Development of innovative new therapeutic strategies for endometrial cancer
| Project/Area Number |
16K11141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
永坂 岳司 川崎医科大学, 医学部, 准教授 (30452569)
春間 朋子 岡山大学, 大学病院, 助教 (60751774)
平松 祐司 岡山大学, 医歯薬学総合研究科, 特命教授 (80218817)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 子宮体癌 / Epigenetic変異 / MGMT / MSH2メチル化 / メチル化 / MSI / Pole / PD-1 / PD-1L / MLH1/MSH2 promoter / MGMT promotor / Precision Medicine / Personalized Medicine |
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| Outline of Final Research Achievements |
We examined clinic-pathological features with gene mutations for endometrial cancer. To do better research of innovative new therapeutic strategies, it is important that we study with personalized Medicine inclusive epigenetic mutations. We examined O6-methylguanine-DNA methyltransferase (MGMT), and MSH2 methylation, which contributes to the prognosis and drug effects of colorectal cancer. In endometrial cancer, the expression of MGMT and MSH2 methylation were 0.8 and 2.4%.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮体癌と大腸癌はいずれも疾患に多くリンチ症候群が含まれ，メチル化が深く関わっている。大腸癌の予後や薬剤効果に寄与するBiomarkerの1つであるMGMに注目し，子宮体癌での検討を行った。MGMTはDNA修復酵素であり，アルキル化剤よる殺細胞作用を阻害する。このMGMT活性はそのpromoter領域のメチル化によって制御されていることが知られ，そこで我々はMGMT発現に対し研究を子宮体癌で行ったが子宮体癌では患者122症例中唯一1例のみであり, また他メチル化のMSH2メチル化も2.4％と子宮体癌は大腸癌と比較して,子宮体癌は大腸癌ほどメチル化に深く関わっていないことを認めた。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.2018
Author(s)
Haruma T, Nagasaka T, Nakamura K, Haraga J, Nyuya A, Nishida T, Goel A, Masuyama H, Hiramatsu Y
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Journal Title
PLoS One
Volume: 13
Issue: 4
Pages: e0195655-e0195655
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles.2018
Author(s)
Mori Y, Nyuya A, Yasui K, Toshima T, Kawai T, Taniguchi F, Kimura K, Inada R, Nishizaki M, Haraga J, Nakamura K, Umeda Y, Kishimoto H, Fujiwara T, Katata Y, Yamaguchi Y, Nagasaka T.
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Journal Title
Oncotarget
Volume: 27;9(23)
Issue: 23
Pages: 16477-16488
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Pretreatment prognostic nutritional index is a significant predictor of prognosis in patients with cervical cancer treated with concurrent chemoradiotherapy.2016
Author(s)
Haraga J, Nakamura K, Omichi C, Nishida T, Haruma T, Kusumoto T, Seki N, Masuyama H, Katayama N, Kanazawa S, Hiramatsu Y.
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Journal Title
Mol Clin Oncol.
Volume: 5(5):
Pages: 567-574
Related Report
Peer Reviewed / Open Access
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