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Development of a measurement apparatus "Sweep Frequency Impedance Meter (SFI)", which diagnoses middle and inner ear dysfunctions

Research Project

Project/Area Number 16K11194
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionTohoku Bunka Gakuen University

Principal Investigator

Wada Hiroshi  東北文化学園大学, 健康社会システム研究科, 教授 (30111264)

Co-Investigator(Kenkyū-buntansha) 濱西 伸治  仙台高等専門学校, 総合工学科, 准教授 (00374968)
村越 道生  金沢大学, フロンティア工学系, 准教授 (70570901)
Research Collaborator KEI Joseph  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords診断装置 / 中耳・内耳 / SFI / 聴覚医学
Outline of Final Research Achievements

Conventional fixed-frequency tympanometry has been widely used and has especially been acknowledged as a valuable method for the diagnosis of secretory otitis media. However, the use of conventional fixed-frequency tympanometry has been demonstrated as too inaccurate for diagnosis of other middle ear dysfunctions.
In our research, an attempt was made to develop a measuring apparatus : Sweep Frequency Impedance Meter (SFI). Considering acoustic and structural resonance effects upon the frequency characteristics of an SFI probe tip, it was designed to have flat frequency characteristics at frequencies of 0.1 - 6.0 kHz. The dynamic characteristics of ears of human subjects were measured using this apparatus. Subsequently, measurement results were compared with results of numerical simulations.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したSFIでヒトの耳を計測すると,これまで十分に解明されてこなかった,周波数領域0.1 kHzから6.0 kHzでの中耳動特性が明らかとなる.さらに,このSFIで中耳・内耳疾患を計測すると,中耳・内耳疾患をかなりの精度で診断できるようになる.このSFIは,将来的には中耳・内耳疾患の診断装置と新生児の難聴スクリーニング用装置になる可能性を秘めている.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (58 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (9 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (37 results) (of which Int'l Joint Research: 11 results,  Invited: 7 results) Book (1 results) Remarks (5 results)

  • [Int'l Joint Research] クインズランド大学/タウンズビル病院(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] スタンダード大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] クインズランド大学/タウンズビル病院(オーストラリア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] スタンフォード大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] クインズランド大学/タウンズビル病院(オーストラリア)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] スダンフォード大学(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Predictive Accuracy of Sweep Frequency Impedance Technology in Identifying Conductive Conditions in Newborns2018

    • Author(s)
      Aithal V, Kei J, Driscoll C, Murakoshi M, Wada H
    • Journal Title

      Journal of the American Academy of Audiology

      Volume: 29 Issue: 2 Pages: 106-117

    • DOI

      10.3766/jaaa.16077

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sweep frequency impedance measures in young infants: developmental characteristics from birth to 6 months2017

    • Author(s)
      Venkatesh Aithal, Joseph Kei, Carlie Driscoll, Michio Murakoshi and Hiroshi Wada
    • Journal Title

      International Journal of Audiology

      Volume: 56 Issue: 3 Pages: 154-163

    • DOI

      10.1080/14992027.2016.1244867

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of (2-aminophenyl) methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells2017

    • Author(s)
      Wataru Nabeyama, Kenji Ishihara, Hyun Seung Ban, Hiroshi Wada, Hiroyuki Nakamura
    • Journal Title

      Bioorganic & Medical Chemistry

      Volume: 25 Pages: 2601-2608

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis by finite element method of dynamic characteristics of the external ear canal in neonates2017

    • Author(s)
      Michio MURAKOSHI, Shohei TAKEDA and Hiroshi WADA
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 12 Issue: 2 Pages: 16-00596-16-00596

    • DOI

      10.1299/jbse.16-00596

    • NAID

      130005695185

    • ISSN
      1880-9863
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis by sweep frequency impedance (SFI) meter of 226-Hz and 1,000-Hz tympanometries in neonates2017

