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Development of a new treatment for young women with early stage of uterine endometrial cancer to preserve their fertility

Research Project

Project/Area Number 16K11086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

KOYAMA SHINSUKE  大阪大学, 医学系研究科, 招へい教員 (30528005)

Co-Investigator(Kenkyū-buntansha) 中村 仁美  大阪大学, 医学系研究科, 助教 (80467571)
木村 正  大阪大学, 医学系研究科, 教授 (90240845)
熊澤 惠一  東京大学, 医学部附属病院, 講師 (90444546)
Research Collaborator KOIZUMI Kaori  大阪大学, 大学院医学系研究科 産婦人科
KANEDA Yasufumi  大阪大学, 大学院医学系研究科 遺伝子治療学
NISAHIKAWA Tomoyuki  大阪大学, 大学院医学系研究科 遺伝子治療学
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生殖医学 / 妊孕性温存 / 初期子宮体癌
Outline of Final Research Achievements

Diagnosis of uterine endometrial cancer have increased worldwide in recent years. The standard initial treatment for endometrial cancer is hysterectomy, bilateral salpingo-oophorectomy, and assessment of retroperitoneal lymph nodes. It has been reported that approximately 5.5% of women with endometrial cancer are younger than 40 years of age in Japan. Young women with endometrial cancer often show a history of ovary dysfunction, anovulation, primary sterility (have never been pregnant), and they have a strong desire to preserve fertility. It is necessary to develop a new treatment, which can be administrated to the uterine locally and can re-target cancer cells to save normal cells for fertility preservation. In the current study, we developed a local uterine gene delivery system using HVJ-E vector. In this study we tried to optimize HVJ-E vector to treat young women with early stage of uterine endometrial cancer to preserve their fertility.

Academic Significance and Societal Importance of the Research Achievements

ヒト子宮は経腟的に直接的なアプローチができる臓器であるにもかかわらず、現在子宮に対するdrug delivery system (DDS)としては子宮内避妊器具であるレボノルゲストレル徐放型子宮内避妊システムおよびプロゲステロン腟坐剤しかない。動物モデルにおける子宮に対する遺伝子導入方法ですら、遺伝子導入効率を検討されたものはあまりない。HVJ-Eベクターは子宮に高効率に遺伝子導入できる事が確認されている。HVJ-Eベクターそのものの抗腫瘍効果だけでなく、高濃度のプロゲステロンや抗がん剤をHVJ-Eベクターにより送達する事により、より短期間に効果的な治療方法が提案できる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (89 results)

All 2019 2018 2017 2016 2015

All Journal Article (35 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 32 results,  Open Access: 18 results,  Acknowledgement Compliant: 3 results) Presentation (54 results)

  • [Journal Article] Novel biomarker profiles in experimental aged maternal mice with hypertensive disorders of pregnancy.2019

    • Author(s)
      Furuya, K. Kumasawa, K. Nakamura, H. Nishimori, K. Kimura, T.
    • Journal Title

      Hypertens Res.

      Volume: 42(1) Issue: 1 Pages: 29-39

    • DOI

      10.1038/s41440-018-0092-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertensive disorders of pregnancy: Disease models2019

    • Author(s)
      Furuya, K. Kumasawa, K. Nakamura, H. Iriyama, T. Nagamatsu, T. Osuga, Y. Fujii, T.
    • Journal Title

      Journal of Translational Science D

      Volume: Epub ahead of print Issue: 1 Pages: 1-5

    • DOI

      10.15761/jts.1000314

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arginase controls soluble vascular endothelial growth factor receptor 1 (sFlt1) to maintain pregnancy homeostasis2018

    • Author(s)
      Tanaka Hiroko、Kumasawa Keiichi、Kakigano Aiko、Mimura Kazuya、Endo Masayuki、Tomimatsu Takuji、Kimura Tadashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 499 Issue: 2 Pages: 150-155

    • DOI

      10.1016/j.bbrc.2018.03.086

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Obstetric outcome in patients with a unicornuate uterus after laparoscopic resection of a rudimentary horn2018

