, Hiroaki SHIBAHARA
    • Organizer
      米国生殖医学会(ASRM)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 流産時脱落膜NK細胞に発現するNKp46から不育症のリスク因子を知る2022

    • Author(s)
      福井 淳史、麦 楚セン、佐伯 信一朗、竹山 龍、山谷 文乃、柴原 浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] NKp46の発現率が妊娠率に影響を及ぼすかの検討2022

    • Author(s)
      竹山 龍、福井 淳史、麦 楚セン、佐伯 信一朗、山谷 文乃、柴原 浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 子宮内膜症における腹水中NK細胞受容体の発現強度の解析2022

    • Author(s)
      佐伯 信一朗、福井 淳史、麦 楚セン、山口 桃李、竹山 龍、山谷 文乃、柴原 浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 子宮圧迫縫合術(Uterine compression suture:UCS)後のAsherman症候群に対して外来子宮鏡手術が有効であった一例2022

    • Author(s)
      松井 萌、加藤 徹、味村 史穂、山口 桃李、上東 真理子、竹山 龍、福井 淳史、田中 宏幸、澤井 英明、柴原 浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 不妊治療の最適なステップアップ~一般不妊治療からARTまでゴナドトロピン製剤を使いこなす~2022

    • Author(s)
      福井淳史
    • Organizer
      日本産科婦人科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Fertility preservation by ovarian tissue cryopreservation for pediatric cancer patients in our department2022

    • Author(s)
      Yu Wakimoto、Nana Ogino、Hidetake Kamei、Yukiko Sugiyama、Toru Kato、Ayano Yamaya、Atsushi Fukui、Akiko Hasegawa、Hiroaki Shibahara
    • Organizer
      日本産科婦人科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 子宮内膜症における腹水中 NK 細胞受容体の発現強度およびサイトカイン産生解析2022

    • Author(s)
      佐伯信一朗,福井 淳史,竹山 龍,山谷 文乃,柴原 浩章
    • Organizer
      日本生殖医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 外来子宮鏡処置を考える2022

    • Author(s)
      福井淳史
    • Organizer
      日本生殖医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Immunological approach and its treatments for repeated implantation failures2022

    • Author(s)
      Atsushi FUKUI, Kohei NAKAGAWA, Kazuya TAKEDA, Hidetake KAMEI, Ryu TAKEYAMA, Yu WAKIMOTO, Ayano YAMAYA, Hiroaki Shibahara
    • Organizer
      JSAR regional symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 子宮および末梢血NK細胞におけるGM-CSF産生と胚培養液選択2022

    • Author(s)
      浮田祐司、福井淳史、佐伯信一朗、福田愛作、松山毅彦、池田智明、柴原浩章
    • Organizer
      日本IVF学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 不育症の診断と治療2021

    • Author(s)
      福井淳史
    • Organizer
      日本産科婦人科学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 子宮内膜症における腹水中NK細胞の活性性受容体および抑制性受容体発現2021

    • Author(s)
      山谷文乃、福井淳史、麦チューシャン、佐伯信一朗、竹山龍、加藤徹、柴原浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 子宮NK細胞に発現する活性性および抑制性受容体共発現の意義2021

    • Author(s)
      竹山 龍、福井 淳史、麦チューシャン、山谷 文乃、柴原 浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] NK細胞におけるNKp46受容体発現強度の違いは生殖に影響を与えるのか2021

    • Author(s)
      麦チューシャン、福井淳史、山本真由、佐伯信一朗、竹山龍、山谷文乃、柴原浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 反復着床不全の病態解明と治療法開発への免疫学的アプローチ2021

    • Author(s)
      福井淳史
    • Organizer
      日本受精着床学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 子宮内膜症における腹水中NK細胞受容体の発現強度の解析2021

    • Author(s)
      佐伯信一朗、福井淳史、麦チューシャン、竹山龍、加藤徹、山谷文乃、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 脱落膜NK細胞に発現するNKp46から免疫異常を有する不育症を知る2021

    • Author(s)
      山本真由、福井淳史、麦チューシャン、岡村直哉、佐伯信一朗、竹山龍、山谷文乃、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 生殖異常患者子宮NK細胞に発現する活性性受容体および抑制性受容体の共発現の意義2021

    • Author(s)
      竹山 龍、福井 淳史、麦チューシャン、山谷文乃、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2021 Research-status Report
  • [Presentation] NKp46dim NKと NKp46bright NK細胞は生殖に異なる影響を与えるのか2021

    • Author(s)
      麦チューシャン、福井淳史、佐伯信一朗、竹山龍、山谷文乃、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 子宮内膜CD56陽性NK細胞の精液刺激法によるリスク因子不明不育症患者のサイトカイン産生能の検討2021

