Azoospermia caused by gene disruption of lipid metabolism related gene

• Project/Area Number: 16K11121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Tokyo University of Science
• Principal Investigator: Yamatoya Kenji 東京理科大学, 理工学部応用生物科学科, 助教 (80447309)
• Co-Investigator(Kenkyū-buntansha): 宮戸 健二 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 室長 (60324844)
• Research Collaborator: Kawano Natsuko
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 精子形成

Outline of Final Research Achievements

In this study, we analyzed the fertility of PLCz conditional knock out mice created by homologous recombination using ES cells. The floxed male mice were fertile, but the homozygous knockout male mice were infertile due to spermatogenic disorder. Spermatocytes successfully under went meiosis and became round spermatids, but sloughing of spermatids at stage V caused the azoospermia. However, the gene knockout using CRISPER/Cas system did not lead to azoospermia. We could not confirm any abnormal expression of genes in vicinity of the target gene.

Academic Significance and Societal Importance of the Research Achievements

ES細胞を用いた相同組み換えによって作成した本研究で使用したコンディショナルノックアウトマウスは精子形成不全による雄性不妊であることが明らかとなった。CRISPER/Casシステムによる遺伝子破壊では、精子形成に著しい異常はなく、卵の活性化に重要であることが明らかにされた。このことは、このコンディショナルマウスでは単純に標的遺伝子が欠損したのではなく、ドミナントネガティブな効果が現れていると考えられる。作製手法の影響を再考し、本マウスにおける雄性不妊の一端を明らかにした。今後の完全解明に重要な基礎となる。これは遺伝子操作に関して作製から表現型の解明まで慎重な解析が要求されることを示す。

Research Products

• [Journal Article] Membrane protein CD9 is repositioned and released to enhance uterine function. (2019)
  • Author(s): Iwai M, Hamatani T, Nakamura A, Kawano N, Kanai S, Kang W, Yoshii N, Odawara Y, Yamada M, Miyamoto Y, Saito T, Saito H, Miyado M, Umezawa A, Miyado K, Tanaka M.
  • Journal Title: Laboratory Investigation Volume: 99 Issue: 2 Pages: 200-209
  • DOI: 10.1038/s41374-018-0145-1
  • Peer Reviewed / Open Access
• [Journal Article] Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion (2018)
  • Author(s): Ito Chizuru、Yamatoya Kenji、Yoshida Keiichi、Fujimura Lisa、Sugiyama Hajime、Suganami Akiko、Tamura Yutaka、Hatano Masahiko、Miyado Kenji、Toshimori Kiyotaka
  • Journal Title: Reproduction Volume: 156 Issue: 6 Pages: 579-590
  • DOI: 10.1530/rep-18-0394
  • Peer Reviewed / Open Access
• [Journal Article] Chemotactic behavior of egg mitochondria in response to sperm fusion in mice (2018)
  • Author(s): Iwai Maki、Harada Yuichirou、Miyabayashi Rinako、Kang Woojin、Nakamura Akihiro、Kawano Natsuko、Miyamoto Yoshitaka、Yamada Mitsutoshi、Hamatani Toshio、Miyado Mami、Yoshida Keiichi、Saito Hidekazu、Tanaka Mamoru、Umezawa Akihiro、Miyado Kenji
  • Journal Title: Heliyon Volume: 4 Issue: 11 Pages: e00944-e00944
  • DOI: 10.1016/j.heliyon.2018.e00944
  • Peer Reviewed / Open Access
• [Journal Article] Degradation of phosphate polymer polyP enhances lactic fermentation in mice. (2018)
  • Author(s): Nakamura A, Kawano N, Motomura K, Kuroda A, Sekiguchi K, Miyado M, Woojin K, Miyamoto Y, Hanai M, Iwai M, Yamada M, Hamatani T, Saito T, Saito H, Tanaka M, Umezawa A, Miyado K.
  • Journal Title: Genes Cells. Volume: 23(10) Issue: 10 Pages: 904-914
  • DOI: 10.1111/gtc.12639
  • Peer Reviewed / Open Access
• [Journal Article] Autophagy-disrupted LC3 abundance leads to death of supporting cells of human oocytes. (2018)
  • Author(s): Kang W, Ishida E, Yamatoya K, Nakamura A, Miyado M, Miyamoto Y, Iwai M, Tatsumi K, Saito T, Saito K, Kawano N, Hamatani T, Umezawa A, Miyado K, Saito H.