    • Author(s)
      Sawada, M. Kakigano, A. Matsuzaki, S. Takiuchi, T. Mimura, K. Kumasawa, K. Endo, M. Ueda, Y. Yoshino, K. Kimura, T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: - Issue: 6 Pages: 1080-1086

    • DOI

      10.1111/jog.13622

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogels on frozen-thawed human ovarian tissue in a xenograft model2018

    • Author(s)
      Tanaka, A. Nakamura, H. Tabata, Y. Fujimori, Y. Kumasawa, K. Kimura, T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 44 Issue: 10 Pages: 1947-1955

    • DOI

      10.1111/jog.13726

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of pregnancy after frozen-thawed embryo transfer via in vivo intrauterine oxidation-reduction potential measurements: a pilot study2018

    • Author(s)
      Nakamura, H. Hosono, T. Taniguchi, T. Kumasawa, K. Goa, S. Ono, M. Kimura, T.
    • Journal Title

      Reprod Med Biol

      Volume: 17 Issue: 3 Pages: 255-261

    • DOI

      10.1002/rmb2.12098

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vaginal bioelectrical impedance determines uterine receptivity in mice2018

    • Author(s)
      Nakamura, H. Hosono, T. Kumasawa, K. Jones, C. J. P. Aplin, J. D. Kimura, T.
    • Journal Title

      Hum Reprod

      Volume: 33 Pages: 2241-2248

    • DOI

      10.1093/humrep/dey313

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Are naive T cells and class-switched memory (IgD(-) CD27(+)) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy2018

    • Author(s)
      Shigeta, N. Nakamura, H. Kumasawa, K. Imai, K. Saito, S. Sakaguchi, S. Kimura, T.
    • Journal Title

      Med Hypotheses

      Volume: 121 Pages: 36-41

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension2018

    • Author(s)
      Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, Kumasawa K, Yoshimori T, Ikawa M, Saito S
    • Journal Title

      Am. J. Pathol.

      Volume: 188 Issue: 11 Pages: 2474-2486

    • DOI

      10.1016/j.ajpath.2018.07.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of pregnancy after frozen-thawed embryo transfer via in vivo intrauterine oxidation-reduction potential measurements:a pilot study2018

    • Author(s)
      Nakamura, H. Hosono, T. Taniguchi, T. Kumasawa, K. Goa, S. Ono, M. Kimura, T.
    • Journal Title

      Reprod Med Biol

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel biomarker profiles in experimental aged maternal mice with hypertensive disorders of pregnancy2018

    • Author(s)
      Furuya, K. Kumasawa, K. Nakamura, H. Nishibori, K. Kimura, T.
    • Journal Title

      Hypertension Research

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arginase controls soluble vascular endothelial growth factor receptor 1(Flt1) to maintain pregnancy homeostasis2018

    • Author(s)
      Tanaka, H. Kumasawa, K. Kakigano, A. Mimura, K. Endo, M. Tomimatsu, T. Kimura, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble Flt-1 has cytotoxic effects on BeWo choriocarcinoma cells2017

    • Author(s)
      Yamashita, M. Kumasawa, K. Miyake, T. Nakamura, H. Kimura, T.
    • Journal Title

      Reprod Sci

      Volume: - Issue: 6 Pages: 830-836

    • DOI

      10.1177/1933719117698575

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective evaluation of uterine receptivity in mice2017

    • Author(s)
      Nakamura, H. Hosono, T. Kumasawa, K. Kimura, T.
    • Journal Title

      Reprod Fertil Dev

      Volume: - Issue: 4 Pages: 619-623

    • DOI

      10.1071/rd17209

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of lipid metabolism on male fertility2017

    • Author(s)
      Kim N, Nakamura H, Masaki H, Kumasawa K, Hirano KI, Kimura
    • Journal Title

