• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Predictive diagnosis of endometriosis-associated malignant transformation by iron concentration measurement using magnetic resonance spectroscopic imaging.

Research Project

Project/Area Number 16K11150
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

YOSHIMOTO CHIHARU  奈良県立医科大学, 医学部, 助教 (00526725)

Co-Investigator(Kenkyū-buntansha) 棚瀬 康仁  奈良県立医科大学, 医学部, 助教 (20423915)
小林 浩  奈良県立医科大学, 医学部, 教授 (40178330)
赤坂 珠理晃  奈良県立医科大学, 医学部, 助教 (90526724)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords子宮内膜症 / 癌化 / 鉄 / MRスペクトロスコピー / ヘムオキシゲナーゼ1 / チョコレート嚢胞 / ヘムオキシゲナーゼ1 / マクロファージ / 内膜症関連卵巣癌 / 鉄濃度 / 酸化 / 抗酸化 / 早期診断 / 医療・福祉 / 発癌
Outline of Final Research Achievements

We evaluate the clinical application of MR relaxometry in a series of ovarian endometriosis (OE) and endometriosis-associated ovarian cancer (EAOC). A prospective study of diagnostic accuracy was conducted among 82 patients (67 OE and 15 EAOC) to compare MR relaxometry and biochemical measurement of cyst fluid total iron concentration. Transverse relaxation rate R2 value was determined using a single-voxel, multi-echo MR sequence (HISTO) by a 3T-MR system.
The results in vivo R2 values were highly correlated with total iron concentrations. Compared to OE, EAOC exhibit decreased in vivo R2 values and total iron levels, regardless of their age, menopausal status and cyst size. The use of in vivo R2 values retained excellent accuracy in distinguishing EAOC versus OE (sensitivity and specificity: 86% and 94%). We have demonstrated that MR relaxometry provides a noninvasive predictive tool to discriminate between EAOC and OE.

Academic Significance and Societal Importance of the Research Achievements

チョコレート嚢胞は頻度の高い疾患で、チョコレート嚢胞から発症しやすい卵巣明細胞腺癌は特に我が国で発生頻度が高く一般的な上皮性卵巣癌と比較して抗癌剤抵抗性を示し、予後不良なことが知られている。そのため、本研究により、癌化の過程で鉄濃度の変化がおこるメカニズムが証明できれば、腫瘍内の鉄濃度測定により癌化のリスク評価もできるようになり、さらには癌化の予防法の開発に繋がる可能性も秘めている。また、肝臓の鉄沈着は肝癌発生のリスクである、といった「鉄と発癌」の関係が示唆されている他の臓器にも応用できる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Journal Article] Comparison of redox parameters in ovarian endometrioma and its malignant transformation2018

    • Author(s)
      Fujimoto Yoshikatsu、Imanaka Shogo、Yamada Yuki、Ogawa Kenji、Ito Fuminori、Kawahara Naoki、Yoshimoto Chiharu、Kobayashi Hiroshi
    • Journal Title

      Oncology Letters

      Volume: 16 Pages: 5257-5264

    • DOI

      10.3892/ol.2018.9242

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis2018

    • Author(s)
      Kobayashi Hiroshi、Yamada Yuki、Kawahara Naoki、Ogawa Kenji、Yoshimoto Chiharu
    • Journal Title

      Oncology Letters

      Volume: 17 Pages: 1196-1202

    • DOI

      10.3892/ol.2018.9721

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis2018

    • Author(s)
      Kobayashi Hiroshi、Yamada Yuki、Kawahara Naoki、Ogawa Kenji、Yoshimoto Chiharu
    • Journal Title

      Oncology Reports

      Volume: 41 Pages: 1729-1738

    • DOI

      10.3892/or.2018.6946

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of M2 macrophages expressing heme oxygenase-1 in malignant transformation of ovarian endometrioma2018

    • Author(s)
      Yamada Y.Uchiyama T., Ito F., Kawahara N., Ogawa K., Obayashi C., Kobayashi H.
    • Journal Title

      Pathol Res Pract.

