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Analysis of biomarker for preemptive medicine from perinatal period to prevent the metabolic syndrome

Research Project

Project/Area Number 16K11088
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOkayama University

Principal Investigator

Masuyama Hisashi  岡山大学, 医歯薬学総合研究科, 教授 (30314678)

Co-Investigator(Kenkyū-buntansha) 平松 祐司  岡山大学, 医歯薬学総合研究科, 特命教授 (80218817)
Research Collaborator NOBUMOTO Etsuko  
MITSUI Takashi  
EGUCHI Takeshi  
TAMADA Shoko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsバイオマーカー / 妊娠糖尿病 / 妊娠高血圧症候群 / メタボリック症候群 / プログラミング / 胎生期 / 継代的影響
Outline of Final Research Achievements

The links between obesity in parents and their offspring and the role of genes and a shared environment are not completely understood. In this study, we examined whether the offspring from dams exposed to a high fat diet during pregnancy (OH mice) exhibited hypertension, insulin resistance and hyperlipidemia along with epigenetic changes in the expression of adipocytokine genes. Our data demonstrated that the exposure to an HFD in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin and leptin gene expressions.

Academic Significance and Societal Importance of the Research Achievements

母体肥満・耐糖能異常下の子宮内環境による胎児プログラミングの変化がもたらす肥満・耐糖能関連遺伝素因への影響を示す最適なバイオマーカー候補として、アディポサイトカイン遺伝子のエピゲノム変化を同定した。生活習慣病発症を抑制し健やかな次世代育成に繋がる“先制医療”の実用化を目指すためのヒトでの応用を目指す上での端緒となる基盤研究結果と考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (40 results)

All 2019 2018 2017 2016

All Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 20 results,  Open Access: 11 results,  Acknowledgement Compliant: 3 results) Presentation (16 results) (of which Invited: 11 results) Book (3 results)

  • [Journal Article] Successful Delivery after Abdominal Radical Trachelectomy, Using Transabdominal Cerclage in Early Pregnancy2019

    • Author(s)
      Tamada S, Masuyama H, Hayata K, Eto E, Mitsui T, Eguchi T, Maki J, Tani K.
    • Journal Title

      Acta Medica Okayama

      Volume: 73 Issue: 2 Pages: 173-176

    • DOI

      10.18926/AMO/56653

    • NAID

      120006620041

    • URL

      https://ousar.lib.okayama-u.ac.jp/56653

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sarcopenia Is Not a Prognostic Factor of Outcome in Patients With Cervical Cancer Undergoing Concurrent Chemoradiotherapy or Radiotherapy2019

    • Author(s)
      MATSUOKA HIROFUMI、NAKAMURA KEIICHIRO、MATSUBARA YUKO、IDA NAOYUKI、NISHIDA TAKESHI、OGAWA CHIKAKO、KATSI KUNIAKI、KANAZAWA SUSUMU、MASUYAMA HISASHI
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 2 Pages: 933-939

    • DOI

      10.21873/anticanres.13196

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT2019

    • Author(s)
      Suzumori N, Sekizawa A, Samura O, Yotsumoto J, Sago H,et al
    • Journal Title

      Prenatal Diagnosis

      Volume: 39(2) Issue: 2 Pages: 100-106

    • DOI

      10.1002/pd.5408

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of Angiogenic Factors via Protein Kinase C and Hypoxia-induced Factor-1α Pathways under High-glucose Conditions in the Placenta2018

    • Author(s)
      Mitsui T, Tani K, Maki J, Eguchi T, Tamada S, Eto E, Hayata K, Masuyama H.
    • Journal Title

      Acta Medica Okayama

      Volume: 72 Issue: 4 Pages: 359-367

    • DOI

      10.18926/AMO/56171

    • NAID

      120006501281

    • URL

      https://ousar.lib.okayama-u.ac.jp/56171

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Influence of Chemotherapy-Induced Peripheral Neuropathy on Quality of Life of Gynecologic Cancer Survivors2018

    • Author(s)
      Matsuoka Hirofumi、Nakamura Keiichiro、Matsubara Yuko、Ida Naoyuki、Saijo Masayuki、Ogawa Chikako、Masuyama Hisashi
    • Journal Title

      International Journal of Gynecologic Cancer

      Volume: 28 Issue: 7 Pages: 1394-1402

    • DOI

      10.1097/igc.0000000000001320

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.2018

    • Author(s)
      Haruma T, Nagasaka T, Nakamura K, Haraga J, Nyuya A, Nishida T, Goel A, Masuyama H, Hiramatsu Y
    • Journal Title

      PLoS One

      Volume: 13 Issue: 4 Pages: e0195655-e0195655

    • DOI

      10.1371/journal.pone.0195655

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy2018

    • Author(s)
      Suzumori , Sekizawa A,Yotsumoto J, et al
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 224 Pages: 165-169