      Biochem Biophs Res Commun

      Volume: 8;485(3) Issue: 3 Pages: 686-692

    • DOI

      10.1016/j.bbrc.2017.02.103

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-chain fatty acid triglyceride (TG) metabolism disorder impairs male fertility: a study using adipose triglyceride lipase deficient mice2017

    • Author(s)
      Masaki, H. Kim, N. Nakamura, H. Kumasawa, K. Kamata, E. Hirano, K. I. Kimura, T.
    • Journal Title

      Mol Hum Reprod

      Volume: 23 Issue: 7 Pages: 452-460

    • DOI

      10.1093/molehr/gax031

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment and repair of uterine scar dehiscence during cesarean section2017

    • Author(s)
      Sawada, M. Matsuzaki, S. Nakae, R. Iwamiya, T. Kakigano, A. Kumasawa, K. Ueda, Y. Endo, M. Kimura, T.
    • Journal Title

      Clin Case Rep

      Volume: 5 Issue: 2 Pages: 145-149

    • DOI

      10.1002/ccr3.766

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of acute sheehan’s syndrome and literature review: a rare but life-threatening complication of postpartum hemorrhage2017

    • Author(s)
      Matsuzaki, S. Endo, M. Ueda, Y. Mimura, K. Kakigano, A. Egawa-Takata, T. Kumasawa, K. Yoshino, K. Kimura, T.
    • Journal Title

      BMC Pregnancy Childbirth

      Volume: 17 Issue: 1 Pages: 188-188

    • DOI

      10.1186/s12884-017-1380-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery2017

    • Author(s)
      Owa, T. Mimura, K. Kakigano, A. Matsuzaki, S. Kumasawa, K. Endo, M. Tomimatsu, T. Kimura, T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Issue: 7 Pages: 1132-1138

    • DOI

      10.1111/jog.13336

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of perioperative complications associated with uterine compression sutures2017

    • Author(s)
      Suzuki, Y. Matsuzaki, S. Mimura, K. Kumasawa, K. Tomimatsu, T. Endo, M. Kimura, T.
    • Journal Title

      Int J Gynaecol Obstet

      Volume: 139 Issue: 1 Pages: 28-33

    • DOI

      10.1002/ijgo.12249

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful anticoagulant therapy for disseminated intravascular coagulation during conservative management of placenta percreta: a case report and literature review2017

    • Author(s)
      Matsuzaki, S. Yoshino, K. Endo, M. Tomimatsu, T. Takiuchi, T. Mimura, K. Kumasawa, K. Ueda, Y. Kimura, T.
    • Journal Title

      BMC Pregnancy Childbirth

      Volume: 17 Issue: 1 Pages: 443-443

    • DOI

      10.1186/s12884-017-1634-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery2017

    • Author(s)
      Owa T, Mimura K, Kakigano A, Matsuzaki S, Kumasawa K, Endo M, Tomimatsu T, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: in press

    • Related Report
      2016 Research-status Report
  • [Journal Article] Placenta accreta following laparoscopic adenomyomectomy: a case report2017

    • Author(s)
      Matsuzaki S, Yoshino K, Tomimatsu T, Takiuchi T, Kumasawa K, Kimura T.
    • Journal Title

      CEOG

      Volume: in press

    • Related Report
      2016 Research-status Report
  • [Journal Article] Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction.2016

    • Author(s)
      Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T.
    • Journal Title

      Hypertens Res

      Volume: 40(4) Issue: 4 Pages: 305-310

    • DOI

      10.1038/hr.2016.152

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Placenta accreta following hysteroscopic myomectomy.2016

    • Author(s)
      Tanaka M, Matsuzaki S, Matsuzaki S, Kakigano A, Kumasawa K, Ueda Y, Endo M, Kimura T.
    • Journal Title

      Clin Case Rep

      Volume: 4(6) Issue: 6 Pages: 541-544

    • DOI

      10.1002/ccr3.562

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of abdominal pregnancy following in vitro fertilization and embryo transfer treated with laparoscopic surgery2016

    • Author(s)
      Koyama S, Yoshino A, Okuno K, Naoi H, Watanabe M, Ozaki K, Shiki Y.
    • Journal Title