    • Author(s)
      Michio Murakoshi, Kyosuke Sano, Nattikan Kanka, Naoto Yoshida, Shinji Hamanishi, Hiromichi Kiyokawa, Risako Kakuta, Sreedevi Aithale, Venkatesh Aithale, Joseph Kei, Carlie Driscoll, Andrew Swanston, Sachiko Matsutani, Toshimitsu Kobayashi and Hiroshi Wada
    • Journal Title

      Procedia IUTAM

      Volume: 24 Pages: 5-14

    • DOI

      10.1016/j.piutam.2017.08.038

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 聴覚のメカニクスに学ぶ -内耳組織から膜タンパク質まで-(Learn from the mechanics of hearing -From the inner ear tissue to the membrane protein-)2017

    • Author(s)
      村越道生
    • Journal Title

      応用物理学会有機分子・バイオエレクトロニクス分科会研究会会誌

      Volume: 28 Pages: 4-8

    • Related Report
      2017 Research-status Report
  • [Journal Article] 三列に並ぶ外有毛細胞の役割とその分子構造(The role of the outer hair cells stacked in three rows and its molecular structure)2017

    • Author(s)
      村越道生
    • Journal Title

      日本音響学会誌

      Volume: 73 Pages: 662-669

    • Related Report
      2017 Research-status Report
  • [Journal Article] Mechanics of inner and outer hair cells2016

    • Author(s)
      和田仁
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 59 Issue: 3 Pages: 161-169

    • DOI

      10.4295/audiology.59.161

    • NAID

      130005282000

    • ISSN
      0303-8106, 1883-7301
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of ear canal static pressure on the dynamic behaviour of outer and middle ear in newborns2016

    • Author(s)
      Venkatesh Aithal, Joseph Kei, Carlie Driscoll, Michio Murakoshi, Hiroshi Wada
    • Journal Title

      International Journal of Pediatric Otorhinolaryngology

      Volume: 82 Pages: 64-72

    • DOI

      10.1016/j.ijporl.2015.12.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 聴覚過敏関連遺伝子欠損マウスを用いた聴覚機能の解析2019

    • Author(s)
      秋元将吾,濱西伸治,霜田靖
    • Organizer
      第24回高専シンポジウムin Oyama,2019年1月26日,小山
    • Related Report
      2018 Annual Research Report
  • [Presentation] 眼電図( EOG )を用いた ALS 患者におけるコミュニケーションツールの開発2019

    • Author(s)
      作田和輝, 渡邊隆, 濱西伸治
    • Organizer
      日本機械学会 東北学生会 第49 回学生員卒業研究発表講演会,2019年3月5日,秋田
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中耳腔が中耳動特性に与える影響2019

    • Author(s)
      南條真友子, 濱西伸治 , 和田仁
    • Organizer
      日本機械学会 東北学生会 第49 回学生員卒業研究発表講演会,2019年3月5日,秋田
    • Related Report
      2018 Annual Research Report
  • [Presentation] 有限要素モデルによる中耳・内耳病変診断装置用プローブの検討2018

    • Author(s)
      濱西伸治,村越道生,和田仁
    • Organizer
      日本機械学会第31回バイオエンジニアリング講演会,郡山,2018年12月14-15日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 防具モデル用いた面打撃シミュレーション2018

    • Author(s)
      濱西伸治
    • Organizer
      第51回 日本武道学会,2018年9月4日,東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characteristics of the external- and middle-ear dynamics in neonates2018

    • Author(s)
      Murakoshi M, Aithal V, Hamanishi S, Kei J, Wada H
    • Organizer
      The 8th International Symposium on Middle-Ear Mechanics in Research and Otology (MEMRO2018), July 5-9, 2018, Shanghai, China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of chronological age on neonatal tympanogram with 226-Hz probe tone2018