    • DOI

      10.1016/j.ejogrb.2018.03.048

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful pregnancy located in a uterine cesarean scar: A case report2018

    • Author(s)
      Tamada Shoko、Masuyama Hisashi、Maki Jota、Eguchi Takeshi、Mitsui Takashi、Eto Eriko、Hayata Kei、Hiramatsu Yuji
    • Journal Title

      Case Reports in Women's Health

      Volume: 14 Pages: 8-10

    • DOI

      10.1016/j.crwh.2017.03.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells.2018

    • Author(s)
      Fujita S, Hasegawa T, Nishiyama Y, Fujisawa S, Nakano Y, Nada T, Iwata N, Kamada Y, Masuyama H, Otsuka F
    • Journal Title

      J Steroid Biochem Mol Biol.

      Volume: 印刷中 Pages: 73-79

    • DOI

      10.1016/j.jsbmb.2018.03.004

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic nutritional index as a predictor of survival in patients with recurrent cervical cancer.2018

    • Author(s)
      Ida N, Nakamura K, Saijo M, Kusumoto T, Masuyama H
    • Journal Title

      Mol Clin Oncol.

      Volume: 8 Pages: 257-263

    • DOI

      10.3892/mco.2017.1508

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest: A case report2018

    • Author(s)
      Kamada Yasuhiko、Sakamoto Ai、Kotani Sayoko、Masuyama Hisashi
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 44 Issue: 4 Pages: 797-800

    • DOI

      10.1111/jog.13578

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of resting energy expenditure and body composition in Japanese pregnant women with diabetes.2018

    • Author(s)
      Eto E, Maki J, Tamada S, Mitsui T, Hayata K, Hiramatsu Y, Masuyama H.
    • Journal Title

      J Diabetes Investig.

      Volume: 印刷中 Issue: 4 Pages: 959-966

    • DOI

      10.1111/jdi.12795

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upregulation of angiogenic factors via protein kinase C and hypoxia-induced factor-1α pathways under high-glucose conditions in the placenta.2018

    • Author(s)
      Mitsui T, Tani K, Maki J, Eguchi T, Tamada S, Eto E, Hayata K, Masuyama H
    • Journal Title

      Acta Medica Okayama

      Volume: 印刷中

    • NAID

      120006501281

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Influence of Adverse Effects on Quality of Life of Survivors of Gynecologic Cancer.2017

    • Author(s)
      Omichi C, Nakamura K, Haraga J, Ida N, Saijo M, Nishida T, Kusumoto T, Masuyama H.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 27 Issue: 9 Pages: 2014-2019

    • DOI

      10.1097/igc.0000000000001125

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ここが知りたい産婦人科周術期管理-糖代謝異常合併妊娠-2017

    • Author(s)
      増山 寿,牧 尉太,平松祐司.
    • Journal Title

      産科と婦人科

      Volume: 84 Pages: 147-151

    • Related Report
      2016 Research-status Report
  • [Journal Article] Differences in uterine artery blood flow and fetal growth between the early and late onset of pregnancy-induced hypertension.2016

    • Author(s)
      Mitsui T, Masuyama H, Maki J, Tamada S, Hirano Y, Eto E, Nobumoto E, Hayata K, Hiramatsu Y.
    • Journal Title

      J Med Ultrasonics.

      Volume: 43 Issue: 4 Pages: 509-517

    • DOI

      10.1007/s10396-016-0729-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse Adiponectin and Leptin gene promoters.2016

    • Author(s)
      Masuyama H, Mitsui T, Eguchi T, Tamada S, Hiramatsu Y.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 311 Issue: 1 Pages: E236-E245

    • DOI

      10.1152/ajpendo.00095.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anti-cancer agents in ovarian cancer cells.2016

    • Author(s)
      Masuyama H, Nakamura K, Nobumoto E, Hiramatsu Y.
    • Journal Title

      Int J Oncol

      Volume: 49 Issue: 3 Pages: 1211-1220

    • DOI

      10.3892/ijo.2016.3611

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high fat diet-fed pregnant mice via constitutive androstane receptor.2016

    • Author(s)
      Masuyama H, Mitsui T, Maki J, Tani K, Nakamura K, Hiramatsu Y.
    • Journal Title

      Mol Cell Biochem

      Volume: 419 Issue: 1-2 Pages: 185-192

    • DOI

      10.1007/s11010-016-2772-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sex differences in early growth during the first three years of life in offspring from mothers with pregnancy-induced hypertension.2016

    • Author(s)
      Mitsui T, Masuyama H, Eguchi T, Tamada S, Eto E, Hayata K, Hiramatsu Y.
    • Journal Title

      Pregnancy Hypertens.