      Gynecol Minim Invasive Ther

      Volume: 5 Issue: 3 Pages: 132-133

    • DOI

      10.1016/j.gmit.2015.04.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased Anti-mullerian Hormone (AMH) after delivery: case report2016

    • Author(s)
      Kumasawa K, Yasui Y, Nakamura H, Kimura T.
    • Journal Title

      Gynecol Obstet

      Volume: 4 Issue: 3 Pages: 17-18

    • DOI

      10.11648/j.jgo.20160403.12

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case report of conjoined oocytes with independent zona pellucida from polycystic ovary syndrome2016

    • Author(s)
      Tanaka A, Nakamura H, Kumasawa K, Tsutsui T, Furuya K, Kim N, Koizumi K, Kimura T.
    • Journal Title

      Gynecol Obstet

      Volume: 4 Issue: 5 Pages: 25-29

    • DOI

      10.11648/j.jgo.20160405.11

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] History of chiamydia trachomatis infection threatens fertility in women with unilateral tubal occlusion2016

    • Author(s)
      Goa S, Kumasawa K, Ono M, Taniguchi T.
    • Journal Title

      Gynecol Obstet

      Volume: 4 Issue: 6 Pages: 34-37

    • DOI

      10.11648/j.jgo.20160406.11

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report2016

    • Author(s)
      Koyama S, Okuno K, Naoi H, Watanabe M, Ozaki K, Shiki, Y.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 42 Issue: 4 Pages: 467-470

    • DOI

      10.1111/jog.12930

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cervical varix complicated by placenta previa: A case report and literature review.2016

    • Author(s)
      Tanaka M, Matsuzaki S, Kumasawa K, Suzuki Y, Endo M, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 42 Issue: 7 Pages: 883-889

    • DOI

      10.1111/jog.12969

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful conservative management of placenta percreta: Investigation by serial magnetic resonance imaging of the clinical course and a literature review.2016

    • Author(s)
      Sawada M, Matsuzaki S, Mimura K, Kumasawa K, Endo M, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 42 Issue: 12 Pages: 1858-1863

    • DOI

      10.1111/jog.13121

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells.2016

    • Author(s)
      Miyake T, Kumasawa K, Sato N, Takiuchi T, Nakamura H, Kimura T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 24853-24853

    • DOI

      10.1038/srep24853

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 陣痛(分娩)発来機序2016

    • Author(s)
      古谷毅一郎、熊澤恵一、木村正
    • Journal Title

      周産期医学

      Volume: 46 Pages: 271-275

    • Related Report
      2016 Research-status Report
  • [Journal Article] Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.2015

    • Author(s)
      Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
    • Journal Title

      Gynecol Obstet Invest

      Volume: Epub ahead of print Issue: 4 Pages: 1-6

    • DOI

      10.1159/000441780

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 当院における医学的適応による妊孕性温存の現状2019

    • Author(s)
      山田光泰. 伴田美佳. 佐治史恵. 三宅達也. 中村仁美. 瀧内 剛. 木村 正.
    • Organizer
      第7回関西生殖医学集談会 第51回関西アンドロロジーカンファレンス
    • Related Report
      2018 Annual Research Report
  • [Presentation] Obstetric and neonatal complications in pregnancies achieved by oocyte donation in our institution2018

    • Author(s)
      Takahashi, N. Miyake, T. Nakamura, H. Kakigano, A. Takiuchi, T. Matsuzaki, S. Mimura, K. Kumasawa, K. Tomimatsu, T. Endo, M. Kimura, T.
    • Organizer
      第70日本産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A novel of biomarker profiles in experimental aged maternal mouse with hypertensive disorders of pregnancy2018

    • Author(s)
      Furuya, K. Kumasawa, K. Nakamura, H. Kimura, T.
    • Organizer
      第70日本産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The efficacy of uterine compression suture as a procedure in the management of primary atonic bleedin : a historical cohort study2018

