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Therapeutic strategies to correct utero environment for preventing NCDs in offspring

Research Project

Project/Area Number 16K11092
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionEhime University

Principal Investigator

SUGIYAMA TAKASHI  愛媛大学, 医学系研究科, 教授 (10263005)

Co-Investigator(Kenkyū-buntansha) 藤岡 徹  愛媛大学, 医学系研究科, 准教授 (10253303)
松原 圭一  愛媛大学, 医学系研究科, 寄附講座教授 (80263937)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords子宮内環境 / 炎症 / インスリン抵抗性 / DOHaD / epigenetics / 妊娠 / 次世代 / 生活習慣病 / マウス / 子宮内過栄養 / 抗炎症 / エピジェネティクス / PUFA / 多価不飽和脂肪酸
Outline of Final Research Achievements

Animal experiments using mice showed that high-fat-diet in pregnant mice affected fetal metabolism through inflammatory changes in adipose tissue, and offspring from their pregnant mice are likely to develop non-communicable diseases (NCDs) in later life. On the other hand, it was found that when fish oil having an anti-inflammatory effect is administered during pregnancy, the degree of NCDs onset is reduced, and the expression of some inflammatory cytokines were slightly reduced. These results suggest that fish oil supplement in pregnant mothers may lead to the health of children as well as mothers in future.

Academic Significance and Societal Importance of the Research Achievements

お母さんの肥満が次世代である子どもの将来の健康に悪影響を及ぼす可能性が明らかとなった。この現象には炎症が関連する可能性があり、まず妊娠前に減量することが必要であるが、妊娠前から妊娠中に魚油を摂取することがお母さんおよび次世代の健康のために有効である可能性が判明した。ただし、これらの結果はマウスにおける検討結果であり、今後、ヒトにおいて検討する必要があろう。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (4 results)

  • [Journal Article] Paternal height has an impact on fetal growth in a Japanese population:2019

    • Author(s)
      Takagi K, Iwama N, Metoki H, Matsubara Y, Uchikura Y, Matsubara K, Nishigori H, Saito M, Fujiwara I, Sakurai K, Kuriyama S, Arima T, Nakai K, Yaegashi N, Sugiyama T
    • Journal Title

      Journal of Developmental Origins of Health Disease

      Volume: 11 Issue: 5 Pages: 1-13

    • DOI

      10.1017/s2040174418001162

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in the prevalence of gestational diabetes mellitus according to gestational age at 75-g oral glucose tolerance test, in Japan: The JAGS trial.2019

    • Author(s)
      Iwama N, Sugiyama T, Metoki H, Kusaka H, Yaegashi N, Sagawa N, Hiramatsu Y, Toyoda N
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 6 Pages: 1576-1585

    • DOI

      10.1111/jdi.13044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 母体の高脂肪食が次世代の生活習慣病発症に関与するメカニズムの検討2018

    • Author(s)
      内倉友香、松原圭一、藤岡徹、杉山 隆
    • Organizer
      日本女性医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pre-pregnancy BMI is a better indicator of LGA infants compared with plasma glucose levels of a 75-g OGTT in early pregnancy in Japan: Taking into account changes of 75-g OGTT in pregnancy2018

    • Author(s)
      Sugiyama T, Hiramatsu, Y, Omori Y
    • Organizer
      The annual Diabetic Pregnancy Study Group Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DOHaD研究を巡る最近の話題2018

    • Author(s)
      杉山 隆
    • Organizer
      第61回日本糖尿病学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DOHaDの概念および妊娠糖尿病の考え方2018

    • Author(s)
      杉山 隆
    • Organizer
      第34回日本糖尿病・妊娠学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肥満症関連疾患からみた肥満「産婦人科視点からみた肥満症」2017

    • Author(s)
      杉山 隆
    • Organizer
      第38回日本肥満学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] A maternal diet with moderately high-fat modulates adipose gene expression of glucose, lipid metabolism in the offspring2017

    • Author(s)
      Takashi Sugiyama
    • Organizer
      10th World Congress on DOHaD
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肥満と女性2016

    • Author(s)
      杉山 隆
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京都(東京ファッションタウンビル)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 妊娠を通して考えるファミリーヘルスケア2016

    • Author(s)
      杉山 隆
    • Organizer
      第40回日本産科婦人科栄養・代謝研究会
    • Place of Presentation
      札幌市(北海道大学 学術交流会館)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Book] 日本体質医学会雑誌2018

    • Author(s)
      杉山 隆
    • Total Pages
      6
    • Publisher
      日本体質医学会
    • Related Report
      2018 Annual Research Report
  • [Book] 糖尿病プラクティス2017

    • Author(s)
      杉山 隆
    • Total Pages
      128
    • Publisher
      医師薬出版
    • Related Report
      2017 Research-status Report
  • [Book] 臨床婦人科産科2016

    • Author(s)
      杉山 隆
    • Total Pages
      6
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 糖尿病プラクティス2016

    • Author(s)
      杉山 隆
    • Total Pages
      4
    • Publisher
      医歯薬出版
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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