      Volume: 6 Issue: 4 Pages: 361-366

    • DOI

      10.1016/j.preghy.2016.08.238

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 妊娠初期診断GDMの特徴と診断における有用性と意義"JAGS trialによる再検討".2016

    • Author(s)
      牧 尉太, 平野友美加, 増山 寿, 杉山 隆, 豊田長康, 平松祐司
    • Journal Title

      糖尿病と妊娠

      Volume: 16 Pages: 132-136

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 少子高齢化社会における産婦人科のミッション2018

    • Author(s)
      増山 寿
    • Organizer
      岡山医学会・鶴翔会・岡山大学関連病院長会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 周産期疾患と生活習慣病2018

    • Author(s)
      増山 寿
    • Organizer
      東海周産期研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Curative medicineからPreventive/preemptive medicineへー周産期からみた生活習慣病発症リスク2018

    • Author(s)
      増山 寿
    • Organizer
      第92回兵庫県産科婦人科学会総会ならびに学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 周産期から見たPreemptive Medicine2018

    • Author(s)
      増山 寿
    • Organizer
      第31回長野県周産期研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インスリン抵抗性と周産期疾患2018

    • Author(s)
      増山 寿
    • Organizer
      第45回東京成長ホルモン成長因子セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 周産期から見たPreemptive medicine2018

    • Author(s)
      増山 寿
    • Organizer
      平成30年度熊本県母体保護法指定医師研修会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インスリン抵抗性と周産期疾患ーCurative medicineからPreemptive medicineへー2018

    • Author(s)
      増山 寿
    • Organizer
      島根産婦人科ホルモン依存症疾患研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生涯研修プログラム「周産期疾患の生活習慣病リスクとその管理」妊娠糖尿病2017

    • Author(s)
      増山 寿
    • Organizer
      第69回日本産科婦人科学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 周産期疾患と生活習慣病2017

    • Author(s)
      増山 寿
    • Organizer
      第92回徳島産科婦人科合同学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 周産期疾患と生活習慣病2017

    • Author(s)
      増山 寿
    • Organizer
      姫路産婦人科医会学術講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] <ワークショップ>「妊娠高血圧症候群の母体より出生した児の3歳までの身体発育の性差」2017

    • Author(s)
      光井 崇,谷 和祐,牧 尉太,江口武志,玉田祥子,衛藤英理子,早田 桂,増山 寿
    • Organizer
      第38回日本妊娠高血圧学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] <シンポジウム>本邦におけるGDMは本当に2型糖尿病になりやすいのか?その頻度は?フォローアップを確実に行うためには?ーTime to Act「GDM既往女性のフォローアップ率の低さに対する対策~当院の改革~2017

    • Author(s)
      牧 尉太,衛藤英理子,平松祐司,増山 寿
    • Organizer
      第33回日本糖尿病・妊娠学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 「DOHaDと肥満」“Diabetes begets diabetes”-肥満・耐糖能異常素因の世代間連鎖-2016

    • Author(s)
      増山 寿,平松祐司
    • Organizer
      第37回日本肥満学会 ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 糖代謝異常妊婦の安静時代謝量2016

    • Author(s)
      衛藤英理子,岡本和浩,柏原麻子,牧 尉太,江口武志,玉田祥子,光井 崇,平野友美加,早田 桂,増山 寿,平松祐司
    • Organizer
      第52回日本周産期・新生児医学会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 「妊婦の栄養代謝」“Diabetes begets diabetes”メカニズムの解明に向けて-2016

    • Author(s)
      増山 寿,江口武志,玉田祥子,光井 崇,平野友美加,衛藤英理子,延本悦子,早田 桂,瀬川友功,平松祐司
    • Organizer
      第68回日本産科婦人科学会 ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 妊娠高血圧症候群の発症時期による新生児,乳幼児期の発育への影響2016

    • Author(s)
      光井 崇, 増山 寿,岡本和浩,柏原麻子,谷 和祐,牧 尉太,江口武志,玉田祥子,衛藤英理子,早田 桂,平松祐司
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Book] 改訂第2版 妊婦の糖代謝異常 診療・管理マニュアル2018

    • Author(s)
      増山 寿
    • Total Pages
      310
    • Publisher
      メジカルビュー社
    • Related Report
      2018 Annual Research Report
  • [Book] 産科婦人科疾患最新の治療2016-20182016

    • Author(s)
      増山 寿
    • Total Pages
      356
    • Publisher
      南江堂
    • Related Report
      2016 Research-status Report
  • [Book] 周産期医学必修知識(第8版)2016

    • Author(s)
      増山 寿
    • Total Pages
      1271
    • Publisher
      東京医学社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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