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Cryopreservation of ovarian tissue

Research Project

Project/Area Number 16K11089
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTokyo Medical University (2019)
Okayama University (2016)

Principal Investigator

Motohashi Hideyuki  東京医科大学, 医学部, 兼任助教 (20554380)

Co-Investigator(Kenkyū-buntansha) 中塚 幹也  岡山大学, 保健学研究科, 教授 (40273990)
舟橋 弘晃  岡山大学, 環境生命科学研究科, 教授 (50284089)
若井 拓哉  岡山大学, 環境生命科学研究科, 准教授 (60557768)
高山 修  岡山大学, 環境生命科学研究科, 客員研究員 (80650879)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords卵巣凍結保存 / 移植・再生医療 / 発生・分化 / 再生医学 / 細胞・組織 / 応用動物
Outline of Final Research Achievements

The cancer treatments in young women such as anti-cancer drugs and radiation can affect fertility by several biologic systems. The purpose of this study was to develop a novel cryopreservation method for ovarian tissue. In this study, an improved vitrification for ovarian tissue resulted in survival and subsequent development in vivo and oocyte maturation in vitro after cryopreservation.

Academic Significance and Societal Importance of the Research Achievements

若年女性ががんに罹患すると、抗がん剤や放射線治療によって不妊になるリスクが増大するが、本研究では卵巣凍結保存法の改良を通じて、若年女性がん患者でもがん治癒後に子供を持つ希望が生まれ、少子化の緩和と生殖医学の発展への一助となる。

Report

(1 results)
  • 2019 Final Research Report ( PDF )

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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