  • Journal Title: Biochem Biophys Rep. Volume: 21(15) Pages: 107-114
  • DOI: 10.1016/j.bbrep.2018.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Denaturation of Lysozyme with Visible-light-responsive Photocatalysts of Ground Rhodium-doped and Ground Rhodium-antimony-co-doped Strontium Titanate (2018)
  • Author(s): Usuki Sho、Yamatoya Kenji、Kawamura Yuki、Yamaguchi Yuichi、Suzuki Norihiro、Katsumata Ken-ichi、Terashima Chiaki、Fujishima Akira、Kudo Akihiko、Nakata Kazuya
  • Journal Title: Journal of Oleo Science Volume: 67 Issue: 12 Pages: 1521-1533
  • DOI: 10.5650/jos.ess18155
  • NAID: 130007539094
  • ISSN: 1345-8957, 1347-3352
  • Peer Reviewed
• [Journal Article] Rewritable superhemophobic and superhemophilic wettability pattern based on titanium dioxide with Ag loading (2018)
  • Author(s): Tran Minh Quang、Yamaguchi Yuichi、Yamatoya Kenji、Horikoshi Satoshi、Nakata Kazuya
  • Journal Title: Inorganic Chemistry Communications Volume: 96 Pages: 1-4
  • DOI: 10.1016/j.inoche.2018.07.043
  • Peer Reviewed
• [Journal Article] Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg. (2018)
  • Author(s): Yoshida K, Kang W, Nakamura A, Kawano N, Hanai M, Miyado M, Miyamoto Y, Iwai M, Hamatani T, Saito H, Miyado K and Umezawa A.
  • Journal Title: Reprod Toxicol. Volume: 76 Pages: 71-77
  • DOI: 10.1016/j.reprotox.2018.01.001
  • Peer Reviewed
• [Journal Article] Rewritable superhemophobic and superhemophilic wettability pattern based on titanium dioxide (2018)
  • Author(s): Tran Minh Quang、Yamaguchi Yuichi、Yamatoya Kenji、Horikoshi Satoshi、Nakata Kazuya
  • Journal Title: Materials Letters Volume: 213 Pages: 51-53
  • DOI: 10.1016/j.matlet.2017.11.024
  • Peer Reviewed
• [Journal Article] Efficient photocatalytic degradation of gaseous acetaldehyde over ground Rh-Sb co-doped SrTiO3 under visible light irradiation (2018)
  • Author(s): Yuichi Yamaguchi, Sho Usuki, Kenji Yamatoya, Norihiro Suzuki, Ken-ichi Katsumata, Chiaki Terashima, Akira Fujishima, Akihiko Kudo, and Kazuya Nakata
  • Journal Title: RSC Adv. Volume: 8 Issue: 10 Pages: 5331-5337
  • DOI: 10.1039/c7ra11337d
  • Peer Reviewed / Open Access
• [Journal Article] Selective Inactivation of Bacteriophage in the Presence of Bacteria by Use of Ground Rh-Doped SrTiO3 Photocatalyst and Visible Light (2017)
  • Author(s): Y. Yamaguchi, S. Usuki, Y. Kanai, K. Yamatoya, N. Suzuki, K. Katsumata, C. Terashima, T. Suzuki, A. Fujishima, H. Sakai, A. Kudo, and K. Nakata
  • Journal Title: ACS Applied Materials & Interfaces Volume: 9 Issue: 37 Pages: 31393-31400
  • DOI: 10.1021/acsami.7b07786
  • Peer Reviewed
• [Journal Article] Birth weights and Down syndrome in neonates delivered after frozen-thawed embryo transfer: Six-year study (2007-2012) on the national assisted reproduction registry data in Japan (2017)
  • Author(s): Yamatoya K, Saito K, Saito T, Kang W, Nakamura A, Miyado M, Kawano N, Miyamoto Y, Umezawa A, Miyado K, Saito H
  • Journal Title: Reproductive Medicine and Biology Volume: 16 Issue: 2 Pages: 228-234
  • DOI: 10.1002/rmb2.12033
  • Peer Reviewed / Open Access
• [Journal Article] Exosomes versus microexosomes: Shared components but distinct functions (2017)
  • Author(s): Miyado K, Kang W, Yamatoya K, Hanai M, Nakamura A, Mori T, Miyado M, Kawano N
  • Journal Title: J Plant Res Volume: 130 Issue: 3 Pages: 479-483
  • DOI: 10.1007/s10265-017-0907-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproductiontran . (2017)
  • Author(s): Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H*.
