Metabolomic analysis and identification of the predictor of hypertensive disorder of pregnancy.
| Project/Area Number |
16K11096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
花田 俊勝 大分大学, 医学部, 教授 (10363350)
酒井 久美子 大分大学, 医学部, 助教 (60225753)
花田 克浩 大分大学, 医学部, 助教 (90581009)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 妊娠高血圧症候群 / メタボローム解析 / オートファジー / 低酸素 / ヒト胎盤 / ペントースリン酸経路 / Keap1-Nrf2システム / 臍帯静脈血管内皮細胞 / 胎盤絨毛細胞 / 胎盤 / HUVEC |
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| Outline of Final Research Achievements |
Hypertensive disorder of pregnancy is the most famous perinatal complication to result hypertension and proteinuria during pregnancy. However, the total picture does not yet become clear because the condition of a patient is complicated. We hypothesized that abnormal placentas are under hypoxia, malnutrition and aging. So, we focused on the placental autophagy and the metabolomic analysis. Based on the results of our research, multivariate analysis elucidated the change of the primary metabolites in the placenta tissues via chaperon-mediated autophagy, comprehensively. As a result, We were able to clarify an unknown pathologic part and several predictor candidates.
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| Academic Significance and Societal Importance of the Research Achievements |
妊娠高血圧症候群におけるオートファジーの関与と胎盤組織の一次代謝産物からみたペントースリン酸経路の活性化をリンクさせることができた興味深い結果を報告した。特にペントースリン酸回路を介した中心代謝経路の関与の発見は今後の複雑な胎盤機能を解明していく上で、有意義な結果が得られたと考えられる。今後は今回明らかにしたシャペロン介在性オートファジー・Keap1-Nrf2 system・ペントースリン酸経路のクロストークとその関連因子の解明が妊娠高血圧症候群そのものの病態解明や病態予知因子の探索に重要なカギを握る可能性が高く学術的にも意義深い研究と考えられる。
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Immune escape by loss of heterozygosis of HLA genes facilitated the transmission of diffuse large B cell lymphoma from mother to offspring2020
Author(s)
Goto, HironoriHirano, Naoki Inoue, Masanori Takano, Kuniko Ogata, Masao Kishida, Tetsuko Arakane, Motoki Daa, Tsutomu Nishida, Yoshihiro Suenobu, Souichi et al.
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Journal Title
Br J Haematol
Volume: 189
Issue: 6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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