    • Author(s)
      當麻絢子、福井淳史、山谷文乃、横田恵、福原理恵、横山良仁
    • Organizer
      日本受精着床学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 子宮内膜症における腹水中NK細胞受容体の発現強度の解析2021

    • Author(s)
      佐伯信一朗、福井淳史、麦チューシャン、山谷文乃、竹山 龍、加藤徹、脇本 裕、柴原浩章
    • Organizer
      日本生殖医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 流産患者の脱落膜NK細胞NKp46発現、サイトカイン解析とその意義2021

    • Author(s)
      山谷文乃、福井淳史、麦チューシャン、佐伯信一朗、竹山龍、柴原浩章
    • Organizer
      日本生殖医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] NKp46は蛍光強度によって生殖に異なる影響を与えるのか2021

    • Author(s)
      麦チューシャン、福井淳史、佐伯信一朗、竹山龍、山谷文乃、柴原浩章
    • Organizer
      日本生殖医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Prediction of pregnancy outcome using NKp46 expression on uterine NK cells2021

    • Author(s)
      Atsushi Fukui
    • Organizer
      米国生殖医学会(ASRM)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 子宮NK細胞に発現する活性性受容体と抑制性受容体共発現の意義2020

    • Author(s)
      竹山龍、福井淳史、柴原浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Do NKp46dim and NKp46bright receptors on uterine NK cell play different role in reproduction?2020

    • Author(s)
      Chuxian Mai, Atsushi Fukui, Hiroaki Shibahara
    • Organizer
      日本産科婦人科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 不育症・着床不全症例に対する免疫グロブリン療法・イントラリピッド療法2020

    • Author(s)
      福井淳史
    • Organizer
      東北ART研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Recent available endometrial evaluation in IVF-ET program using endometrial immunological analysis2020

    • Author(s)
      Atsushi Fukui
    • Organizer
      米国生殖医学会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 反復着床不全とNK細胞2020

    • Author(s)
      福井淳史
    • Organizer
      日本受精着床学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 子宮内膜NK細胞に発現する受容体共発現とサイトカイン産生の意義2019

    • Author(s)
      竹山龍、福井淳史、柴原浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Co-expression of CD16 and other inhibitory or activating receptors on uterine endometrial NK cells2019

    • Author(s)
      Chuxian Mai, Atsushi Fukui, Maya Omote, Yuta Fujii, Ryu Takeyama, Yuji Ukita, Hiroaki Shibahara
    • Organizer
      日本産科婦人科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Stimulation method using semen for uterine NK cells and cytokine production of women with unexplained recurrent pregnancy loss2019

    • Author(s)
      Ayako Taima, Atsushi Fukui, Ayano Funamizu, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama
    • Organizer
      日本産科婦人科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 着床周辺期における免疫異常とその対策2019

    • Author(s)
      福井淳史
    • Organizer
      着床ワークショップ in 沖縄
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 反復着床不全の病態解明への免疫学的な取り組み2019

    • Author(s)
      浮田祐司、福井淳史、浮田美里、表 摩耶、杉山由希子、藤井雄太、 竹山 龍、加藤 徹、脇本 裕、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 子宮NK細胞に発現する活性性受容体と2019

    • Author(s)
      竹山龍、福井 淳史、山谷文乃、福原理恵、横山良仁、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 反復着床不全患者に対する治療成績の検討2019

    • Author(s)
      浮田美里、浮田祐司、表摩耶、杉山由希子、藤井雄太、 竹山龍、加藤徹、脇本 裕、福井淳史、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2019 Research-status Report
  • [Presentation] NK細胞におけるCD16発現の違いは生殖に影響を与えるのか?2019

    • Author(s)
      麦楚、福井淳史、竹山龍、山本真由、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 妊娠の成立維持におけるNK細胞の関わり2019

    • Author(s)
      福井淳史
    • Organizer
      せとうちART研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 着床環境と免疫2019

    • Author(s)
      福井淳史
    • Organizer
      日本卵子学会生殖補助医療胚培養士セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Immunological abnormality and its modification for women with IVF failures2019

    • Author(s)
      Atsushi Fukui, Ryu Takeyama, Chuxian Mai, Mayu Yamamoto, Ayano Yamaya, Megumi Yokota, Yuji Ukita, Rie Fukuihara, Hiroaki Shibahara
    • Organizer
      国際生殖免疫学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Relationship between NCR expression on NK cells and natural pregnancies after surgical treatment for severe endometriosis2019