    • Author(s)
      Kanka N, Murakoshi M, Hamanishi S, Wada H
    • Organizer
      The 8th International Symposium on Middle-Ear Mechanics in Research and Otology (MEMRO2018), July 5-9, 2018, Shanghai, China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新生児のための聴覚スクリーニング装置の開発(Development of a hearing screening system for newborns)2018

    • Author(s)
      村越道生,濱西伸治,和田仁
    • Organizer
      第57回日本生体医工学会大会,札幌,2018年6月19-21日
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cochlear amplifierの温故知新(Cochlear amplifier: past, present and future)2018

    • Author(s)
      村越道生
    • Organizer
      第66回聴覚生理研究会,日本聴覚医学会,2018年10月18日,神戸
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生後数日から半年までの新生児の外耳及び中耳の動特性解析(Analysis of the dynamic behavior of the external and middle ears in neonates from a few days to 6 months)2018

    • Author(s)
      村越道生,和田仁
    • Organizer
      第63回日本聴覚医学会総会・学術講演会,神戸,2018年10月17-19日
    • Related Report
      2018 Annual Research Report
  • [Presentation] Que sera, sera (Whatever will be, will be)2018

    • Author(s)
      村越道生
    • Organizer
      第1回出藍会総会,若手・学生による座談会,日本機械学会第29回バイオフロンティア講演会,2018年10月24-25日,千葉
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新生児聴覚スクリーニング(NHS)用広域周波数インピーダンスメーターの開発(Development of a wideband frequency impedance meter for neonatal hearing screening (NHS))2018

    • Author(s)
      山田健吾,村越道生,和田仁
    • Organizer
      日本機械学会第31回バイオエンジニアリング講演会,郡山,2018年12月14-15日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 剣道打撃時の骨導に及ぼす頭部軟組織の影響2018

    • Author(s)
      菊地航平,濱西伸治
    • Organizer
      日本機械学会 東北学生会 第48 回学生員卒業研究発表講演会,福島県郡山市,2018年3月7日
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨導マップによる剣道難聴発生メカニズムの解明2017

    • Author(s)
      濱西伸治,KIM Namkeun,青木良浩,和田仁
    • Organizer
      第29回バイオエンジ二アリング講演会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Year and Date
      2017-01-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Difference in the dynamic behavior of the hearing apparatus between neonates and adults: the effects on tympanometry2017

    • Author(s)
      Murakoshi M, Hamanishi S, Wada H
    • Organizer
      The XXVI Congress of the International Society of Biomechanics (ISB2017) incorporating the 9th Asian-Pacific Conference on Biomechanics (AP Biomech 2017), July 23-27, 2017, Brisbane, Australia
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dynamic characteristics of neonatal ear up to 6 kHz using a finite element modeling approach2017

    • Author(s)
      Hamanishi S, Murakoshi M, Wada H
    • Organizer
      The XXVI Congress of the International Society of Biomechanics (ISB2017) incorporating the 9th Asian-Pacific Conference on Biomechanics (AP Biomech 2017), July 23-27, 2017, Brisbane, Australia
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decipherment of the membrane structure of the inner ear motor protein prestin by force spectroscopy2017

    • Author(s)
      Murakoshi M, Wada H
    • Organizer
      The 5th Switzerland-Japan Workshop on Biomechanics (SJB2017), September 14-17, 2017, Zermatt, Switzerland
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic characteristic changing of the external ear canal wall with an increase in neonatal chronological age2017

    • Author(s)
      Nattikan K, Murakoshi M, Hamanishi S, Wada H
    • Organizer
      The 5th Switzerland-Japan Workshop on Biomechanics (SJB2017), September 14-17, 2017, Zermatt, Switzerland
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CHO細胞を用いたHisタグ標識プレスチン発現システムの構築(Construction of an expression system of the His-tagged prestin using Chinese hamster ovary cells)2017

    • Author(s)
      勝田廉弥,村越道生,松崎健一郎,和田仁
    • Organizer
      日本機械学会第29回バイオエンジニアリング講演会,名古屋,2017年1月19-20日
    • Related Report
      2017 Research-status Report
  • [Presentation] 外傷刺激による内耳外有毛細胞傷害が引き起こすコルチ器の動的挙動解析(Numerical analysis of the changes in the dynamic behavior of the organ of Corti caused by the cochlear outer hair cell injury due to traumatic stimuli)2017

    • Author(s)
      並河伶弥,松崎健一郎,村越道生
    • Organizer
      日本機械学会九州学生会第48回卒業研究発表講演会,那覇,2017年3月3日
    • Related Report
      2017 Research-status Report
  • [Presentation] 聴覚のメカニクスに学ぶ -内耳組織から膜タンパク質まで-2017

    • Author(s)
      村越道生
    • Organizer
      応用物理学会有機分子・バイオエレクトロニクス分科会研究会「有機分子・バイオエレクトロニクスの最新動向と応用展開」,2017年6月6日,北九州
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 内耳タンパク質モータープレスチンを安定発現する哺乳動物細胞株の構築(Construction of a mammalian cell line stably expressing the inner-ear motor protein prestin)2017

    • Author(s)
      村越道生,和田仁
    • Organizer
      第62回日本聴覚医学会総会・学術講演会,福岡,2017年10月18-20日
    • Related Report
      2017 Research-status Report
  • [Presentation] Avi タグ標識プレスチン発現 CHO 細胞の構築とフローサイトメトリーによる高発現株の選択(Establishment of CHO cells expressing Avi-tagged prestin and selection of high expressing lines by flow cytometry)2017

    • Author(s)
      松野光太郎,松崎健一郎,村越道生
    • Organizer
      日本機械学会第28回バイオフロンティア講演会,徳島,2017年10月27-29日
    • Related Report
      2017 Research-status Report
  • [Presentation] サリチル酸誘導体による感音難聴を引き起こすペンド変異の局在回復(Restoration of localization pendrin mutants causing sensorineural hearing loss by salicylate derivatives)2017

    • Author(s)
      茶縁泰樹,松崎健一郎,村越道生
    • Organizer
      日本機械学会第28回バイオフロンティア講演会,徳島,2017年10月27-29日
    • Related Report
      2017 Research-status Report
  • [Presentation] 聴覚のメカニズムとその計測・制御(Hearing mechanism and its measurement and control)2017

    • Author(s)
      村越道生
    • Organizer
      SICE九州フォーラム2017,鹿児島,2017年11月24日
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] アフィニティタグ標識された遺伝子組換え内耳モータータンパク質のCHO発現システムの構築(Development of CHO expression systems of recombinant inner-ear motor proteins having different affinity tags)2017

    • Author(s)
      村越道生,和田仁
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会,京都,2017年12月14-15日
    • Related Report
      2017 Research-status Report
  • [Presentation] 出後から6か月までの新生児外耳道壁の動的特性変化(Changes of dynamic characteristics in the neonatal external ear canal wall from birth to 6 months)2017

    • Author(s)
      カンカー・ナッティカーン,村越道生,濱西伸治,和田仁
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会,京都,2017年12月14-15日
    • Related Report
      2017 Research-status Report
  • [Presentation] Impact-induced bone conduction simulation to determine the cause of hearing loss in kendo players2017

    • Author(s)
      Hamanishi S, Namkeun K, Mo S
    • Organizer
      2017 International Budo Conference, Sept. 6-7, 2017, Osaka, Japan
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improvement of skills in interactive teaching through objective and quantitative evaluation by students and teachers2017

    • Author(s)
      Wako K, Sekido M, Hamanishi S, Okumura M, Takeda J, Ishi H, Miyazaki Y, Hongo S, Sakuraba H, Yamada H, Yairi S, Yagyu H, Matsubara M, Suzuki K, Tanaka Y, Oshima M
    • Organizer
      11th International Symposium on Advances in Technology Education (ISATE2017), Sept. 19-21, 2017, Singapore
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 聴覚の工学的考察とその応用2017

    • Author(s)
      村越道生
    • Organizer
      一般社団法人近畿化学協会エレクトロニクス部門平成28年度第3回研究会
    • Place of Presentation
      大阪科学技術センター(大阪)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 外有毛細胞の損失による聴力低下メカニズム -有限要素法を用いた解析-2016

    • Author(s)
      村越道生,和田仁
    • Organizer
      第61回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      盛岡グランドホテル(盛岡)
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Dynamic characteristics of the outer and middle ears in neonates2016

    • Author(s)
      Hiroshi Wada, Michio Murakoshi, Venkatesh Aithal, Joseph Kei, Shinji Hamanishi, Carlie Driscoll, Andrew Swanston
    • Organizer
      33rd World Congress of Audiology
    • Place of Presentation
      Vancouver (Canada)
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 内・外有毛細胞のメカニクス2016

    • Author(s)
      和田仁
    • Organizer
      日本音響学会2016年秋季研究発表会
    • Place of Presentation
      富山大学(富山市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Physiological and computational approaches to determine the cause of hearing loss in Kendo players2016

    • Author(s)
      Shinji Hamanishi, Namkeun Kim, Yoshihiro Aoki, Hiroshi Wada
    • Organizer
      IUTAM Symposium on Advances in Biomechanics of Hearing
    • Place of Presentation
      Stuttgart (Germany)
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of neonatal tympanometry using SFI data2016

    • Author(s)
      Michio Murakoshi, Nattikan Kanka, Shinji Hamanishi, Hiroshi Wada
    • Organizer
      IUTAM Symposium on Advances in Biomechanics of Hearing
    • Place of Presentation
      Stuttgart (Germany)
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新生児の中耳動特性解析 -Sweep Frequency Impedance(SFI)メータを用いて-2016

    • Author(s)
      和田仁,松谷幸子,小林俊光,清川裕道,角田梨紗子,村越道生,濱西伸治,Venkatesh Aithal, Joseph Kei
    • Organizer
      日本聴覚医学会 第11回ERA・OAE研究会
    • Place of Presentation
      慶應義塾大学病院(東京)
    • Related Report
      2016 Research-status Report
  • [Presentation] 三列に並ぶ外有毛細胞の協調運動と蝸牛増幅2016

    • Author(s)
      村越道生,和田仁
    • Organizer
      日本聴覚医学会 第11回ERA・OAE研究会
    • Place of Presentation
      慶應義塾大学病院(東京)
    • Related Report
      2016 Research-status Report
  • [Book] 聴覚検査の実際  改訂4版 第I部 聴覚検査の予備知識 3. 音の基礎知識2017

    • Author(s)
      和田仁
    • Total Pages
      6
    • Publisher
      南山堂
    • ISBN
      9784525370442
    • Related Report
      2017 Research-status Report
  • [Remarks] 東北文化学園大学科学技術学部知能情報システム学科和田研究室

    • URL

      http://web.tbgu.ac.jp/ait/wada/index.html

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Remarks] 金沢大学理工研究域フロンティア工学系生体機械工学研究室

    • URL

      http://www.me.se.kanazawa-u.ac.jp/biomech/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 仙台高等専門学校 名取キャンパス 教員業績公開(濱西伸治)

    • URL

      http://natori.sendai-nct.ac.jp/cgi-bin/list/list.cgi?id=7&mode=show

    • Related Report
      2018 Annual Research Report
  • [Remarks] 鹿児島大学工学部機械工学科村越研究室

    • URL

      http://www.mech.kagoshima-u.ac.jp/~michio/

    • Related Report
      2017 Research-status Report
  • [Remarks] 仙台高等専門学校 名取キャンパス 教員業績公開(濱西伸治)

    • URL

      https://www.sendai-nct.ac.jp/wp-content/themes/omc/files/college/113_03_02.pdf

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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