  • Journal Title: PLoS Genetics. Volume: 13 Issue: 1 Pages: e1006578-e1006578
  • DOI: 10.1371/journal.pgen.1006578
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased incidence of post-term delivery and Cesarean section after frozen-thawed embryo transfer during a hormone replacement cycle (2016)
  • Author(s): Saito K, Miyado K, Yamatoya K, Kuwahara A, Inoue E, Miyado M, Fukami M, Ishikawa T, Saito T, Kubota T, Saito H
  • Journal Title: J Assist Reprod Genet Volume: 34 Issue: 4 Pages: 465-470
  • DOI: 10.1007/s10815-017-0869-7
  • Peer Reviewed / Open Access
• [Journal Article] 体外受精における人工的操作とヒト成長への影響 (2016)
  • Author(s): 宮戸健二、大和屋健二、齊藤和毅、河野菜摘子、齊藤英和
  • Journal Title: ＨＯＲＭＯＮＥ ＦＲＯＮＴＩＥＲ ＩＮ ＧＹＮＥＣＯＬＯＧＹ Volume: 23 Pages: 167-171
• [Presentation] SPACA1 cleavage during acrosome reaction allows for translocation of IZUMO1 to the equatorial segment. (2018)
  • Author(s): Yamatoya K., Kousaka M., Ito C., Yanagida M., Araki Y., Toshimori K.
  • Organizer: Society for the Study of Reproduction, 51stAnnual Meeting New Oreans, Louisiana, (USA)
  • Int'l Joint Research
• [Presentation] メソポーラスチタニアによるメタン分解 (2018)
  • Author(s): 上田侑紀、大和屋健二、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、酒井秀樹、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 光触媒を用いたシアン化カリウムの分解による有用物質の探索 (2018)
  • Author(s): 水野裕彬、岩崎耕大、大和屋健二、鈴木孝宗、勝又健一、寺島千晶、赤松允顕、酒井健一、酒井秀樹、中田一弥、藤嶋昭
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 光触媒反応を利用した有機過酸化物の生成と微生物の不活化 (2018)
  • Author(s): 仲谷滉祐、岩崎耕大、臼杵翔、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、大和屋健二、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 光触媒反応を用いたL体希少糖の生成 (2018)
  • Author(s): 廣嶋駿、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、大和屋健二、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 可視光応答型Rh-doped SrTiO3がアミノ酸およびジペプチドに与える影響 (2018)
  • Author(s): 小沢友弥、臼杵翔、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、大和屋健二、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 酸化チタン光触媒によるAnabaenaの殺菌と機構解析 (2018)
  • Author(s): 田野雅貴、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、大和屋健二、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 酸化チタン光触媒を用いた二糖類の分解と希少糖の生成 (2018)
  • Author(s): 遠藤瑞輝、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、大和屋健二、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 金属イオンドープ光触媒を用いた希少糖の生成 (2018)
  • Author(s): 岩崎耕大、大和屋健二、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、酒井秀樹、中田一弥
  • Organizer: 第24回シンポジウム 光触媒反応の最近の展開
• [Presentation] 精子先体局在ポリシアル化タンパク質の解析 (2018)
  • Author(s): 中村悠基、石黒桜子、大和屋健二、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] 精子先体局在ポリシアル酸の機能解析 (2018)
  • Author(s): 石黒桜子、中村悠基、大和屋健二、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] 希少糖が種子発芽に与える影響 (2018)
  • Author(s): 瀬町崇浩、臼杵翔、大和屋健二、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] 新規オキシリオピン プラケブリンAの新規薬理活性と標的タンパク質の探索 (2018)
  • Author(s): 樺澤美咲、大和屋健二、倉持幸司、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] SPESP1の生理的機能の解明 (2018)
  • Author(s): 本間莉乃、大和屋健二、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] SPACA1の機能解析 (2018)
  • Author(s): 寺山由夏、大和屋健二、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] 希少糖の薬理活性の解析 (2018)
  • Author(s): 宇佐見智子、高橋友花、大和屋健二、中田一弥
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] DMSOフリー、血清フリー保存液による細胞の凍結保存 (2018)
  • Author(s): 永井悠也、大和屋健二、寺本直純、中田一弥、八木透、宮本義孝
  • Organizer: 第41回日本分子生物学会年会パシフィコ横浜（神奈川県）
• [Presentation] 天然物エポラクタエンとその誘導体のアポトーシス誘導メカニズムの解析 (2018)
  • Author(s): 養田智香、友重秀介、大和屋健二、中田一弥、森田明典、池北雅彦、倉持幸司
  • Organizer: 第62回 日本薬学会 関東支部大会
• [Presentation] 金属イオンドープ光触媒を用いた希少糖の生成 (2018)
  • Author(s): 岩崎耕大、山口友一、大和屋健二、鈴木孝宗、勝又健一、寺島千晶、藤嶋昭、酒井秀樹、中田一弥
  • Organizer: 日本化学会第98春季年会