    • Author(s)
      Ayano Yamaya, Atsushi Fukui, Ayako Taima, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama
    • Organizer
      国際生殖免疫学会
    • Related Report
      2019 Research-status Report
  • [Presentation] The expression of NKp46 on uterine NK cells and Cytokines Production by NK cells in women with recurrent pregnancy loss2019

    • Author(s)
      Mayu Yamamoto, Atsushi Fukui, Ryu Takeyama, Mai Chuxian, Yuji Ukita, Hiroaki Shibahara
    • Organizer
      国際生殖免疫学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Cytokines production and co-expression of activating and inhibitory receptors of uterine NK cells in women with RPL2019

    • Author(s)
      Ryu Takeyama, Atsushi Fukui, Ayano Yamaya, Yuji Ukita, Mayu Yamamoto, Mai Chuxian, Hiroaki Shibahara
    • Organizer
      国際生殖免疫学会
    • Related Report
      2019 Research-status Report
  • [Presentation] In regards to different density of CD16 on NK cells, are they play different role in reproductive outcome?2019

    • Author(s)
      麦楚嫻、福井淳史、竹山龍、山本真由、柴原浩章
    • Organizer
      国際生殖免疫学会
    • Related Report
      2019 Research-status Report
  • [Presentation] NK細胞におけるCD16発現の違いは生殖に影響を与えるのか?2019

    • Author(s)
      麦楚、福井淳史、竹山龍、山本真由、柴原浩章
    • Organizer
      日本生殖医学会会
    • Related Report
      2019 Research-status Report
  • [Presentation] RPL女性における子宮内膜NK細胞の活性性受容体と抑制性受容体の共発現とサイトカイン産生2019

    • Author(s)
      竹山龍、福井 淳史、麦楚、山本真由、山谷 文乃、浮田 祐司、柴原 浩章
    • Organizer
      日本生殖医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 免疫異常を有する着床不全・不育症患者に対するイントラリピッド療法の検討2019

    • Author(s)
      横田恵、福原理恵、福井淳史、横山良仁
    • Organizer
      日本生殖医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 子宮内膜NK細胞に発現する活性性および抑制性受容体共発現の意義2018

    • Author(s)
      福井淳史、柴原浩章
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 子宮内膜NK細胞に発現する受容体共発現の不育症症例における意義2018

    • Author(s)
      竹山龍、福井淳史、柴原浩章
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Successful pregnancy in a case of repeated implantation failure (RIF) due to elevated Th1/Th2 using intravenous immunoglobulin treatment (IVIG)2018

    • Author(s)
      Shibahara H, Omote M, Takeyama R, Sugiyama Y, Fujii Y, Ukita Y, Wakimoto Y, Fukui A
    • Organizer
      American Society for reproductive immunology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Natural cytotoxicity receptors expression and cytokines production of natural killer cells in patients with endometriosis2018

    • Author(s)
      Ayano Yamaya, Atsushi Fukui, Ayako Taima, Kohei Fuchinoue, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama
    • Organizer
      American Society for reproductive immunology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The co-expression of activating and inhibitory receptors and cytokines production for uterine NK cells2018

    • Author(s)
      Ryu Takeyama, Atsushi Fukui, Ayano Funamizu, Yu Wakimoto, Rie Fukuhara, Akiko Hasegawa, Hiroaki Shibahara
    • Organizer
      American Society for reproductive immunology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Co-expression of activating and inhibitory receptors on uterine endometrial NK cells2018

    • Author(s)
      Atsushi Fukui, Ryu Takeyama, Ayano Yamaya, Yu Wakimoto, Rie Fukuhara, Akiko Hasegawa, Hiroaki Shibahara
    • Organizer
      American Society for reproductive immunology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ability of cytokines production by uterine NK cell stimulated by semen2018

    • Author(s)
      Ayako Taima, Atsushi Fukui, Ayano Funamizu, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama
    • Organizer
      American Society for reproductive immunology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] NK cell abnormality and its treatment in women with reproductive failures2018

    • Author(s)
      Fukui A, Funamizu A, Takeyama R, Yokota M, Fukuhara R, Shibahara H
    • Organizer
      International symposium for immunology of reproducvtion
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 子宮NK細胞に発現する受容体共発現の意義2018

    • Author(s)
      竹山龍、福井淳史、柴原浩章
    • Organizer
      第36回日本受精着床学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 子宮内膜NK細胞に発現する 活動性と抑制性受容体共発現の意義2018

    • Author(s)
      竹山 龍, 福井 淳史, 山谷 文乃, 福原 理恵, 横山 良仁, 柴原浩章
    • Organizer
      第63回日本生殖医学会学術講演会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 子宮NK細胞に発現する活性性および抑制性受容体共発現とサイトカイン産生の意義2018

