| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Formalin-fixed paraffin embedded (FFPE) tissue specimens of uterine leiomyosarcoma were used for gene expression profile analysis (SurePrint G3Human GE8x60K v3, agilent), and digital count gene expression analysis (ncounter) compared with normal uterine muscle tissue specimens. Using PanCancerImmune Profiling for Human panel, difference of immune environment was analyzed between normal and leiomyosarcoma tissues. We found that the number of immune cells decreased in leiomyosarcoma compared with normal tissue. Additionally, we analyzed the relationship between tumor immunity and prognosis among six leiomyosarcoma patients with stage I disease who underwent hysterectomy+bilateral salpingooophorectomy and adjuvant chemotherapy. T cell immunity was activated in the patients who survived after 12 months after initial treatment compared with those who died within 12 months.
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