• [Presentation] エタノールと光触媒により生成した有機過酸化物による芽胞菌死滅の機構解明 (2018)
  • Author(s): 石岡瞬, 山口友一, 佐久間貴大, 勝又健一, 寺島千晶, 藤嶋昭, 鈴木智順, 大和屋健二, 中田一弥
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] 可視光応答型RhドープSrTiO3による抗ファージ機構の解析 (2017)
  • Author(s): 臼杵翔、山口友一、寺島千晶、勝又健一、鈴木孝宗、鈴木智順、藤嶋昭、工藤昭彦、大和屋健二、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 希少糖の細胞毒性メカニズムの解析 (2017)
  • Author(s): 高橋友花、大和屋健二、吉見陽児、池北雅彦、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] SPACA1切断酵素の探索 (2017)
  • Author(s): 香坂茉莉花、大和屋健二、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] SPESP1切断酵素の探索 (2017)
  • Author(s): 酒井萌花、大和屋健二、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] シスタンシェおよびニトラリア植物抽出物の糖化抑制効果の解析 (2017)
  • Author(s): 直原沙来、井上沙樹子、大和屋健二、吉見陽児、加藤智彦、池北雅彦、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] ニトラリアエキス中の新規有用物質の探索 (2017)
  • Author(s): 井上沙樹子、直原沙来、大和屋健二、加藤智彦、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 新規合成レチノ安息香酸の催奇性 (2017)
  • Author(s): 和田有輝子、小峰卓也、大和屋健二、吉見陽児、斎藤慎一、池北雅彦、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] オキシリピンPlakevulinAの新規薬剤活性の探索 (2017)
  • Author(s): 樺澤美咲、大和屋健二、倉持幸司、池北雅彦、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 新規合成レチノ安息香酸のレチノイン酸およびレチノイン酸結合タンパク質への影響 (2017)
  • Author(s): 小峰卓也、和田有輝子、大和屋健二、斎藤慎一、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 再生医療・細胞医療におけるDMSOフリー、血清フリーの細胞凍結保存液の開発 (2017)
  • Author(s): 永井悠也、大和屋健二、寺本直純、中田一弥、八木透、宮本義孝
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 希少糖が種子発芽に与える影響 (2017)
  • Author(s): 瀬町崇浩、長尾将成、臼杵翔、大和屋健二、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] シアノバクテリアに対する希少糖の生物活性探索 (2017)
  • Author(s): 松宮瑞穂、瀬町崇浩、田野雅貴、鞆達也、大和屋健二、中田一弥
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Photocatalytic Production of Rare Sugars with Metal-Ion-Doped TiO2 (2017)
  • Author(s): Koudai Iwasaki, Yuichi Yamaguchi, Kenji Yamatoya, Norihiro Suzuki, Ken-ichi Katsumata, Chiaki Terashima, Akira Fujishima, Hideki Sakai, Kazuya Nakata
  • Organizer: Photocatalysis 2 &SIEMME'23
  • Int'l Joint Research
• [Presentation] Design of organic peroxide generation with metal-supported photocatalyst and application to sporicidal performance (2017)
  • Author(s): Kodai Iwasaki, Yuichi Yamaguchi, Kenji Yamatoya, Chiaki Terashima, Kenichi Katsumata, Norihiro Suzuki, Akira Fujishima, Hideki Sakai,Kazuya Nakata
  • Organizer: Bio-resources: feeding a sustainable chemical industry: Faraday Discussion
  • Int'l Joint Research
• [Presentation] Effect of photocatalysts on lysozyme (2017)
  • Author(s): Y. Kawamura, S. Usuki, Y. Yamaguchi, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, A. Kudo, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Sterilization Mechanism of Anabaena by TiO2 photocatalysis (2017)
  • Author(s): M. Tano, T. Tomo, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Photocatalytic Inactivation for Synechocystis (2017)
  • Author(s): H. Nakayama, M. Tano, T. Tomo, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Generation of Rare Sugars by Photocatalytic Oxidation of Sugar Alcohols (2017)
  • Author(s): Y. Nakamura, T. Tsutsumi, T. Takeuchi, Y. Kanai, N. Suzuki, K. Katsumata, C. Terashima, M. Abe, A. Fujishima, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Photocatalytic Decomposition of Monosaccharide Ketose Toward Production of Rare Sugars (2017)
  • Author(s): T. Tsutsumi, Y. Kanai, C. Terashima, K. Katsumata, N. Suzuki, M. Abe, A. Fujishima, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Decomposition of Disaccharide by Photocatalysis Toward Production of Disaccharide Rare Sugars (2017)