      Volume: 215 Issue: 4 Pages: 639-643

    • DOI

      10.1016/j.prp.2018.12.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis2017

    • Author(s)
      Yoshimoto C, Takahama J, Iwabuchi T, Uchikoshi M, Shigetomi H, Kobayashi H.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 16 Issue: 2 Pages: 137-145

    • DOI

      10.2463/mrms.mp.2016-0028

    • NAID

      130005589292

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyst fluid hemoglobin species in endometriosis and its malignant transformation:The role of metallobiology.2016

    • Author(s)
      Iwabuchi T, Yoshimoto.C, Shigetomi H, Kobayashi H.
    • Journal Title

      Oncology Letters

      Volume: 11 Issue: 5 Pages: 3384-3388

    • DOI

      10.3892/ol.2016.4383

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 新規MRI技術を活用したチョコレート嚢胞の癌化の早期発見法2016

    • Author(s)
      5.重富洋志,高濱潤子,岩渕拓也,打越雅人,岩井加奈,新納恵美子,伊東史学,吉元千陽,棚瀬康仁,春田祥治,川口龍二,佐道俊幸,小林 浩,吉川公彦
    • Journal Title

      産婦人科の進歩

      Volume: 68 Pages: 347-349

    • NAID

      130005277034

    • Related Report
      2016 Research-status Report
  • [Presentation] 卵巣チョコレート嚢胞の癌化の鑑別におけるMR スペクトロスコピーの有用性2018

    • Author(s)
      河原直紀, 小川憲二,山田有紀,吉元千陽,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮内膜症の癌化におけるヘムオキシゲナーゼ1(HO-1)の抗酸化作用2018

    • Author(s)
      小川憲二, 山田有紀,河原直紀,吉元千陽,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] MRスペクトロスコピーを用いた卵巣チョコレート嚢胞の癌化の新たな鑑別法2018

    • Author(s)
      河原直紀,小川憲二,山田有紀,吉元千陽,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第138回近畿産科婦人科学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] MRスペクトロスコピー/近赤外線を用いたチョコレート嚢胞の癌化の新規診断法2018

    • Author(s)
      小川憲二,河原直紀,山田有紀,吉元千陽,川口龍二,佐道俊幸,小林 浩
    • Organizer
      平成30年度奈良県産婦人科医会総会ならびに学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 卵巣チョコレート嚢胞の癌化の鑑別にMR スペクトロスコピーが有用であった2症例2018

    • Author(s)
      河原直紀,小川憲二,山田有紀,吉元千陽,小林 浩
    • Organizer
      第60回日本婦人科腫瘍学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮内膜症の癌化:臨床へのトランスレーショナルリサーチ2018

    • Author(s)
      小林 浩
    • Organizer
      子宮内膜症若手医師セミナーin 米子
    • Related Report
      2018 Annual Research Report
  • [Presentation] Role of heme oxygenase 1(ho-1) in malignant transformation of ovarian endometriosis.2018

    • Author(s)
      Ogawa K, Yamada Y, Kawahara N, Yoshimoto C, Kawaguchi R, Sado T, Kobayashi H
    • Organizer
      The 17th Biennial Meeting of the International Gynecologic Cancer Society (IGCS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヘムオキシゲナーゼ1(HO-1)の抗酸化作用と子宮内膜症の癌化との関連2018

    • Author(s)
      小川憲二,山田有紀,内山智子,岩淵拓也,河原直紀,吉元千陽,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第39回日本エンドメトリオーシス学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] MR スペクトロスコピーを用いた卵巣チョコレート嚢胞の癌化の新たな鑑別法2018

    • Author(s)
      河原直紀,小川憲二,山田有紀,吉元千陽,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第39回日本エンドメトリオーシス学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Redox balance and heme oxygenase 1 state in iron-induced carcinogenesis in ovarian endometrioma.2017

    • Author(s)
      Ito F, Yamada Y, Yoshimoto C, Shigetomi H, Kawaguchi R, Fujii E, Sado T, Kobayashi H.
    • Organizer
      第69回 日本産科婦人科学会学術講演会
    • Place of Presentation
      広島
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Noninvasive diagnosis of malignant transformation of ovarian endometrioma: A study on metallobiology.2017