    • Author(s)
      竹山龍、福井淳史、山谷文乃、福原理恵、杉山由希子、脇本裕、横山良仁、柴原浩章
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] NK細胞産生サイトカインおよびNK1/NK2比をより簡便・確実に測定する2018

    • Author(s)
      山本真由、福井淳史、麦楚嫻、竹山龍、藤井雄太、浮田祐司、柴原浩章
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] NK細胞上CD16発現強度の違いによるNK細胞機能の検討2018

    • Author(s)
      麦楚嫻、福井淳史、竹山龍、山本真由、表摩耶、加藤徹、柴原浩章
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 精液刺激法による2018

    • Author(s)
      當麻絢子、福井淳史、山谷文乃、横田恵 福原理恵、横山良仁
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 子宮内膜NK細胞に発現する活性性および抑制性受容体共発現の生理学的意義2017

    • Author(s)
      福井淳史、淵之上康平、船水文乃、柴原浩章
    • Organizer
      日本産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮内膜症における子宮内膜NK細胞Natural Cytotoxicity Receptor発現2017

    • Author(s)
      船水文乃、福井淳史、當麻絢子、淵之上康平、福原理恵、横山良仁
    • Organizer
      日本産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] サイトカインと着床2017

    • Author(s)
      福井淳史
    • Organizer
      着床Workshop in Okinawa
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 子宮内膜症患者の子宮内膜NK細胞におけるNatural Cytotoxicity Receptor発現2017

    • Author(s)
      船水文乃、福井淳史、福原理恵、當麻絢子、佐々木幸江、中村理果、横山良仁
    • Organizer
      日本受精着床学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 精液刺激により産生された子宮内膜NK細胞サイトカインの検討2017

    • Author(s)
      當麻絢子、福井淳史、淵之上康平、千葉仁美、鴨井舞衣、船水文乃、福原理恵、横山良仁
    • Organizer
      日本産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 不育症症例における子宮内膜NK細胞に発現する活性性および抑制性受容体共発現の意義2017

    • Author(s)
      竹山龍、福井淳史、淵之上康平、船水文乃、福原理恵、柴原浩章
    • Organizer
      日本受精着床学会
    • Related Report
      2017 Research-status Report
  • [Presentation] NK cells and reproduction ~our progress in NK cell study~2017

    • Author(s)
      Atsushi Fukui, Ayano Funamizu, Rie Fukuhara, Ryu Takeyama, Yu Wakimoto, Akiko Hasegawa, Hiroaki Shibahara
    • Organizer
      American Society for Reproductive Immunology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The co-expression of activating and inhibitory receptors and cytokines production for uterine NK cells2017

    • Author(s)
      Ryu Takeyama, Atsushi Fukui, Ayano Funamizu, Yu Wakimoto, Rie Fukuhara, Akiko Hasegawa, Hiroaki Shibahara
    • Organizer
      American Society for Reproductive Immunology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of NK cells in reproduction2017

    • Author(s)
      Atsushi Fukui
    • Organizer
      Symposium of KYU priority Research Center
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 子宮内膜NK細胞に発現する活性性および抑制性受容体共発現2017

    • Author(s)
      竹山龍、福井淳史、淵之上康平、船水文乃、福原理恵、柴原浩章
    • Organizer
      日本生殖医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮内膜NK細胞に発現する受容体共発現の不育症症例における意義2017

    • Author(s)
      竹山龍、福井淳史、淵之上康平、船水文乃、福原理恵、柴原浩章
    • Organizer
      日本生殖免疫学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮内膜症における子宮内膜NK細胞NKp46発現2017

    • Author(s)
      船水文乃、福井淳史、當麻絢子、横田恵、福原理恵、佐々木幸江、中村理果、横山良仁
    • Organizer
      日本生殖免疫学会
    • Related Report
      2017 Research-status Report
  • [Presentation] NK細胞異常を有する不妊症・不育症に対する新しい治療法2016

    • Author(s)
      福井淳史
    • Organizer
      日本生殖免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 不育症患者の子宮内膜NK細胞における活性性・抑制性レセプターの共発現についての検討2016

    • Author(s)
      加藤暢子、福井淳史、淵之上康平、當麻絢子、船水文乃、横山良仁
    • Organizer
      日本生殖免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] NK cell abnormality and its treatment in women with reproductive failures such as implantation failure and recurrent pregnancy loss2016

    • Author(s)
      福井淳史
    • Organizer
      日韓ARTカンファレンス
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2024-01-30  

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