    • Author(s)
      Sawada, M. Matsuzaki, S. Miyake, T. Kakigano, A. Takiuchi, T. Mimura, K. Kumasawa, K. Endo, M. Tomimatsu, T. Kimura, T.
    • Organizer
      第70日本産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Obstetric Outcome of Subsequent Pregnancy following Uterine Artery Embolization for postpartum hemorrhage2018

    • Author(s)
      Jitsumori, M. Mastuzaki, S. Miyake, T. Kakigano, A. Takiuchi, T. Mimura, K. Kumasawa, K. Endo, M. Tomimatsu, T. Kimura, T.
    • Organizer
      第70日本産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Promotion of a new technique for cesarean section at full dilatation2018

    • Author(s)
      Shimura, K. Kakigano, A. Miyake, T. Takiuchi, T. Matsuzaki, S. Mimura, K. Kumasawa, K. Endo, M. Tomimatsu, T. Kimura, T.
    • Organizer
      第70日本産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Robson 分類による分娩の評価2018

    • Author(s)
      清水亜麻. 味村和哉. 三宅達也. 柿ヶ野藍子. 松崎慎哉. 熊澤恵一. 遠藤誠之. 脇本 哲. 田口貴子. 竹村昌彦. 冨松拓治. 木村 正.
    • Organizer
      第70回日本産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院における無痛分娩の検討2018

    • Author(s)
      小谷知紘. 橋本香映. 中塚えりか. 三宅達也. 柿ヶ野藍子. 松崎慎哉. 味村和也. 熊澤恵一. 遠藤誠之. 木村 正.
    • Organizer
      第138回近畿産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊娠後期のNIPTにてTrisomy13陽性となり,診断確定前の管理方針に苦慮した1例2018

    • Author(s)
      鈴木敦子. 味村和哉. 三宅達也. 中塚えりか. 柿ケ野藍子. 松崎慎哉. 熊澤恵一. 遠藤誠之. 木村 正.
    • Organizer
      第138回近畿産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分娩後に網膜剥離を発症した妊娠高血圧腎症の一例2018

    • Author(s)
      角田紗保里. 柿ヶ野藍子. 中塚えりか. 三宅達也. 松崎慎哉. 味村和哉. 熊澤惠一. 遠藤誠之. 木村 正.
    • Organizer
      第138回近畿産科婦人科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 前置胎盤に対する産褥子宮全摘術後の病理組織検査で子宮体癌が判明した1例2018

    • Author(s)
      塩見真由. 松崎慎哉. 田中稔恵. 澤田真明. 三宅達也. 柿ヶ野藍子. 味村和哉. 熊澤惠一. 遠藤誠之. 木村 正.
    • Organizer
      第54回日本周産期・新生児医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 前置癒着胎盤の子宮内胎児死亡症例に対して待機療法後経腟分娩を行った1例2018

    • Author(s)
      谷口茉利子. 松崎慎哉. 三宅達也. 柿ヶ野藍子. 味村和哉. 熊澤惠一. 遠藤誠之. 冨松拓治. 木村 正.
    • Organizer
      第54回日本周産期・新生児医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 担癌患者の妊娠症例に関する後方視的検討2018

    • Author(s)
      柿ヶ野藍子. 三宅達也. 瀧内 剛. 松崎慎哉. 味村和哉. 熊澤惠一. 遠藤誠之. 冨松拓治. 木村 正.
    • Organizer
      第54回日本周産期・新生児医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院における妊娠中期の中絶や流産処置を行った335例の検討2018

    • Author(s)
      味村和哉. 遠藤誠之. 三宅達也. 柿ヶ野藍子. 瀧内 剛. 松崎慎哉. 熊澤惠一. 冨松拓治. 木村 正.
    • Organizer
      第54回日本周産期・新生児医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊娠中に初めて診断された巨大腎血管筋脂肪腫合併妊娠の1例2018

    • Author(s)
      祝小百合. 柿ヶ野藍子. 三宅達也. 瀧内 剛. 松崎慎哉. 味村和哉. 熊澤惠一. 遠藤誠之. 冨松拓治. 木村 正.
    • Organizer
      第54回日本周産期・新生児医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂質代謝と男性生殖-基礎検討からの提案-2018

    • Author(s)
      中村仁美. 金 南孝. 正木秀武. 熊澤恵一. 平野賢一. 木村 正.
    • Organizer
      中村仁美. 金 南孝. 正木秀武. 熊澤恵一. 平野賢一. 木村 正.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当施設における卵子提供により妊娠症例18症例の周産期および新生児予後に関する検討2018

    • Author(s)
      三宅達也. 高橋直子. 山田光泰. 福田弥生. 小泉花織. 中村仁美. 瀧内 剛. 熊澤恵一. 木村 正.
    • Organizer
      第63回日本生殖医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Preeclampsiaの診断と治療~日本発のエビデンス2018

    • Author(s)
      熊澤恵一
    • Organizer
      第39回 日本妊娠高血圧学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] FGRの新しい治療方法2018

    • Author(s)
      熊澤恵一
    • Organizer
      第6回 新胎児研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂質代謝の男性生殖能に対する影響2018

    • Author(s)
      金南孝、中村仁美、正木秀武、熊澤恵一、平野賢一、木村正
    • Organizer
      第6回関西生殖医学集談会第50回関西アンドロロジーカンファレンス合同研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院で妊娠中に抗凝固療法を施行した症例の検討2018

    • Author(s)
      神田昌子、熊澤恵一、河田真由子、伴田美佳、高橋直子、田中雄介、山田光泰、桑鶴知一郎、福田弥生、山下美智子、佐藤紀子、小泉花織、三宅達也、瀧内剛、中村仁美、木村正
    • Organizer
      第6回関西生殖医学集談会第50回関西アンドロロジーカンファレンス合同研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮底部横切開を行った30 例の後方視的検討2017

    • Author(s)
      澤田真明. 松崎慎哉. 木瀬康人. 岩宮 正. 味村和哉. 熊澤恵一. 遠藤誠之. 冨松拓治. 木村 正.
    • Organizer
      第69回日本産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Obstetric outcome of Jehovah’s Witnesses:a single-institution experience2017

    • Author(s)
      Tanaka, M., Matsuzaki, S., Kakigano, A., Kinose, Y., Iwamiya, T., Mimura, K., Kumasawa, K., Endo, M.Kimura, T.
    • Organizer
      第69回日本産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 双胎妊娠一児無脳症の2症例2017

    • Author(s)
      中江 彩. 味村和哉. 岩宮 正. 瀧内 剛. 松崎慎哉. 熊澤恵一. 遠藤誠之. 木村 正.
    • Organizer
      第136回近畿産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当科における腹腔鏡手術における術中出血対処法2017

    • Author(s)
      志岐保彦. 藤原 奨. 八木茉莉. 白石真理子. 栗谷健太郎. 渡辺正洋. 香山晋輔.
    • Organizer
      第136回近畿産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト凍結融解卵巣組織移植片における生体分解ゼラチンハイドロゲルを用いたbasic fibroblast growth (bFGF)徐放の効果2017

    • Author(s)
      田中絢香. 中村仁美. 田畑泰彦. 藤森由香. 熊澤恵一. 木村 正.
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Preeclampsiaを合併した巨大絨毛膜下血腫の一例2017

    • Author(s)
      塩見真由. 岩宮 正. 山下紗弥. 甲村奈緒子. 瀧内 剛. 味村和哉. 松崎慎哉. 熊澤惠一. 遠藤誠之. 木村 正.
    • Organizer
      第53回日本周産期・新生児医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] エホバの証人の分娩転帰2017

    • Author(s)
      田中稔恵. 松崎慎哉. 柿ヶ野藍子. 木瀬康人. 岩宮 正. 味村和哉. 熊澤惠一. 遠藤誠之. 木村 正.
    • Organizer
      第53回日本周産期・新生児医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院における妊娠中期中絶症例について2017