    • Author(s)
      Ito F, Yoshimoto C, Takahama J, Iwabuchi T, Yamada Y, Shigetomi H, Tanase Y, Kawaguchi R, Sado T, Kobayashi H.
    • Organizer
      The 56th Annual Congress & The 6th International Symposium of TAOG
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Redox balance and heme oxygenase 1 s tate in iron-induced carcinogenesis in ovarian endometrioma.2017

    • Author(s)
      Ito F, Yamada Y, Yoshimoto C, Shigetomi H, Kawaguchi R, Fujii E, Sado T, Kobayashi H.
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮内膜症性嚢胞の癌化におけるヘムオキシゲナーゼ1(HO-1)の役割2017

    • Author(s)
      山田有紀,吉元千陽,内山智子,岩渕拓也,小川憲二,河原直紀,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第22回日本病態プロテアーゼ学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮内膜症性嚢胞の微小環境におけるヘムオキシゲナーゼ(HO-1)の役割2017

    • Author(s)
      山田有紀, 小川憲二,吉元千陽,内山智子,岩渕拓也,河原直紀,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第16回日本婦人科がん分子標的研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 卵巣内膜症性嚢胞癌化におけるレドックス制御 Redox regulation in malignant transformation of endometriotic cyst2016

    • Author(s)
      伊東史学,吉元千陽,重富洋志,小林 浩
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] A new MRI sequence to discriminatebetween benign endometriotic cysts and endometriosis-associated ovarian cancer.2016

    • Author(s)
      Ito F, Yoshimoto C, Takahama J, Yamada Y, Shigetomi H, Tanase Y, Kawaguchi R, Sado T, Kobayashi H
    • Organizer
      5th Asian Congerence on Endometriosis(ACE2016)
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-09-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] チョコレート嚢胞癌化におけるヘムオキシナーゼ1の動態2016

    • Author(s)
      伊東史学,内山智子,岩渕拓也,山田有紀,吉元千陽,重富洋志,川口龍二,佐道俊幸,小林 浩
    • Organizer
      JSAWI第17回シンポジウム
    • Place of Presentation
      淡路
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 内膜症性嚢胞癌化におけるヘム鉄を中心としたレドックス動態2016

    • Author(s)
      伊東史学,吉元千陽,岩渕拓也,岩井加奈,山田有紀,重富洋志,棚瀬康仁,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第15回日本婦人科がん分子標的研究会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-19
    • Related Report
      2016 Research-status Report
  • [Presentation] チョコレート嚢胞液中の鉄代謝物は子宮内膜症性良性腫瘍の悪性化を評価するためのバイオマーカーとして有用である Iron related metabolites in cyst fluid as useful biomarkers to distinguish malignant transformation from benign endometriotic cysts.2016

    • Author(s)
      岩渕拓也,吉元千陽,北條 渉,伊東史学,小林 浩
    • Organizer
      第27回日本微量元素学会
    • Place of Presentation
      京都
    • Year and Date
      2016-07-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ヘムに着目した内膜症性嚢胞の癌化2016

    • Author(s)
      伊東史学,吉元千陽,岩渕拓也,岩井加奈,山田有紀,重富洋志,棚瀬康仁,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第58回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      鳥取
    • Year and Date
      2016-07-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 内膜症性嚢胞癌化におけるレドックス制御2016

    • Author(s)
      伊東史学,吉元千陽,岩渕拓也,高濱潤子,重光愛子,赤坂珠理晃, 重富洋志,棚瀬康仁,成瀬勝彦,川口龍二,佐道俊幸,小林 浩
    • Organizer
      第21回生殖医学フォーラム
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Magnetic resonance spectroscopy can be used to discriminate between benign endometriotic cysts and endometriosis associated ovarian cancer.2016

    • Author(s)
      Ito F, Yoshimoto C, Shigetomi H, Tanase Y, Haruta S, Kawaguchi R, Sado T, Kobayashi H.
    • Organizer
      第68回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Remarks] 婦人科研究紹介

    • URL

      https://nara-obgyn.com/gynecology_research/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi