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Etiology and prognostic value of VZV-specific cell-mediated immunity in Ramsay Hunt syndrome

Research Project

Project/Area Number 16K11201
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionOsaka Medical College

Principal Investigator

Haginomori Shin-Ichi  大阪医科大学, 医学部, 教授 (90291799)

Co-Investigator(Kenkyū-buntansha) 櫟原 崇宏  大阪医科大学, 医学部, 助教 (20624240)
和田 晋一  香川県立保健医療大学, 保健医療学部, 准教授 (80784355)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsRamsay Hunt症候群 / 顔面神経麻痺 / 水痘・帯状疱疹ウイルス / 細胞性免疫 / ウイルス再活性化 / Hunt症候群 / 細胞性免疫能 / 発症機序 / 免疫学 / ウィルス / 神経科学
Outline of Final Research Achievements

The aim of this study was to clarify the characteristics of the VZV-specific cell-mediated immunity (CMI) in Hunt syndrome compared to that in Bell's palsy, and to obtain its role in the development of Hunt syndrome.
We measured the VZV-specific CMI of peripheralblood mononuclear cells using ELOSPOT assay. As the results, VZV-specific CMI in Hunt syndrome is low at disease onset and increases rapidly thereafter, then decreases gradually. In contrast, there was no correlation between the CMI and days from the onset in the Bell's palsy.
Consequently, reduced VZV-specific CMI may play an important role in the reactivation of VZV in the facial nerve, leading to Hunt syndrome. There was no relationship observed between the CMI and prognosis of Hunt syndrome.

Academic Significance and Societal Importance of the Research Achievements

Hunt症候群は予後不良な顔面神経麻痺である。現在の治療法では改善に限界があり、今後は発症予防に軸足を置く必要がある。本研究ではHunt症候群の発症にVZV特異的細胞性免疫能の低下が関与すること、また発症後急激に上昇した免疫能は徐々に低下することが明らかになった。2014年より小児における水痘ワクチンが定期接種化され、水痘患者は減少した。他方、水痘患者に接する機会が減少しVZV特異的細胞性免疫能の低下した成人において、今後Hunt症候群が増加する可能性が高い。Hunt症候群を始め帯状疱疹などVZV再活性化による疾患を予防するため、成人における帯状疱疹ワクチン接種の推進が重要と考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (35 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (20 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] ワクチン接種歴のある男児に発症した髄膜炎を伴う不全型Ramsay Hunt症候群例2020

    • Author(s)
      菊岡祐介,萩森伸一,綾仁悠介,鈴木 学,河田 了
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 113 Pages: 359-363

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 顔面神経麻痺の診断と治療~笑顔を取り戻すために~2019

    • Author(s)
      萩森伸一
    • Journal Title

      大阪医科大学雑誌

      Volume: 78 Pages: 89-95

    • NAID

      40022161960

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 末梢性顔面神経麻痺の予後予測2019

    • Author(s)
      綾仁悠介、萩森伸一、谷内政崇、尾崎昭子、乾 崇樹、稲中優子、河田 了
    • Journal Title

      Facial N Res Jpn

      Volume: 39 Pages: 131-133

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latency shift in compound muscle action potentials during electroneurography in facial palsy2019

    • Author(s)
      Ayani Y, Haginomori S, Wada S, Nakano H, Hamada M, Ichihara T, Inui T, Inaka Y, Ozaki A, Kawata R
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 276 Issue: 12 Pages: 3281-3286

    • DOI

      10.1007/s00405-019-05634-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroneurography value as an indicator of high risk for the development of moderate-to-severe synkinesis after Bell's palsy and Ramsay Hunt syndrome.2019

    • Author(s)
      Nakano H, Haginomori SI, Wada SI, Ayani Y, Kawata R, Saura R
    • Journal Title

      Acta Otolaryngol

      Volume: 139 Issue: 9 Pages: 823-827

    • DOI

      10.1080/00016489.2019.1633474

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent benign pleomorphic adenoma of the parotid gland: facial nerve identification and risk factors for facial nerve paralysis at reoperation2019

    • Author(s)
      Kuriyama T, Kawata R, Higashino M, Nishikawa S, Inui T, Terada T, Haginomori SI, Kurisu Y, Hirose Y
    • Journal Title