    • Author(s)
      遠藤誠之. 松崎慎哉. 熊澤惠一. 味村和哉. 瀧内 剛. 柿ヶ野藍子.
    • Organizer
      第53回日本周産期・新生児医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 分娩後大量出血に対する子宮動脈塞栓術により内側の大部分が壊死した子宮を温存し、月経が再開した一例2017

    • Author(s)
      瀧内 剛. 柿ヶ野藍子. 松崎慎哉. 熊澤恵一, 遠藤誠之. 木村 正.
    • Organizer
      第53回日本周産期・新生児医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Breakdown of loop electrode of bipolar TCR due to unexpected contact with return-electrode in fibroid resection2017

    • Author(s)
      Shiki, Y. Kuroda, M. Deguchi, T. Shiraishi, M. Kuritani, K. Watanabe, M. Koyama, S.
    • Organizer
      18th APAGE Annual Congress 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Laparoscopic surgery using decomposable needle-shaft clamp in malignant cases; reduced port diameter instead of reduced port number2017

    • Author(s)
      Shiki, Y. Kuroda, M. Deguchi, T. Shiraishi, M. Kuritani, K. Watanabe, M. Koyama, S.
    • Organizer
      18th APAGE Annual Congress 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Management of intraoperative hemorrhage in laparoscopic surgery2017

    • Author(s)
      Shiki, Y. Kuroda, M. Deguchi, T. Shiraishi, M. Kuritani, K. Watanabe, M. Koyama, S.
    • Organizer
      18th APAGE Annual Congress 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Strategy for laparoscopic hysterectomy with extensive intraabdominal adhesion due to previous cesarean section2017

    • Author(s)
      Shiki, Y. Kuroda, M. Deguchi, T. Shiraishi, M. Kuritani, K. Watanabe, M. Koyama, S.
    • Organizer
      18th APAGE Annual Congress 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Venous anastomosis on proximal side of deep uterine vein: unmasking difficulty inherent in manipulating posterior leaf of VUL2017

    • Author(s)
      Shiki, Y. Kuroda, M. Deguchi, T. Shiraishi, M. Kuritani, K. Watanabe, M. Koyama, S.
    • Organizer
      18th APAGE Annual Congress 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 排卵誘発から1週後に外因性hCGにより卵巣過剰刺激症候群を発症した1例2017

    • Author(s)
      香林正樹. 熊澤惠一. 山田光泰. 桑鶴知一郎. 福田弥生. 小泉花織. 瀧内 剛. 中村仁美. 木村 正.
    • Organizer
      第137回近畿産科婦人科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Uterine compression sutureに伴う周術期合併症の検討2017

    • Author(s)
      澤田真明. 松崎慎哉. 三宅達也. 柿ヶ野藍子. 味村和哉. 熊澤恵一. 遠藤誠之. 木村 正.
    • Organizer
      第40回日本産婦人科手術学会
    • Related Report
      2017 Research-status Report
  • [Presentation] A novel of biomarker profiles in experimental aged maternal mouse with pregnancy induced hypertension2016

    • Author(s)
      Kumasawa K, Nakamura H, Kimura T.
    • Organizer
      19th Congress of the Federation of Asia and Oceania Perinatal Societies (FAOPS 2016)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 子宮底部横切開の安全性・有用性における後方視的検討2016

    • Author(s)
      澤田真明、松崎慎哉、木瀬康人、松本有里、味村和哉、熊澤恵一. 遠藤誠之. 木村 正.
    • Organizer
      第39回日本産婦人科手術学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 分娩後子宮型羊水塞栓症にて心肺停止蘇生後,当院へ搬送となり母体死亡に至った1症例2016

    • Author(s)
      香林正樹、遠藤雅之、木瀬康人、岩宮 正、松崎慎哉、味村和哉、熊澤恵一、木村 正.
    • Organizer
      第135回近畿産科婦人科学会
    • Place of Presentation
      京都
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 成熟嚢胞性奇形腫の手術後に腹腔内播種を認めた一例2016

