| Project/Area Number |
16K11089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical University (2019)
Okayama University (2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中塚 幹也 岡山大学, 保健学研究科, 教授 (40273990)
舟橋 弘晃 岡山大学, 環境生命科学研究科, 教授 (50284089)
若井 拓哉 岡山大学, 環境生命科学研究科, 准教授 (60557768)
高山 修 岡山大学, 環境生命科学研究科, 客員研究員 (80650879)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 卵巣凍結保存 / 移植・再生医療 / 発生・分化 / 再生医学 / 細胞・組織 / 応用動物 |
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| Outline of Final Research Achievements |
The cancer treatments in young women such as anti-cancer drugs and radiation can affect fertility by several biologic systems. The purpose of this study was to develop a novel cryopreservation method for ovarian tissue. In this study, an improved vitrification for ovarian tissue resulted in survival and subsequent development in vivo and oocyte maturation in vitro after cryopreservation.
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| Academic Significance and Societal Importance of the Research Achievements |
若年女性ががんに罹患すると、抗がん剤や放射線治療によって不妊になるリスクが増大するが、本研究では卵巣凍結保存法の改良を通じて、若年女性がん患者でもがん治癒後に子供を持つ希望が生まれ、少子化の緩和と生殖医学の発展への一助となる。
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