      Auris Nasus Larynx

      Volume: 46 Issue: 5 Pages: 779-784

    • DOI

      10.1016/j.anl.2019.02.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 耳科手術後のめまい・顔面神経麻痺2019

    • Author(s)
      萩森伸一
    • Journal Title

      耳喉頭頸

      Volume: 91 Pages: 292-296

    • Related Report
      2018 Research-status Report
  • [Journal Article] Operative technique for benign submandibular gland mass without identifying the mandibular branch of the facial nerve.2018

    • Author(s)
      Kikuoka Y, Kawata R, Higashino M, Terada T, Haginomori SI
    • Journal Title

      Auris Nasus Larynx

      Volume: 45 Pages: 1221-1226

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顔面神経麻痺を伴った小児急性リンパ性白血病の1例ー診断および治療のピットフォールとその対策ー2018

    • Author(s)
      綾仁悠介、萩森伸一、尾崎昭子、稲中優子、櫟原崇宏、河田 了
    • Journal Title

      Facial N Res Jpn

      Volume: 38 Pages: 152-154

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顔面神経機能検査2018

    • Author(s)
      萩森伸一
    • Journal Title

      日本医師会雑誌

      Volume: 147

    • Related Report
      2018 Research-status Report
  • [Journal Article] 昨年、顔面神経麻痺になりました。繰り返すことはあるでしょうか?2018

    • Author(s)
      萩森伸一
    • Journal Title

      耳喉頭頸

      Volume: 90 Pages: 92-93

    • Related Report
      2018 Research-status Report
  • [Journal Article] A new electroneurography as a prognostic tool for marginal mandibular nerve paralysis after parotid gland surgery: A preliminary evaluation2017

    • Author(s)
      Haginomori SI, Wada SI, Ichihara T, Terada T, Kawata R
    • Journal Title

      Auris Nasus Larynx

      Volume: 印刷中 Issue: 5 Pages: 602-606

    • DOI

      10.1016/j.anl.2017.01.002

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Large Intracavernous carotid artery aneurysm2017

    • Author(s)
      Suzuki M, Haginomori S, Terada T, Inui T, Ayani Y, Ozaki A, Kawata R, Yamamoto K
    • Journal Title

      Otol Neutrotol

      Volume: 38 Issue: 6 Pages: e188-e189

    • DOI

      10.1097/mao.0000000000001443

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顔面神経麻痺に対する電気生理学的検査2017

    • Author(s)
      萩森伸一
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 120 Issue: 10 Pages: 1266-1267

    • DOI

      10.3950/jibiinkoka.120.1266

    • NAID

      130006201570

    • ISSN
      0030-6622, 1883-0854
    • Related Report
      2017 Research-status Report
  • [Journal Article] 難治性の顔面神経麻痺の治療-私の工夫ー2017

    • Author(s)
      萩森伸一
    • Journal Title

      ENTONI

      Volume: 203 Pages: 62-69

    • Related Report
      2017 Research-status Report
  • [Journal Article] 顔面神経麻痺-難治例の診断と治療2017

    • Author(s)
      萩森伸一
    • Journal Title

      大阪府耳鼻咽喉科医会会報

      Volume: 86 Pages: 46-69

    • Related Report
      2017 Research-status Report
  • [Journal Article] 顔面神経麻痺-難治例の診断と治療2017

    • Author(s)
      萩森伸一
    • Journal Title

      大阪府耳鼻咽喉科医会会報

      Volume: 86 Pages: 46-69

    • Related Report
      2016 Research-status Report
  • [Journal Article] Varicella-zoster virus-specific cell-mediated immunity in Ramsay Hunt syndrome2016

    • Author(s)
      Haginomori S, Ichihara T, Mori A, Kanazawa A, Kawata R, Tang H, Mori Y
    • Journal Title

      Laryngoscope

      Volume: 126 Issue: 1

    • DOI

      10.1002/lary.25441

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 大阪医科大学耳鼻咽喉科・頭頸部外科を受診した顔面神経麻痺例の臨床統計2016