    • Author(s)
      小川美祈、藤谷真弓、出口朋実、渡邊佑子、行岡慶介、香山晋輔、塩路光徳、辻江智子、脇本昭憲.
    • Organizer
      第56回日本産科婦人科内視鏡学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 地域周産期母子医療センターよりハイボリュームセンターへの腹腔鏡下手術 研修:エクセルシートを用いたTLHにおける手術時間短縮と手技向上の試み2016

    • Author(s)
      塩路光徳、鶴長香南子、小川美祈、渡邊佑子、出口朋実、行岡慶介、香山晋輔、藤谷真弓、高橋佳世子、辻江智子、脇本昭憲、山本善光、足立和繁.
    • Organizer
      第56回日本産科婦人科内視鏡学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 腹腔鏡下付属器摘除術後に尿路感染、脱水症のため再入院となった独居高齢者の一例2016

    • Author(s)
      辻江智子、小川美祈、行岡慶介、香山晋輔、塩路光徳、藤谷真弓、徳平 厚、脇本昭憲.
    • Organizer
      第56回日本産科婦人科内視鏡学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 産褥出血後に発症した卵巣静脈血栓症の一例2016

    • Author(s)
      小川美祈、 辻江智子、 出口朋実.、渡邊佑子、行岡慶介、 池田佳代、香山晋輔、塩路光徳、藤谷真弓、蒲池圭一、徳平 厚、脇本昭憲.
    • Organizer
      第52回日本周産期・新生児医学会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 一卵性の二絨毛膜二羊膜双胎妊娠で,両児が軟骨無形成症であった症例2016

    • Author(s)
      李 享相、 瀧内 剛、遠藤誠之、柿ヶ野藍子、松本有里、 髙田友美、 松崎慎哉、熊澤惠一、夫 律子、木村 正.
    • Organizer
      第134回近畿産科婦人科学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Trophoblast specific conditional Atg7 knockout pregnant mice develop gestational hyoertension2016

    • Author(s)
      Aoki A, Nakashima A, Kumasawa, K, Saito S.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Soluble VEGF receptor 1 (sFLT1) induces death of ovarian and colorectal cancer cells in a non-apoptotic way2016

    • Author(s)
      Miyake T, Kumasawa K, Sato N, Takiuchi T, Nakamura H, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparative analysis of 15-years ago and the current cesarean delivery rates using 10-group classification2016

    • Author(s)
      Owa T, Mimura K, Kakigano A, Matsumono Y, Takata T, Matsuzaki S, Kumasawa K, Endo M, Tomimatsu T, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Cervical varix complicated by placenta previa: a case presentation and literature review2016

    • Author(s)
      Tanaka M, Matsuzaki S, Matsumoto Y, Kakigano A, Kumasawa K, Koyama S, Endo M, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Rule out the adherent placenta: evaluation with magnetic resonance imaging2016

    • Author(s)
      Okada A, Matsuzaki S, Matsumoto Y, Kakigano A, Kumasawa K, Koyama S, Endo M, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Succesful pregnancy in a woman complicated Stage 4 extracranial arteriovenous malformation with2016

    • Author(s)
      Yamada M, Kakigano A, Takiuchi T, Matsumoto Y, Matsuzaki S, Kumasawa K, Koyama S, Endo M, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Pregnancy-related cystic ovarian tumor-A case report2016

    • Author(s)
      Ito Y,Kakigano A, Takiuchi T, Matsumoot Y, Matsuzaki S, Kumasawa K, Koyama S, Endo M, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Obstetric outcome after laparoscopic removal of rudimentary horn2016

    • Author(s)
      Sawada M, Kakigano A, Matsumoto Y, Takata T, Matsuzaki S, Kumasawa K, Koyama S, Endo M, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Perioperative complications after uterine compression sutures2016

    • Author(s)
      Suzuki Y, Matsuzaki S, Matsumoto Y, Kakigano A, Takiuchi T, Kumasawa K, Koyama S, Endo M, Kimura T.
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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