| Project/Area Number |
16K11114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
日根 幸太郎 東邦大学, 医学部, 助教 (50729308)
大路 斐子 東邦大学, 医学部, 助教 (90385641)
與田 仁志 東邦大学, 医学部, 教授 (90589053)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 双胎間輸血症候群 / 超音波ドプラ法 / 超音波2Dトラッキング法 / 胎児循環 / 胎児心不全 / 超音波パルスドプラ法 / NT-proBNP / Fractional Shortening / Fractional shortening / アルドステロン / 胎児・新生児学 / 超音波診断学 / 産科学 |
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| Outline of Final Research Achievements |
To establish a diagnostic and management method for fetal circulatory insufficiency in twin-to-twin transfusion syndrome (TTTS), we validated the evaluation of fetal cardiac diastolic function using the ultrasound pulsed doppler method. The results showed that the Dual-gate Doppler evaluation of fetal left and right ventriclar E/e' was useful to assess the circadian function in the recipient twin in the early onset of TTTS.
We also demonstrated for the first time that an ultrasound 2D tracking system can be used to measure fractional shortening of the ventricle, which is an indicator of fetal contractility. It is hoped that this time the same method will be applied clinically.
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| Academic Significance and Societal Importance of the Research Achievements |
双胎間輸血症候群は一絨毛膜双胎の約10％に発症する生命予後ないし神経学的発達予後の不良の疾患である。本研究では、双胎間輸血症候群の認められる胎児循環不全の早期診断法の探索と胎児循環の定量的な評価法の確立を目的として遂行され、Dual-gate Doppler法によるE/e'の測定や2Dトラッキング法によるfractional shorteningの計測が有用であることが世界で初めて明らかとなった。
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