  • Author(s): T. Takeuchi, Y. Kanai, N. Suzuki, K. Katsumata, C. Terashima, M. Abe, A. Fujishima, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Sporicidal Mechanism by WO3 Photocatalysis in the Presence of Ethanol (2017)
  • Author(s): S. Ishioka, S. Usuki, Y. Yamaguchi, T. Sakuma, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, T. Suzuki, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Improvement of seed germination using photocatalyst (2017)
  • Author(s): M. Nagao, S. Usuki, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, H. Wada, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Photocatalytic Production of Rare Sugars with Metal-Ion-Doped TiO2 (2017)
  • Author(s): K. Iwasaki, Y. Yamaguchi, K. Yamatoya, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, H. Sakai, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Production of L-Rare Sugars from Monosaccharide by Photocatalytic Oxidation (2017)
  • Author(s): H. Hiroshima, T. Takeuchi, T. Tsutsumi, Y. Kanai, N. Suzuki, K. Katsumata, C. Terashima, M. Abe, A. Fujishima, K. Yamatoya, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Production of Rare Sugars from Photocatalytic Oxidation of Sugar Alcohol with Metal-Supported Photocatalys (2017)
  • Author(s): H. Suzuki, K. Iwasaki, Y. Yamaguchi, K. Yamatoya, N. Suzuki, K. Katsumata, C. Terashima, A. Fujishima, H. Sakai, K. Nakata
  • Organizer: Photocatalysis 2 & SIEMME'23
  • Int'l Joint Research
• [Presentation] Function analysis of CD9 and egg exosome-mediated membrane fusion process in fertilization (2016)
  • Author(s): Maito Hanai, Kanako Hayami, Kenji Yamatoya, Woojin Kang, Natsuko Kawano, Kenji Miyado
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Physiological activity of Cistanche and Nitraria extracts in mammals (2016)
  • Author(s): Saki Naohara, Kenji Yamatoya, Yoji Yoshimi , Tomohiko Kato , Kazuya Nakata , Masahiko Ikekita
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Exploratory research of physiological activity of newly synthesized benzoic acid derivative having a retinoid activity (2016)
  • Author(s): Yukiko Wada, Kenji Yamatoya, Yoji Yoshimi, Shinichi Saito, Kazuya Nakata, Masahiko Ikekita
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Pharmacology of Rare sugars in hypoxic conditions (2016)
  • Author(s): Yuka Takahashi, Kenji Yamatoya, Yoji Yoshimi, Kazuya Nakata, Masahiko Ikekita
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Analysis of mitochondrial dysfunction induced by Ridaifen-G in mammalian cells (2016)
  • Author(s): Kousuke Yamada, Kenji Yamatoya, Yoji Yoshimi, Manabu Morita, Takuya Yamaki, Nozomi Ota, Natsumi Shibata, Isamu Shiina, Kazuya Nakata, Masahiko Ikekita
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Searching the enzyme responsible for the cleavage of sperm equatorial segment protein 1 in the mouse (2016)
  • Author(s): Kenji Yamatoya, Kazuya Nakata, Masahiko Ikekita
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Tamaki Seki, Kenji Yamatoya, Kazuya Nakata, Masahiko Ikekita (2016)
  • Author(s): Searching the enzyme responsible for the cleavage of sperm acrosome membrane-associated protein 1 in the mouse
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Exploration of the new drug substance of the natural compound indicating bioactivity (2016)
  • Author(s): Misaki Kabasawa, Kenji Yamatoya, Koji Kuramochi, Kazuya Nakata, Masahiko Ikekita
  • Organizer: The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa convention center. Okinawa, (Japan)
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] レチノイド化合物及び医薬組成物 (2018)
  • Inventor(s): 斎藤慎一、大和屋健二、池北雅彦、吉見陽児、和田有輝子、小峰卓也
  • Industrial Property Rights Holder: 学校法人東京理科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018