    • Author(s)
      櫟原崇宏、萩森伸一、菊岡祐介、金沢敦子、森 京子、和田晋一、河田 了
    • Journal Title

      Facial N Res Jpn

      Volume: 36 Pages: 109-111

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 治療かんら考える顔面神経麻痺の評価と診断2016

    • Author(s)
      萩森伸一
    • Journal Title

      ENTONI

      Volume: 198 Pages: 1-10

    • Related Report
      2016 Research-status Report
  • [Presentation] 水痘ワクチン接種後に不顕性感染から不全型Hunt症候群をきたした一例2019

    • Author(s)
      菊岡祐介、和田將輝、鈴木 学、綾仁悠介、萩森伸一、河田 了
    • Organizer
      第350回日本耳鼻咽喉科学会大阪地方連合会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 顔面神経麻痺の診断と治療~笑顔を取り戻すために~2019

    • Author(s)
      萩森伸一
    • Organizer
      大阪医科大学 令和元年 秋季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 顔面神経麻痺の診断と治療2019

    • Author(s)
      萩森伸一
    • Organizer
      第64回宮崎県耳鼻咽喉科懇話会臨床セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 顔面神経麻痺-評価と治療-2019

    • Author(s)
      萩森伸一
    • Organizer
      平成30年度高槻市医師会耳鼻咽喉科部会講習会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 大阪医科大学耳鼻咽喉科・頭頸部外科を受診した顔面神経麻痺例の臨床統計2018

    • Author(s)
      尾﨑昭子、萩森伸一、稲中優子、綾仁悠介、野呂恵起、櫟原崇宏、河田 了
    • Organizer
      第119回日本耳鼻咽喉科学会総会・学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 顔面神経麻痺を伴った小児急性リンパ性白血病の1例ー診断および治療のピットフォールとその対策ー2018

    • Author(s)
      綾仁悠介、萩森伸一、尾崎昭子、稲中優子、櫟原崇宏、河田 了
    • Organizer
      第41回日本顔面神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 顔面神経麻痺の診断と治療ー笑顔をとり戻すために2018

    • Author(s)
      萩森伸一
    • Organizer
      第31回大阪医大女医会 各科医療勉強会
    • Related Report
      2018 Research-status Report
  • [Presentation] Varicella-zoster virus (VZV)-specific cell-mediated immunity in Ramsay Hunt syndrome2017

    • Author(s)
      Haginomori S, Ichihara T, Ayani Y, Terada T, Kawata R
    • Organizer
      13rd International Facial Nerve Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 顔面神経麻痺の診断と治療ーQOL改善のための総合診療2017

    • Author(s)
      萩森伸一
    • Organizer
      平成29年大阪医科大学仁泉会広島県支部総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] ウイルス性顔面神経麻痺の発症と診断・治療、そして今後の展望2017

    • Author(s)
      萩森伸一
    • Organizer
      ウイルス性顔面神経麻痺研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 顔面神経麻痺の臨床統計2017

    • Author(s)
      尾崎昭子、萩森伸一、綾仁悠介、櫟原崇宏、金沢敦子、河田 了
    • Organizer
      第27回日本耳科学会総会・学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 大阪医科大学耳鼻咽喉科・頭頸部外科を受診した顔面神経麻痺例の臨床統計2016

    • Author(s)
      櫟原崇宏、萩森伸一、菊岡祐介、金沢敦子、森 京子、和田晋一、河田 了
    • Organizer
      第39回日本顔面神経学会
    • Place of Presentation
      大阪市
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 顔面神経麻痺の診断と治療~ヘルペスウイルスをめぐる最近の話題と難治例に対する総合診療~2016

    • Author(s)
      萩森伸一
    • Organizer
      平成28年豊中市医師会第5回学術講演会
    • Place of Presentation
      豊中市
    • Related Report
      2016 Research-status Report
  • [Presentation] 顔面神経麻痺-難治例の診断と治療2016

    • Author(s)
      萩森伸一
    • Organizer
      第115回大阪府耳鼻咽喉科医会講習会
    • Place of Presentation
      大阪市
    • Related Report
      2016 Research-status Report
  • [Remarks] 研究テーマ:顔面神経麻痺発症機序の基礎研究・予後評価の臨床研究

    • URL

      http://oto-osaka-med.jp/introduction/research-theme/

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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